Compounds > 3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole

3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole and dihydroguaiaretic-acid

3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole has been researched along with dihydroguaiaretic-acid* in 1 studies

Other Studies

1 other study(ies) available for 3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole and dihydroguaiaretic-acid

Article	Year
Suppression of the SOS-inducing activity of Trp-P-1 and aflatoxin B1 by meso-dihydroguaiaretic acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu test. Bioscience, biotechnology, and biochemistry, 1998, Volume: 62, Issue:7 The methanol extract from Machilus thunbergii showed a suppressive effect on umu gene expression of the SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which requires liver metabolizing enzymes. The methanol extract from M. thunbergii was successively re-extracted with chloroform, butanol and water. A suppressive compound in the chloroform extract fraction was isolated by SiO2 column chromatography and identified as meso-dihydroguaiaretic acid by GC-MS, and 1H- and 13C-NMR spectroscopy. Meso-dihydroguaiaretic acid inhibited of the SOS-inducing activity of Trp-P-1 in the umu test. Gene expression was suppressed by 62% at less than 0.18 mumol/ml, the ID50 value being 0.08 mumol/ml. Compound 1 was also assayed with aflatoxin B1 (AfB1) and showed a suppressive effect. Topics: Aflatoxin B1; Carbolines; Chloroform; DNA Damage; Gas Chromatography-Mass Spectrometry; Guaiacol; Lauraceae; Lignans; Magnetic Resonance Spectroscopy; Mutagens; Plant Extracts; Salmonella typhimurium; SOS Response, Genetics	1998

Article

Year

Suppression of the SOS-inducing activity of Trp-P-1 and aflatoxin B1 by meso-dihydroguaiaretic acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu test.

Bioscience, biotechnology, and biochemistry, 1998, Volume: 62, Issue:7

The methanol extract from Machilus thunbergii showed a suppressive effect on umu gene expression of the SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which requires liver metabolizing enzymes. The methanol extract from M. thunbergii was successively re-extracted with chloroform, butanol and water. A suppressive compound in the chloroform extract fraction was isolated by SiO2 column chromatography and identified as meso-dihydroguaiaretic acid by GC-MS, and 1H- and 13C-NMR spectroscopy. Meso-dihydroguaiaretic acid inhibited of the SOS-inducing activity of Trp-P-1 in the umu test. Gene expression was suppressed by 62% at less than 0.18 mumol/ml, the ID50 value being 0.08 mumol/ml. Compound 1 was also assayed with aflatoxin B1 (AfB1) and showed a suppressive effect.

Topics: Aflatoxin B1; Carbolines; Chloroform; DNA Damage; Gas Chromatography-Mass Spectrometry; Guaiacol; Lauraceae; Lignans; Magnetic Resonance Spectroscopy; Mutagens; Plant Extracts; Salmonella typhimurium; SOS Response, Genetics

1998