Compounds > 3-deazaguanosine

Page last updated: 2024-09-03

3-deazaguanosine and guanine

3-deazaguanosine has been researched along with guanine in 12 studies

Compound Research Comparison

Studies (3-deazaguanosine)	Trials (3-deazaguanosine)	Recent Studies (post-2010) (3-deazaguanosine)	Studies (guanine)	Trials (guanine)	Recent Studies (post-2010) (guanine)
26	0	2	16,278	822	4,809

Protein Interaction Comparison

Protein	Taxonomy	3-deazaguanosine (IC50)	guanine (IC50)
Purine nucleoside phosphorylase	Homo sapiens (human)		5

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (91.67)	18.7374
1990's	1 (8.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Berry, DA; Cook, PD; Gilbertsen, RB	1
Cook, PD; Dea, P; Meyer, RB; Mian, AM; Robins, RK; Rousseau, RJ	1
Cook, PD; Dea, P; Ivanovics, G; Meyer, RB; Mian, AM; Rousseau, RJ	1
Plunkett, W; Saunders, PP	1
Jacobsen, SJ; Mangum, JH; Nyhan, WL; Page, TM; Robins, RK	1
Plunkett, W; Robins, RK; Saunders, PP; Spindler, CD; Tan, MT	1
Jacobsen, SJ; Mangum, JH; Nyhan, WL; Page, T; Robins, RK; Scheele, J; Smejkal, RM	1
Adams, AD; Canonico, PG; Cook, PD; Dalley, NK; Gupta, PK; McKernan, PA; Revankar, GR; Robins, RK	1
Chiang, PK; Lucas, DL; Robins, RK; Webster, HK; Wiesmann, WP; Wright, DG	1
Berman, JD; Lee, LS; Revankar, GR; Robins, RK	1
Matthews, TR; Miller, JP; Miller, M; Robins, RK; Streeter, DG	1
Chao, LY; Loo, TL; Robins, RK; Saunders, PP	1

Reviews

1 review(s) available for 3-deazaguanosine and guanine

Article	Year
Metabolism and action of purine nucleoside analogs. Pharmacology & therapeutics, 1991, Volume: 49, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Cladribine; Deoxyadenosines; Guanine; Guanosine; Humans; Purine Nucleosides; Ribavirin; Vidarabine	1991

Other Studies

11 other study(ies) available for 3-deazaguanosine and guanine

Article	Year
Synthesis of 8-amino-3-deazaguanine via imidazole precursors. Antitumor activity and inhibition of purine nucleoside phosphorylase. Journal of medicinal chemistry, 1986, Volume: 29, Issue:10 Topics: Animals; Antineoplastic Agents; Guanine; Humans; Leukemia L1210; Lymphocytes; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship	1986
Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors. Journal of the American Chemical Society, 1976, Mar-17, Volume: 98, Issue:6 Topics: Animals; Antimetabolites; Guanine; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Imidazoles; Methods; Mice	1976
Letter: A new class of potent guanine antimetabolites. Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors. Journal of the American Chemical Society, 1975, May-14, Volume: 97, Issue:10 Topics: Antimetabolites; Cyclization; Guanine; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Imidazoles; Methods	1975
The metabolism of 3-deazaguanine and 3-deazaguanosine by human cells in culture. The International journal of biochemistry, 1986, Volume: 18, Issue:10 Topics: Cells, Cultured; DNA; Fibroblasts; Guanine; Guanosine; Guanosine Monophosphate; Humans; Hypoxanthine Phosphoribosyltransferase; Mutation; Phosphorylation; RNA	1986
3-Deazaguanosine is metabolized to the triphosphate derivative in Chinese hamster cells deficient in hypoxanthine-guanine phosphoribosyltransferase. The Journal of biological chemistry, 1986, May-15, Volume: 261, Issue:14 Topics: Alkaline Phosphatase; Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Female; Formates; Guanine; Guanosine; Guanosine Triphosphate; Hypoxanthine Phosphoribosyltransferase; Inosine; Ovary; Thymidine	1986
Studies on the mechanism of cytotoxicity of 3-deazaguanosine in human cancer cells. Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:1 Topics: Adenine; Cell Division; Cells, Cultured; DNA; Formates; GMP Reductase; Guanine; Guanosine; Humans; NADH, NADPH Oxidoreductases; Neoplasms; Purines	1985
Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides. Journal of medicinal chemistry, 1984, Volume: 27, Issue:11 Topics: Animals; Antineoplastic Agents; Antiviral Agents; Guanine; Guanosine; Leukemia L1210; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Parainfluenza Virus 3, Human; Simplexvirus; Vaccinia virus; Vesicular stomatitis Indiana virus	1984
Effects of 3-deazaguanosine and 3-deazaguanine on the growth and maturation of the human promyelocytic leukemia cell line, HL-60. Advances in experimental medicine and biology, 1984, Volume: 165 Pt B Topics: Antimetabolites; Cell Division; Cell Line; Guanine; Guanosine; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Myeloid, Acute; Mycophenolic Acid	1984
Activity of purine analogs against Leishmania tropica within human macrophages in vitro. Antimicrobial agents and chemotherapy, 1983, Volume: 24, Issue:2 Topics: Allopurinol; Antiprotozoal Agents; Formycins; Guanine; Guanosine; Humans; In Vitro Techniques; Leishmania; Macrophages; Purines; Ribonucleosides; Thionucleosides	1983
7-Ribosyl-3-deazaguanine--mechanism of antibacterial action. Biochemical pharmacology, 1980, Jun-15, Volume: 29, Issue:12 Topics: Animals; Anti-Bacterial Agents; Biotransformation; Carcinoma, Ehrlich Tumor; Drug Resistance, Microbial; Escherichia coli; Guanine; Guanosine; Humans; Hypoxanthines; In Vitro Techniques; Liver; Purines; Pyrimidines; Rats	1980
Actions of 3-deazaguanine and 3-deazaguanosine on variant lines of Chinese hamster ovary cells. Biochemical pharmacology, 1981, Aug-15, Volume: 30, Issue:16 Topics: Adenine Phosphoribosyltransferase; Adenosine Kinase; Animals; Antineoplastic Agents; Cells, Cultured; Cricetinae; Cricetulus; Deoxycytidine Kinase; Female; Guanine; Guanosine; Hypoxanthine Phosphoribosyltransferase; Ovary; Purine Nucleotides	1981