Page last updated: 2024-09-03

3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and indican

3-carboxy-4-methyl-5-propyl-2-furanpropionic acid has been researched along with indican in 26 studies

Compound Research Comparison

Studies
(3-carboxy-4-methyl-5-propyl-2-furanpropionic acid)
Trials
(3-carboxy-4-methyl-5-propyl-2-furanpropionic acid)
Recent Studies (post-2010)
(3-carboxy-4-methyl-5-propyl-2-furanpropionic acid)
Studies
(indican)
Trials
(indican)
Recent Studies (post-2010) (indican)
100638802
1006381,08454667

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19903 (11.54)18.7374
1990's3 (11.54)18.2507
2000's11 (42.31)29.6817
2010's7 (26.92)24.3611
2020's2 (7.69)2.80

Authors

AuthorsStudies
Asaba, H; Deguchi, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T1
Deguchi, T; Endou, H; Kusuhara, H; Otagiri, M; Sugiyama, Y; Takadate, A1
Benet, LZ; Frassetto, L; Huang, Y; Sun, H1
Mabuchi, H; Nakahashi, H2
Maeda, K; Niwa, T; Takeda, N; Tatematsu, A1
De Jong, M; Docter, R; Everts, ME; Hennemann, G; Krenning, EP; Lim, CF; Moerings, EP; Visser, TJ1
Bernard, B; de Jong, M; Docter, R; Hennemann, G; Krenning, EP; Lim, CF; van Toor, H1
Bernard, BF; de Jong, M; Docter, R; Hennemann, G; Krenning, EP; Lim, CF1
De Smet, R; Dhondt, A; Duym, P; Lameire, N; Lesaffer, G; Vanholder, R1
Maruyama, T; Otagiri, M; Shimada, H; Takadate, A; Tsutsumi, Y1
De Smet, R; Lameire, N; Vanholder, R1
Ivanov, AI; Korneeva, LN; Lindup, WE; Maslenny, VN; Nikolaev, VG; Niwa, T; Sarnatskaya, VV; Tjia, J; Yushko, LA1
Berland, Y; Brunet, P; Cerini, C; Dou, L1
Deguchi, T; Kouno, Y; Otagiri, M; Takadate, A; Terasaki, T1
Grinenko, DV; Mikhalovsky, SV; Nikolaev, AV; Nikolaev, VG; Sakhno, LA; Sarnatskaya, VV; Yushko, LA1
Kawai, K; Nishii, R; Nishio, T; Takamura, N; Tokunaga, J; Yoshimoto, M1
Boelaert, J; Eloot, S; Glorieux, G; Lynen, F; Sandra, P; Van Landschoot, M; Vanholder, R; Waterloos, MA1
Niwa, T1
Furukubo, T; Hiraoka, S; Hosoda, S; Izumi, S; Minegaki, T; Miyoshi, A; Nagano, Y; Nishiguchi, K; Shiraishi, A; Tsujimoto, M; Yamakawa, T1
Dhondt, A; Eloot, S; Glorieux, G; Neirynck, N; Van Biesen, W; Vanholder, R1
Furukubo, T; Izumi, S; Minegaki, T; Nishiguchi, K; Oda, T; Ogino, H; Shinmoto, T; Tachiki, H; Tsujimoto, M; Uchiyama, H; Yamakawa, T; Yoshida, T1
Ichimura, Y; Ideuchi, H; Oda, M; Saitoh, H; Takamatsu, H; Takeda, K2
André, C; Bennis, Y; Bodeau, S; Caillard, P; Choukroun, G; Cluet, Y; Kamel, S; Liabeuf, S; Maizel, J; Titeca-Beauport, D1
Ando, T; Itoh, H; Mimata, H; Oda, A; Ohno, K; Ono, H; Sato, B; Sato, H; Shin, T; Suzuki, Y; Tanaka, R1

Reviews

3 review(s) available for 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and indican

ArticleYear
Protein-bound uremic solutes: the forgotten toxins.
    Kidney international. Supplement, 2001, Volume: 78

    Topics: Animals; Cresols; Furans; Hippurates; Homocysteine; Humans; Indican; Intestinal Mucosa; Kinetics; Propionates; Protein Binding; Proteins; Renal Dialysis; Toxins, Biological; Uremia

2001
Protein-bound uremic retention solutes.
    Advances in renal replacement therapy, 2003, Volume: 10, Issue:4

    Topics: Animals; Blood Proteins; Cresols; Furans; Hippurates; Homocysteine; Humans; Indican; Propionates; Renal Dialysis; Uremia

2003
Removal of protein-bound uraemic toxins by haemodialysis.
    Blood purification, 2013, Volume: 35 Suppl 2

    Topics: Blood Proteins; Cresols; Furans; Human Umbilical Vein Endothelial Cells; Humans; Indican; Membranes, Artificial; Propionates; Reactive Oxygen Species; Renal Dialysis; Sulfuric Acid Esters; Uremia

2013

Trials

1 trial(s) available for 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and indican

ArticleYear
Influences of haemodialysis on the binding sites of human serum albumin: possibility of an efficacious administration plan using binding inhibition.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:7

    Topics: Adult; Aged; Barbiturates; Binding Sites; Carbon Radioisotopes; Diazepam; Diuretics; Fatty Acids, Nonesterified; Female; Furans; Furosemide; Hippurates; Humans; Indican; Kidney Failure, Chronic; Male; Middle Aged; Propionates; Protein Binding; Renal Dialysis; Serum Albumin; Treatment Outcome; Warfarin

2008

Other Studies

22 other study(ies) available for 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and indican

ArticleYear
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.
    Kidney international, 2002, Volume: 61, Issue:5

    Topics: Animals; Anions; Biological Transport; Dose-Response Relationship, Drug; Female; Furans; Indican; Kidney; Kidney Failure, Chronic; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Propionates; Rats; Rats, Wistar; Toxins, Biological; Tritium; Uremia; Uricosuric Agents; Xenopus laevis

2002
Characterization of uremic toxin transport by organic anion transporters in the kidney.
    Kidney international, 2004, Volume: 65, Issue:1

    Topics: Animals; DNA, Complementary; GABA Modulators; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Tubules, Proximal; LLC-PK1 Cells; Male; Organ Culture Techniques; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Pravastatin; Rats; Rats, Sprague-Dawley; Swine; Toxins, Biological; Transfection; Uremia

2004
Effects of uremic toxins on hepatic uptake and metabolism of erythromycin.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:11

    Topics: Animals; Cell Line; Dogs; Dose-Response Relationship, Drug; Erythromycin; Furans; Indican; Liver; Male; Propionates; Rats; Rats, Wistar; Uremia

2004
Inhibition of hepatic glutathione S-transferases by a major endogenous ligand substance present in uremic serum.
    Nephron, 1988, Volume: 49, Issue:4

    Topics: Animals; Cattle; Dinitrochlorobenzene; Furans; Glutathione Transferase; Humans; Indican; Indoleacetic Acids; Liver; Propionates; Protein Binding; Rats; Serum Albumin; Uremia

1988
Displacement by anionic drugs of endogenous ligands bound to albumin in uremic serum.
    Therapeutic drug monitoring, 1988, Volume: 10, Issue:3

    Topics: Binding Sites; Furans; Hippurates; Humans; Indican; Indoleacetic Acids; Propionates; Protein Binding; Salicylates; Salicylic Acid; Serum Albumin; Uremia; Warfarin

1988
Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography.
    Clinical chemistry, 1988, Volume: 34, Issue:11

    Topics: Albumins; beta 2-Microglobulin; Chromatography, High Pressure Liquid; Furans; Humans; Indican; Propionates; Renal Dialysis; Salicylates; Uremia

1988
Effects of a furan fatty acid and indoxyl sulfate on thyroid hormone uptake in cultured anterior pituitary cells.
    The American journal of physiology, 1995, Volume: 268, Issue:5 Pt 1

    Topics: Animals; Cells, Cultured; Furans; Indican; Male; Osmolar Concentration; Pituitary Gland, Anterior; Propionates; Rats; Rats, Wistar; Thyrotropin; Thyroxine; Triiodothyronine

1995
Transport of thyroxine into cultured hepatocytes: effects of mild non-thyroidal illness and calorie restriction in obese subjects.
    Clinical endocrinology, 1994, Volume: 40, Issue:1

    Topics: Bilirubin; Biological Transport; Cells, Cultured; Diet, Reducing; Fatty Acids, Nonesterified; Furans; Humans; Indican; Liver; Obesity; Propionates; Thyroxine; Triiodothyronine

1994
A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:2

    Topics: Adsorption; Animals; Biological Transport; Cells, Cultured; Furans; Hippurates; Humans; Indican; Iodides; Kidney Failure, Chronic; Liver; Male; Propionates; Rats; Rats, Wistar; Renal Dialysis; Thyroxine; Uremia

1993
Intradialytic removal of protein-bound uraemic toxins: role of solute characteristics and of dialyser membrane.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:1

    Topics: Aged; Aged, 80 and over; Creatinine; Cresols; Female; Furans; Hippurates; Humans; Indican; Kidneys, Artificial; Male; Membranes, Artificial; Middle Aged; Propionates; Protein Binding; Renal Dialysis; Toxins, Biological; Urea; Uremia

2000
Decreased bilirubin-binding capacity in uremic serum caused by an accumulation of furan dicarboxylic acid.
    Nephron, 2000, Volume: 85, Issue:1

    Topics: Adult; Bilirubin; Furans; Humans; Indican; Kidney Failure, Chronic; Male; Middle Aged; Propionates; Protein Binding; Serum Albumin; Uremia

2000
Effect of protein-bound uraemic toxins on the thermodynamic characteristics of human albumin.
    Biochemical pharmacology, 2002, Apr-01, Volume: 63, Issue:7

    Topics: Albumins; Furans; Hippurates; Humans; Indican; Propionates; Thermodynamics

2002
Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats.
    Pharmaceutical research, 2005, Volume: 22, Issue:4

    Topics: Animals; Biological Transport; Carbon Radioisotopes; Estrone; Furans; Hippurates; Indican; Indoleacetic Acids; Kidney; Male; Metabolic Clearance Rate; Organic Anion Transport Protein 1; Organic Cation Transport Proteins; p-Aminohippuric Acid; Penicillin G; Propionates; Rats; Rats, Wistar; Serum; Tritium

2005
New approaches to the removal of protein-bound toxins from blood plasma of uremic patients.
    Artificial cells, blood substitutes, and immobilization biotechnology, 2007, Volume: 35, Issue:3

    Topics: Adsorption; Binding Sites; Calorimetry, Differential Scanning; Charcoal; Furans; Hemoperfusion; Hippurates; Humans; Hydrogen-Ion Concentration; Indican; Membranes, Artificial; Plasma; Propionates; Protein Binding; Reference Values; Renal Dialysis; Serum Albumin; Toxins, Biological; Treatment Outcome; Uremia

2007
A novel UPLC-MS-MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients.
    Analytical and bioanalytical chemistry, 2013, Volume: 405, Issue:6

    Topics: Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Cresols; Female; Furans; Glucuronides; Hippurates; Humans; Indican; Indoleacetic Acids; Male; Propionates; Renal Insufficiency, Chronic; Severity of Illness Index; Sulfuric Acid Esters; Tandem Mass Spectrometry; Uremia; Uric Acid

2013
Effects of decreased vitamin D and accumulated uremic toxin on human CYP3A4 activity in patients with end-stage renal disease.
    Toxins, 2013, Aug-19, Volume: 5, Issue:8

    Topics: Cell Line, Tumor; Cytochrome P-450 CYP3A; Erythromycin; Furans; Hippurates; Humans; Indican; Indoleacetic Acids; Kidney Failure, Chronic; Liver; Microsomes, Liver; Pregnane X Receptor; Propionates; Receptors, Calcitriol; Receptors, Steroid; RNA, Messenger; Steroid Hydroxylases; Toxins, Biological; Vitamin D; Vitamin D3 24-Hydroxylase

2013
Does the adequacy parameter Kt/V(urea) reflect uremic toxin concentrations in hemodialysis patients?
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Aged; Aged, 80 and over; beta 2-Microglobulin; Biomarkers; Creatinine; Cresols; Diabetes Mellitus; Female; Furans; Glucuronides; Hippurates; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Multivariate Analysis; Propionates; Renal Dialysis; Sulfuric Acid Esters; Treatment Outcome; Urea; Uremia; Uric Acid

2013
Uremic toxins enhance statin-induced cytotoxicity in differentiated human rhabdomyosarcoma cells.
    Toxins, 2014, Sep-03, Volume: 6, Issue:9

    Topics: Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Survival; Drug Synergism; Furans; Hippurates; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indican; Indoleacetic Acids; Pravastatin; Propionates; Rhabdomyosarcoma; Simvastatin; Toxins, Biological; Uremia

2014
[Plasma concentrations of anionic uremic toxins in hemodialysis patients and their effects on protein binding of pravastatin].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2015, Volume: 135, Issue:6

    Topics: Aged; Aged, 80 and over; Female; Furans; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Pravastatin; Propionates; Protein Binding; Renal Dialysis; Serum Albumin

2015
Correlations between Plasma Levels of Anionic Uremic Toxins and Clinical Parameters in Hemodialysis Patients.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2016, Volume: 136, Issue:8

    Topics: Aged; Aged, 80 and over; Biomarkers; Blood Urea Nitrogen; Creatinine; Female; Furans; Glomerular Filtration Rate; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Predictive Value of Tests; Propionates; Renal Dialysis; Renal Insufficiency, Chronic

2016
Two rapid, accurate liquid chromatography tandem mass spectrometry methods for the quantification of seven uremic toxins: An application for describing their accumulation kinetic profile in a context of acute kidney injury.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Sep-01, Volume: 1152

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Biomarkers; Chromatography, Liquid; Cresols; Female; Furans; Hippurates; Humans; Indican; Limit of Detection; Linear Models; Male; Middle Aged; Propionates; Reproducibility of Results; Tandem Mass Spectrometry

2020
Highly sensitive simultaneous quantification of indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry.
    Journal of separation science, 2022, Volume: 45, Issue:10

    Topics: Chromatography, High Pressure Liquid; Furans; Humans; Indican; Pharmaceutical Preparations; Propionates; Tandem Mass Spectrometry; Uremia

2022