3-deazaguanine has been researched along with guanine in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (53.85) | 18.7374 |
| 1990's | 8 (20.51) | 18.2507 |
| 2000's | 6 (15.38) | 29.6817 |
| 2010's | 4 (10.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berry, DA; Cook, PD; Gilbertsen, RB | 1 |
| Cook, PD; Dea, P; Meyer, RB; Mian, AM; Robins, RK; Rousseau, RJ | 1 |
| Chao, LY; Loo, TL; Robins, RK; Saunders, PP | 2 |
| Cook, PD; Dea, P; Ivanovics, G; Meyer, RB; Mian, AM; Rousseau, RJ | 1 |
| Plunkett, W; Saunders, PP | 1 |
| Creaven, PJ; Pendyala, L; Whitfield, LR | 1 |
| Akman, S; Carr, B; DeLap, R; Doroshow, J; Flanagan, B; Goldberg, D; Grove, W; Leong, L; Margolin, K; Odujinrin, O | 1 |
| Jolley, WB; Revankar, GR; Robins, RK; Sanghvi, YS; Sharma, BS | 1 |
| Borchardt, KA; Chen, YC; Liu, LA | 1 |
| Jacobsen, SJ; Mangum, JH; Nyhan, WL; Page, TM; Robins, RK | 1 |
| Ardalan, B; Luna, MK; Singh, G | 1 |
| Kennedy, KA; Mandel, HG; Pieper, RO | 1 |
| Mandel, HG; Pieper, RO | 1 |
| Plunkett, W; Robins, RK; Saunders, PP; Spindler, CD; Tan, MT | 1 |
| Barrows, LR; Mandel, HG; Pieper, RO | 1 |
| Besserer, JA; Boritzki, TJ; Fry, DW; Jackson, RC; Leopold, WR; Pattison, IC | 1 |
| De Clercq, E; Kawana, F; Shigeta, S | 1 |
| Adams, AD; Canonico, PG; Cook, PD; Dalley, NK; Gupta, PK; McKernan, PA; Revankar, GR; Robins, RK | 1 |
| Barnett, BB; Clark, SM; Sidwell, RW; Smee, DF; Spendlove, RS | 1 |
| Ardalan, B; Chandrasekaran, B | 1 |
| Chiang, PK; Lucas, DL; Robins, RK; Webster, HK; Wiesmann, WP; Wright, DG | 1 |
| Berman, JD; Lee, LS; Revankar, GR; Robins, RK | 1 |
| Irwin, D; Mandel, HG; Rivest, RS | 2 |
| Khwaja, TA | 1 |
| Asawa, S; Konno, K; Shigeta, S; Sudo, K; Watanabe, W; Yokota, T | 1 |
| Spratt, TE | 1 |
| Cheng, YC; Dutschman, GE; Lin, TS; Liu, MC; Luo, MZ; Mozdziesz, DE; Sartorelli, AC | 1 |
| Blandino, M; Meyer, AS; Spratt, TE | 1 |
| Glekas, A; McCain, MD; Meyer, AS; Schultz, SS; Spratt, TE | 1 |
| Ong, HC; Zimmerman, SC | 1 |
| Sasami, T; Seio, K; Sekine, M; Tawarada, R | 1 |
| Ohkubo, A; Sasami, T; Seio, K; Sekine, M | 1 |
| Dekanski, D; Isakovic, A; Mitrovic, DM; Petrovic, MM; Scepanovic, L | 1 |
| Barnes, MH; Brown, NC; Butler, MM; Dvoskin, S; Gambino, JJ; Long, ZY; Wright, GE; Xu, WC; Zhi, CX | 1 |
| Bazzi, S; Marek, R; Novotný, J; Yurenko, YP | 1 |
| Day, CW; Evans, WJ; Nicolaou, KC; Smee, DF; Tarbet, EB | 1 |
| Kondhare, D; Leonard, P; Seela, F; Zhou, X | 1 |
1 review(s) available for 3-deazaguanine and guanine
| Article | Year |
|---|---|
Metabolism and action of purine nucleoside analogs.
Topics: 2-Chloroadenosine; Adenosine; Cladribine; Deoxyadenosines; Guanine; Guanosine; Humans; Purine Nucleosides; Ribavirin; Vidarabine | 1991 |
1 trial(s) available for 3-deazaguanine and guanine
| Article | Year |
|---|---|
3-Deazaguanine: report of a phase I trial and drug-related cardiac toxicity.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Drug Evaluation; Drugs, Investigational; Female; Guanine; Heart Failure; Humans; Male; Middle Aged; Myocardium; Neoplasms | 1990 |
37 other study(ies) available for 3-deazaguanine and guanine
| Article | Year |
|---|---|
Synthesis of 8-amino-3-deazaguanine via imidazole precursors. Antitumor activity and inhibition of purine nucleoside phosphorylase.
Topics: Animals; Antineoplastic Agents; Guanine; Humans; Leukemia L1210; Lymphocytes; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship | 1986 |
Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors.
Topics: Animals; Antimetabolites; Guanine; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Imidazoles; Methods; Mice | 1976 |
Action of 3-deazaguanine in Escherichia coli.
Topics: Anti-Bacterial Agents; Bacterial Proteins; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Guanine; RNA, Bacterial | 1979 |
Letter: A new class of potent guanine antimetabolites. Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors.
Topics: Antimetabolites; Cyclization; Guanine; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Imidazoles; Methods | 1975 |
Clinical pharmacokinetics of 3-deazaguanine.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Drug Evaluation; Guanine; Half-Life; Humans; Infusions, Intravenous; Regression Analysis; Time Factors | 1991 |
Low molecular weight human T-cell response immunopotentiator: alpha-2'-deoxy-3-deazaguanosine.
Topics: Adjuvants, Immunologic; B-Lymphocytes; Cyclosporins; Deoxyguanosine; Guanine; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Mitogens; Molecular Weight; Phytohemagglutinins; T-Lymphocytes | 1990 |
The effects of 3-deazaguanine on Rous sarcoma virus transformation.
Topics: Animals; Antiviral Agents; Avian Sarcoma Viruses; Cats; Cell Transformation, Viral; Guanine; Temperature | 1990 |
The metabolism of 3-deazaguanine and 3-deazaguanosine by human cells in culture.
Topics: Cells, Cultured; DNA; Fibroblasts; Guanine; Guanosine; Guanosine Monophosphate; Humans; Hypoxanthine Phosphoribosyltransferase; Mutation; Phosphorylation; RNA | 1986 |
Studies on the mechanism of 3-deazaguanine cytotoxicity in L1210-sensitive and -resistant cell lines.
Topics: Adenine Phosphoribosyltransferase; Animals; Antimetabolites, Antineoplastic; Cell Division; Drug Resistance; Formates; Guanine; Hypoxanthine Phosphoribosyltransferase; IMP Dehydrogenase; Leukemia L1210; Male; Mice; Mice, Inbred DBA; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1988 |
DNA-directed actions of 3-deazaguanine: effects on DNA integrity and DNA elongation/ligation.
Topics: Animals; DNA; DNA Damage; Dose-Response Relationship, Drug; Guanine; Leukemia L1210; Tumor Cells, Cultured | 1988 |
Interrelationship of 3-deazaguanine-induced growth inhibitory actions in L1210 cells.
Topics: Animals; Cell Survival; DNA; Guanine; Leukemia L1210; Protein Biosynthesis; RNA, Messenger; Tumor Cells, Cultured | 1988 |
3-Deazaguanosine is metabolized to the triphosphate derivative in Chinese hamster cells deficient in hypoxanthine-guanine phosphoribosyltransferase.
Topics: Alkaline Phosphatase; Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Female; Formates; Guanine; Guanosine; Guanosine Triphosphate; Hypoxanthine Phosphoribosyltransferase; Inosine; Ovary; Thymidine | 1986 |
Correlation of biochemical effects and incorporation of 3-deazaguanine into nucleic acids to cytotoxicity in L1210 cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Survival; DNA, Neoplasm; Guanine; Guanosine Triphosphate; Leukemia L1210; Neoplasm Proteins; RNA, Neoplasm | 1986 |
Dezaguanine mesylate: a new antipurine antimetabolite.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Survival; Cells, Cultured; DNA, Neoplasm; Drug Evaluation; Guanine; Humans; Kinetics; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Purines; Time Factors | 1985 |
Inhibitory effects of several antiviral compounds on the replication of respiratory syncytial virus in vitro.
Topics: Amides; Antiviral Agents; Cytidine; Dose-Response Relationship, Drug; Guanine; HeLa Cells; Humans; Pyrazoles; Respiratory Syncytial Viruses; Ribavirin; Ribonucleosides; Ribose; Tubercidin; Virus Replication | 1985 |
Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Guanine; Guanosine; Leukemia L1210; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Parainfluenza Virus 3, Human; Simplexvirus; Vaccinia virus; Vesicular stomatitis Indiana virus | 1984 |
Inhibition of rotaviruses by selected antiviral substances: mechanisms of viral inhibition and in vivo activity.
Topics: Adenine; Animals; Antiviral Agents; Guanine; Mice; Mice, Inbred Strains; Peptide Biosynthesis; Reoviridae; Reoviridae Infections; Ribavirin; RNA, Viral; Rotavirus | 1982 |
Determination of 3-deazaguanine in mice plasma by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Guanine; Mice; Time Factors | 1984 |
Effects of 3-deazaguanosine and 3-deazaguanine on the growth and maturation of the human promyelocytic leukemia cell line, HL-60.
Topics: Antimetabolites; Cell Division; Cell Line; Guanine; Guanosine; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Myeloid, Acute; Mycophenolic Acid | 1984 |
Activity of purine analogs against Leishmania tropica within human macrophages in vitro.
Topics: Allopurinol; Antiprotozoal Agents; Formycins; Guanine; Guanosine; Humans; In Vitro Techniques; Leishmania; Macrophages; Purines; Ribonucleosides; Thionucleosides | 1983 |
3-Deazaguanine: inhibition of initiation of translation in L1210 cells.
Topics: Animals; Antimetabolites; Guanine; Kinetics; Leukemia L1210; Mice; Peptide Chain Initiation, Translational; Protein Biosynthesis; RNA, Neoplasm; Transcription, Genetic | 1982 |
Purine analogs revisited: interference in protein formation.
Topics: Animals; Azaguanine; Cells, Cultured; DNA, Neoplasm; Guanine; Leukemia L1210; Mice; Neoplasm Proteins; Polyribosomes; Protein Biosynthesis; Purines; RNA, Neoplasm; Thioguanine | 1982 |
3-deazaguanine, a candidate drug for the chemotherapy of breast carcinomas?
Topics: Adenocarcinoma; Animals; Antimetabolites; Breast Neoplasms; Cell Line; Female; Guanine; Leukemia, Experimental; Mice; Neoplasm Transplantation; Rats | 1982 |
Actions of 3-deazaguanine and 3-deazaguanosine on variant lines of Chinese hamster ovary cells.
Topics: Adenine Phosphoribosyltransferase; Adenosine Kinase; Animals; Antineoplastic Agents; Cells, Cultured; Cricetinae; Cricetulus; Deoxycytidine Kinase; Female; Guanine; Guanosine; Hypoxanthine Phosphoribosyltransferase; Ovary; Purine Nucleotides | 1981 |
Use of lactate dehydrogenase to evaluate the anti-viral activity against influenza A virus.
Topics: Amides; Animals; Antiviral Agents; Cell Line; Colorimetry; Coloring Agents; Cytidine; Dogs; Guanine; Influenza A virus; L-Lactate Dehydrogenase; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Tetrazolium Salts; Thiazoles | 1995 |
Klenow fragment-DNA interaction required for the incorporation of nucleotides opposite guanine and O6-methylguanine.
Topics: Antimetabolites; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA Polymerase I; Guanine; Kinetics; Thymine Nucleotides | 1997 |
Synthesis of 2'-methylene-substituted 5-azapyrimidine, 6-azapyrimidine, and 3-deazaguanine nucleoside analogues as potential antitumor/antiviral agents.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Aza Compounds; Drug Screening Assays, Antitumor; Guanine; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; Humans; Indicators and Reagents; Leukemia L1210; Mice; Microbial Sensitivity Tests; Molecular Structure; Pyrimidines; Tumor Cells, Cultured | 1999 |
Escherichia coli DNA polymerase I (Klenow fragment) uses a hydrogen-bonding fork from Arg668 to the primer terminus and incoming deoxynucleotide triphosphate to catalyze DNA replication.
Topics: Arginine; Binding Sites; Catalysis; DNA Polymerase I; DNA Replication; Escherichia coli; Guanine; Hydrogen Bonding; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Uridine Triphosphate | 2004 |
Fidelity of mispair formation and mispair extension is dependent on the interaction between the minor groove of the primer terminus and Arg668 of DNA polymerase I of Escherichia coli.
Topics: Arginine; Base Pair Mismatch; Base Sequence; Binding Sites; DNA Polymerase I; DNA Replication; DNA, Bacterial; Escherichia coli; Guanine; Hydrogen Bonding; Kinetics; Oligodeoxyribonucleotides | 2005 |
Higher affinity quadruply hydrogen-bonded complexation with 7-deazaguanine urea.
Topics: Guanine; Hydrogen Bonding; Kinetics; Molecular Structure; Phenazines; Urea | 2006 |
Synthesis of 2'-O-methyl-RNAs incorporating a 3-deazaguanine, and UV melting and computational studies on its hybridization properties.
Topics: Base Pairing; Computational Biology; Cytosine; Guanine; Hydrogen Bonding; Nucleic Acid Denaturation; Nucleic Acid Hybridization; Oligonucleotide Probes; Organophosphorus Compounds; Ultraviolet Rays | 2006 |
Synthesis and hybridization properties of 2'-O-methyl-RNA incorporating 3-deazaguanine derivatives.
Topics: Base Pair Mismatch; Base Pairing; Guanine; Methylation; Nucleic Acid Hybridization; RNA; Temperature | 2005 |
Mechanism of 3-deazaguanine transport in the rat heart.
Topics: Adenine; Adenosine; Animals; Dinitrophenols; Female; Guanine; In Vitro Techniques; Male; Myocardium; Nucleoside Transport Proteins; Radioisotope Dilution Technique; Rats; Sodium; Thymidine; Thymine; Tritium | 2006 |
7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity.
Topics: Animals; Anti-Bacterial Agents; DNA Polymerase III; Enzyme Inhibitors; Escherichia coli; Gram-Positive Bacteria; Guanine; Mice; Microbial Sensitivity Tests; Staphylococcal Infections | 2011 |
Designing a New Class of Bases for Nucleic Acid Quadruplexes and Quadruplex-Active Ligands.
Topics: G-Quadruplexes; Guanine; Hydrogen Bonding; Ligands; Nucleic Acid Conformation; Nucleic Acids | 2015 |
Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds.
Topics: A549 Cells; Antimetabolites; Antiviral Agents; Benzimidazoles; Enterovirus A, Human; Enterovirus D, Human; Guanine; HeLa Cells; Humans; Oxadiazoles; Oxazoles; Oximes; Picornaviridae; Piperazines; Piperidines; Pyridazines; Rhabdomyosarcoma; Rhinovirus; Ribavirin; Sulfonamides | 2016 |
Anomeric 5-Aza-7-deaza-2'-deoxyguanosines in Silver-Ion-Mediated Homo and Hybrid Base Pairs: Impact of Mismatch Structure, Helical Environment, and Nucleobase Substituents on DNA Stability.
Topics: Base Pair Mismatch; Base Pairing; Cations, Monovalent; Cytosine; Deoxycytidine; Deoxyguanosine; DNA; Glycosylation; Guanine; Models, Molecular; Nucleic Acid Conformation; Oligonucleotides; Silver; Structure-Activity Relationship; Thermodynamics | 2019 |