3-deazaneplanocin has been researched along with adenosine in 149 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (3.36) | 18.7374 |
| 1990's | 6 (4.03) | 18.2507 |
| 2000's | 11 (7.38) | 29.6817 |
| 2010's | 104 (69.80) | 24.3611 |
| 2020's | 23 (15.44) | 2.80 |
| Authors | Studies |
|---|---|
| Arnett, G; Fuller, RW; Goldstein, BM; Haines, DR; Hollingshead, M; Marquez, VE; McPherson, H; Parsons, JL; Shannon, WM; Tseng, CK | 1 |
| Balzarini, J; Borchardt, RT; Borcherding, DR; Cools, M; De Clercq, E; Drach, JC; Kitaoka, S; Konno, T; Marquez, VE | 1 |
| De Clercq, E | 2 |
| Chiang, PK; Glazer, RI; Hartman, KD; Knode, MC; Marquez, VE; Richard, MM; Tseng, CK | 1 |
| Glazer, RI; Haines, DR; Knode, MC; Marquez, VE; Tseng, CK | 1 |
| Bu, G; Oxenrider, KA; Sitz, TO | 1 |
| Tsiftsoglou, AS; Vizirianakis, IS | 2 |
| De Clercq, E; González, M; Jashés, M; López-Lastra, M; Sandino, A | 1 |
| Clark, SH; Hamre, MR; Mirkin, BL | 1 |
| Cheong, CH; Hong, SH; Jeong, SY; Kim, HS; Kim, IK; Lee, JH | 1 |
| Avila, A; Avila, JL; Marquez, VE; Polegre, MA | 1 |
| Bray, M; Driscoll, J; Huggins, JW | 1 |
| Bray, M | 1 |
| Baker, RO; Bray, M; Geisbert, T; Raymond, JL | 1 |
| Chen, W; Jiang, X; Karuturi, RK; Lee, PL; Liu, ET; Tan, J; Tan, PB; Yang, X; Yu, Q; Zhuang, L | 1 |
| Chan, MT; Cheyette, BN; Jiang, X; Kivimäe, S; Lee, PL; Li, J; Liu, ET; Stanton, LW; Tan, J; Yang, X; Yu, Q; Zhuang, L | 1 |
| Abe, M; Cortez, CC; Jones, PA; Kelly, TK; Liang, G; Marquez, VE; Miranda, TB; Yoo, CB | 1 |
| Atadja, P; Balusu, R; Bhalla, KN; Buckley, KM; Chen, J; Fernandez, P; Fiskus, W; Jillella, A; Koul, S; Marquez, VE; Rao, R; Shi, H; Sreekumar, A; Ustun, C; Wang, Y | 1 |
| Cornelissen-Steijger, P; Drost, R; Evers, B; Jonkers, J; Joosse, SA; Liu, X; Nederlof, P; Pietersen, AM; Puppe, J; van Lohuizen, M; Yu, Q | 1 |
| Chan, E; Marquez, VE; Sun, F; Wu, Z; Yang, X; Yu, Q | 1 |
| Crabb, SJ; Hayden, A; Johnson, PW; Packham, G | 1 |
| Agarwal, P; Atadja, P; Deleu, S; Eriksson, M; Fristedt, C; Fryknäs, M; Jernberg-Wiklund, H; Kalushkova, A; Lemaire, M; Nilsson, K; Oberg, F; Osterborg, A; Vanderkerken, K | 1 |
| Chan, E; Ong, JC; Sun, F; Yu, Q | 1 |
| Choi, YL; Hasegawa, H; Hayashi, T; Imaizumi, Y; Kamihira, S; Mano, H; Marquez, VE; Miyazaki, Y; Moriwaki, Y; Osaka, A; Sasaki, D; Tsukasaki, K; Yamada, Y; Yanagihara, K | 1 |
| Ciechanover, A; de Bie, P; Marquez, VE; Sadeh, R; Zoabi, M | 1 |
| Chiba, T; Imazeki, F; Iwama, A; Kanai, F; Konuma, T; Miyagi, S; Negishi, M; Saraya, A; Suzuki, E; Tada, M; Tanaka, S; Yokosuka, O | 1 |
| Bi, C; Chen, CS; Cheong, LL; Chng, WJ; Huang, G; Liu, SC; Xie, Z; Yu, Q; Zhou, J | 1 |
| Bi, C; Cheong, LL; Chng, WJ; Koh, TL; Liu, SC; Mahara, S; Tay, KG; Yu, Q; Zhou, J | 1 |
| Balasubramanian, S; Chew, YC; Choudhury, SR; Eckert, RL; Han, B; Marquez, VE | 1 |
| Carmona, FJ; Esteller, M; Fernandez, AF; Imai, K; Jacinto, FV; Marquez, VE; Puertas, S; Shinomura, Y; Taniguchi, H; Villanueva, A; Yamamoto, H | 1 |
| Boeckel, JN; Bonig, H; Dimmeler, S; Farcas, R; Koyanagi, M; Marquez, VE; Ohtani, K; Urbich, C; Vlachojannis, GJ; Zeiher, AM | 1 |
| Bueno, R; De Rienzo, A; Fetsch, P; Filie, A; Hong, JA; Inchauste, S; Kemp, CD; Liu, F; Mani, H; Marquez, VE; Mathur, A; Meltzer, PA; Rao, M; Ripley, RT; Schrump, DS; Walker, RL; Xi, S; Yang, M; Zhang, M; Zhu, YJ | 1 |
| Clark, AT; Diaz Perez, SV; Kim, R; Li, Z; Marquez, VE; Patel, S; Plath, K | 1 |
| Chan, E; Li, J; Sun, F; Yu, Q | 1 |
| Crea, F; Danesi, R; Marquez, VE; Paolicchi, E | 1 |
| Chinnaiyan, AM; He, S; Kato, K; Kuick, R; Liu, Y; Mani, RS; Marquez, VE; Mineishi, S; Mochizuki, K; Nieves, E; Varambally, S; Wang, J; Xie, F; Zhang, Y | 1 |
| Kim, JH; Shin, YJ | 1 |
| Alimova, I; Dubuc, A; Foreman, NK; Harris, P; Marquez, VE; Northcott, PA; Taylor, MD; Venkataraman, S; Vibhakar, R | 1 |
| Amanatiadou, EP; Tezias, SS; Tsiftsoglou, AS; Vizirianakis, IS | 1 |
| Li, X; Xu, F | 1 |
| Avan, A; Crea, F; Danesi, R; Funel, N; Galvani, E; Giovannetti, E; Honeywell, RJ; Marquez, VE; Paolicchi, E; Peters, GJ | 1 |
| Bay, BH; Cheng, LL; Chia, NY; Itahana, K; Itahana, Y; Lei, ZD; Pandey, A; Rozen, S; Tan, P; Tan, PH; Thike, AA; Voorhoeve, PM; Wu, Y; Yu, Q; Yu, Y; Zhang, SL | 1 |
| Chen, Q; Liu, C; Schneller, SW | 1 |
| Dosaka-Akita, H; Kikuchi, E; Kikuchi, J; Kinoshita, I; Marquez, VE; Nishimura, M; Oizumi, S; Sakakibara-Konishi, J; Shimizu, Y; Takashina, T | 1 |
| Atadja, P; Balusu, R; Bhalla, K; Fiskus, W; Ganguly, S; Hembruff, SL; Marquez, VE; Mudunuru, U; Rao, R; Smith, JE; Sotomayor, E; Tao, J | 1 |
| Benoit, YD; Gudas, LJ; Laursen, KB; Lipkin, SM; Witherspoon, MS | 1 |
| Endo-Munoz, L; Gannon, OM; Hazar-Rethinam, M; Merida de Long, L; Saunders, NA | 1 |
| Figg, WD; Peer, CJ; Rao, M; Schrump, DS; Shahbazi, S; Spencer, SD; Steeg, PS | 1 |
| Bi, C; Chng, WJ; Choo, SN; Huang, G; Koh, TL; Lin, B; Liu, SC; Ng, SB; Selvarajan, V; Shimizu, N; Tan, J; Tay, JL; Wang, S; Yan, J; Yu, Q | 1 |
| Chung, AY; Hui, KM; Huynh, H; Lam, PY; Lim, KH; Ooi, LL; Sia, KC | 1 |
| Chai, CL; Cheng, X; Goh, YL; Li, Z; Santhanakrishnan, S; Tam, EK; Wong, SY; Yao, SQ | 1 |
| Cui, J; Liu, PS; Ma, YH; Pang, YX; Shen, L | 1 |
| Au, SL; Lee, JM; Ng, IO; Wong, CC; Wong, CM | 1 |
| Li, L; Rong, R; Wang, J; Xu, M; Zhu, T | 1 |
| Kim, KC; Lee, JK | 1 |
| Bhutia, YD; Cho, JH; Chu, CK; Davis, F; Dhar, S; Govindarajan, R; Hung, SW; Marrache, S; Mody, H; Zastre, J | 1 |
| Donovan, NC; Hoon, DSB; Irie, RF; Tanaka, R; Yu, Q | 1 |
| Baba, H; Beppu, T; Hashimoto, D; Hayashi, H; Kuroki, H; Mima, K; Nakagawa, S; Okabe, H; Sakamoto, K; Sakamoto, Y; Tokunaga, R; Yokoyama, N | 1 |
| Cheng, J; Jiang, H; Li, Q; Li, Z; Qiu, J; Wang, D; Wang, Y; Yang, J; Ye, J; Yuan, C; Zhang, W | 1 |
| Alisi, A; Ceccarelli, S; Crudele, A; De Stefanis, C; Gaspari, S; Gnani, D; Locatelli, F; Marquez, VE; Nobili, V; Rota, R; Vella, S | 1 |
| Fujiwara, T; Fukuhara, N; Harigae, H; Ichinohasama, R; Inoue, A; Ishizawa, K; Katsuoka, Y; Kobayashi, M; Okitsu, Y; Onishi, Y; Saitoh, H | 1 |
| Cui, B; Guan, H; Hou, P; Ji, M; Shi, B; Yang, Q | 1 |
| Behrens, C; Coombes, KR; Girard, L; Heymach, J; Hong, WK; Lee, JJ; Lin, HY; Minna, JD; Nilsson, MB; Riquelme, E; Simon, G; Suraokar, M; Wang, J; Wistuba, II | 1 |
| Bauge, C; Bazille, C; Benateau, H; Boumediene, K; Girard, N; Lhuissier, E; Llombart-Bosch, A | 1 |
| Kaminska, B; Maleszewska, M; Steranka, A | 1 |
| Lee, PL; Lee, ST; Li, Z; Lim, YP; Wee, ZN; Yu, Q | 1 |
| Chen, J; Fu, Y; Li, C; Pang, B; Shen, K; Zhao, J | 1 |
| Creasy, CL; McCabe, MT | 1 |
| Angelini, GD; Caporali, A; Emanueli, C; Floris, I; Marchetti, M; Meloni, M; Mitić, T; Urrutia, R | 1 |
| Hsiao, HH; Liu, TP; Lo, HL; Wei, LS; Yang, PM | 1 |
| Cahu, J; DaCosta, L; Gaudichon, J; Martens, AC; Milano, F; Renoir, JM; Sola, B | 1 |
| Aleström, P; Collas, P; Ostrup, O; Reiner, AH | 1 |
| Chai, CL; Goh, YL; Hill, J; Jiang, X; Lee, PL; Li, Z; Lim, CZ; Nguyen, TM; Ong, EH; Santhanakrishnan, S; Tam, EK; Tan, TW; Wong, SY; Yang, H; Yu, Q | 1 |
| Chen, F; Deng, L; Mo, Q; Song, Y; Wei, L; Wu, B; Yao, Y; Zhang, L | 1 |
| Borchardt, C; Clemens, D; Dirksen, U; Frühwald, MC; Kool, M; Unland, R | 1 |
| Hatta, M; Ikebe, T; Naganuma, K; Yamazaki, J | 1 |
| Han, L; Jiang, K; Kang, C; Liu, X; Ning, X; Shi, Z; Zhang, A; Zhang, Q | 1 |
| Abdulla, MH; Al-Obeed, O; Alajez, NM; Aldahmash, A; Hamam, R; Kassem, M; Mohammed, MA; Vishnubalaji, R | 1 |
| Anderson, TD; Sharakhov, IV; Sharma, A | 1 |
| Guo, R; Han, L; Kang, CS; Li, ZX; Liu, X; Ning, XH; Zhang, AL; Zhang, QY | 1 |
| Berkova, Z; Braun, FK; Chandra, J; Mathur, R; Samaniego, F; Sehgal, L; Wilkie-Grantham, R | 1 |
| Geutskens, SB; Goedhart, M; Haasnoot, GW; Miggelbrink, XM; Muggen, AF; van den Elsen, PJ; van Eggermond, MC; van Zwet, E; Wierda, RJ | 1 |
| Ingram, DR; Lazar, AJ; Ma, X; Pollock, RE; Torres, KE; Yang, X; Zhang, P | 1 |
| Chan, E; Duan, X; Lee, L; Sun, F; Wang, X; Yu, Q; Zhang, Z | 1 |
| Berr, F; Di Fazio, P; Illig, R; Jakab, M; Kiesslich, T; Mayr, C; Neureiter, D; Ocker, M; Pichler, M; Stoecklinger, A; Wagner, A | 1 |
| Chen, Q; Gorden, JD; Liu, C; Schneller, SW | 1 |
| Agata, K; Hayashi, S; Inoue, T; Kawaguchi, A; Kawasumi-Kita, A; Kobayashi, T; Nishide, H; Ogino, H; Tamura, K; Tsuru, K; Tsutsumi, R; Uchiyama, I; Yokoyama, H | 1 |
| Fu, H; Shen, J; Su, J; Wu, D; Xu, M; Zhang, F; Zhou, H | 1 |
| Cartron, G; Cavalli, G; Herviou, L; Klein, B; Moreaux, J | 1 |
| Du, GY; Liu, Y; Wu, TC; Zhang, FJ; Zhang, HS | 1 |
| Aparicio, A; Chung, W; Estécio, MR; Issa, JP; Jelinek, J; Kleb, B; Maity, S; Marquez, VE; Navone, NM; Tahir, S; Tzelepi, V; Zhang, J | 1 |
| Comizzoli, P; Phillips, TC; Wildt, DE | 1 |
| Dosaka-Akita, H; Kikuchi, J; Kinoshita, I; Nishimura, M; Oizumi, S; Sakakibara-Konishi, J; Shimizu, Y; Takashina, T | 1 |
| Clemens, D; Dirksen, U; Hotfilder, M; Klco-Brosius, S; Pettke, A; Potratz, J; Schaefer, C | 1 |
| Gou, X; Huang, C; Liang, Y; Liu, L; Senavirathna, LK; Xiao, X | 1 |
| AlSaggar, M; Govindarajan, R; Griffin, J; Hung, SW; Mody, HR | 1 |
| Andrews, C; Biron, VL; Côté, DW; Harris, J; Idris, S; Kostiuk, M; Lindsay, C; O'Connell, DA; Seikaly, H | 1 |
| Chu, DCK; Di Paolo, D; Hardy, T; Leslie, J; Luli, S; Mann, DA; Mann, J; Mendivil, EJ; Moran Salvador, E; Oakley, F; Page, A; Perri, P; Ponzoni, M; Sabater, L; Sharkey, V; Singh, US; Tsukamoto, H; Zeybel, M | 1 |
| Borutinskaitė, V; Jasnauskaitė, M; Navakauskienė, R; Stirblytė, I; Valiulienė, G | 1 |
| Cruz-Monserrate, Z; Govindarajan, R; Griffin, J; Hung, SW; Mody, HR; Pathak, RK | 1 |
| Averink, TV; Brumatti, G; Ekert, PG; Holik, AZ; Infusini, G; Sandow, JJ; Webb, AI | 1 |
| Du, Z; Gao, Y; Luo, Y; Wang, N; Wang, P; Wu, G; Yang, B; Zhang, Y; Zhu, Z | 1 |
| Bogunia-Kubik, K; Ciechomska, M; Maslinski, W; Merdas, M; Morgiel, E; Swierkot, J; Wiland, P; Zarecki, P | 1 |
| Alcantara, M; Bertrand, P; Bouzelfen, A; Jardin, F; Kora, H; Latouche, JB | 1 |
| Kawamoto, T; Tanaka, Y; Uchiyama, N | 1 |
| Allas, L; Aury-Landas, J; Baugé, C; Bazille, C; Bouhout, S; Boumédiene, K; Chesneau, C; Leclercq, S | 1 |
| Clermont, PL; Crea, F; Fornaro, L | 1 |
| Duan, L; Maki, CG; Perez, RE; Zhou, Y | 1 |
| Chen, D; Cheng, L; Liu, Y; Wang, Y; Xiao, L; Yan, N; Zhang, J; Zheng, S | 1 |
| Aburatani, H; Hirakawa, Y; Kanki, Y; Mimura, I; Nakaki, R; Nangaku, M; Suzuki, Y; Tanaka, T | 1 |
| Brand, OJ; Jenkins, G; Knox, AJ; Pang, L; Pasini, A | 1 |
| Bayliss, G; Guan, Y; Tolbert, T; Zang, X; Zhao, TC; Zhou, X; Zhuang, S | 1 |
| Bowlin, TL; Cardinale, S; Chen, Q; Liu, C; Schneller, SW | 1 |
| Alahmari, B; Choi, J; Cooper, M; DiPersio, JF; Ritchey, J; Ziga, E | 1 |
| Aoki, Y; Hara, Y; Hoshino, M; Inoue, K; Ishiyama, A; Komaki, H; Mizobe, Y; Ohno, T; Shimizu-Motohashi, Y; Suzuki, S; Takeda, S; Takeshita, E; Takizawa, H | 1 |
| Hou, X; Liu, N; Ni, J; Qiu, A; Shi, Y; Wang, X; Xu, L; Zheng, X; Zhuang, S | 1 |
| Farkash, EA; He, Y; Rohraff, DM; Sawalha, AH; Schonfeld, M; Tsou, PS | 1 |
| Chen, D; Li, H; Luo, X; Ma, R; Wen, W; Wen, Y; Wu, S; Xu, R | 1 |
| Fernandez-Lima, F; Michalkova, V; Noriega, FG; Nouzova, M; Ramirez, CE | 1 |
| Assié, G; Batisse-Lignier, M; Bertherat, J; Djari, C; Drelon, C; Lefrançois-Martinez, AM; Martinez, A; Mathieu, M; Pointud, JC; Ragazzon, B; Rodriguez, S; Sahut-Barnola, I; Septier, A; Tabbal, H; Tauveron, I; Val, P | 1 |
| Akpa, CA; Dimitrova, L; Hummel, M; Kleo, K; Lenze, D; Oker, E | 1 |
| Chen, Q; Smith, A | 1 |
| Bai, J; Bao, X; Li, Z; Liu, N; Liu, X; Lv, D; Ren, H; Sun, H; Tang, L; Zhang, Q; Zhou, X; Zhuang, S | 1 |
| Liu, N; Ma, X; Qiu, A; Shi, Y; Tao, M; Wang, Y; Zang, X; Zhuang, S | 1 |
| Adouane, D; Aury-Landas, J; Baugé, C; Boumediene, K; Delépée, R; Girard, N; Lhuissier, E | 1 |
| Dvořák Tomaštíková, E; Ercan, U; Finke, A; Krečmerová, M; Niezgodzki, I; Nowicka, A; Otmar, M; Pecinka, A; Poppenberger, B; Procházková, K; Rozhon, W; Schubert, I; Tokarz, B; Zwyrtková, J | 1 |
| Castresana, JS; De La Rosa, J; Idoate, MA; Meléndez, B; Rey, JA; Urdiciain, A; Zazpe, I; Zelaya, MV | 2 |
| Chen, HW; Han, F; Liu, P; Wang, J; Wang, Q; Xiang, S; Xu, J; Zheng, J; Zou, JX | 1 |
| Akpa, CA; Beule, D; Capper, D; Dettmer, K; Dimitrova, L; Hummel, M; Kleo, K; Lenze, D; López, C; Messerschmidt, C; Oefner, PJ; Oehl-Huber, K; Oker, E; Schoeler, A; Siebert, R; Tomaszewski, N; Wagener, R | 1 |
| Pan, YM; Rao, ZQ; Wan, SS; Yang, WJ; Yang, YN | 1 |
| Han, K; Jia, Y; Li, P; Lou, Z; Qiao, Y; Wen, S; Zhang, P; Zhang, Y; Zhao, N; Zhou, P | 1 |
| Du, W; Duan, R; Guo, W | 1 |
| Baghdadi, M; Itoh, M; Murata, T; Otsuka, R; Sasaki, A; Sasaki, E; Seino, KI; Tsuji, H; Wada, H | 1 |
| Liebisch, M; Wolf, G | 1 |
| Chen, C; Chen, J; Gong, H; Li, W; Li, Y; Liu, C; Liu, H; Liu, M; Shi, R; Yuan, Y; Zhang, H; Zhang, Z | 1 |
| Chen, D; Li, H; Li, J; Lu, T; Luo, X; Ma, R; Sun, W; Wen, W; Xu, R | 1 |
| Ding, C; He, F; Jiang, Y; Jin, L; Wang, H; Wang, J; Wang, L; Xiang, C; Zhang, Y; Zhao, Y; Zhong, F | 1 |
| Amin, SG; Belinsky, SA; Desai, DH; Do, K; Filipczak, PT; Hutt, JA; Juri, D; Picchi, MA; Tellez, CS | 1 |
| Haverkamp, C; Liu, C; Schneller, SW | 1 |
| Akalın, H; Baskol, G; Baskol, M; Kilic, E; Özel, M | 1 |
| Basler, CF; Gibbons, JS; Khadka, S; Liu, C; Schneller, SW; Tufariello, JM; Wang, L; Williams, CG | 1 |
| Cheng, L; Hou, C; Xiao, L; Yan, N; Zhao, L; Zheng, S | 1 |
| Cao, X; Chen, Z; Han, S; He, W; Liang, Y; Ma, H; Qin, A; Rong, K; Xu, S; Yang, X; Zhao, J; Zhou, Y | 1 |
| Barua, A; Barua, S; Chander, Y; Godara, B; Gulati, BR; Khandelwal, N; Kumar, N; Kumar, R; Nagori, H; Pal, Y; Tripathi, BN; Verma, A | 1 |
| Feng, Y; Gu, J; He, Y; Huang, K; Kang, B; Li, X; Li, Y; Liu, J; Long, B; Mai, Y; Pan, G; Shan, Y; Sun, Y; Wang, T; Wen, R; Zhang, C; Zhang, T; Zhang, W; Zhang, X; Zhu, Y | 1 |
| Kurata, Y; Mimura, I; Nangaku, M; Tanaka, T; Yamazaki, T | 1 |
6 review(s) available for 3-deazaneplanocin and adenosine
| Article | Year |
|---|---|
S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Hydrolases; Models, Biological; Tubercidin; Virus Replication | 1987 |
Polycomb genes and cancer: time for clinical application?
Topics: Adenosine; Animals; Antineoplastic Agents; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Neoplastic Stem Cells; Polycomb Repressive Complex 2; Polycomb-Group Proteins | 2012 |
The role of histone methyltransferase EZH2 in myelodysplastic syndromes.
Topics: Adenosine; DNA Methylation; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Mutation; Myelodysplastic Syndromes; Polycomb-Group Proteins; Repressor Proteins | 2012 |
EZH2 as a potential target in cancer therapy.
Topics: Adenosine; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Humans; Neoplasms; Neoplastic Stem Cells; Polycomb Repressive Complex 2; Small Molecule Libraries | 2014 |
EZH2 in normal hematopoiesis and hematological malignancies.
Topics: Adenosine; B-Lymphocytes; Cell Differentiation; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Ethylenediamines; Gene Expression Regulation; Hematologic Neoplasms; Hematopoiesis; Hematopoietic Stem Cells; Histones; Humans; Indoles; Methylation; Polycomb Repressive Complex 2; Precision Medicine; Pyrazoles; Pyridones | 2016 |
EZH2: a novel target for cancer treatment.
Topics: Adenosine; Antineoplastic Agents; Benzamides; Biphenyl Compounds; Cell Cycle; Cell Transformation, Neoplastic; Clinical Trials as Topic; Combined Modality Therapy; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Histone Code; Histones; Humans; Methylation; Morpholines; Multicenter Studies as Topic; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Polycomb Repressive Complex 2; Pyridones; Structure-Activity Relationship; Transcriptional Activation; Tumor Microenvironment | 2020 |
143 other study(ies) available for 3-deazaneplanocin and adenosine
| Article | Year |
|---|---|
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Avian Sarcoma Viruses; Chemical Phenomena; Chemistry; Hydrolases; Mice; Parainfluenza Virus 3, Human; Simplexvirus; Vaccinia virus; Vero Cells; Vesicular stomatitis Indiana virus; Yellow fever virus | 1989 |
Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives.
Topics: Adenosine; Animals; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; HeLa Cells; Mice; Reoviridae; Respirovirus; Rotavirus; Simplexvirus; Vaccinia virus; Vesicular stomatitis Indiana virus; Virus Replication | 1989 |
3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cell Division; Cell Line; Cell Survival; Cricetinae; Humans; Hydrolases; Leukemia, Myeloid, Acute; Liver | 1986 |
3-Deazaneplanocin A: a new inhibitor of S-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells.
Topics: Adenosine; Adenosylhomocysteinase; Cell Line; Colonic Neoplasms; Humans; Hydrolases; Kinetics; Methionine; Methylation; RNA, Ribosomal; RNA, Transfer; S-Adenosylhomocysteine; Uridine | 1986 |
Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures.
Topics: Adenosine; Animals; Carcinoma, Ehrlich Tumor; In Vitro Techniques; Methylation; Methyltransferases; Mice; RNA Caps; S-Adenosylhomocysteine | 1993 |
Induction of murine erythroleukemia cell differentiation is associated with methylation and differential stability of poly(A)+ RNA transcripts.
Topics: Actins; Adenosine; Animals; Cell Differentiation; Cell Division; Cycloleucine; Dimethyl Sulfoxide; Erythrocytes; Erythropoiesis; Globins; Hemoglobins; Kinetics; Leukemia, Erythroblastic, Acute; Methylation; Mice; Neoplasm Proteins; Peroxidases; Peroxiredoxin III; Peroxiredoxins; Proto-Oncogene Proteins c-myc; Ribonucleotides; RNA Caps; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1996 |
Inhibitors of infectious pancreatic necrosis virus (IPNV) replication.
Topics: Adenosine; Adenosylhomocysteinase; Amides; Animals; Antiviral Agents; Cell Line; DNA; Foscarnet; Hydrolases; IMP Dehydrogenase; Infectious pancreatic necrosis virus; Orotidine-5'-Phosphate Decarboxylase; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Salmon; Viral Plaque Assay; Virus Replication | 1996 |
Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Cell Division; Drug Resistance, Neoplasm; Enzyme Inhibitors; Hydrolases; Male; Methionine Adenosyltransferase; Methylation; Mice; Mice, Inbred A; Neuroblastoma; S-Adenosylhomocysteine; S-Adenosylmethionine; Tritium; Tumor Cells, Cultured | 1995 |
3-Deazaadenosine analogues inhibit the production of tumour necrosis factor-alpha in RAW264.7 cells stimulated with lipopolysaccharide.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cell Line; Depression, Chemical; Hydrolases; Interleukin-1; Isomerism; Lipopolysaccharides; Macrophages; Mice; Protein Biosynthesis; Transcription, Genetic; Tubercidin; Tumor Necrosis Factor-alpha | 1996 |
Specific inhibitory effect of 3-deazaneplanocin A against several Leishmania mexicana and L. braziliensis strains.
Topics: Adenosine; Animals; Enzyme Inhibitors; Female; Humans; Leishmania braziliensis; Leishmania mexicana; Macrophages; Mice; Mice, Inbred BALB C; Species Specificity; Trypanosoma; Trypanosoma cruzi | 1997 |
Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; Ebolavirus; Enzyme Inhibitors; Female; Hemorrhagic Fever, Ebola; Hydrolases; Mice; Mice, Inbred BALB C; Mice, SCID; S-Adenosylhomocysteine; Tubercidin | 2000 |
The role of the Type I interferon response in the resistance of mice to filovirus infection.
Topics: Adenosine; Animals; Animals, Suckling; Antibodies; Antiviral Agents; Disease Susceptibility; DNA-Binding Proteins; Filoviridae; Filoviridae Infections; Gene Deletion; Immunization; Injections, Intraperitoneal; Injections, Subcutaneous; Interferon Type I; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Mice, SCID; Receptor, Interferon alpha-beta; Receptors, Interferon; Species Specificity; STAT1 Transcription Factor; Survival Rate; Trans-Activators; Virulence; Weight Loss | 2001 |
3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice.
Topics: Adenosine; Animals; Disease Models, Animal; Ebolavirus; Female; Hemorrhagic Fever, Ebola; Immunohistochemistry; Interferon-alpha; Liver; Mice; Mice, Inbred BALB C; Viremia | 2002 |
Blockade of murine erythroleukemia cell differentiation by hypomethylating agents causes accumulation of discrete small poly(A)- RNAs hybridized to 3'-end flanking sequences of beta(major) globin gene.
Topics: Adenosine; Animals; Base Sequence; Blotting, Northern; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cycloleucine; Cytoplasm; Dimethyl Sulfoxide; DNA; DNA Methylation; DNA Primers; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Globins; Kruppel-Like Transcription Factors; Leukemia, Erythroblastic, Acute; Mice; Models, Genetic; Molecular Sequence Data; Poly A; Repressor Proteins; RNA; RNA, Messenger; Transcription Factor AP-1; Transcription Factors; Transcriptional Activation | 2005 |
John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Enzyme Inhibitors; History, 20th Century; History, 21st Century; Humans; Mice; Viral Proteins; Virus Diseases; Viruses | 2005 |
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.
Topics: Adenosine; Adenosylhomocysteinase; Apoptosis; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Histones; Humans; Methylation; Polycomb-Group Proteins; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; RNA Polymerase II; RNA, Small Interfering | 2007 |
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Adenosylhomocysteinase; Apoptosis; Azacitidine; beta Catenin; Colorectal Neoplasms; Decitabine; Dishevelled Proteins; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Oligonucleotide Array Sequence Analysis; Phosphoproteins; Promoter Regions, Genetic; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transfection; Wnt Proteins | 2008 |
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
Topics: Adenosine; Azacitidine; Blotting, Western; Cell Line; Cell Line, Tumor; Decitabine; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Keratin-7; Methylation; Molecular Structure; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2009 |
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.
Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carrier Proteins; Cell Cycle; DNA-Binding Proteins; Drug Evaluation, Preclinical; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; HL-60 Cells; Humans; Hydroxamic Acids; Indoles; Leukemia, Myeloid, Acute; Neoplasm Proteins; Nuclear Proteins; Panobinostat; Polycomb Repressive Complex 2; Transcription Factors; Treatment Outcome; Tumor Cells, Cultured | 2009 |
BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.
Topics: Adenosine; Animals; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; DNA Repair; Drug Delivery Systems; Enhancer of Zeste Homolog 2 Protein; Female; Gene Knockdown Techniques; Genes, BRCA1; Histone-Lysine N-Methyltransferase; Humans; Mice; Mutation; Polycomb Repressive Complex 2; Recombinant Fusion Proteins; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering | 2009 |
Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells.
Topics: Adenosine; Antigens, Neoplasm; Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Cluster Analysis; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Methylation; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factors | 2009 |
S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition.
Topics: Adenosine; Adenosylhomocysteinase; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Drug Synergism; Female; Histone Deacetylase Inhibitors; Humans; Lipid Metabolism; Protein Kinase Inhibitors; Receptor, ErbB-2 | 2011 |
Polycomb target genes are silenced in multiple myeloma.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Apoptosis; Blotting, Western; Cadherins; Cell Line, Tumor; Cells, Cultured; Chemokine CXCL12; Chromatin Immunoprecipitation; Computational Biology; DNA Methylation; GATA2 Transcription Factor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Interferon Regulatory Factors; Kaplan-Meier Estimate; Mice; Multiple Myeloma; Panobinostat; Polycomb-Group Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
Quantification of 3-deazaneplanocin A, a novel epigenetic anticancer agent, in rat biosamples by hydrophilic interaction liquid chromatography-tandem mass spectrometric detection.
Topics: Adenosine; Animals; Antineoplastic Agents; Chromatography, Liquid; Digestive System; Hydrophobic and Hydrophilic Interactions; Least-Squares Analysis; Lung; Myocardium; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Tissue Distribution; Tubercidin | 2011 |
Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy.
Topics: Adenosine; Base Sequence; Blotting, Western; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Histones; Humans; Hydroxamic Acids; Indoles; Intracellular Signaling Peptides and Proteins; Leukemia-Lymphoma, Adult T-Cell; Lysine; Methylation; MicroRNAs; Oligonucleotide Array Sequence Analysis; Panobinostat; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2011 |
PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins.
Topics: Adenosine; Cell Line; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Humans; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Proteasome Endopeptidase Complex; Protein Methyltransferases; Repressor Proteins; Transcription Factors; Ubiquitin-Protein Ligases; Ubiquitination | 2011 |
3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Liver Neoplasms; Mice; Neoplastic Stem Cells; Polycomb Repressive Complex 2; Transcription Factors | 2012 |
Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells.
Topics: Adenosine; Apoptosis; Arachidonate 5-Lipoxygenase; Biphenyl Compounds; Caspases; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Humans; Multiple Myeloma; Nitrophenols; Piperazines; Polycomb Repressive Complex 2; Sulfonamides; Transcription Factors | 2011 |
The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML.
Topics: Adenosine; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Carrier Proteins; Cell Proliferation; Chromatin Immunoprecipitation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epigenomics; Female; Gene Expression Profiling; Gene Silencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Reactive Oxygen Species; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Transcription Factors; Tumor Cells, Cultured | 2011 |
(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells.
Topics: Acetylation; Adenosine; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carrier Proteins; Caspases; Catechin; Cell Cycle; Cell Proliferation; Cells, Cultured; DNA Methylation; DNA-Binding Proteins; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Histone Deacetylase 1; Histones; Humans; Keratinocytes; Membrane Potential, Mitochondrial; Neoplasm Proteins; Nuclear Proteins; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Repressor Proteins; Skin Neoplasms; Transcription Factors; Ubiquitination | 2011 |
Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer.
Topics: Adenosine; Animals; Breast Neoplasms; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Humans; Kruppel-Like Transcription Factors; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Polycomb Repressive Complex 2; Prostatic Neoplasms; RNA Interference; Transcription Factors; Transfection | 2012 |
Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells.
Topics: Acetylation; Adenosine; Apoptosis; Cell Hypoxia; Cell Lineage; Cells, Cultured; Cellular Senescence; DNA Methylation; Endothelial Cells; Enzyme Induction; Hematopoietic Stem Cells; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Jumonji Domain-Containing Histone Demethylases; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Promoter Regions, Genetic; Protein Processing, Post-Translational; RNA, Messenger | 2011 |
Polycomb repressor complex-2 is a novel target for mesothelioma therapy.
Topics: Adenosine; Adult; Aged; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Mesothelioma; Mice; Mice, Nude; MicroRNAs; Oligonucleotide Array Sequence Analysis; Pleural Neoplasms; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Real-Time Polymerase Chain Reaction; Repressor Proteins; RNA, Messenger; RNA, Small Interfering; Transcription Factors | 2012 |
Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin.
Topics: Adenosine; Butyrates; Cell Culture Techniques; Cell Differentiation; Cell Line; Cellular Reprogramming; Chromatin; Chromosomes, Human, X; Embryonic Stem Cells; Epigenesis, Genetic; Female; Humans; RNA, Long Noncoding; RNA, Untranslated | 2012 |
Loading 3-deazaneplanocin A into pegylated unilamellar liposomes by forming transient phenylboronic acid-drug complex and its pharmacokinetic features in Sprague-Dawley rats.
Topics: Adenosine; Animals; Antineoplastic Agents; Area Under Curve; Boronic Acids; Delayed-Action Preparations; Drug Carriers; Drug Stability; Female; Half-Life; Liposomes; Polyethylene Glycols; Rats; Rats, Sprague-Dawley | 2012 |
Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells.
Topics: Adenosine; Animals; Apoptosis; Cells, Cultured; Disease Progression; Enzyme Inhibitors; Graft vs Host Disease; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Isoantigens; Lymphocyte Activation; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Substrate Specificity; T-Lymphocytes; Up-Regulation | 2012 |
The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells.
Topics: Adenosine; Blotting, Western; Cell Line, Tumor; Cell Movement; DNA-Binding Proteins; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Polycomb Repressive Complex 2; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3; Transcription Factors | 2012 |
Targeting the enhancer of zeste homologue 2 in medulloblastoma.
Topics: Adenosine; Adolescent; Apoptosis; Blotting, Western; Case-Control Studies; Cell Cycle; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cerebellar Neoplasms; Cerebellum; Child; Colony-Forming Units Assay; DNA Copy Number Variations; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Flow Cytometry; Histones; Humans; Luciferases; Medulloblastoma; Neoplastic Stem Cells; Polycomb Repressive Complex 2; RNA, Small Interfering; Spheroids, Cellular; Transcription Factors; Tumor Cells, Cultured | 2012 |
Cloning and characterization of polyA- RNA transcripts encoded by activated B1-like retrotransposons in mouse erythroleukemia MEL cells exposed to methylation inhibitors.
Topics: Adenosine; Animals; beta-Globins; Cell Differentiation; Cell Line, Tumor; Cloning, Molecular; Cycloleucine; Dimethyl Sulfoxide; DNA Methylation; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; Poly A; Retroelements; RNA | 2012 |
Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with gemcitabine in pancreatic cancer cells.
Topics: AC133 Antigen; Adenosine; Antigens, CD; Antimetabolites, Antineoplastic; Apoptosis; Cadherins; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Line, Tumor; Cell Movement; Deoxycytidine; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Equilibrative Nucleoside Transporter 1; Gemcitabine; Gene Expression; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Membrane Transport Proteins; Pancreatic Neoplasms; Peptides; Polycomb Repressive Complex 2; Spheroids, Cellular; Tumor Cells, Cultured | 2012 |
TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep).
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Immunoblotting; Male; Methylation; Middle Aged; Mutation; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Stomach Neoplasms; Tumor Suppressor Protein p53; Ubiquitination; Young Adult | 2012 |
3-Bromo-3-deazaneplanocin and 3-bromo-3-deazaaristeromycin: synthesis and antiviral activity.
Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Crystallography, X-Ray; HeLa Cells; Humans; Molecular Conformation; Vero Cells; Virus Replication; Viruses | 2012 |
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.
Topics: Adenosine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; G1 Phase Cell Cycle Checkpoints; Gene Expression; Gene Knockdown Techniques; Histones; Humans; Inhibitory Concentration 50; Lung Neoplasms; Methylation; Neoplasm Proteins; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; RNA Interference; Transcription Factors | 2012 |
Superior efficacy of a combined epigenetic therapy against human mantle cell lymphoma cells.
Topics: Adenosine; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Proliferation; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression; Gene Knockdown Techniques; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Lymphoma, Mantle-Cell; Mice; Mice, Inbred NOD; Mice, SCID; Muscle Proteins; Neoplasm Proteins; Panobinostat; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Protein Binding; RNA Interference; SKP Cullin F-Box Protein Ligases; Transcription Factors; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2012 |
Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells.
Topics: Adenosine; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; HT29 Cells; Humans; MCF-7 Cells; Neoplasm Proteins; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Transcription Factors; Tretinoin | 2013 |
Dysregulation of the repressive H3K27 trimethylation mark in head and neck squamous cell carcinoma contributes to dysregulated squamous differentiation.
Topics: Adenosine; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Histones; Humans; Methylation; Mice; Polycomb Repressive Complex 2; RNA Interference; Squamous Cell Carcinoma of Head and Neck; Transplantation, Heterologous | 2013 |
A rapid ultra HPLC-MS/MS method for the quantitation and pharmacokinetic analysis of 3-deazaneplanocin A in mice.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Drug Stability; Least-Squares Analysis; Liquid-Liquid Extraction; Mice; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tubercidin | 2013 |
EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity.
Topics: Adenosine; Adolescent; Adult; Aged; Aged, 80 and over; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Killer Cells, Natural; Lymphoma, T-Cell; Male; MicroRNAs; Middle Aged; Mutagenesis; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Up-Regulation; Young Adult | 2013 |
Preclinical evaluation of transcriptional targeting strategy for human hepatocellular carcinoma in an orthotopic xenograft mouse model.
Topics: Adenosine; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression; Genetic Therapy; Genetic Vectors; Humans; Liver Neoplasms; Mice; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Transgenes; Xenograft Model Antitumor Assays | 2013 |
Cell-based proteome profiling using an affinity-based probe (AfBP) derived from 3-deazaneplanocin A (DzNep).
Topics: Adenosine; Azides; Cell Line; Chromatography, High Pressure Liquid; Click Chemistry; Epigenomics; Humans; MCF-7 Cells; Microscopy, Confocal; Proteome; Tandem Mass Spectrometry | 2013 |
3-Deazaneplanocin A is a promising therapeutic agent for ovarian cancer cells.
Topics: Adenosine; Antineoplastic Agents; Apoptosis; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme Inhibitors; Female; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Ovarian Neoplasms; Polycomb Repressive Complex 2 | 2013 |
EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers.
Topics: Actin Cytoskeleton; Adenosine; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Histones; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; RNA, Messenger; Tumor Suppressor Proteins | 2013 |
Modulation of allogeneic CD8+ T-cell response by DZNep controls GVHD while preserving hematopoietic chimerism.
Topics: Adenosine; Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Fas Ligand Protein; Female; Graft vs Host Disease; Granzymes; Hematopoietic Stem Cell Transplantation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Male; Methylation; Mice; Mice, Inbred C3H; T-Lymphocytes, Cytotoxic; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transplantation Chimera; Transplantation Tolerance; Transplantation, Homologous; Tumor Necrosis Factor-alpha | 2013 |
DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells.
Topics: Adenosine; Adenosylhomocysteinase; Cell Death; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Protein Methyltransferases | 2013 |
Pharmacological reversal of histone methylation presensitizes pancreatic cancer cells to nucleoside drugs: in vitro optimization and novel nanoparticle delivery studies.
Topics: Adenosine; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Delayed-Action Preparations; Deoxycytidine; DNA Methylation; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Gemcitabine; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Nanoparticles; Nucleosides; Pancreatic Neoplasms; Xenopus | 2013 |
Tumor necrosis factor-α and apoptosis induction in melanoma cells through histone modification by 3-deazaneplanocin A.
Topics: Adenosine; Adenosylhomocysteinase; Apoptosis; Cell Line, Tumor; Histones; Humans; Melanoma; Skin Neoplasms; Tumor Necrosis Factor-alpha | 2014 |
Epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A inhibits the growth of cholangiocarcinoma cells.
Topics: Adenosine; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p27; Deoxycytidine; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epigenesis, Genetic; G1 Phase Cell Cycle Checkpoints; Gemcitabine; Humans; Polycomb Repressive Complex 2; RNA Interference; RNA, Small Interfering | 2014 |
The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer.
Topics: Adenosine; Animals; Apoptosis; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Female; Humans; Male; Mice; Mice, Nude; Middle Aged; Molecular Targeted Therapy; Polycomb Repressive Complex 2; Random Allocation; RNA, Small Interfering; Tongue Neoplasms; Transfection; Tumor Cells, Cultured | 2013 |
EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD.
Topics: Adenosine; Animals; Disease Models, Animal; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Fatty Liver; Hep G2 Cells; Histones; Humans; MicroRNAs; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Polycomb Repressive Complex 2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2013 |
3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation.
Topics: Adenosine; Cell Differentiation; Cell Proliferation; Cells, Cultured; Erythroblasts; Erythroid Cells; Gene Expression Regulation; Humans; K562 Cells; Methyltransferases; Repressor Proteins; Tumor Suppressor Proteins | 2014 |
PRIMA-1, a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.
Topics: Adenosine; Animals; Apoptosis; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Humans; Mice; Mice, Nude; Mutant Proteins; Thyroid Neoplasms; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2014 |
VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenosine; Animals; Antineoplastic Agents; Carboplatin; Cell Line, Tumor; Cell Proliferation; Cisplatin; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Mice, Nude; MicroRNAs; Molecular Targeted Therapy; Polycomb Repressive Complex 2; Signal Transduction; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2014 |
3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells.
Topics: Adenosine; Apoptosis; Cell Line, Tumor; Cell Movement; Chondrosarcoma; Enzyme Inhibitors; Flow Cytometry; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
The effects of selected inhibitors of histone modifying enzyme on C6 glioma cells.
Topics: Acetylation; Adenosine; Animals; Azepines; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Epigenesis, Genetic; Glioma; Histones; Hydroxamic Acids; Piperazines; Quinazolines; Rats; Valproic Acid | 2014 |
EZH2-mediated inactivation of IFN-γ-JAK-STAT1 signaling is an effective therapeutic target in MYC-driven prostate cancer.
Topics: Adenosine; Animals; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Humans; Interferon gamma Receptor; Interferon-gamma; Janus Kinases; Male; Mice; Mice, Nude; Polycomb Repressive Complex 2; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; Receptors, Interferon; Signal Transduction; STAT1 Transcription Factor | 2014 |
EZH2-induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in ovarian cancer.
Topics: Adenosine; Carcinogenesis; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Female; Gene Knockdown Techniques; Histones; Humans; Lysine; Methylation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Polycomb Repressive Complex 2; rho GTP-Binding Proteins; RNA, Small Interfering; Survival Analysis; Tumor Suppressor Proteins | 2015 |
EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia.
Topics: Adenosine; Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Femoral Artery; Hindlimb; Histones; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Ischemia; Male; Mice; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Polycomb Repressive Complex 2; Primary Cell Culture; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Transcription, Genetic | 2015 |
S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells.
Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line, Tumor; Cell Survival; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Knockdown Techniques; Hep G2 Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Indazoles; Niacinamide; Phenylurea Compounds; Polycomb Repressive Complex 2; Pyridones; S-Adenosylmethionine; Sorafenib | 2015 |
Deazaneplanocin a is a promising drug to kill multiple myeloma cells in their niche.
Topics: Adenosine; Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Caspases; Cell Line, Tumor; Cell Proliferation; Drug Interactions; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Mice; Multiple Myeloma; Polycomb Repressive Complex 2; Pyrazines; Syndecan-1; Xenograft Model Antitumor Assays | 2014 |
The specific alteration of histone methylation profiles by DZNep during early zebrafish development.
Topics: Adenosine; Animals; Embryo, Nonmammalian; Embryonic Development; Gene Expression Regulation, Developmental; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Methylation; Promoter Regions, Genetic; Transcriptome; Zebrafish | 2014 |
3-Deazaneplanocin A and neplanocin A analogues and their effects on apoptotic cell death.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; HCT116 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Structure-Activity Relationship; Transplantation, Heterologous | 2015 |
Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer.
Topics: Adenosine; Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Movement; Cell Proliferation; DNA Methylation; Enzyme Inhibitors; Female; Flow Cytometry; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunoenzyme Techniques; Lysine; Methyltransferases; Mice; Mice, Nude; Neoplastic Stem Cells; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2014 |
Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell lines.
Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Proliferation; Decitabine; Doxorubicin; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Molecular Targeted Therapy; Polycomb Repressive Complex 2; Rhabdoid Tumor; Vorinostat | 2015 |
Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Line, Tumor; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Keratin-13; Methylation; Mouth Neoplasms; Promoter Regions, Genetic; Transcriptional Activation | 2014 |
DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression.
Topics: Adenosine; Animals; Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Decitabine; Disease Progression; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Histones; Humans; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Polycomb Repressive Complex 2; Stomach Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer.
Topics: Adenosine; Adult; Aged; Base Sequence; Cell Movement; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genome, Human; Humans; Male; MicroRNAs; Middle Aged; Molecular Sequence Data; Polycomb Repressive Complex 2; RNA, Messenger | 2015 |
Toxicological assays for testing effects of an epigenetic drug on development, fecundity and survivorship of malaria mosquitoes.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Anopheles; Dose-Response Relationship, Drug; Female; Fertility; Insect Vectors; Insecticide Resistance; Insecticides; Malaria; Male; Mosquito Control; S-Adenosylhomocysteine; Survival Rate | 2015 |
[DZNep raises miR-200c expression to delay the invasion and migration of MGC-803 gastric carcinoma cells].
Topics: Adenosine; Cadherins; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; MicroRNAs; Protein Methyltransferases; Repressor Proteins; Transcription Factors; Zinc Finger E-box Binding Homeobox 2; Zinc Finger E-box-Binding Homeobox 1 | 2015 |
Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis.
Topics: Adenosine; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cells, Cultured; Humans; Lymphoma, B-Cell; Methyltransferases; Proteolysis; TNF-Related Apoptosis-Inducing Ligand | 2015 |
A role for KMT1c in monocyte to dendritic cell differentiation: Epigenetic regulation of monocyte differentiation.
Topics: Acetylation; Adenosine; Azepines; Cell Adhesion Molecules; Cell Differentiation; Chromatin; Chromatin Assembly and Disassembly; Dendritic Cells; Epigenesis, Genetic; Gene Expression Profiling; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Lectins, C-Type; Methylation; Monocytes; Primary Cell Culture; Quinazolines; Receptors, Cell Surface; Signal Transduction; Transcription, Genetic | 2015 |
Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway.
Topics: 3' Untranslated Regions; Adenosine; Animals; Antineoplastic Agents; Apoptosis; beta Karyopherins; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Epithelial-Mesenchymal Transition; Female; Humans; Mice; Mice, SCID; MicroRNAs; Nerve Sheath Neoplasms; Polycomb Repressive Complex 2; Signal Transduction; Up-Regulation | 2015 |
Preclinical pharmacokinetic studies of 3-deazaneplanocin A, a potent epigenetic anticancer agent, and its human pharmacokinetic prediction using GastroPlus™.
Topics: Adenosine; Animals; Antineoplastic Agents; Epigenesis, Genetic; Half-Life; Humans; Male; No-Observed-Adverse-Effect Level; Rats; Rats, Wistar | 2015 |
3-Deazaneplanocin A May Directly Target Putative Cancer Stem Cells in Biliary Tract Cancer.
Topics: Adenosine; Biliary Tract Neoplasms; Biomarkers, Tumor; Cell Death; Cell Line, Tumor; Cell Survival; Cyclins; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Neoplastic Stem Cells; Polycomb Repressive Complex 2; RNA, Messenger | 2015 |
2- and 3-Fluoro-3-deazaneplanocins, 2-fluoro-3-deazaaristeromycins, and 3-methyl-3-deazaneplanocin: Synthesis and antiviral properties.
Topics: Adenosine; Antiviral Agents; Humans; Molecular Structure | 2015 |
Epigenetic modification maintains intrinsic limb-cell identity in Xenopus limb bud regeneration.
Topics: Adenosine; Animals; Animals, Genetically Modified; Base Sequence; Chromatin Immunoprecipitation; DNA Methylation; DNA Primers; Epigenesis, Genetic; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; High-Throughput Nucleotide Sequencing; Histone Code; Histones; In Situ Hybridization; Limb Buds; Molecular Sequence Data; Polymerase Chain Reaction; Regeneration; Sequence Analysis, DNA; Xenopus | 2015 |
Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A.
Topics: Adenosine; Cell Line, Tumor; Cell Proliferation; Chemokine CXCL10; CpG Islands; Histones; Humans; Lysine; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Up-Regulation | 2015 |
EZH2 phosphorylation regulates Tat-induced HIV-1 transactivation via ROS/Akt signaling pathway.
Topics: Adenosine; Amino Acid Substitution; Chromatin Immunoprecipitation; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Genes, Reporter; HeLa Cells; HIV-1; Humans; Mutagenesis, Site-Directed; Mutant Proteins; Phosphorylation; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Recombinant Fusion Proteins; RNA Interference; Signal Transduction; tat Gene Products, Human Immunodeficiency Virus; Transcriptional Activation; Virus Activation | 2015 |
Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas.
Topics: Adenosine; Animals; Carcinoma, Small Cell; Cell Line, Tumor; Cell Lineage; CpG Islands; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Promoter Regions, Genetic; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Xenograft Model Antitumor Assays | 2016 |
Incidence of methylated histones H3K4 and H3K79 in cat germinal vesicles is regulated by specific nuclear factors at the acquisition of developmental competence during the folliculogenesis.
Topics: Adenosine; Animals; Cats; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Histones; Methylation; Methyltransferases; Oocytes; Ovarian Follicle; Sonication | 2016 |
Combined inhibition of EZH2 and histone deacetylases as a potential epigenetic therapy for non-small-cell lung cancer cells.
Topics: Acetylation; Adenosine; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin-Dependent Kinase Inhibitor p27; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; ErbB Receptors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Methylation; Mice; Mice, Inbred BALB C; Mutation; Phosphorylation; Polycomb Repressive Complex 2; Signal Transduction; Vorinostat; Xenograft Model Antitumor Assays | 2016 |
Suberanilohydroxamic acid (vorinostat) synergistically enhances the cytotoxicity of doxorubicin and cisplatin in osteosarcoma cell lines.
Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cisplatin; Doxorubicin; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Osteosarcoma; Vorinostat | 2016 |
EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis.
Topics: Adenosine; Adult; Animals; Bleomycin; Cell Differentiation; Cells, Cultured; Enhancer of Zeste Homolog 2 Protein; Female; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Lung; Mice; Mice, Inbred C57BL; Myofibroblasts; Pulmonary Fibrosis; RNA, Small Interfering; Transforming Growth Factor beta; Up-Regulation | 2016 |
Inhibition of S-Adenosylmethionine-Dependent Methyltransferase Attenuates TGFβ1-Induced EMT and Metastasis in Pancreatic Cancer: Putative Roles of miR-663a and miR-4787-5p.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Histones; Humans; Methyltransferases; Mice; MicroRNAs; Pancreatic Neoplasms; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays | 2016 |
Investigation of EZH2 pathways for novel epigenetic treatment strategies in oropharyngeal cancer.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Humans; Immunohistochemistry; Indazoles; Oropharyngeal Neoplasms; Papillomavirus Infections; Polymerase Chain Reaction; Pyridones; Tumor Cells, Cultured | 2016 |
A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.
Topics: Adenosine; Animals; Biomarkers; Carbon Tetrachloride; Collagen Type I; Disease Models, Animal; Disease Progression; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation; Hepatic Stellate Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Liver Cirrhosis; Male; Mice; Myofibroblasts | 2017 |
Anti-leukemic effects of HDACi Belinostat and HMTi 3-Deazaneplanocin A on human acute promyelocytic leukemia cells.
Topics: Acetylation; Adenosine; Apoptosis; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Drug Interactions; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; HL-60 Cells; Humans; Hydroxamic Acids; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Sulfonamides; Transcription Factors; Tretinoin | 2017 |
miR-202 Diminishes TGFβ Receptors and Attenuates TGFβ1-Induced EMT in Pancreatic Cancer.
Topics: Adenosine; Animals; Capecitabine; Cell Line, Tumor; Deoxycytidine; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Lentivirus; Mice; MicroRNAs; Pancreatic Neoplasms; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays | 2017 |
Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death.
Topics: Adenosine; Animals; Carcinogenesis; Cell Death; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Leukemia, Myeloid, Acute; Mice; Molecular Targeted Therapy; Proteomics | 2017 |
Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells.
Topics: Adenosine; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Hepatocellular; Cell Proliferation; Cellular Senescence; Chromatin; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Epigenomics; Hep G2 Cells; Histones; Humans; Liver Neoplasms; Metabolic Networks and Pathways; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Suppressor Protein p53 | 2017 |
The role of microRNA-5196 in the pathogenesis of systemic sclerosis.
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Female; Fos-Related Antigen-2; Histone Deacetylase Inhibitors; Humans; Interleukin-8; Leukocytes, Mononuclear; Male; Matrix Metalloproteinases; MicroRNAs; Middle Aged; Oxidative Stress; Peptides, Cyclic; Reactive Oxygen Species; Scleroderma, Systemic; Tissue Inhibitor of Metalloproteinase-1; Toll-Like Receptor 8; Transfection | 2017 |
Heterogeneous epigenetic regulation of HACE1 in Burkitt- Lymphoma-derived cells.
Topics: Adenosine; Burkitt Lymphoma; Cell Line, Tumor; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Promoter Regions, Genetic; RNA, Messenger; Ubiquitin-Protein Ligases | 2017 |
Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a.
Topics: Adenosine; Adenosylhomocysteinase; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; MicroRNAs; Prostatic Neoplasms; RNA, Small Interfering; Transcriptional Activation | 2017 |
Anti-inflammatory and chondroprotective effects of the S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin A, in human articular chondrocytes.
Topics: Adenosine; Adenosylhomocysteinase; Anti-Inflammatory Agents; Cartilage, Articular; Cells, Cultured; Chondrocytes; Cytoprotection; Dinoprostone; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Interleukin-1beta; Matrix Metalloproteinases; Osteoarthritis; Protective Agents; Protein Interaction Maps | 2017 |
Elevated expression of a pharmacologic Polycomb signature predicts poor prognosis in gastric and breast cancer.
Topics: Adenosine; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Male; Polycomb-Group Proteins; Stomach Neoplasms; Survival Analysis; Up-Regulation | 2017 |
DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a.
Topics: Adenosine; Apoptosis; Humans; Imidazoles; Piperazines; Proto-Oncogene Proteins c-bcl-2 | 2018 |
DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice.
Topics: Adenosine; Amino Acid Motifs; Animals; Calpain; Disease Models, Animal; Epigenesis, Genetic; Female; Histones; Humans; Lysine; Male; Methylation; Mice; Mice, Inbred ICR; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Retina; Retinal Degeneration | 2018 |
Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.
Topics: Adenosine; Animals; Biomarkers; Cells, Cultured; Fibrosis; Gene Expression Profiling; Gene Expression Regulation; Genome; Humans; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury | 2018 |
Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation.
Topics: Adenosine; Azacitidine; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Decitabine; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Fibroblasts; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung; Promoter Regions, Genetic; T-Cell Intracellular Antigen-1; Transforming Growth Factor beta1; Vorinostat | 2018 |
Targeting enhancer of zeste homolog 2 protects against acute kidney injury.
Topics: Acute Kidney Injury; Adenosine; Adherens Junctions; Animals; Apoptosis; Cadherins; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Epithelial Cells; Folic Acid; Hydrogen Peroxide; Jumonji Domain-Containing Histone Demethylases; Kidney; Kidney Tubules; Lipocalin-2; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Phosphatidylethanolamine Binding Protein; Phosphorylation; Proto-Oncogene Proteins c-raf; Reperfusion Injury; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3; Zonula Occludens-1 Protein | 2018 |
6'-Fluoro-3-deazaneplanocin: Synthesis and antiviral properties, including Ebola.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Chlorocebus aethiops; Ebolavirus; Influenza A Virus, H1N1 Subtype; Inhibitory Concentration 50; Vero Cells | 2018 |
Selective targeting of histone modification fails to prevent graft versus host disease after hematopoietic cell transplantation.
Topics: Adenosine; Animals; Benzamides; Biphenyl Compounds; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Histone Code; Histones; Humans; Indoles; Methylation; Mice; Morpholines; Pyridones; T-Lymphocytes | 2018 |
Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride.
Topics: Adenosine; Adolescent; Adult; Child; Exons; Humans; Male; Mesenchymal Stem Cells; Models, Biological; Muscular Dystrophy, Duchenne; MyoD Protein; Oligonucleotides, Antisense | 2019 |
3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression.
Topics: Acute Kidney Injury; Adenosine; Animals; Apoptosis; Cadherins; Caspase 3; Cell Line; Cell Line, Tumor; Cisplatin; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Histones; Humans; JNK Mitogen-Activated Protein Kinases; Kidney Function Tests; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Protective Agents; RNA, Small Interfering; Signal Transduction | 2019 |
Inhibition of EZH2 Ameliorates Lupus-Like Disease in MRL/lpr Mice.
Topics: Adenosine; Adult; Animals; Antibodies, Antinuclear; Antibody Formation; B-Lymphocytes; CD4-Positive T-Lymphocytes; Cell Proliferation; Cytokines; Enhancer of Zeste Homolog 2 Protein; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Lymph Nodes; Lymphocyte Count; Male; Mice; Mice, Inbred MRL lpr; Middle Aged; Monocytes; Neutrophils; Proteinuria; RNA, Messenger; Spleen; Survival Rate; T-Lymphocytes | 2019 |
Epigenetic Modification of Enhancer of Zeste Homolog 2 Modulates the Activation of Dendritic Cells in Allergen Immunotherapy.
Topics: Adenosine; Adult; Cell Proliferation; Dendritic Cells; Desensitization, Immunologic; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Humans; Interleukin-10; Interleukin-6; Male; Patient Compliance; Rhinitis, Allergic; Young Adult | 2019 |
Inhibition of juvenile hormone synthesis in mosquitoes by the methylation inhibitor 3-deazaneplanocin A (DZNep).
Topics: Adenosine; Aedes; Animals; Female; Insect Proteins; Juvenile Hormones; Methylation; Methyltransferases | 2019 |
EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness.
Topics: Adenosine; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Animals; Cell Cycle Proteins; Cell Proliferation; Chromatin Immunoprecipitation; Computational Biology; E2F1 Transcription Factor; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Humans; Indoles; Mice, Knockout; Multivariate Analysis; Proportional Hazards Models; Ribonucleoside Diphosphate Reductase; Securin | 2019 |
DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.
Topics: Adenosine; Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Humans; Lymphoma, Large B-Cell, Diffuse; Mutation; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-bcl-6; Proto-Oncogene Proteins c-myc; Translocation, Genetic | 2019 |
l-like 3-deazaneplanocin analogues: Synthesis and antiviral properties.
Topics: Adenosine; Antiviral Agents; Arenaviridae; Arenaviridae Infections; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Molecular Structure | 2019 |
Novel pharmacological inhibition of EZH2 attenuates septic shock by altering innate inflammatory responses to sepsis.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Bacterial Load; Cytokines; Enhancer of Zeste Homolog 2 Protein; Humans; Immunity, Innate; Jumonji Domain-Containing Histone Demethylases; Lung; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; Phagocytosis; Sepsis | 2019 |
Genetic or pharmacologic blockade of enhancer of zeste homolog 2 inhibits the progression of peritoneal fibrosis.
Topics: Adenosine; Animals; Apoptosis; Cell Movement; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Epithelial-Mesenchymal Transition; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Peritoneal Fibrosis; Peritoneum; RNA Interference; RNA, Small Interfering; Signal Transduction | 2020 |
The Antitumoral Effect of the S-Adenosylhomocysteine Hydrolase Inhibitor, 3-Deazaneplanocin A, is Independent of EZH2 but is Correlated with EGFR Downregulation in Chondrosarcomas.
Topics: Adenosine; Animals; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Chondrosarcoma; DNA Damage; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; ErbB Receptors; Histones; Humans; Male; Mice; Mice, Nude; Protein Interaction Maps; RNA Interference; RNA, Small Interfering; S-Adenosylhomocysteine | 2019 |
Comparative analysis of epigenetic inhibitors reveals different degrees of interference with transcriptional gene silencing and induction of DNA damage.
Topics: Adenosine; Arabidopsis; Azacitidine; Chromosome Aberrations; Cytidine; Decitabine; DNA Damage; DNA Methylation; DNA Repair; Epigenesis, Genetic; Gene Silencing; Heterochromatin; RNA Interference; Tandem Repeat Sequences | 2020 |
The synergistic effect of DZ‑NEP, panobinostat and temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells.
Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Panobinostat; Temozolomide; Tumor Cells, Cultured | 2020 |
S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis.
Topics: Adenosine; Antigens, Ly; Apoptosis; Cell Line, Tumor; Cell Survival; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Homeostasis; Humans; Methyltransferases; Oxidation-Reduction; Proteolysis; Reactive Oxygen Species; Repressor Proteins; S-Adenosylhomocysteine; Tamoxifen; Urokinase-Type Plasminogen Activator | 2020 |
Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model.
Topics: Adenosine; Adenosylhomocysteinase; Apoptosis; Cell Proliferation; DNA Copy Number Variations; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Humans; Lymphoma, B-Cell; Tumor Cells, Cultured | 2020 |
Inhibition of EZH2 alleviates angiogenesis in a model of corneal neovascularization by blocking FoxO3a-mediated oxidative stress.
Topics: Adenosine; Animals; Cells, Cultured; Corneal Neovascularization; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Forkhead Box Protein O3; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Transcription, Genetic | 2020 |
Quantifying the Fast Dynamics of HClO in Living Cells by a Fluorescence Probe Capable of Responding to Oxidation and Reduction Events within the Time Scale of Milliseconds.
Topics: Adenosine; Animals; Apoptosis; Fluorescent Dyes; HL-60 Cells; Humans; Hypochlorous Acid; Mice; Oxidation-Reduction; RAW 264.7 Cells; Reactive Oxygen Species; Time Factors | 2020 |
Induction of macrophage-like immunosuppressive cells from common marmoset ES cells by stepwise differentiation with DZNep.
Topics: Adenosine; Animals; Callithrix; Cell Differentiation; Embryonic Stem Cells; Enzyme Inhibitors; Histone Methyltransferases; Immunosuppression Therapy; Macrophages; Mice; Monocytes; Myeloid Cells; Phenotype; Transplantation, Homologous | 2020 |
AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3.
Topics: Adenosine; Animals; Cell Line; Diabetic Nephropathies; Disease Models, Animal; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Glycation End Products, Advanced; Humans; Intracellular Signaling Peptides and Proteins; Mice; Podocytes; RNA, Small Interfering | 2020 |
EZH2 inhibitors reverse resistance to gefitinib in primary EGFR wild-type lung cancer cells.
Topics: Adenosine; Adult; Aged; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Genes, erbB-1; Humans; Indazoles; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; Protein Kinase Inhibitors; Pyridones; RNA Interference; RNA, Neoplasm; RNA, Small Interfering; Signal Transduction | 2020 |
DZNep attenuates allergic airway inflammation in an ovalbumin-induced murine model.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Hypersensitivity; Inflammation; Lung; Mice; Mice, Inbred BALB C; Ovalbumin | 2021 |
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis.
Topics: Adenosine; Animals; Apoptosis; Benzazepines; Bile Ducts; Carbon Tetrachloride; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Hepatic Stellate Cells; Humans; Indoles; Interleukin-10; Jumonji Domain-Containing Histone Demethylases; Ligation; Liver; Liver Cirrhosis; Mice; Pyridones; Pyrimidines; Rats; RNA Interference | 2021 |
Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Benzamides; Biphenyl Compounds; Cell Proliferation; Chromatin Assembly and Disassembly; CpG Islands; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epigenesis, Genetic; Epithelial Cells; Female; Histone Code; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Mice; Morpholines; Neoplasms; Phenotype; Pyridones; Transcriptome | 2021 |
APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells.
Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Colony-Forming Units Assay; Drug Screening Assays, Antitumor; Drug Synergism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mutation; Panobinostat; Quinuclidines; Temozolomide; Tumor Suppressor Protein p53 | 2021 |
Enantiomeric 4'-truncated 6'-fluoro-3-deazaneplanocin and its 3-bromo derivative: Synthesis and antiviral properties, including Ebola and Marburg.
Topics: Adenosine; Antiviral Agents; Dose-Response Relationship, Drug; Ebolavirus; Marburgvirus; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2021 |
The Effect of
Topics: Adenosine; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Tumor Cells, Cultured | 2021 |
Mechanisms of anti-vesicular stomatitis virus activity of deazaneplanocin and its 3-brominated analogs.
Topics: Adenosine; Animals; Antiviral Agents; Chlorocebus aethiops; Inhibitory Concentration 50; Methylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Transcription, Genetic; Vero Cells; Vesicular stomatitis Indiana virus; Virus Replication | 2021 |
DZNep protects against retinal ganglion cell death in an NMDA-induced mouse model of retinal degeneration.
Topics: Adenosine; Animals; Cell Count; Cell Death; Disease Models, Animal; Electroretinography; Intravitreal Injections; Male; Mice; N-Methylaspartate; Retinal Degeneration; Retinal Ganglion Cells | 2021 |
DZNep promotes mouse bone defect healing via enhancing both osteogenesis and osteoclastogenesis.
Topics: Adenosine; Animals; Bone Resorption; Cell Differentiation; Epigenesis, Genetic; Mice; NF-kappa B; Osteoclasts; Osteogenesis; RANK Ligand | 2021 |
S-adenosylmethionine-dependent methyltransferase inhibitor DZNep blocks transcription and translation of SARS-CoV-2 genome with a low tendency to select for drug-resistant viral variants.
Topics: Adenosine; Animals; Chick Embryo; Chlorocebus aethiops; Chromatin Immunoprecipitation Sequencing; DNA Methylation; Drug Resistance, Viral; Genome, Viral; Heterogeneous Nuclear Ribonucleoprotein A1; Humans; Lethal Dose 50; Methyltransferases; Mice; Protein Biosynthesis; Rabbits; RNA, Viral; SARS-CoV-2; Specific Pathogen-Free Organisms; Transcription, Genetic; Vero Cells | 2022 |
Vitamin C promotes anti-leukemia of DZNep in acute myeloid leukemia.
Topics: Adenosine; Ascorbic Acid; Enhancer of Zeste Homolog 2 Protein; Histone Methyltransferases; Humans; Leukemia, Myeloid, Acute | 2022 |
Dznep, a histone modification inhibitor, inhibits HIF1α binding to TIMP2 gene and suppresses TIMP2 expression under hypoxia.
Topics: Acute Kidney Injury; Adenosine; Animals; Disease Models, Animal; Epigenesis, Genetic; Histone Code; Humans; Mice; Tissue Inhibitor of Metalloproteinase-2 | 2023 |