Compounds > 3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole

3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole and cinnamaldehyde

3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole has been researched along with cinnamaldehyde* in 1 studies

Other Studies

1 other study(ies) available for 3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole and cinnamaldehyde

Article	Year
Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens. Mutagenesis, 1997, Volume: 12, Issue:4 The effects of dietary bioantimutagens (compounds which have been shown to inhibit mutagenesis via interaction with DNA repair processes) on spontaneous and heterocyclic amine (HCA)-induced micronucleus (MN) frequencies were studied in metabolically competent human hepatoma (Hep-G2) cells. All the compounds tested (coumarin, vanillin, caffeine, tannic acid and cinnamaldehyde) caused a moderate increase of MN numbers in Hep-G2 cells at high concentrations (500 microg/ml); only tannic acid was also active at lower dose levels. In combination experiments with the HCA 2-amino-3-methylimidazo-[3,4-f]quinoline (IQ), post-treatment of the cells with bioantimutagens resulted in a pronounced (75-90%) decrease in MN. The most drastic effects were seen with vanillin, coumarin and caffeine which were active at concentrations < or = 5 microg/ml. Further experiments indicated that these compounds also attenuate the mutagenic effects of other HCAs (PhIP, MeIQ, MeIQx, Trp-P-1). Topics: Acrolein; Amines; Antimutagenic Agents; Benzaldehydes; Caffeine; Carbolines; Carcinoma, Hepatocellular; Coumarins; DNA Repair; Heterocyclic Compounds; Humans; Hydrolyzable Tannins; Imidazoles; Micronucleus Tests; Mutagens; Quinolines; Tumor Cells, Cultured	1997

Article

Year

Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens.

Mutagenesis, 1997, Volume: 12, Issue:4

The effects of dietary bioantimutagens (compounds which have been shown to inhibit mutagenesis via interaction with DNA repair processes) on spontaneous and heterocyclic amine (HCA)-induced micronucleus (MN) frequencies were studied in metabolically competent human hepatoma (Hep-G2) cells. All the compounds tested (coumarin, vanillin, caffeine, tannic acid and cinnamaldehyde) caused a moderate increase of MN numbers in Hep-G2 cells at high concentrations (500 microg/ml); only tannic acid was also active at lower dose levels. In combination experiments with the HCA 2-amino-3-methylimidazo-[3,4-f]quinoline (IQ), post-treatment of the cells with bioantimutagens resulted in a pronounced (75-90%) decrease in MN. The most drastic effects were seen with vanillin, coumarin and caffeine which were active at concentrations < or = 5 microg/ml. Further experiments indicated that these compounds also attenuate the mutagenic effects of other HCAs (PhIP, MeIQ, MeIQx, Trp-P-1).

Topics: Acrolein; Amines; Antimutagenic Agents; Benzaldehydes; Caffeine; Carbolines; Carcinoma, Hepatocellular; Coumarins; DNA Repair; Heterocyclic Compounds; Humans; Hydrolyzable Tannins; Imidazoles; Micronucleus Tests; Mutagens; Quinolines; Tumor Cells, Cultured

1997