3-aminobenzamide has been researched along with niacinamide in 124 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 50 (40.32) | 18.7374 |
1990's | 55 (44.35) | 18.2507 |
2000's | 12 (9.68) | 29.6817 |
2010's | 7 (5.65) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Boer, R; Bürkle, A; Eltze, T; Klein, T; McDonald, MC; Thiemermann, C; Wagner, T; Weinbrenner, S | 1 |
Ferraris, DV | 1 |
Chu, Z; Dong, G; He, G; Wang, X; Xu, Y; Zhu, Q | 1 |
Ge, Z; Li, R; Sun, Q; Tan, H; Wang, J; Wang, X; Wang, Y | 1 |
Chen, Y; Jiao, H; Li, Z; Xie, Z; Yang, Y; Zhao, W; Zhou, Y | 1 |
Bessler, WG; Hauschildt, S; Mülsch, A; Scheipers, P | 1 |
Burkart, V; Kallmann, B; Kolb, H; Kolb-Bachofen, V; Kröncke, KD | 1 |
Hiromatsu, Y; Nonaka, K; Sato, M; Yamada, K | 1 |
Johnson, JB; Meier, HL | 1 |
Dennert, G; Landon, C; Nowicki, M; Sugawara, S | 1 |
Drevenstedt, B; Hoshino, J; Kröger, H; Schalge, S | 1 |
Bouffler, SD; Downes, CS; Jha, B; Johnson, RT | 1 |
Bessler, WG; Hauschildt, S; Scheipers, P | 1 |
Kohda, T; Oishi, M; Yamagoe, S | 1 |
Hanafusa, T; Kono, N; Miyagawa, J; Otsuka, A; Tarui, S | 1 |
Dietel, M; Hilz, H; Ludwig, A; Müller, K; Schäfer, G | 1 |
Costlow, M; Essani, N; Fishman, M | 1 |
Janssen, M; Loesberg, C; Smets, LA; Van Rooij, H | 1 |
Miyajima, E; Nonaka, K; Yamada, K | 1 |
Bergamini, E; Fierabracci, V; Masiello, P; Novelli, M | 1 |
Nonaka, K; Ryu, E; Yamada, K | 1 |
Inada, Y; Itaya-Hironaka, A; Kamiya, T; Tanaka, Y; Tsuyuki, M; Yoshihara, K | 1 |
Behrman, HR; Preston, SL | 1 |
Akiyama, Y; Heike, T; Kito, T; Kubota, M; Mikawa, H; Takimoto, T | 1 |
Andreoli, SP | 1 |
Cleaver, JE; Jostes, R; Molero, M; Morgan, WF; Reese, JA | 1 |
Cossarizza, A; Franceschi, C; Marini, M; Monti, D; Ortolani, C; Zunica, G | 1 |
Ganeshaguru, K; Hoffbrand, AV; Latini, L; Piga, A | 1 |
Benjamin, RC; Jacobson, EL; Jacobson, MK; Moss, J; Rankin, PW | 1 |
Islam, F; Mandel, P; Masmoudi, A | 1 |
Lane, DA; Nadeau, D | 1 |
Enomoto, T; Hanaoka, F; Kamatani, N; Matsuta, K; Morita, T; Nakano, K; Otsuka, F; Takeuchi, F; Tanimoto, K; Yamada, M | 1 |
Bergamini, E; Cubeddu, TL; Frosina, G; Masiello, P | 1 |
Cochrane, CG; Hinshaw, DB; Hyslop, PA; Schraufstatter, IU; Sklar, LA; Spragg, RG | 1 |
de Murcia, G; Déry, CV; Lamarre, D; Morin, N; Poirier, GG; Weber, J | 1 |
Chen, XR; Dai, YF; Yu, YN | 1 |
Akiyama, Y; Kiriyama, Y; Kubota, M; Mikawa, H; Seto, S; Takimoto, T; Tanizawa, A | 1 |
Colon-Otero, G; Jensen, DE; McGrath, E; Quesenberry, PJ; Sando, JJ; Sims, JL | 1 |
Wiencke, JK | 1 |
Barankiewicz, J; Cohen, A | 1 |
González Cappa, SM; Isola, EL; Lammel, EM | 1 |
Berger, NA; Berger, SJ; Krothapalli, D; Manory, I; Sudar, DC | 1 |
Leeper, DB; Martin, JH; Rowley, R | 1 |
Hayward, AR; Herberger, M | 1 |
Agarwal, S; Drysdale, BE; Shin, HS | 1 |
Chen, G; Pan, QC | 1 |
Armato, U; Menapace, L; Romano, F | 1 |
Bologni, A; Brunelli, MA; Cossarizza, A; Franceschi, C; Gatti, C; Marini, M; Monti, D; Zunica, G | 1 |
Schwartz, JL; Weichselbaum, RR | 1 |
Gowans, BJ; Henderson, JF; Hunting, DJ | 1 |
Brown, DM; Brown, JM; Hirst, DG; Horsman, MR | 2 |
Huet, J; Laval, F | 1 |
Adewunmi, AI; Enwonwu, CO; Okolie, EE | 1 |
Denda, A; Emi, Y; Konishi, Y; Mikami, S; Nakae, D; Ohnishi, T; Takahashi, S | 1 |
Althaus, FR; Pitot, HC | 1 |
Denda, A; Emi, Y; Konishi, Y; Mikami, S; Nakae, D; Ohnishi, T; Takahashi, S; Yokose, Y | 1 |
Ben-Hur, E; Elkind, MM; Utsumi, H | 2 |
Barra, R; Kuhr, WG; Lea, MA; Randolph, V | 1 |
McCord, JM; Mossman, BT; Mullins, DW; Patton, NJ; Wilson, GL | 1 |
Hori, T | 1 |
Kidwell, WR; Nolan, NL | 1 |
Okamoto, H; Yamamoto, H | 1 |
Nagai, H; Okamoto, H; Uchigata, Y; Yamamoto, H | 1 |
Williams, GT | 1 |
Ittel, ME; Jongstra-Bilen, J; Mandel, P; Rochette-Egly, C | 1 |
Kidwell, WR; Purnell, MR | 1 |
Brown, DM; Brown, JM; Evans, JW | 1 |
Miwa, K; Miyazaki, I; Okamoto, H; Takashima, T; Yamamoto, H; Yonemura, Y | 1 |
Bohr, V; Klenow, H | 1 |
Kerrigan, D; Pommier, Y; Zwelling, LA | 1 |
Akabane, A; Kato, I; Okamoto, H; Takasawa, S; Unno, M; Yonekura, H; Yoshimoto, T | 1 |
Coppola, S; Ghibelli, L; Maresca, V; Nosseri, C | 1 |
Coppola, S; Dini, L; Ghibelli, L; Maresca, V; Nosseri, C | 1 |
Buard, A; Dong, HY; Jaurand, MC; Laval, F; Lévy, F; Renier, A | 1 |
Askew, JN; Benson, RS; Watson, AJ | 1 |
Holm, BA; Hudak, BB; Maloney, C; Sokolowski, J; Tufariello, J | 1 |
Hung, MC; Klostergaard, J; Tang, P | 2 |
Cossarizza, A; Franceschi, C; Malorni, W; Monti, D; Rainaldi, G; Rivabene, R; Salvioli, S; Straface, E | 1 |
An, S; Cui, Y; Gutstein, WH; Jabr, S; Maturana, JA; Wu, JM | 1 |
Burkart, V; Bürkle, A; Hartmann, B; Heller, B; Kolb, H; Kröncke, KD; Radons, J; Rodriguez, ML | 1 |
Henry, D; Panizzon, KL; Wallis, RA; Wasterlain, CG | 1 |
Chypre, C; Hog, F; Jesser, M; Mandel, P | 1 |
Nata, K; Okamoto, H; Takasawa, S; Yonekura, H | 1 |
Berglund, T; Kalbin, G; Ohlsson, AB; Rydström, J; Strid, A | 1 |
Chau, YP; Kuo, ML; Shiah, SG; Wang, JH | 1 |
Brennan, SA; Newsholme, P | 1 |
Drapier, JC; Le Page, C; Pellat-Deceunynck, C; Wietzerbin, J | 1 |
Bessler, W; Flad, HD; Hauschildt, S; Heine, H; Scheipers, P; Schwarz, K; Ullmer, A | 1 |
Akagi, T; Cao, L; Kondo, E; Matsuo, Y; Minowada, J; Yamadori, I; Yoshino, T | 1 |
Cookson, MR; Ince, PG; Shaw, PJ | 1 |
Drapier, JC; Le Page, C; Sanceau, J; Wietzerbin, J | 1 |
Caputi, AP; Cuzzocrea, S; Zingarelli, B | 2 |
Hinds, CJ; Thiemermann, C; Wray, GM | 1 |
Saldeen, J; Welsh, N | 1 |
Amor, Y; Babiychuk, E; Inzé, D; Levine, A | 1 |
Bowes, J; McDonald, MC; Piper, J; Thiemermann, C | 1 |
Al-Saffar, NM; Clarke, PA; Cunningham, DC; DiStefano, F; Griffiths, JR; Leach, MO; McCoy, CL; Robertson, D; Ronen, SM; Smith, TA; Titley, J | 1 |
Cheng, JS; Sun, AY | 1 |
Caputi, AP; Costantino, G; Cuzzocrea, S; Zingarelli, B | 1 |
Chatterjee, PK; Cuzzocrea, S; Thiemermann, C | 1 |
Caputi, AP; Costantino, G; Cuzzocrea, S; Sottile, A; Teti, D; Zingarelli, B | 1 |
Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E; Rombolà, L; Sautebin, L | 1 |
Banerjee, A; Barton, HA; Bensard, DD; McIntyre, RC; Pulido, EJ; Selzman, CH; Shames, BD | 1 |
Jett, M; Yan, Z; Yang, DC | 1 |
Grant, RS; Kapoor, V; Matanovic, G; Passey, R; Smythe, G | 1 |
Filipe, HM; McDonald, MC; Thiemermann, C | 1 |
Chatterjee, PK; Cuzzocrea, S; Otto, M; Thiemermann, C; Zacharowski, K | 1 |
Dai, YR; Tian, Rh; Yan, CH; Zhang, GY | 1 |
Bloch, K; Bloch, O; Harel, A; Vardi, P | 1 |
Altuğ, S; Demiryürek, AT; Eşiyok, S; Yildiz, G | 1 |
Karlsson, E; Saldeen, J; Tillmar, L; Welsh, N | 1 |
Akbay, E; Atik, U; Bozlu, M; Canpolat, B; Cayan, S; Eskandari, G | 1 |
Hara, A; Hoshino, T; Murashita, H; Nishimura, B; Oikawa, K; Tabuchi, K; Tobita, T; Uemaetomari, I | 1 |
Gupta, S; Kaul, CL; Sharma, SS | 1 |
Bilko, D; Newton, CJ; Renner, U; Stalla, GK; Tichomirowa, M | 1 |
Linning, KD; Olson, LK; Szabo, C; Tai, MH; Ye, DZ | 1 |
Demiryürek, AT; Turan, NN | 1 |
Lau-Cam, CA; Pandya, KG; Patel, MR | 1 |
Armagan, G; Bayrakdar, ET; Kanit, L; Koylu, E; Uyanikgil, Y; Yalcin, A | 1 |
Herrera, DG; Ieraci, A | 1 |
1 review(s) available for 3-aminobenzamide and niacinamide
Article | Year |
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Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.
Topics: Animals; Antineoplastic Agents; Binding Sites; Drug Discovery; Drug Industry; Enzyme Inhibitors; History, 20th Century; History, 21st Century; Humans; Ischemia; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Research | 2010 |
123 other study(ies) available for 3-aminobenzamide and niacinamide
Article | Year |
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Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.
Topics: Animals; Cell Line; Cell Line, Tumor; Fibroblasts; Humans; Imidazoles; Isoquinolines; Kinetics; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyridines; Quinolones; Rats; Rats, Wistar; Recombinant Proteins; Solubility; Structure-Activity Relationship | 2008 |
Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Imidazoles; Mice; Molecular Structure; Neoplasms, Experimental; Niacinamide; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2013 |
Design, synthesis and biological evaluation of pyridazino[3,4,5-de]quinazolin-3(2H)-one as a new class of PARP-1 inhibitors.
Topics: Animals; Catalytic Domain; Drug Design; Models, Molecular; Molecular Structure; Neuroprotective Agents; PC12 Cells; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Binding; Pyridazines; Quinazolines; Rats | 2015 |
Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Structure; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Structure-Activity Relationship | 2015 |
Induction of nitric oxide synthase in L929 cells by tumour-necrosis factor alpha is prevented by inhibitors of poly(ADP-ribose) polymerase.
Topics: Amino Acid Oxidoreductases; Animals; Benzamides; Cell Line; Cell Survival; Cycloheximide; Cytosol; DNA; Enzyme Induction; Fibroblasts; Kinetics; Mice; Niacinamide; Nitric Oxide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerase Inhibitors; Protein Biosynthesis; RNA; Tumor Necrosis Factor-alpha | 1992 |
Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide.
Topics: Acetylcysteine; Animals; Benzamides; Cell Survival; Cells, Cultured; Free Radical Scavengers; In Vitro Techniques; Islets of Langerhans; Kinetics; Niacinamide; Nitric Oxide; Nitroprusside; Penicillamine; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Inbred Strains; S-Nitroso-N-Acetylpenicillamine; Sodium Cyanide; Thioctic Acid; Thiosulfate Sulfurtransferase; Vasodilator Agents | 1992 |
Nicotinamide and 3-aminobenzamide inhibit recombinant human interferon-gamma-induced HLA-DR antigen expression, but not HLA-A, B, C antigen expression, on cultured human thyroid cells.
Topics: Benzamides; Cells, Cultured; Flow Cytometry; Graves Disease; HLA-A Antigens; HLA-B Antigens; HLA-C Antigens; HLA-DR Antigens; Humans; Interferon-gamma; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Recombinant Proteins; Thyroid Gland | 1992 |
The determination and prevention of cytotoxic effects induced in human lymphocytes by the alkylating agent 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD).
Topics: Benzamides; Cell Survival; Cytotoxicity Tests, Immunologic; Humans; Lymphocytes; Mustard Gas; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors | 1992 |
Nicotinamide and 3-aminobenzamide interfere with receptor-mediated transmembrane signaling in murine cytotoxic T cells: independence of Golgi reorientation from calcium mobilization and inositol phosphate generation.
Topics: Animals; Benzamides; Calcium; Concanavalin A; Cytotoxicity, Immunologic; Golgi Apparatus; Granzymes; Inositol Phosphates; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred Strains; Niacinamide; Phosphatidylinositols; Receptors, Antigen, T-Cell; Serine Endopeptidases; Signal Transduction; T-Lymphocytes, Cytotoxic | 1991 |
Influence of ADP-ribosyltransferase inhibitors on the intracellular NAD and ATP levels in Ehrlich ascites tumor cells: implication for the altered NAD + ATP-dependent cellular sensitivity to the cytotoxic agents.
Topics: Adenosine Triphosphate; Animals; Azacitidine; Benzamides; Carcinoma, Ehrlich Tumor; Female; Mice; Microsomes; NAD; NAD+ Nucleosidase; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Tumor Cells, Cultured | 1990 |
Abnormal sister-chromatid exchange induction by 3-aminobenzamide in an SV40-transformed Indian muntjac cell line: relationships with DNA maturation and DNA-strand breakage.
Topics: Animals; Benzamides; Bromodeoxyuridine; Cell Line, Transformed; Cell Survival; Deer; DNA Damage; DNA Replication; Fibroblasts; Kinetics; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Simian virus 40; Sister Chromatid Exchange | 1991 |
Inhibitors of poly (ADP-ribose) polymerase suppress lipopolysaccharide-induced nitrite formation in macrophages.
Topics: Adenosine Diphosphate Ribose; Amino Acid Oxidoreductases; Animals; Benzamides; Bone Marrow Cells; Lipopolysaccharides; Lymphocyte Activation; Macrophages; Mice; Mice, Inbred BALB C; Niacinamide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerase Inhibitors | 1991 |
Poly(ADP-ribose) polymerase inhibitors suppress UV-induced human immunodeficiency virus type 1 gene expression at the posttranscriptional level.
Topics: Benzamides; beta-Galactosidase; Blotting, Northern; Chloramphenicol O-Acetyltransferase; Coumarins; Gene Expression; Genes, tat; Genes, Viral; HeLa Cells; HIV-1; Humans; Kinetics; Niacinamide; Plasmids; Poly(ADP-ribose) Polymerase Inhibitors; Restriction Mapping; Transcription, Genetic; Transfection; Ultraviolet Rays | 1991 |
Nicotinamide and 3-aminobenzamide reduce interferon-gamma-induced class II MHC (HLA-DR and -DP) molecule expression on cultured human endothelial cells and fibroblasts.
Topics: Animals; Benzamides; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fibroblasts; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Interferon-gamma; Islets of Langerhans; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors | 1991 |
Nicotinamide and nicotinamide analogues as antitumor promoters in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminobenzoates; Animals; Antineoplastic Agents; Benzamides; Benzoates; Benzoic Acid; Cell Division; Clone Cells; DNA Replication; Female; Keratinocytes; Kinetics; meta-Aminobenzoates; Mice; Mice, Inbred Strains; Niacinamide; Papilloma; Poly(ADP-ribose) Polymerase Inhibitors; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors.
Topics: Animals; Antibodies; Benzamides; Calcimycin; Cytotoxicity, Immunologic; Cytotoxins; Down-Regulation; Genetic Variation; Macrophage Activation; Mice; Niacinamide; Pertussis Toxin; Poly(ADP-ribose) Polymerase Inhibitors; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella | 1990 |
Intracellular inhibition of mono(ADP-ribosylation) by meta-iodobenzylguanidine: specificity, intracellular concentration and effects on glucocorticoid-mediated cell lysis.
Topics: 3-Iodobenzylguanidine; ADP Ribose Transferases; Animals; Benzamides; Cell-Free System; Cholera Toxin; Dexamethasone; Erythrocyte Membrane; Iodobenzenes; Leukemia L1210; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Tumor Cells, Cultured | 1990 |
Inhibition of cytokine-induced MHC class II but not class I molecule expression on mouse islet cells by niacinamide and 3-aminobenzamide.
Topics: Animals; Benzamides; Biological Factors; Cells, Cultured; Cytokines; Diabetes Mellitus, Experimental; Genes, MHC Class I; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Interferon-gamma; Islets of Langerhans; Major Histocompatibility Complex; Mice; Niacinamide; Tumor Necrosis Factor-alpha | 1990 |
Protection by 3-aminobenzamide and nicotinamide against streptozotocin-induced beta-cell toxicity in vivo and in vitro.
Topics: Animals; Benzamides; Blood Glucose; Diabetes Mellitus, Experimental; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Niacinamide; Rats; Rats, Inbred Strains | 1990 |
Protective effect of nicotinamide and 3-aminobenzamide on islet cell damage induced by gamma-interferon and tumor necrosis factor.
Topics: Animals; Benzamides; Cell Survival; Cells, Cultured; Drug Synergism; Female; Interferon-gamma; Islets of Langerhans; Male; Mice; Mice, Inbred Strains; Niacinamide; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1990 |
Retinoic acid-induced differentiation-specific, C-kinase-dependent phosphorylation of cytosolic 44 and 32 kDa proteins in HL-60 cells.
Topics: Benzamides; Bucladesine; Calcium; Cell Differentiation; Cell Extracts; Cells, Cultured; Cytosol; Dimethyl Sulfoxide; Electrophoresis, Polyacrylamide Gel; Humans; Molecular Weight; Niacinamide; Phosphorylation; Protein Kinase C; Proteins; Tretinoin | 1990 |
Luteolytic actions of peroxide in rat ovarian cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Benzamides; Corpus Luteum; Cyclic AMP; Dinoprost; DNA Repair; Female; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Kinetics; Luteinizing Hormone; Niacinamide; Ovary; Progesterone; Rats; Sexual Maturation | 1989 |
Induction of histidine decarboxylase in rat basophilic leukemia cells by interferon and prevention of its effect in coincubation with ADP-ribosyltransferase inhibitors.
Topics: Animals; Benzamides; Carboxy-Lyases; Cell Line; Enzyme Induction; Histidine Decarboxylase; Interferon Type I; Kinetics; Leukemia, Basophilic, Acute; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Rats | 1989 |
Mechanisms of endothelial cell ATP depletion after oxidant injury.
Topics: Adenosine Triphosphate; Benzamides; Cells, Cultured; DNA Damage; Endothelium, Vascular; Enzyme Activation; Glucose Oxidase; Humans; NAD; Niacinamide; Oxidation-Reduction; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Umbilical Veins; Xanthine Oxidase | 1989 |
Quiescent human lymphocytes do not contain DNA strand breaks detectable by alkaline elution.
Topics: Aphidicolin; Benzamides; Diterpenes; DNA Damage; DNA Repair; Humans; Hydrogen-Ion Concentration; Lymphocyte Activation; Lymphocytes; Niacinamide; Phytohemagglutinins; Sister Chromatid Exchange | 1989 |
Inhibition of poly(ADP-ribosyl)ation does not prevent lymphocyte entry into the cell cycle.
Topics: Benzamides; Cell Cycle; Ethanol; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Niacinamide; Nucleoside Diphosphate Sugars; Phytohemagglutinins; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors | 1989 |
Inability of poly-ADP-ribosylation inhibitors to protect peripheral blood lymphocytes from the toxic effects of ADA inhibition.
Topics: Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Benzamides; Colony-Forming Units Assay; Deoxyadenosines; DNA Damage; Humans; Lymphocyte Activation; Lymphocytes; NAD; Niacinamide; Nucleoside Deaminases; Pentostatin; Poly(ADP-ribose) Polymerase Inhibitors | 1989 |
Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Benzamides; Bromodeoxyuridine; Cattle; NAD; NAD+ Nucleosidase; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors | 1989 |
ADP-ribosylation of highly purified rat brain mitochondria.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Animals; Benzamides; Brain; Cell Fractionation; Kinetics; Mitochondria; NAD+ Nucleosidase; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains; Synapses | 1988 |
The cytotoxicity of chrysotile asbestos fibers to pulmonary alveolar macrophages. I. Effects of inhibitors of ADP-ribosyl transferase.
Topics: Animals; Asbestos; Asbestos, Serpentine; Benzamides; beta-Galactosidase; Cell Survival; Cells, Cultured; L-Lactate Dehydrogenase; Macrophages; Male; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Pulmonary Alveoli; Rats; Rats, Inbred Strains | 1988 |
Decrease in the reaction of DNA repair synthesis in response to nicotinamide or 3-aminobenzamide in ultraviolet irradiated systemic lupus erythematosus lymphocytes.
Topics: Benzamides; DNA Repair; Humans; In Vitro Techniques; Lupus Erythematosus, Systemic; Lymphocytes; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Ultraviolet Rays | 1985 |
Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against streptozotocin-induced diabetes.
Topics: Animals; Benzamides; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Insulin Secretion; Islets of Langerhans; Male; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Inbred Strains; Streptozocin | 1985 |
Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.
Topics: Actin Cytoskeleton; Actins; Adenosine Triphosphate; Animals; Benzamides; Calcium; Cell Line; Cell Survival; DNA Repair; Humans; Hydrogen Peroxide; In Vitro Techniques; Lymphocytes; Macrophages; Mice; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Theophylline | 1986 |
Possible role of ADP-ribosylation of adenovirus core proteins in virus infection.
Topics: Adenosine Diphosphate Ribose; Adenoviridae; Benzamides; Cell Line; Cell Nucleus; Chromatin; DNA, Viral; Electrophoresis, Polyacrylamide Gel; Humans; Microscopy, Electron; Niacinamide; Nucleoside Diphosphate Sugars; Viral Core Proteins; Virion | 1986 |
The cell-cycle dependent and the DNA-damaging agent-induced changes of cellular NAD content and their significance.
Topics: 4-Nitroquinoline-1-oxide; Benzamides; Cell Cycle; Cell Line; DNA Damage; DNA Replication; Humans; Interphase; Methyl Methanesulfonate; Methylnitronitrosoguanidine; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 1987 |
Prevention of adriamycin-induced interphase death by 3-aminobenzamide and nicotinamide in a human promyelocytic leukemia cell line.
Topics: Benzamides; Cell Line; Cell Survival; DNA Damage; Doxorubicin; Humans; Interphase; Kinetics; Leukemia, Myeloid, Acute; Methylnitronitrosoguanidine; Niacinamide | 1987 |
Inhibition of hemopoietic growth factor-induced proliferation by adenosine diphosphate-ribosylation inhibitors.
Topics: Adenosine Diphosphate; Animals; Benzamides; Cell Division; Cell Nucleus; Cytosol; Growth Inhibitors; Growth Substances; Hematopoiesis; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Mice; Mice, Inbred CBA; Niacinamide; Ribose; Thymidine | 1987 |
Nicotinamide deficiency in human lymphocytes prevents the [3H]thymidine-induced adaptive response for the repair of X-ray-induced chromosomal damage.
Topics: Benzamides; DNA; DNA Repair; Humans; Lymphocytes; NAD; Niacinamide; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Thymidine | 1987 |
Metabolic consequences of DNA damage: alteration in purine metabolism following poly(ADP ribosyl)ation in human T-lymphoblasts.
Topics: Adenine; Adenosine Triphosphate; Benzamides; Cell Line; Cell Survival; DNA Damage; Glycine; Humans; Methylnitronitrosoguanidine; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Purines; T-Lymphocytes | 1987 |
Trypanosoma cruzi: differentiation to metacyclic trypomastigotes in the presence of ADP-ribosyltransferase inhibitors.
Topics: Animals; Benzamides; Chagas Disease; Mice; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Theophylline; Triatoma; Trypanosoma cruzi | 1987 |
Pyridine nucleotide analog interference with metabolic processes in mitogen-stimulated human T lymphocytes.
Topics: 6-Aminonicotinamide; Adenosine Triphosphate; Benzamides; Carbon Dioxide; Gluconates; Glucose-6-Phosphate; Glucosephosphates; Humans; Lymphocyte Activation; NAD; NADP; Niacinamide; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1987 |
Effect of poly(adenosinediphosphoribose) synthesis inhibitors and structurally related compounds on radiation-induced G2 arrest.
Topics: Aminobenzoates; Animals; Benzamides; Caffeine; Cell Line; Cricetinae; Deoxyadenosines; Interphase; meta-Aminobenzoates; Niacin; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Theophylline | 1988 |
Nicotinamide protects target cells from cell-mediated cytolysis.
Topics: Benzamides; Calcium; Cell Survival; Cytotoxicity, Immunologic; DNA Damage; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lymphocyte Activation; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Receptors, Immunologic; Receptors, Interleukin-2 | 1988 |
Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Animals; Benzamides; Cell Line; Cell Survival; Fibroblasts; Humans; Intracellular Fluid; Kinetics; Mice; NAD; Niacinamide; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1988 |
Potentiation of the antitumor activity of cisplatin in mice by 3-aminobenzamide and nicotinamide.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Carcinoma, Ehrlich Tumor; Cisplatin; Drug Synergism; Female; Male; Mice; Necrosis; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Sarcoma 180 | 1988 |
Inhibitors of ADP-ribosyl transferase suppress the mitogenic actions exerted by tumour promoters, but not those evoked by peptide mitogens, in primary neonatal rat hepatocytes.
Topics: Animals; Animals, Newborn; Benzamides; Carcinogens; Cell Cycle; Cell Nucleus; DNA; Epidermal Growth Factor; In Vitro Techniques; Liver; Mitogens; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Tetradecanoylphorbol Acetate | 1988 |
Effect of ADP-ribosyl transferase inhibitors on the survival of human lymphocytes after exposure to different DNA-damaging agents.
Topics: Benzamides; Cell Survival; DNA Damage; Humans; Lymphocytes; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors | 1988 |
Similar sensitivity of human lymphoblast cells proficient or deficient in nucleotide biosynthesis to the cytotoxic and cell cycle effects of 3-aminobenzamide.
Topics: Aminobenzoates; Benzamides; Cell Cycle; Cell Line; Cell Survival; Humans; Hypoxanthine; Hypoxanthines; Lymphocytes; meta-Aminobenzoates; NAD; NAD+ Nucleosidase; Niacinamide; Nucleotides; Poly(ADP-ribose) Polymerase Inhibitors; Thymidine | 1985 |
Specificity of inhibitors of poly(ADP-ribose) synthesis. Effects on nucleotide metabolism in cultured cells.
Topics: Animals; Benzamides; Cell Division; Cricetinae; Deoxyribonucleotides; DNA; Methylnitrosourea; Mice; NAD; NAD+ Nucleosidase; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Ribonucleotides | 1985 |
Changes in the response of the RIF-1 tumour to melphalan in vivo induced by inhibitors of nuclear ADP-ribosyl transferase.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Body Temperature; Cell Survival; Dose-Response Relationship, Drug; Female; Leukocyte Count; Melphalan; Mice; Mice, Inbred C3H; Niacinamide; Nucleotidyltransferases; Poly(ADP-ribose) Polymerases; Sarcoma, Experimental; Time Factors | 1986 |
Influence of poly(ADP-ribose) synthesis inhibitors on the repair of sublethal and potentially lethal damage in gamma-irradiated mammalian cells.
Topics: 6-Aminonicotinamide; Animals; Benzamides; Cell Line; Cell Survival; Cobalt Radioisotopes; Cricetinae; DNA Repair; Gamma Rays; Humans; In Vitro Techniques; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Radiation Tolerance | 1985 |
Enhancement of melphalan cytotoxicity in vivo and in vitro by inhibitors of poly (ADP-ribose) polymerase.
Topics: Animals; Benzamides; Caffeine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Melphalan; Mice; Mice, Inbred C3H; NAD+ Nucleosidase; Neoplasm Transplantation; Neoplasms, Experimental; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Time Factors | 1984 |
Antimalarial activity of inhibitors of ADP-ribosyl transferase against Plasmodium yoelii infection in mice. 1. Preliminary data.
Topics: Animals; Antimalarials; Benzamides; Chloroquine; Drug Evaluation, Preclinical; Malaria; Male; Mice; Niacinamide; Nucleotidyltransferases; Plasmodium; Poly(ADP-ribose) Polymerases; Theobromine; Theophylline | 1982 |
Possible role of poly(ADP-ribose) polymerase on the early stage of liver carcinogenesis by diethylnitrosamine in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzamides; Diethylnitrosamine; Dimethyl Sulfoxide; Enzyme Activation; gamma-Glutamyltransferase; Liver Neoplasms; NAD+ Nucleosidase; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Inbred Strains; Thymidine | 1983 |
Consequences of altered poly(ADP-ribose) metabolism on hepatocyte functions in vitro.
Topics: Aminobenzoates; Animals; Benzamides; DNA Repair; gamma-Glutamyltransferase; In Vitro Techniques; Liver; NAD+ Nucleosidase; Niacinamide; Nucleotidyltransferases; Pentosyltransferases; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyruvate Kinase; Rats | 1983 |
Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats.
Topics: Animals; Benzamides; Diethylnitrosamine; DNA Repair; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Male; NAD+ Nucleosidase; Necrosis; Niacinamide; Nucleotidyltransferases; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Inbred Strains; Thymidine | 1984 |
Inhibitors of poly (ADP-ribose) synthesis enhance radiation response by differentially affecting repair of potentially lethal versus sublethal damage.
Topics: Animals; Benzamides; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Time Factors | 1984 |
Effects of nicotinamide and structural analogs on DNA synthesis and cellular replication of rat hepatoma cells.
Topics: Animals; Benzamides; Cell Division; Cells, Cultured; DNA, Neoplasm; Liver Neoplasms, Experimental; Methyl Methanesulfonate; Niacinamide; Rats; Rats, Inbred BUF | 1984 |
Mechanisms of streptozotocin- and alloxan-induced damage in rat B cells.
Topics: Alloxan; Animals; Animals, Newborn; Benzamides; Cells, Cultured; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Methylurea Compounds; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Streptozocin; Superoxide Dismutase | 1984 |
High incidence of sister chromatid exchanges and chromatid interchanges in the conditions of lowered activity of poly(ADP-ribose)polymerase.
Topics: Animals; Benzamides; Cell Line; Chromatids; Chromosome Aberrations; Cricetinae; Cricetulus; Crossing Over, Genetic; Female; NAD+ Nucleosidase; Niacinamide; Ovary; Poly(ADP-ribose) Polymerases; Sister Chromatid Exchange | 1981 |
Effect of heat shock on poly(ADP-ribose) synthetase and DNA repair in Drosophila cells.
Topics: Animals; Benzamides; Cell Fractionation; Cell Nucleus; Cells, Cultured; DNA Repair; Drosophila melanogaster; Gamma Rays; Hot Temperature; NAD+ Nucleosidase; Niacinamide; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; X-Rays | 1982 |
Poly(ADP-ribose) synthetase inhibitors enhance streptozotocin-induced killing of insulinoma cells by inhibiting the repair of DNA strand breaks.
Topics: Adenoma, Islet Cell; Animals; Benzamides; Cell Line; Cell Survival; Cricetinae; DNA Repair; Insulinoma; Islets of Langerhans; Mesocricetus; NAD+ Nucleosidase; Neoplasms, Experimental; Niacinamide; Pancreatic Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Streptozocin | 1982 |
Effect of poly(ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis.
Topics: Animals; Benzamides; Diabetes Mellitus, Experimental; Glucose; Islets of Langerhans; Male; NAD+ Nucleosidase; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Proinsulin; Rats; Rats, Inbred Strains | 1983 |
Trypanosoma cruzi: inhibition of intracellular and extracellular differentiation by ADP-ribosyl transferase antagonists.
Topics: Animals; Benzamides; Cell Differentiation; Mice; Niacinamide; Nucleotidyltransferases; Poly(ADP-ribose) Polymerases; Theophylline; Trypanosoma cruzi | 1983 |
Involvement of polyADP-ribose polymerase in the initiation of phytohemagglutinin induced human lymphocyte proliferation.
Topics: Benzamides; DNA Replication; Humans; Lymphocyte Activation; NAD+ Nucleosidase; Niacinamide; Phytohemagglutinins; Poly(ADP-ribose) Polymerases | 1983 |
Temperature sensitivity of poly(ADP-ribose) synthetase in intact cells.
Topics: Animals; Benzamides; Cell Line; Cells, Cultured; Cricetinae; Female; HeLa Cells; Hot Temperature; Humans; In Vitro Techniques; Mammary Glands, Animal; Mice; NAD+ Nucleosidase; Niacinamide; Ovary; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 1983 |
The influence of inhibitors of poly (ADP-ribose) polymerase on X-ray-induced potentially lethal damage repair.
Topics: Animals; Benzamides; Caffeine; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Female; NAD+ Nucleosidase; Niacinamide; Ovary; Poly(ADP-ribose) Polymerase Inhibitors; Thymidine; Time Factors | 1984 |
Amelioration of diabetes mellitus in partially depancreatized rats by poly(ADP-ribose) synthetase inhibitors. Evidence of islet B-cell regeneration.
Topics: Animals; Benzamides; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Islets of Langerhans; Male; NAD+ Nucleosidase; Niacinamide; Pancreatectomy; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Inbred Strains; Regeneration | 1984 |
Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log-phase Chinese hamster cells.
Topics: 4-Aminobenzoic Acid; Animals; Benzamides; Cell Line; Cell Survival; Cricetinae; Cricetulus; Niacinamide; Nucleoside Diphosphate Sugars; Nucleotidyltransferases; ortho-Aminobenzoates; para-Aminobenzoates; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Pyrazinamide; Radiation-Sensitizing Agents | 1984 |
3-Aminobenzamide stimulates unscheduled DNA synthesis and rejoining of strand breaks in human lymphocytes.
Topics: Animals; Aphidicolin; Benzamides; Diterpenes; DNA; DNA Repair; Humans; Leukemia L1210; Lymphocytes; Mice; Niacinamide; Sarcoma 180; Sulfuric Acid Esters; Ultraviolet Rays | 1981 |
Inhibitors of poly-(adenosine diphosphoribose) synthesis slow the resealing rate of x-ray-induced DNA strand breaks.
Topics: Animals; Benzamides; DNA; DNA Repair; Leukemia L1210; Mice; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Time Factors | 1982 |
Nicotinamide inhibits IRF-1 mRNA induction and prevents IL-1 beta-induced nitric oxide synthase expression in pancreatic beta cells.
Topics: Adenosine Triphosphate; Animals; Arginine; Base Sequence; Benzamides; Cell Survival; DNA Primers; DNA-Binding Proteins; Enzyme Induction; Gene Expression; Glucose; Interferon Regulatory Factor-1; Interleukin-1; Islets of Langerhans; Male; Mice; Molecular Sequence Data; Niacinamide; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phosphoproteins; Poly Adenosine Diphosphate Ribose; Polymerase Chain Reaction; Rats; Rats, Wistar; Recombinant Proteins; RNA, Messenger; Transcription Factors | 1995 |
Different basal NAD levels determine opposite effects of poly(ADP-ribosyl)polymerase inhibitors on H2O2-induced apoptosis.
Topics: Apoptosis; Benzamides; Cell Death; Cell Line; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Kinetics; Monocytes; NAD; Niacinamide; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors | 1995 |
The increase in H2O2-induced apoptosis by ADP-ribosylation inhibitors is related to cell blebbing.
Topics: Actins; ADP Ribose Transferases; Apoptosis; Benzamides; Cell Nucleus; Cytochalasin B; Cytochalasin D; Cytoplasm; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Monocytes; Niacinamide; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors | 1995 |
Synthesis of poly(ADP-ribose) in asbestos treated rat pleural mesothelial cells in culture.
Topics: Animals; Asbestos; Asbestos, Crocidolite; Asbestos, Serpentine; Benzamides; Bleomycin; Cells, Cultured; DNA Damage; DNA Repair; Enzyme Activation; Enzyme Inhibitors; Epithelium; Mutagens; Niacinamide; Pleura; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats | 1995 |
Poly(adenosine diphosphate ribose) polymerase inhibition prevents necrosis induced by H2O2 but not apoptosis.
Topics: Aminobenzoates; Apoptosis; Benzamides; Cell Count; Cell Line; DNA Repair; Humans; Hydrogen Peroxide; Intestinal Mucosa; meta-Aminobenzoates; Necrosis; Niacin; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Time Factors | 1995 |
Inhibition of poly(ADP-ribose) polymerase preserves surfactant synthesis after hydrogen peroxide exposure.
Topics: Adenosine Triphosphate; Animals; Benzamides; Deoxyglucose; Free Radical Scavengers; Hydrogen Peroxide; NAD; Niacinamide; Phosphatidylcholines; Poly(ADP-ribose) Polymerase Inhibitors; Pulmonary Alveoli; Pulmonary Surfactants; Rabbits | 1995 |
TNF cytotoxicity: effects of HER-2/neu expression and inhibitors of ADP-ribosylation.
Topics: Adenosine Diphosphate Ribose; Animals; Benzamides; Cell Survival; Dactinomycin; Gene Expression; Humans; Mice; Niacinamide; Oncogene Proteins, Viral; Oncogenes; Poly(ADP-ribose) Polymerase Inhibitors; Receptor, ErbB-2; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Cell death protection by 3-aminobenzamide and other poly(ADP-ribose)polymerase inhibitors: different effects on human natural killer and lymphokine activated killer cell activities.
Topics: 4-Aminobenzoic Acid; Adult; Aminobenzoates; Apoptosis; Benzamides; Benzoates; Benzoic Acid; Cell Line; Cytotoxicity, Immunologic; Humans; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Kinetics; Luminol; Middle Aged; Niacinamide; para-Aminobenzoates; Poly(ADP-ribose) Polymerase Inhibitors; Tumor Cells, Cultured | 1994 |
The anti-proliferative effects of nicotinamide and 3-aminobenzamide on human smooth muscle cells in vitro.
Topics: Aorta, Thoracic; Benzamides; Blotting, Northern; Cell Count; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression; Genes, myc; Humans; Microscopy, Electron; Muscle, Smooth; Niacinamide; RNA, Messenger; Thymidine | 1993 |
Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion.
Topics: 1-Naphthylamine; Animals; Benzamides; Cell Survival; Cells, Cultured; DNA Damage; Enzyme Activation; Islets of Langerhans; Kinetics; NAD; Naphthalimides; Niacinamide; Nitric Oxide; Penicillamine; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinolones; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Time Factors | 1994 |
Neuroprotection against nitric oxide injury with inhibitors of ADP-ribosylation.
Topics: Adenosine Diphosphate Ribose; Animals; Benzamides; Electrophysiology; Hippocampus; In Vitro Techniques; Male; Nervous System Diseases; Neurons; Niacinamide; Nitric Oxide; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Sprague-Dawley; Synapses | 1993 |
Cytoplasmic poly(ADP-ribose)polymerase from mouse plasmacytoma free messenger ribonucleoprotein particles: purification and characterization.
Topics: Animals; Benzamides; Calcium; Chromatography, Affinity; Cytoplasm; DNA; Electrophoresis, Polyacrylamide Gel; Kinetics; Magnesium; Mice; Mice, Inbred BALB C; Molecular Weight; Niacinamide; Plasmacytoma; Poly(ADP-ribose) Polymerases; RNA, Messenger; Thymidine | 1993 |
Cyclic ADP-ribose in insulin secretion from pancreatic beta cells.
Topics: Adenosine Diphosphate Ribose; Animals; Benzamides; Calcium; Cerebellum; Cyclic ADP-Ribose; Dose-Response Relationship, Drug; Glucose; Heparin; Inositol 1,4,5-Trisphosphate; Insulin; Insulin Secretion; Islets of Langerhans; Male; Microsomes; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Wistar; Second Messenger Systems; Streptozocin | 1993 |
ADP-ribosylation inhibitors inhibit cellular RNA synthesis but do not affect expression of manganous superoxide dismutase or heat shock protein 70 in tumor necrosis factor alpha-sensitive and -resistant tumor cells.
Topics: Animals; Base Sequence; Benzamides; Drug Resistance; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Mice; Molecular Sequence Data; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; RNA; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
UV-B- and oxidative stress-induced increase in nicotinamide and trigonelline and inhibition of defensive metabolism induction by poly(ADP-ribose)polymerase inhibitor in plant tissue.
Topics: Alkaloids; Amidines; Benzamides; Enzyme Inhibitors; Glutathione; Glutathione Disulfide; Niacinamide; Oxidative Stress; Phenylalanine Ammonia-Lyase; Pisum sativum; Plants; Poly(ADP-ribose) Polymerase Inhibitors; Ultraviolet Rays; Vanadium Compounds | 1996 |
Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells.
Topics: Apoptosis; Benzamides; Cell Differentiation; DNA, Neoplasm; Electrophoresis, Agar Gel; Enzyme Inhibitors; Flow Cytometry; HL-60 Cells; Humans; Kinetics; Monocytes; Niacinamide; Nitric Oxide; Nitroprusside; Poly(ADP-ribose) Polymerase Inhibitors | 1996 |
Inhibition of nitric oxide induced cytotoxicity in pancreatic b-cells.
Topics: 4-Aminobenzoic Acid; Animals; Benzamides; Benzoates; Benzoic Acid; Enzyme Inhibitors; Glucose; Islets of Langerhans; Kinetics; Niacinamide; Nitric Oxide; para-Aminobenzoates; Poly(ADP-ribose) Polymerase Inhibitors | 1996 |
Effects of inhibitors of ADP-ribosylation on macrophage activation.
Topics: Adenosine Diphosphate Ribose; Benzamides; Cell Line; DNA-Binding Proteins; Enzyme Induction; Enzyme Inhibitors; Interferon Regulatory Factor-1; Macrophage Activation; Macrophages; Niacinamide; Nitric Oxide Synthase; Nitrites; Phosphoproteins; Poly(ADP-ribose) Polymerase Inhibitors | 1997 |
Role of ADP-ribosylation in activated monocytes/macrophages.
Topics: Adenosine Diphosphate Ribose; Animals; Benzamides; Cells, Cultured; Enzyme Inhibitors; Humans; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Monocytes; Niacinamide; Nitric Oxide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 1997 |
Comparison of two methods of staining apoptotic cells of leukemia cell lines. Terminal deoxynucleotidyl transferase and DNA polymerase I reactions.
Topics: Antibodies, Monoclonal; Apoptosis; Benzamides; Cell Nucleus; Coloring Agents; Cytoplasm; Deoxyribonuclease I; DNA Fragmentation; DNA Polymerase I; Enzyme Inhibitors; fas Receptor; Histocytological Preparation Techniques; Humans; In Situ Nick-End Labeling; Leukemia; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Tumor Cells, Cultured; Zinc | 1998 |
Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: role of poly (ADP-ribose) polymerase.
Topics: Animals; Benzamides; Cell Death; Cell Survival; Dactinomycin; DNA Damage; Enzyme Inhibitors; Hybrid Cells; Hydrogen Peroxide; Kinetics; Neuroblastoma; Niacinamide; Nitrates; Oxidants; Phenanthrenes; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Spinal Cord | 1998 |
Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation.
Topics: Animals; Benzamides; DNA-Binding Proteins; Enzyme Induction; Enzyme Inhibitors; Genes, Reporter; Interferon Regulatory Factor-1; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Niacinamide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphoproteins; Poly(ADP-ribose) Polymerase Inhibitors; Promoter Regions, Genetic; Transcription Factors; Transcription, Genetic; Transfection | 1998 |
Peroxynitrate-mediated DNA strand breakage activates poly(ADP-ribose) synthetase and causes cellular energy depletion in a nonseptic shock model induced by zymosan in the rat.
Topics: Animals; Benzamides; Disease Models, Animal; DNA Damage; Energy Metabolism; Enzyme Activation; Macrophages, Peritoneal; Male; Mitochondria; NAD; NG-Nitroarginine Methyl Ester; Niacinamide; Nitrates; Nitric Oxide Synthase; Oxidants; Oxygen Consumption; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Shock; Zymosan | 1998 |
Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin.
Topics: Animals; Benzamides; Endotoxemia; Enzyme Inhibitors; Hemodynamics; Hypotension; Isoquinolines; Kidney; Lactic Acid; Liver; Male; Multiple Organ Failure; Niacinamide; Nitrates; Nitrites; Pancreas; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Succimer | 1998 |
Nicotinamide-induced apoptosis in insulin producing cells is associated with cleavage of poly(ADP-ribose) polymerase.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Benzamides; Cell Line; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Fetus; Islets of Langerhans; Necrosis; NF-kappa B; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley | 1998 |
Role of peroxynitrite and poly (ADP-ribosyl) synthetase activation in cardiovascular derangement induced by zymosan in the rat.
Topics: Animals; Aortic Diseases; Benzamides; Enzyme Activation; Enzyme Inhibitors; Immunohistochemistry; Injections, Intraperitoneal; Male; Niacinamide; Nitrates; Oxidants; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Shock, Cardiogenic; Tyrosine; Zymosan | 1998 |
The involvement of poly(ADP-ribose) polymerase in the oxidative stress responses in plants.
Topics: Apoptosis; Arabidopsis; Benzamides; Blotting, Western; Calcium; Cells, Cultured; DNA Repair; Glycine max; Hydrogen Peroxide; In Situ Nick-End Labeling; Ionophores; NAD; Niacinamide; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; RNA, Antisense; Time Factors; Transformation, Genetic | 1998 |
Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress.
Topics: Aminobenzoates; Animals; Benzamides; Cell Death; Cell Line; Enzyme Inhibitors; Heart; Hydrogen Peroxide; Isoquinolines; Male; meta-Aminobenzoates; Myocardial Reperfusion Injury; Niacin; Niacinamide; Oxidative Stress; Perfusion; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar | 1999 |
Magnetic resonance detects metabolic changes associated with chemotherapy-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Caspases; Cell Survival; Colorectal Neoplasms; Dihydroxyacetone Phosphate; Doxorubicin; Fructosediphosphates; Glycerophosphates; Humans; Iodoacetates; Leukemia L1210; Magnetic Resonance Spectroscopy; Mechlorethamine; NAD; Niacinamide; Tumor Cells, Cultured | 1999 |
Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats.
Topics: ADP Ribose Transferases; Animals; Benzamides; Brain; Enzyme Inhibitors; Ischemic Attack, Transient; Male; Neuroprotective Agents; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Wistar; Reperfusion Injury; Vitamin K 1 | 1998 |
Protective effects of poly (ADP-ribose) synthase inhibitors in zymosan-activated plasma induced paw edema.
Topics: Animals; Benzamides; Complement Activation; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Free Radicals; Immunohistochemistry; Inflammation; Male; Niacinamide; Nitrates; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tyrosine; Zymosan | 1999 |
Inhibitors of poly (ADP-ribose) synthetase protect rat proximal tubular cells against oxidant stress.
Topics: Animals; Benzamides; Catalase; Cells, Cultured; Deferoxamine; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Isoquinolines; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Necrosis; Niacinamide; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Rats | 1999 |
Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat.
Topics: Animals; Benzamides; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Multiple Organ Failure; Niacinamide; Nitrates; Peritonitis; Poly(ADP-ribose) Polymerase Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors; Zymosan | 1999 |
Regulation of prostaglandin production by inhibition of poly (ADP-ribose) synthase in carrageenan-induced pleurisy.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Carrageenan; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indomethacin; Niacinamide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pleurisy; Poly(ADP-ribose) Polymerase Inhibitors; Prostaglandins; Rats | 1999 |
Inhibition of PARS attenuates endotoxin-induced dysfunction of pulmonary vasorelaxation.
Topics: Adenosine Triphosphate; Animals; Benzamides; Cyclic GMP; Endotoxemia; Endotoxins; Enzyme Inhibitors; Lung; Male; Niacinamide; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Pulmonary Circulation; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Vasodilation | 1999 |
Cholera toxin induces tumor necrosis factor alpha production in human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Diphosphate; Benzamides; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoquinolines; Lymphocytes; Monocytes; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Protein Kinase C; Signal Transduction; Sphingosine; Sulfonamides; Transcription, Genetic; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1999 |
Evidence for increased de novo synthesis of NAD in immune-activated RAW264.7 macrophages: a self-protective mechanism?
Topics: Animals; Benzamides; Cell Line; Dexamethasone; Enzyme Inhibitors; Interferon-gamma; Macrophage Activation; Macrophages; Mice; NAD; NG-Nitroarginine Methyl Ester; Niacinamide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerase Inhibitors; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tryptophan Oxygenase | 1999 |
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzamides; Blood Pressure; Creatine Kinase; Creatinine; Enzyme Inhibitors; Heart Rate; Ischemia; Isoquinolines; Kidney; Kidney Diseases; Lipase; Liver; Liver Diseases; Male; Niacinamide; Pancreas; Pancreatic Diseases; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Wistar; Shock, Hemorrhagic; Syndrome; Urea | 1999 |
Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo.
Topics: Anesthesia; Animals; Benzamides; Creatinine; Enzyme Inhibitors; Glomerular Filtration Rate; Isoquinolines; Kidney; Male; Natriuresis; Niacinamide; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Urea | 2000 |
Involvement of poly(ADP-ribose) polymerase and activation of caspase-3-like protease in heat shock-induced apoptosis in tobacco suspension cells.
Topics: Apoptosis; Benzamides; Blotting, Western; Caspase 3; Caspases; Cells, Cultured; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Hot Temperature; Niacinamide; Nicotiana; Peptide Fragments; Plants, Toxic; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 2000 |
Sensitivity of HaCat keratinocytes to diabetogenic toxins.
Topics: Alloxan; Analysis of Variance; Apoptosis; Benzamides; Cell Line; Cell Survival; Enzyme Inhibitors; Guanosine; Humans; Keratinocytes; Necrosis; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Streptozocin | 2002 |
Protective effects of poly (ADP-ribose) synthase inhibitors on digoxin-induced cardiotoxicity in guinea-pig isolated hearts.
Topics: Animals; Arrhythmias, Cardiac; Benzamides; Blood Pressure; Digoxin; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 2002 |
Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis.
Topics: Animals; Apoptosis; Benzamides; Caspases; Cell Cycle; Cell Nucleus; Cytokines; DNA Fragmentation; Dose-Response Relationship, Drug; G2 Phase; HeLa Cells; Humans; Immunoblotting; Jurkat Cells; Membrane Potentials; Mice; Microscopy, Fluorescence; Models, Biological; Niacinamide; NIH 3T3 Cells; Nitric Oxide; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Time Factors; Tumor Suppressor Protein p53; Ultraviolet Rays | 2003 |
The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.
Topics: 1-Naphthylamine; Animals; Benzamides; Isoquinolines; Male; Naphthalimides; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Quinolones; Rats; Rats, Wistar; Reperfusion Injury; Spermatic Cord Torsion; Testis | 2003 |
Involvement of poly(ADP-ribose) synthetase in acoustic trauma of the cochlea.
Topics: Acoustic Stimulation; Action Potentials; Aminobenzoates; Animals; Benzamides; Cochlea; Enzyme Activation; Guinea Pigs; Hearing Loss, Noise-Induced; meta-Aminobenzoates; Neuroprotective Agents; Niacinamide; Otoacoustic Emissions, Spontaneous; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 2003 |
Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats.
Topics: Animals; Antioxidants; Benzamides; Brain Ischemia; Disease Models, Animal; Drug Combinations; Drug Therapy, Combination; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Melatonin; Neuroprotective Agents; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome | 2004 |
The role of poly (adenosine 5'-diphosphate-ribose) polymerase in the response of pituitary tumor cells to reactive oxygen species.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Benzamides; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Endothelium, Vascular; Glucose; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Niacinamide; Oxidants; Pituitary Neoplasms; Poly(ADP-ribose) Polymerases; Rats; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors; Umbilical Veins | 2005 |
MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells.
Topics: Antioxidants; Benzamides; Cells, Cultured; Enzyme Inhibitors; Homeodomain Proteins; Insulin; Insulin-Secreting Cells; Isoquinolines; Maf Transcription Factors, Large; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Promoter Regions, Genetic; RNA, Messenger; Trans-Activators | 2006 |
Preconditioning effects of peroxynitrite in the rat lung.
Topics: Animals; Benzamides; Enzyme Inhibitors; In Vitro Techniques; Ischemic Preconditioning; Lung; Male; Malondialdehyde; Niacinamide; Peroxynitrous Acid; Phenylephrine; Poly(ADP-ribose) Polymerase Inhibitors; Potassium Chloride; Rats; Rats, Wistar; Reperfusion Injury; Uric Acid | 2006 |
Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide.
Topics: Animals; Benzamides; Blood Glucose; Catalytic Domain; Cholesterol; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glutathione; Humans; Insulin; Male; Models, Molecular; Neuroprotective Agents; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Streptozocin; Taurine; Triglycerides; Vitamin B Complex | 2010 |
Ex vivo protective effects of nicotinamide and 3-aminobenzamide on rat synaptosomes treated with Aβ(1-42).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzamides; Brain; Male; Mitochondria; Neurons; Neuroprotective Agents; Niacinamide; Oxidative Stress; Peptide Fragments; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats, Sprague-Dawley; Synaptosomes | 2014 |
Nicotinamide Inhibits Ethanol-Induced Caspase-3 and PARP-1 Over-activation and Subsequent Neurodegeneration in the Developing Mouse Cerebellum.
Topics: Animals; Animals, Newborn; Benzamides; Caspase 3; Cell Death; Central Nervous System Depressants; Cerebellum; Disease Models, Animal; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Male; Mice; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Niacinamide; Poly (ADP-Ribose) Polymerase-1 | 2018 |