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3-amino-1,2,4-benzotriazine and tirapazamine

3-amino-1,2,4-benzotriazine has been researched along with tirapazamine in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (80.00)18.2507
2000's1 (10.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Walton, MI; Wolf, CR; Workman, P1
Riley, RJ; Workman, P1
Edwards, DI; Tocher, JH; Virk, NS1
Adams, GE; Barham, HM; Chinje, EC; Harris, AL; Patterson, AV; Stratford, IJ1
Cahill, A; Jenkins, TC; White, IN1
Graham, MA; Robin, H; Senan, S; Workman, P1
Edwards, DI; Tocher, JH1
Liang, XZ; Lunte, CE; Palsmeier, RK1
Faibushevich, AA; Lunte, CE; McLaughlin, KJ1
Barnes, CL; Gates, KS; Johnson, KM; Parsons, ZD1

Other Studies

10 other study(ies) available for 3-amino-1,2,4-benzotriazine and tirapazamine

ArticleYear
The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
    Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2

    Topics: Animals; Biotransformation; Carbon Monoxide; Cell Hypoxia; Cell Survival; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Tirapazamine; Triazines

1992
Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.
    Biochemical pharmacology, 1992, Jan-22, Volume: 43, Issue:2

    Topics: Animals; Carcinoma 256, Walker; Cell Hypoxia; Cell Line; Chromatography, High Pressure Liquid; Kinetics; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Rats; Tirapazamine; Triazines

1992
Electrochemical properties as a function of pH for the benzotriazine di-N-oxides.
    Free radical research communications, 1990, Volume: 10, Issue:4-5

    Topics: Antineoplastic Agents; Electrochemistry; Hydrogen-Ion Concentration; Oxidation-Reduction; Radiation-Sensitizing Agents; Tirapazamine; Triazines

1990
Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).
    British journal of cancer, 1995, Volume: 72, Issue:5

    Topics: Antineoplastic Agents; Biotransformation; Breast Neoplasms; Cell Hypoxia; Chromatography, High Pressure Liquid; Drug Resistance, Neoplasm; Humans; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases; Oxygen; Prodrugs; Tirapazamine; Triazines; Tumor Cells, Cultured

1995
Metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) by purified DT-diaphorase under aerobic and anaerobic conditions.
    Biochemical pharmacology, 1993, Jan-26, Volume: 45, Issue:2

    Topics: Anaerobiosis; Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Dicumarol; DNA; Hydrogen-Ion Concentration; NAD(P)H Dehydrogenase (Quinone); NADP; Oxidation-Reduction; Time Factors; Tirapazamine; Triazines; Tumor Cells, Cultured

1993
Development and validation of a sensitive solid-phase-extraction and high-performance liquid chromatography assay for the bioreductive agent tirapazamine and its major metabolites in mouse and human plasma for pharmacokinetically guided dose escalation.
    Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:3

    Topics: Animals; Antineoplastic Agents; Biotransformation; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Stability; Humans; Mice; Reproducibility of Results; Sensitivity and Specificity; Tirapazamine; Triazines

1995
Electrochemical studies of tirapazamine: generation of the one-electron reduction product.
    Free radical research, 1994, Volume: 21, Issue:5

    Topics: Antineoplastic Agents; Electrochemistry; Free Radicals; Oxidation-Reduction; Tirapazamine; Triazines

1994
Dual-electrode amperometric detection for the determination of SR4233 and its metabolites with microbore liquid chromatography.
    Journal of pharmaceutical and biomedical analysis, 1995, Volume: 14, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Biotransformation; Calibration; Chromatography, Liquid; Electrochemistry; Electrodes; Indicators and Reagents; Male; Microdialysis; Muscles; Rats; Tirapazamine; Triazines

1995
Microdialysis sampling with on-line microbore HPLC for the determination of tirapazamine and its reduced metabolites in rats.
    The Analyst, 2000, Volume: 125, Issue:1

    Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Electronic Data Processing; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Tirapazamine; Triazines

2000
Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    The Journal of organic chemistry, 2014, Aug-15, Volume: 79, Issue:16

    Topics: Alkylating Agents; Antineoplastic Agents; Cyclic N-Oxides; DNA Damage; Gas Chromatography-Mass Spectrometry; Hypoxia; Mechlorethamine; Molecular Structure; Oxidation-Reduction; Prodrugs; Tirapazamine; Triazines

2014