Page last updated: 2024-09-03

3-deazaguanosine and guanosine

3-deazaguanosine has been researched along with guanosine in 22 studies

Compound Research Comparison

Studies (3-deazaguanosine)	Trials (3-deazaguanosine)	Recent Studies (post-2010) (3-deazaguanosine)	Studies (guanosine)	Trials (guanosine)	Recent Studies (post-2010) (guanosine)
26	0	2	4,442	26	1,036

Research

Studies (22)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (77.27)	18.7374
1990's	1 (4.55)	18.2507
2000's	2 (9.09)	29.6817
2010's	1 (4.55)	24.3611
2020's	1 (4.55)	2.80

Authors

Authors	Studies
Cook, PD; Dea, P; Meyer, RB; Mian, AM; Robins, RK; Rousseau, RJ	1
Cook, PD; Dea, P; Ivanovics, G; Meyer, RB; Mian, AM; Rousseau, RJ	1
Plunkett, W; Saunders, PP	1
Jacobsen, SJ; Mangum, JH; Nyhan, WL; Page, TM; Robins, RK	1
Robins, RK; Saunders, PP; Spindler, CD; Tan, MT	1
Berman, JD; Chapman, WL; Hanson, WL; Jackson, JE; Klein, RS; Lovelace, JK; Waits, VB	1
Plunkett, W; Robins, RK; Saunders, PP; Spindler, CD; Tan, MT	1
Jacobsen, SJ; Mangum, JH; Nyhan, WL; Page, T; Robins, RK; Scheele, J; Smejkal, RM	1
Gupta, PK; Revankar, GR; Robins, RK	1
Adams, AD; Canonico, PG; Cook, PD; Dalley, NK; Gupta, PK; McKernan, PA; Revankar, GR; Robins, RK	1
Cuatrecasas, P; Deeprose, RD; Duncan, GS; Elion, GB; Schmitges, CJ; Wolberg, G; Zimmerman, TP	1
Barnett, BB; Clark, SM; Sidwell, RW; Smee, DF; Spendlove, RS	1
Boyd, VL; Jacobsen, SJ; Mangum, JH; Nyhan, WL; Page, TT; Robins, RK; Smejkal, RM	1
Burns, NJ; Kirsi, JJ; McKernan, PA; Murray, BK; North, JA; Robins, RK	1
Chiang, PK; Lucas, DL; Robins, RK; Webster, HK; Wiesmann, WP; Wright, DG	1
Berman, JD; Lee, LS; Revankar, GR; Robins, RK	1
Matthews, TR; Miller, JP; Miller, M; Robins, RK; Streeter, DG	1
Chao, LY; Loo, TL; Robins, RK; Saunders, PP	1
Cheng, YC; Dutschman, GE; Gullen, EA; Lin, TS; Liu, MC; Luo, MZ; Mozdziesz, DE; Sartorelli, AC	1
Sasami, T; Seio, K; Sekine, M	1
Flemmich, L; Kreutz, C; Mairhofer, E; Micura, R	1
Hinotani, N; Minakawa, N; Saito-Tarashima, N	1

Reviews

1 review(s) available for 3-deazaguanosine and guanosine

Article	Year
Metabolism and action of purine nucleoside analogs. Pharmacology & therapeutics, 1991, Volume: 49, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Cladribine; Deoxyadenosines; Guanine; Guanosine; Humans; Purine Nucleosides; Ribavirin; Vidarabine	1991

Other Studies

21 other study(ies) available for 3-deazaguanosine and guanosine

Article	Year
Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors. Journal of the American Chemical Society, 1976, Mar-17, Volume: 98, Issue:6 Topics: Animals; Antimetabolites; Guanine; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Imidazoles; Methods; Mice	1976
Letter: A new class of potent guanine antimetabolites. Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors. Journal of the American Chemical Society, 1975, May-14, Volume: 97, Issue:10 Topics: Antimetabolites; Cyclization; Guanine; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Imidazoles; Methods	1975
The metabolism of 3-deazaguanine and 3-deazaguanosine by human cells in culture. The International journal of biochemistry, 1986, Volume: 18, Issue:10 Topics: Cells, Cultured; DNA; Fibroblasts; Guanine; Guanosine; Guanosine Monophosphate; Humans; Hypoxanthine Phosphoribosyltransferase; Mutation; Phosphorylation; RNA	1986
Phosphorylation of 3-deazaguanosine by nicotinamide riboside kinase in Chinese hamster ovary cells. Cancer research, 1989, Dec-01, Volume: 49, Issue:23 Topics: Animals; Cell Line; Cell Survival; Cricetinae; Guanosine; NAD; Niacinamide; Phosphorylation; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Substrate Specificity	1989
Activity of purine analogs against Leishmania donovani in vivo. Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:1 Topics: Administration, Oral; Allopurinol; Animals; Cricetinae; Formycins; Guanosine; Injections, Intramuscular; Inosine; Leishmania donovani; Leishmaniasis, Visceral; Liver; Male; Meglumine; Meglumine Antimoniate; Mesocricetus; Organometallic Compounds; Saimiri; Spleen	1987
3-Deazaguanosine is metabolized to the triphosphate derivative in Chinese hamster cells deficient in hypoxanthine-guanine phosphoribosyltransferase. The Journal of biological chemistry, 1986, May-15, Volume: 261, Issue:14 Topics: Alkaline Phosphatase; Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Female; Formates; Guanine; Guanosine; Guanosine Triphosphate; Hypoxanthine Phosphoribosyltransferase; Inosine; Ovary; Thymidine	1986
Studies on the mechanism of cytotoxicity of 3-deazaguanosine in human cancer cells. Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:1 Topics: Adenine; Cell Division; Cells, Cultured; DNA; Formates; GMP Reductase; Guanine; Guanosine; Humans; NADH, NADPH Oxidoreductases; Neoplasms; Purines	1985
A new synthesis of certain 7-(beta-D-ribofuranosyl) and 7-(2-deoxy-beta-D-ribofuranosyl) derivatives of 3-deazaguanine via the sodium salt glycosylation procedure. Nucleic acids research, 1985, Jul-25, Volume: 13, Issue:14 Topics: Chemical Phenomena; Chemistry; Deoxyguanosine; Guanosine; Methods; Sodium Chloride	1985
Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides. Journal of medicinal chemistry, 1984, Volume: 27, Issue:11 Topics: Animals; Antineoplastic Agents; Antiviral Agents; Guanine; Guanosine; Leukemia L1210; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Parainfluenza Virus 3, Human; Simplexvirus; Vaccinia virus; Vesicular stomatitis Indiana virus	1984
Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes. Proceedings of the National Academy of Sciences of the United States of America, 1980, Volume: 77, Issue:10 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenylyl Cyclases; Animals; Cyclic AMP; Enzyme Activation; Guanosine; Lymphocytes; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine	1980
Inhibition of bluetongue and Colorado tick fever orbiviruses by selected antiviral substances. Antimicrobial agents and chemotherapy, 1981, Volume: 20, Issue:4 Topics: 3-Deazauridine; Adenine; Antiviral Agents; Bluetongue virus; Cells, Cultured; Colorado tick fever virus; Guanosine; Reoviridae; Ribavirin	1981
Novel nucleoside inhibitors of guanosine metabolism as antitumor agents. Advances in enzyme regulation, 1984, Volume: 22 Topics: Adenocarcinoma; Antineoplastic Agents; Cell Division; Cell Line; Clone Cells; Drug Synergism; Formates; Guanosine; Humans; Lung Neoplasms; Purines; Ribavirin; Ribonucleosides	1984
Broad-spectrum synergistic antiviral activity of selenazofurin and ribavirin. Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:4 Topics: Antiviral Agents; DNA, Viral; Drug Combinations; Drug Synergism; Guanosine; Organoselenium Compounds; Ribavirin; Ribonucleosides; RNA, Viral; Selenium	1984
Effects of 3-deazaguanosine and 3-deazaguanine on the growth and maturation of the human promyelocytic leukemia cell line, HL-60. Advances in experimental medicine and biology, 1984, Volume: 165 Pt B Topics: Antimetabolites; Cell Division; Cell Line; Guanine; Guanosine; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Myeloid, Acute; Mycophenolic Acid	1984
Activity of purine analogs against Leishmania tropica within human macrophages in vitro. Antimicrobial agents and chemotherapy, 1983, Volume: 24, Issue:2 Topics: Allopurinol; Antiprotozoal Agents; Formycins; Guanine; Guanosine; Humans; In Vitro Techniques; Leishmania; Macrophages; Purines; Ribonucleosides; Thionucleosides	1983
7-Ribosyl-3-deazaguanine--mechanism of antibacterial action. Biochemical pharmacology, 1980, Jun-15, Volume: 29, Issue:12 Topics: Animals; Anti-Bacterial Agents; Biotransformation; Carcinoma, Ehrlich Tumor; Drug Resistance, Microbial; Escherichia coli; Guanine; Guanosine; Humans; Hypoxanthines; In Vitro Techniques; Liver; Purines; Pyrimidines; Rats	1980
Actions of 3-deazaguanine and 3-deazaguanosine on variant lines of Chinese hamster ovary cells. Biochemical pharmacology, 1981, Aug-15, Volume: 30, Issue:16 Topics: Adenine Phosphoribosyltransferase; Adenosine Kinase; Animals; Antineoplastic Agents; Cells, Cultured; Cricetinae; Cricetulus; Deoxycytidine Kinase; Female; Guanine; Guanosine; Hypoxanthine Phosphoribosyltransferase; Ovary; Purine Nucleotides	1981
Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents. Nucleosides, nucleotides & nucleic acids, 2001, Volume: 20, Issue:12 Topics: Animals; Antineoplastic Agents; Antiviral Agents; Biochemistry; Drug Screening Assays, Antitumor; Guanosine; Halogens; Hepatitis B virus; HIV-1; Humans; Inhibitory Concentration 50; Leukemia L1210; Microbial Sensitivity Tests; Tumor Cells, Cultured	2001
Synthesis and base recognition ability of oligoribonucleotides incorporating 2'-O-methyl-3-deazaguanosine. Nucleic acids symposium series (2004), 2004, Issue:48 Topics: Base Pair Mismatch; Base Pairing; Guanosine; Oligoribonucleotides	2004
Access to 3-Deazaguanosine Building Blocks for RNA Solid-Phase Synthesis Involving Hartwig-Buchwald C-N Cross-Coupling. Organic letters, 2019, 06-07, Volume: 21, Issue:11 Topics: Guanosine; Molecular Structure; Organophosphorus Compounds; RNA; Solid-Phase Synthesis Techniques	2019
Convenient Synthesis of 3-Deazapurine Nucleosides (3-Deazainosine, 3-Deazaadenosine and 3-Deazaguanosine) Using Inosine as a Starting Material. Current protocols, 2021, Volume: 1, Issue:11 Topics: Guanosine; Inosine; Nucleosides; Tubercidin	2021