Compounds > 3-7-11-15-tetramethyl-1-2-3-hexadecanetriol

3-7-11-15-tetramethyl-1-2-3-hexadecanetriol and maleimide

3-7-11-15-tetramethyl-1-2-3-hexadecanetriol has been researched along with maleimide* in 1 studies

Other Studies

1 other study(ies) available for 3-7-11-15-tetramethyl-1-2-3-hexadecanetriol and maleimide

Article	Year
Epidermal growth factor receptor-targeted lipid nanoparticles retain self-assembled nanostructures and provide high specificity. Nanoscale, 2015, Feb-21, Volume: 7, Issue:7 Next generation drug delivery utilising nanoparticles incorporates active targeting to specific sites. In this work, we combined targeting with the inherent advantages of self-assembled lipid nanoparticles containing internal nano-structures. Epidermal growth factor receptor (EGFR)-targeting, PEGylated lipid nanoparticles using phytantriol and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-PEG-maleimide amphiphiles were created. The self-assembled lipid nanoparticles presented here have internal lyotropic liquid crystalline nano-structures, verified by synchrotron small angle X-ray scattering and cryo-transmission electron microscopy, that offer the potential of high drug loading and enhanced cell penetration. Anti-EGFR Fab' fragments were conjugated to the surface of nanoparticles via a maleimide-thiol reaction at a high conjugation efficiency and retained specificity following conjugation to the nanoparticles. The conjugated nanoparticles were demonstrated to have high affinity for an EGFR target in a ligand binding assay. Topics: Cryoelectron Microscopy; Drug Carriers; ErbB Receptors; Fatty Alcohols; Humans; Immunoglobulin Fab Fragments; Ligands; Lipids; Liposomes; Liquid Crystals; Maleimides; Nanoparticles; Nanotechnology; Particle Size; Phosphatidylethanolamines; Recombinant Proteins; Scattering, Radiation; Sulfhydryl Compounds; X-Rays	2015

Article

Year

Epidermal growth factor receptor-targeted lipid nanoparticles retain self-assembled nanostructures and provide high specificity.

Nanoscale, 2015, Feb-21, Volume: 7, Issue:7

Next generation drug delivery utilising nanoparticles incorporates active targeting to specific sites. In this work, we combined targeting with the inherent advantages of self-assembled lipid nanoparticles containing internal nano-structures. Epidermal growth factor receptor (EGFR)-targeting, PEGylated lipid nanoparticles using phytantriol and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-PEG-maleimide amphiphiles were created. The self-assembled lipid nanoparticles presented here have internal lyotropic liquid crystalline nano-structures, verified by synchrotron small angle X-ray scattering and cryo-transmission electron microscopy, that offer the potential of high drug loading and enhanced cell penetration. Anti-EGFR Fab' fragments were conjugated to the surface of nanoparticles via a maleimide-thiol reaction at a high conjugation efficiency and retained specificity following conjugation to the nanoparticles. The conjugated nanoparticles were demonstrated to have high affinity for an EGFR target in a ligand binding assay.

Topics: Cryoelectron Microscopy; Drug Carriers; ErbB Receptors; Fatty Alcohols; Humans; Immunoglobulin Fab Fragments; Ligands; Lipids; Liposomes; Liquid Crystals; Maleimides; Nanoparticles; Nanotechnology; Particle Size; Phosphatidylethanolamines; Recombinant Proteins; Scattering, Radiation; Sulfhydryl Compounds; X-Rays

2015