3-7-11-15-tetramethyl-1-2-3-hexadecanetriol has been researched along with cinnamaldehyde* in 2 studies
2 other study(ies) available for 3-7-11-15-tetramethyl-1-2-3-hexadecanetriol and cinnamaldehyde
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Dual drug-loaded cubic liquid crystal gels for transdermal delivery: inner structure and percutaneous mechanism evaluations.
The goal of this paper was to develop and evaluate dual component-loaded with the hydrophilic sinomenine hydrochloride (SH) and lipophilic cinnamaldehyde (CA) cubic liquid crystal gels for transdermal delivery. The gels was prepared with a vortex method using phytantriol/water (70:30, w/w) and characterized by polarized light microscopy, small-angle X-ray scattering and rheology. The inner structure of the gels were Pn3m cubic phase and exhibited a pseudoplastic fluid behavior. Furthermore, the Topics: Acrolein; Administration, Cutaneous; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Carriers; Drug Combinations; Drug Compounding; Drug Evaluation, Preclinical; Drug Liberation; Fatty Alcohols; Gels; Hydrophobic and Hydrophilic Interactions; Liquid Crystals; Male; Morphinans; Rats; Skin; Water | 2019 |
Phytantriol-based lyotropic liquid crystal as a transdermal delivery system.
The purpose of this study was examined the feasibility of using phytantriol-based cubic and hexagonal liquid crystal preparation for the percutaneous administration of trans‑cinnamaldehyde (TCA). TCA-loaded lyotropic liquid crystal formulations were prepared and characterized, their skin permeability in vitro and in vivo was evaluated. Preliminary pharmacodynamics were also investigated in adjuvant arthritics (AA) rats. The formulations were identified respectively as cubic and hexagonal structure. The in vitro permeability study exhibited that both cubic and hexagonal liquid crystal improved the cumulative permeation quantity and permeation rates of TCA compared with home-made gel. The results of an in vivo transdermal permeability experiment showed that the area under the curve [AUC Topics: Acrolein; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Delivery Systems; Fatty Alcohols; Interleukin-1beta; Knee Joint; Liquid Crystals; Male; Rats; Rats, Wistar; Skin; Skin Absorption; Tumor Necrosis Factor-alpha | 2018 |