3-chloro-L-tyrosine has been researched along with mocetinostat in 36 studies
| Studies (3-chloro-L-tyrosine) | Trials (3-chloro-L-tyrosine) | Recent Studies (post-2010) (3-chloro-L-tyrosine) | Studies (mocetinostat) | Trials (mocetinostat) | Recent Studies (post-2010) (mocetinostat) |
|---|---|---|---|---|---|
| 81 | 1 | 26 | 21,735 | 390 | 8,606 |
| Protein | Taxonomy | 3-chloro-L-tyrosine (IC50) | mocetinostat (IC50) |
|---|---|---|---|
| Histone deacetylase 3 | Homo sapiens (human) | 0.7851 | |
| Nuclear receptor corepressor 1 | Homo sapiens (human) | 0.022 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.57 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.102 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.102 | |
| Histone deacetylase 4 | Homo sapiens (human) | 0.5717 | |
| Histone deacetylase 1 | Homo sapiens (human) | 0.3433 | |
| Histone deacetylase 7 | Homo sapiens (human) | 0.6725 | |
| Histone deacetylase 2 | Homo sapiens (human) | 0.3537 | |
| Histone deacetylase 11 | Homo sapiens (human) | 0.6386 | |
| Histone deacetylase 8 | Homo sapiens (human) | 0.6725 | |
| Histone deacetylase 6 | Homo sapiens (human) | 0.5717 | |
| Histone deacetylase 5 | Homo sapiens (human) | 0.6725 | |
| Nuclear receptor corepressor 2 | Homo sapiens (human) | 0.045 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (16.67) | 18.2507 |
| 2000's | 17 (47.22) | 29.6817 |
| 2010's | 12 (33.33) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Kettle, AJ | 2 |
| Crowley, JR; Hazen, SL; Heinecke, JW; Hsu, FF; Mueller, DM | 1 |
| Hazen, SL; Heinecke, JW | 1 |
| Halliwell, B | 1 |
| Crowley, JR; Hazen, SL; Heinecke, JW; Mueller, DM | 1 |
| Abu-Soud, HM; Hazen, SL; Podrez, EA | 1 |
| Cross, CE; Eiserich, JP; Marelich, GP; Nguyen, MN; Shigenaga, MK; Van Der Vliet, A | 1 |
| Anderson, MM; Brennan, ML; Crowley, JR; Hazen, SL; Heinecke, JW; Jacob, JS; Lim, LL; Lusis, AJ; Mehta, AC; Qu, XD; Shi, W; Shih, DM; Wang, X | 1 |
| Belaaouaj, A; Brennan, ML; Byun, J; Gaut, JP; Heinecke, JW; Henderson, JP; Hotchkiss, RS; Lusis, AJ; Richter, GM; Tran, HD; Yeh, GC | 1 |
| Heinecke, JW; Himmelfarb, J; Loseto, G; McMenamin, ME | 1 |
| Belaaouaj, A; Byun, J; Carroll, JA; Gaut, JP; Heinecke, JW; Hotchkiss, RS; Lauber, WM; Tran, HD | 1 |
| Crowley, JR; Heinecke, JW; Rosen, H | 1 |
| Buss, IH; Darlow, BA; Kettle, AJ; Mogridge, N; Senthilmohan, R; Winterbourn, CC | 1 |
| Bergt, C; Brunzell, J; Byun, J; Chait, A; Geary, RL; Green, PS; Heinecke, JW; Kassim, SY; McDonald, TO; O'brien, K; Oram, JF; Pennathur, S; Shao, B; Singh, P | 1 |
| Anantharamaiah, GM; Bergt, C; Brunzell, J; Byun, J; Chait, A; Fu, X; Geary, RL; Heinecke, JW; McDonald, TO; O'Brien, K; Oram, JF; Pennathur, S; Singh, P | 1 |
| Choi, DK; Heinecke, JW; Jackson-Lewis, V; Pennathur, S; Perier, C; Przedborski, S; Teismann, P; Tieu, K; Vila, M; Vonsattel, JP; Wu, DC | 1 |
| Cameron, VA; Frampton, CM; Mocatta, TJ; Pilbrow, AP; Richards, AM; Senthilmohan, R; Winterbourn, CC | 1 |
| Chen, CM; Cheng, ML; Chiu, DT; Gu, PW; Ho, HY | 1 |
| Spencer, JP; Whiteman, M | 1 |
| Kagota, S; Kunitomo, M; Otsubo, K; Yamaguchi, Y | 1 |
| Anzalone, R; Cappello, F; Colombo, M; Corrao, S; Di Gangi, C; Di Stefano, A; Eleuteri, E; Farina, F; Giannuzzi, P; La Rocca, G; Loria, T; Magno, F; Martorana, A; Patanè, F; Rinaldi, M; Sansone, F; Zummo, G | 1 |
| Chen, CM; Cheng, ML; Chiu, DT; Gu, PW; Ho, HY; Li, JM; Wang, YL | 1 |
| Andrié, RP; Baldus, S; Böger, RH; Didié, M; Ehmke, H; Eschenhagen, T; Freeman, BA; Friedrichs, K; Fu, X; Hazen, SL; Hirsch-Hoffmann, B; Klingel, K; Klinke, A; Lau, D; Lewalter, T; Meinertz, T; Nickenig, G; Reichenspurner, H; Rudolph, TK; Rudolph, V; Schrickel, JW; Schwoerer, AP; Seniuk, A; Sydow, K; Szoecs, K; Treede, H; von Leitner, EC; Wenzel, U; Willems, S; Zimmermann, WH | 1 |
| De Groote, D; Paquet, P; Piérard, GE | 1 |
| Balding, E; Berry, LJ; Brennan, S; Carlin, JB; Carzino, R; Chapman, AL; de Klerk, N; Douglas, T; Foo, C; Gangell, CL; Garratt, LW; Hall, GL; Harrison, J; Kettle, AJ; Kicic, A; Laing, IA; Logie, KM; Massie, J; Mott, LS; Murray, C; Parsons, F; Pillarisetti, N; Poreddy, SR; Ranganathan, SC; Robertson, CF; Robins-Browne, R; Robinson, PJ; Senthilmohan, R; Skoric, B; Sly, PD; Stick, SM; Sutanto, EN; Thomson, E; Williamson, E | 1 |
| Newbold, P; O'Donnell, C; Stockley, RA; Stone, H; Thong, B; White, P | 1 |
| Beubler, E; Fauler, G; Gauster, M; Heinemann, A; Holzer, M; Koefeler, H; Marsche, G; Pfeifer, T; Schuligoi, R; Stiegler, P; Wadsack, C | 1 |
| Heinecke, JW; Pennathur, S; Shao, B | 1 |
| Celermajer, DS; Davies, MJ; Harmer, JA; Pattison, DI; Talib, J | 1 |
| Delporte, C; Desmet, JM; Dufour, D; Franck, T; Madhoun, P; Moguilevsky, N; Nève, J; Nortier, J; Noyon, C; Raes, M; Rousseau, A; Serteyn, D; Van Antwerpen, P; Vanhaeverbeek, M; Vanhamme, L; Zouaoui Boudjeltia, K | 1 |
| Byun, J; Gillespie, BW; Heinecke, JW; Kaplan, MJ; Pennathur, S; Sands, RL; Saran, R; Slocum, JL; Tang, C; Vivekanandan-Giri, A | 1 |
| Cheng, D; Maghzal, GJ; Stocker, R; Talib, J | 1 |
| Afshinnia, F; Byun, J; Gadegbeku, CA; Kretzler, M; Magnone, MC; Pennathur, S; Valastro, B; Whatling, C; Zeng, L | 1 |
| Atkins, KB; Brosius, FC; Byun, J; Mathew, AV; Pennathur, S; Zeng, L | 1 |
| Bhat, RV; Chua, J; Fritsche-Danielson, R; Gan, LM; Hausenloy, DJ; Hernandez-Resendiz, S; Jonsson, MKB; Knöll, R; Kp, MMJ; Liehn, EA; Lin, YH; Michaëlsson, E; Ramachandra, CJA; Ryden-Markinhuhta, K; Sadayappan, S; Shim, W; Tang, HC; Wong, P | 1 |
1 review(s) available for 3-chloro-L-tyrosine and mocetinostat
| Article | Year |
|---|---|
Myeloperoxidase-generated oxidants and atherosclerosis.
Topics: Aldehydes; Amino Acids; Animals; Arteriosclerosis; Catalysis; Free Radicals; Humans; Lipoproteins, LDL; Nitro Compounds; Oxidants; Oxidation-Reduction; Peroxidase; Tyrosine | 2000 |
35 other study(ies) available for 3-chloro-L-tyrosine and mocetinostat
| Article | Year |
|---|---|
Neutrophils convert tyrosyl residues in albumin to chlorotyrosine.
Topics: Amino Acid Sequence; Humans; Hypochlorous Acid; In Vitro Techniques; Inflammation; Molecular Sequence Data; Neutrophils; Oligopeptides; Peroxidase; Serum Albumin; Tyrosine | 1996 |
Human neutrophils employ chlorine gas as an oxidant during phagocytosis.
Topics: Chlorine; Gas Chromatography-Mass Spectrometry; Humans; Inflammation; Leukocytes; Neutrophil Activation; Neutrophils; Oxidation-Reduction; Peroxidase; Phagocytosis; Phagosomes; Tyrosine | 1996 |
3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
Topics: Aorta; Apolipoproteins B; Arteriosclerosis; Biomarkers; Chlorine; Humans; Hypochlorous Acid; Lipoproteins; Lipoproteins, LDL; Oxidation-Reduction; Peroxidase; Phagocytes; Tyrosine | 1997 |
What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?
Topics: Biomarkers; Free Radicals; Humans; Molecular Structure; Nitrates; Nitric Oxide; Nitrogen Dioxide; Nitrous Acid; Peroxidase; Superoxides; Tyrosine | 1997 |
Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: a sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation.
Topics: Analysis of Variance; Aorta; Arteriosclerosis; Biomarkers; Calibration; Carbon; Carbon Isotopes; Catalysis; Chlorine; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypochlorous Acid; Inflammation; Lipoproteins, LDL; Male; Peroxidase; Sensitivity and Specificity; Tyrosine | 1997 |
Detection of 3-chlorotyrosine in proteins exposed to neutrophil oxidants.
Topics: Blood Proteins; Chlorides; Chromatography, High Pressure Liquid; Electrochemistry; Fluorescence; Humans; Hydrogen Peroxide; Hypochlorous Acid; Neutrophils; Oxidants; Peroxidase; Tyrosine | 1999 |
Myeloperoxidase and protein oxidation in cystic fibrosis.
Topics: Adult; Bronchi; Case-Control Studies; Cell Line; Chromatography, High Pressure Liquid; Cystic Fibrosis; Drug Synergism; Humans; Hydrogen Peroxide; Nitrates; Nitrites; Oxidants; Oxidation-Reduction; Peroxidase; Peroxidases; Proteins; Respiratory System; Sputum; Trachea; Tyrosine | 2000 |
Increased atherosclerosis in myeloperoxidase-deficient mice.
Topics: Animals; Arteriosclerosis; Candida albicans; Humans; Hypochlorous Acid; Mice; Mice, Inbred C57BL; Neutrophils; Oxidation-Reduction; Peroxidase; Phagocytes; Tyrosine | 2001 |
Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.
Topics: Animals; Bromine; Chlorine; Disease Models, Animal; HL-60 Cells; Humans; Hypochlorous Acid; Ions; Klebsiella Infections; Klebsiella pneumoniae; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Oxidants; Peroxidase; Sepsis; Tyrosine | 2001 |
Myeloperoxidase-catalyzed 3-chlorotyrosine formation in dialysis patients.
Topics: Adult; Aged; Blood Proteins; Female; Gas Chromatography-Mass Spectrometry; Humans; Leukocytes; Male; Middle Aged; Oxidative Stress; Peroxidase; Phagocytes; Renal Dialysis; Renal Insufficiency; Tyrosine | 2001 |
Myeloperoxidase produces nitrating oxidants in vivo.
Topics: Animals; Klebsiella Infections; Klebsiella pneumoniae; Mice; Peritonitis; Peroxidase; Reactive Nitrogen Species; Tyrosine | 2002 |
Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis.
Topics: Bacterial Proteins; Chlorides; Humans; Hydrogen Peroxide; Hypochlorous Acid; Neutrophils; Nitrites; Peroxidase; Phagocytosis; Tyrosine | 2002 |
3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome.
Topics: Biomarkers; Chronic Disease; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Neutrophils; Oxidative Stress; Peroxidase; Respiratory Distress Syndrome, Newborn; Trachea; Tyrosine; Ureaplasma Infections; Ureaplasma urealyticum | 2003 |
Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species.
Topics: Arteries; Arteriosclerosis; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Epitopes; Gas Chromatography-Mass Spectrometry; Humans; Immunohistochemistry; Inflammation; Lipid Peroxides; Lipoproteins, HDL; Mass Spectrometry; Nitric Oxide; Nitrogen; Oxygen; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Taurine; Time Factors; Tunica Intima; Tyrosine | 2004 |
The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport.
Topics: Amino Acid Sequence; Apolipoprotein A-I; Arteries; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cholesterol, HDL; Chromatography, Liquid; Humans; Hypochlorous Acid; Mass Spectrometry; Molecular Sequence Data; Peroxidase; Tyrosine | 2004 |
Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amyotrophic Lateral Sclerosis; Animals; Brain; Corpus Striatum; Dopamine; Drug Evaluation, Preclinical; Enzyme Induction; Humans; Huntington Disease; Hypochlorous Acid; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2005 |
Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Neurotransmitter Agents; New Zealand; Peroxidase; Prognosis; Proportional Hazards Models; Protein Carbonylation; Radionuclide Imaging; Retrospective Studies; Sex Factors; Stroke Volume; Tyrosine; Ventricular Dysfunction, Left | 2007 |
Elevated levels of myeloperoxidase, white blood cell count and 3-chlorotyrosine in Taiwanese patients with acute myocardial infarction.
Topics: Acute Disease; Aged; Biomarkers; Female; Humans; Leukocyte Count; Male; Middle Aged; Myocardial Infarction; Peroxidase; Sensitivity and Specificity; Taiwan; Tyrosine | 2008 |
Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivo.
Topics: Animals; Biomarkers; HL-60 Cells; Humans; Hypochlorous Acid; Inflammation; Macrophage Activation; Macrophages; Mice; Neutrophils; Nitrites; Oxidants; Peroxidase; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2008 |
Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blood Glucose; Body Weight; Deoxyguanosine; Disease Models, Animal; Inflammation; Insulin; Lipids; Lipoproteins, LDL; Metabolic Syndrome; Oxidative Stress; Peroxidase; Rats; Rats, Inbred SHR; Tyrosine; Ubiquinone | 2008 |
Oxidative stress induces myeloperoxidase expression in endocardial endothelial cells from patients with chronic heart failure.
Topics: Cells, Cultured; Chronic Disease; Endothelial Cells; Gene Expression; Heart Failure; Humans; Hydrogen Peroxide; Immunohistochemistry; Myocardium; Oxidants; Oxidative Stress; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine; Umbilical Veins | 2009 |
Oxidative damage markers and antioxidants in patients with acute myocardial infarction and their clinical significance.
Topics: Antioxidants; Humans; Inflammation; Myocardial Infarction; Oxidative Stress; Peroxidase; Tyrosine | 2008 |
Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Heart Atria; Humans; Lymphocyte Activation; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neutrophils; Peroxidase; Tyrosine | 2010 |
Functionally active macrophage-derived myeloperoxidase in the skin of drug-induced toxic epidermal necrolysis.
Topics: Adolescent; Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blister; Female; Humans; Hypochlorous Acid; Keratinocytes; Lewis X Antigen; Macrophages; Male; Middle Aged; Peroxidase; Stevens-Johnson Syndrome; Tyrosine | 2010 |
Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis.
Topics: Bronchoalveolar Lavage Fluid; Child; Child, Preschool; Cystic Fibrosis; Disease Progression; Female; Humans; Infant; Inflammation; Male; Neutrophils; Oxidation-Reduction; Peroxidase; Pseudomonas aeruginosa; Respiratory Tract Infections; Tyrosine | 2010 |
3-Chlorotyrosine in sputum of COPD patients: relationship with airway inflammation.
Topics: Aged; Biomarkers; Cell Survival; Female; Humans; Male; Mass Spectrometry; Middle Aged; Neutrophils; Peroxidase; Pulmonary Disease, Chronic Obstructive; Sputum; Tyrosine | 2010 |
Protein carbamylation renders high-density lipoprotein dysfunctional.
Topics: Adult; Aged; Apolipoprotein A-I; Atherosclerosis; CD36 Antigens; Cells, Cultured; Cholesterol; Cyanates; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Macrophages; Mass Spectrometry; Middle Aged; Oxidation-Reduction; Peroxidase; Protein Processing, Post-Translational; Tyrosine | 2011 |
Myeloperoxidase targets apolipoprotein A-I, the major high density lipoprotein protein, for site-specific oxidation in human atherosclerotic lesions.
Topics: Apolipoprotein A-I; Atherosclerosis; Halogenation; Humans; Hypochlorous Acid; Lipoproteins, HDL; Nitrogen; Oxidation-Reduction; Oxidative Stress; Peroxidase; Protein Processing, Post-Translational; Tyrosine | 2012 |
High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine.
Topics: Biomarkers; Blood Proteins; Case-Control Studies; Female; Humans; Male; Oxidants; Oxidation-Reduction; Peroxidase; Smoking; Sulfhydryl Compounds; Thiocyanates; Tyrosine | 2012 |
Simultaneous measurement of protein-bound 3-chlorotyrosine and homocitrulline by LC-MS/MS after hydrolysis assisted by microwave: application to the study of myeloperoxidase activity during hemodialysis.
Topics: Aged; Aged, 80 and over; Animals; Blood Chemical Analysis; Blood Proteins; Chromatography, Liquid; Citrulline; Female; Humans; Hydrolysis; Lysine; Male; Microwaves; Middle Aged; Peroxidase; Renal Dialysis; Tandem Mass Spectrometry; Time Factors; Tyrosine | 2012 |
High density lipoprotein is targeted for oxidation by myeloperoxidase in rheumatoid arthritis.
Topics: Adult; Aged; Apolipoprotein A-I; Arthritis, Rheumatoid; Cardiovascular Diseases; Case-Control Studies; Cholesterol; Female; Halogenation; Humans; Lipoproteins, HDL; Male; Middle Aged; Oxidation-Reduction; Peptide Mapping; Peroxidase; Tandem Mass Spectrometry; Tyrosine | 2013 |
Detailed protocol to assess in vivo and ex vivo myeloperoxidase activity in mouse models of vascular inflammation and disease using hydroethidine.
Topics: Animals; Biomarkers; Chromatography, Liquid; Disease Models, Animal; Halogenation; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Mice; Oxidation-Reduction; Peroxidase; Phenanthridines; Tandem Mass Spectrometry; Tyrosine; Vascular Diseases | 2016 |
Myeloperoxidase Levels and Its Product 3-Chlorotyrosine Predict Chronic Kidney Disease Severity and Associated Coronary Artery Disease.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Coronary Artery Disease; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Oxidative Stress; Peroxidase; Renal Insufficiency, Chronic; Risk Factors; Severity of Illness Index; Tyrosine; Young Adult | 2017 |
Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease-accelerated atherosclerosis.
Topics: Animals; Aorta; Atherosclerosis; Blood Urea Nitrogen; Creatinine; Diet, Fat-Restricted; Diet, High-Fat; Dietary Fats; Disease Models, Animal; Disease Progression; Kidney Failure, Chronic; Kidney Function Tests; Lipids; Lipoproteins; Macrophages; Male; Mice; Mice, Knockout; Muscle Proteins; Nephrectomy; Oxidants; Oxidative Stress; Parathyroid Hormone; Peroxidase; Receptors, LDL; Tyrosine; Vasodilation | 2018 |
Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes.
Topics: Animals; Cardiac Myosins; Cardiomyopathy, Hypertrophic; Carrier Proteins; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Humans; Hypertrophy, Left Ventricular; Induced Pluripotent Stem Cells; Male; Mice, Inbred C57BL; Mutation, Missense; Myocardial Contraction; Myocytes, Cardiac; Myosin Heavy Chains; Peroxidase; Phosphorylation; Reactive Oxygen Species; Tyrosine; Ventricular Function, Left | 2022 |