3-azidopyrimethamine has been researched along with pyrimethamine in 5 studies
| Studies (3-azidopyrimethamine) | Trials (3-azidopyrimethamine) | Recent Studies (post-2010) (3-azidopyrimethamine) | Studies (pyrimethamine) | Trials (pyrimethamine) | Recent Studies (post-2010) (pyrimethamine) |
|---|---|---|---|---|---|
| 5 | 0 | 0 | 5,088 | 738 | 1,047 |
| Protein | Taxonomy | 3-azidopyrimethamine (IC50) | pyrimethamine (IC50) |
|---|---|---|---|
| Dihydrofolate reductase | Homo sapiens (human) | 3.1057 | |
| Dihydrofolate reductase | Bos taurus (cattle) | 0.1007 | |
| Beta-hexosaminidase subunit alpha | Homo sapiens (human) | 6.8333 | |
| Beta-hexosaminidase subunit beta | Homo sapiens (human) | 6.4 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 4.3 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.0609 | |
| Dihydrofolate reductase | Pneumocystis carinii | 3.25 | |
| Dihydrofolate reductase | Candida albicans | 5 | |
| Low molecular weight phosphotyrosine protein phosphatase | Homo sapiens (human) | 15.615 | |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | 0.39 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 0.3217 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum 3D7 | 2.48 | |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 2.0727 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baker, ND; Griffin, RJ; Irwin, WJ; Reichert, U; Schmidt, R | 1 |
| Blackledge, G; Fuchs, R; Keizer, HJ; Kerbrat, P; Rankin, E; Somers, R; Sylvester, R; Thomas, D; van Oosterom, A; Verweij, J | 1 |
| Blackledge, GR; Crawford, SM; Hoffman, R; Newlands, ES; Slack, J; Stevens, MF; Stuart, NS | 1 |
| Gescher, A; Kamali, F; Slack, JA | 1 |
| Baker, DC; Hand, ES; Haugwitz, RD; Narayanan, VL; Plowman, J; Rampal, JB; Safavy, A | 1 |
5 other study(ies) available for 3-azidopyrimethamine and pyrimethamine
| Article | Year |
|---|---|
Uptake, cytotoxicity and metabolism of m-azidopyrimethamine and related lipophilic antifolates in SV-K14 human keratinocytes in vivo.
Topics: Animals; Anthralin; Azides; Cell Division; Cell Line, Transformed; Cell Survival; Culture Media; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; In Vitro Techniques; Keratinocytes; Liver; Methotrexate; Mice; Mice, Hairless; Pyrimethamine; Regression Analysis; Skin | 1991 |
A phase II study of M-azido-pyrimethamine ethane sulphonate (MZPES) in advanced, recurrent soft tissue sarcoma. An EORTC Soft Tissue and Bone Sarcoma Group Study.
Topics: Adult; Aged; Azides; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Pyrimethamine; Sarcoma; Soft Tissue Neoplasms | 1989 |
A phase I study of meta-azidopyrimethamine ethanesulphonate (MZPES)--a new dihydrofolate reductase inhibitor.
Topics: Antineoplastic Agents; Azides; Dose-Response Relationship, Drug; Drug Evaluation; Folic Acid Antagonists; Humans; Infusions, Intravenous; Neoplasms; Pyrimethamine; Pyrimidines | 1989 |
Medicinal azides. Part 3. The metabolism of the investigational antitumour agent meta-azidopyrimethamine in mouse tissue in vitro.
Topics: Animals; Antineoplastic Agents; Azides; Kidney; Liver; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Pyrimethamine; Pyrimidines; Subcellular Fractions | 1988 |
Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt (NSC-361456).
Topics: Animals; Antineoplastic Agents; Azides; Drug Evaluation, Preclinical; Drug Stability; Female; Half-Life; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pyrazines; Pyrimethamine; Pyrimidines | 1987 |