3-amino-1,2,4-benzotriazine-1-oxide has been researched along with tirapazamine in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (69.23) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Asakawa, Y; Hashimoto, T; Hiraoka, N; Hori, H; Ikkyu, K; Nagasawa, H; Nakashima, H; Nakashima, K; Nakata, E; Okamoto, Y; Sasaki, Y; Shiro, Y; Sugimoto, H; Uto, Y | 1 |
| Walton, MI; Wolf, CR; Workman, P | 1 |
| Riley, RJ; Workman, P | 1 |
| Edwards, DI; Tocher, JH; Virk, NS | 1 |
| Walton, MI; Workman, P | 1 |
| Adams, GE; Barham, HM; Chinje, EC; Harris, AL; Patterson, AV; Stratford, IJ | 1 |
| Cahill, A; Jenkins, TC; White, IN | 1 |
| Graham, MA; Robin, H; Senan, S; Workman, P | 1 |
| Edwards, DI; Tocher, JH | 1 |
| Liang, XZ; Lunte, CE; Palsmeier, RK | 1 |
| Faibushevich, AA; Lunte, CE; McLaughlin, KJ | 1 |
| Anderson, RF; Denny, WA; Harris, TA; Hay, MP | 1 |
| Brown, JM; Hay, MP; Hogg, A; Pruijn, FB; Siim, BG; Sturman, JR; Wilson, WR | 1 |
13 other study(ies) available for 3-amino-1,2,4-benzotriazine-1-oxide and tirapazamine
| Article | Year |
|---|---|
Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line, Tumor; Drug Screening Assays, Antitumor; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Structure-Activity Relationship; Tirapazamine; Triazines; Tryptophan | 2008 |
The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
Topics: Animals; Biotransformation; Carbon Monoxide; Cell Hypoxia; Cell Survival; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Tirapazamine; Triazines | 1992 |
Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.
Topics: Animals; Carcinoma 256, Walker; Cell Hypoxia; Cell Line; Chromatography, High Pressure Liquid; Kinetics; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Rats; Tirapazamine; Triazines | 1992 |
Electrochemical properties as a function of pH for the benzotriazine di-N-oxides.
Topics: Antineoplastic Agents; Electrochemistry; Hydrogen-Ion Concentration; Oxidation-Reduction; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1990 |
Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Antineoplastic Agents; Biotransformation; Cell Hypoxia; Chromatography, High Pressure Liquid; Cytosol; Kinetics; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; NAD; NADH Dehydrogenase; NADP; Oxidation-Reduction; Quinone Reductases; Tirapazamine; Triazines; Tumor Cells, Cultured; Xanthine Oxidase | 1990 |
Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).
Topics: Antineoplastic Agents; Biotransformation; Breast Neoplasms; Cell Hypoxia; Chromatography, High Pressure Liquid; Drug Resistance, Neoplasm; Humans; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases; Oxygen; Prodrugs; Tirapazamine; Triazines; Tumor Cells, Cultured | 1995 |
Metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) by purified DT-diaphorase under aerobic and anaerobic conditions.
Topics: Anaerobiosis; Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Dicumarol; DNA; Hydrogen-Ion Concentration; NAD(P)H Dehydrogenase (Quinone); NADP; Oxidation-Reduction; Time Factors; Tirapazamine; Triazines; Tumor Cells, Cultured | 1993 |
Development and validation of a sensitive solid-phase-extraction and high-performance liquid chromatography assay for the bioreductive agent tirapazamine and its major metabolites in mouse and human plasma for pharmacokinetically guided dose escalation.
Topics: Animals; Antineoplastic Agents; Biotransformation; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Stability; Humans; Mice; Reproducibility of Results; Sensitivity and Specificity; Tirapazamine; Triazines | 1995 |
Electrochemical studies of tirapazamine: generation of the one-electron reduction product.
Topics: Antineoplastic Agents; Electrochemistry; Free Radicals; Oxidation-Reduction; Tirapazamine; Triazines | 1994 |
Dual-electrode amperometric detection for the determination of SR4233 and its metabolites with microbore liquid chromatography.
Topics: Animals; Antineoplastic Agents; Biotransformation; Calibration; Chromatography, Liquid; Electrochemistry; Electrodes; Indicators and Reagents; Male; Microdialysis; Muscles; Rats; Tirapazamine; Triazines | 1995 |
Microdialysis sampling with on-line microbore HPLC for the determination of tirapazamine and its reduced metabolites in rats.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Electronic Data Processing; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Tirapazamine; Triazines | 2000 |
Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine.
Topics: Acridines; Animals; Binding Sites; DNA; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Delivery Systems; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Hypoxia; Plasmids; Pulse Radiolysis; Solutions; Structure-Activity Relationship; Tirapazamine; Triazines; Water | 2003 |
Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Synergism; Female; Humans; Lung Neoplasms; Mice; Pharyngeal Neoplasms; Tirapazamine; Triazines; Uterine Cervical Neoplasms | 2004 |