Page last updated: 2024-09-02

3,5-dimethyl-3'-isopropyl-l-thyronine and triiodothyronine

3,5-dimethyl-3'-isopropyl-l-thyronine has been researched along with triiodothyronine in 21 studies

Compound Research Comparison

Studies
(3,5-dimethyl-3'-isopropyl-l-thyronine)
Trials
(3,5-dimethyl-3'-isopropyl-l-thyronine)
Recent Studies (post-2010)
(3,5-dimethyl-3'-isopropyl-l-thyronine)
Studies
(triiodothyronine)
Trials
(triiodothyronine)
Recent Studies (post-2010) (triiodothyronine)
290026,2478613,473

Protein Interaction Comparison

ProteinTaxonomy3,5-dimethyl-3'-isopropyl-l-thyronine (IC50)triiodothyronine (IC50)
Thyroid hormone receptor alphaHomo sapiens (human)0.0006
Thyroid hormone receptor betaHomo sapiens (human)0.0006
Proliferating cell nuclear antigenHomo sapiens (human)3.6
Thyroid hormone receptor betaRattus norvegicus (Norway rat)0.0031
Adenosine receptor A1Homo sapiens (human)0.4109

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199016 (76.19)18.7374
1990's4 (19.05)18.2507
2000's1 (4.76)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kubinyi, H1
Apriletti, JW; Baxter, JD; Chiellini, G; Ribeiro, RC; Scanlan, TS; Yoshihara, HA1
Apriletti, JW; Baxter, JD; Scanlan, TS; Yoshihara, HA1
Benson, MC; Burger, A; Huang, YP; Liu, JP; Rivlin, RS1
Dembri, A1
Autissier, N; Dumas, P; Jorgensen, EC; Loireau, A; Michel, O; Michel, R1
Porterfield, SP1
Ballard, PL1
De Nayer, P; Dozin-van Roye, B; Rennotte, B1
De Nayer, P; Dozin-Van-Roye, B1
Ballard, PL; Gonzales, LW1
Chopra, IJ; Huang, TS; Hurd, RE; Solomon, DH2
Bachrach, LK; Burrow, GN; Dibattista, D; Holland, FJ1
Koldovský, O; Litin, BS; Swan, KR1
Bachrach, LK; Burrow, GN; Kent, G; Kudlow, JE; Silverberg, JD1
Anna, JA; Jorgensen, EC; Koldovský, O; Krulich, L; Lindberg, RF; Vaucher, YE1
Gordon, A; Gross, J; Hershman, JM; Jorgensen, EC; Melmed, S; Spira, O1
Jekat, FW; Kemper, FH; Sourgens, H1
Blas, SD; Cody, V; Davis, FB; Davis, PJ; Galindo, J; Warnick, PR1
Arabin, B; Halis, G; Hundertmark, S; Ragosch, V; Weitzel, HK; Zimmermann, B1

Reviews

1 review(s) available for 3,5-dimethyl-3'-isopropyl-l-thyronine and triiodothyronine

ArticleYear
Combined hormonal treatment and lung maturation.
    Seminars in perinatology, 1984, Volume: 8, Issue:4

    Topics: Animals; Drug Therapy, Combination; Female; Fetal Organ Maturity; Glucocorticoids; Humans; In Vitro Techniques; Infant, Newborn; Lung; Phosphatidylcholines; Pregnancy; Receptors, Cell Surface; Receptors, Thyroid Hormone; Respiratory Distress Syndrome, Newborn; Thyroid Gland; Thyroid Hormones; Thyronines; Thyroxine; Triiodothyronine

1984

Other Studies

20 other study(ies) available for 3,5-dimethyl-3'-isopropyl-l-thyronine and triiodothyronine

ArticleYear
Quantitative structure-activity relationships. 2. A mixed approach, based on Hansch and Free-Wilson Analysis.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:5

    Topics: Animals; Aspergillus niger; Bacillus cereus; Bacillus subtilis; Enterococcus faecalis; Haemophilus; Hydrazines; Methacrylates; Microbial Sensitivity Tests; Models, Chemical; Molecular Conformation; Mycobacterium tuberculosis; Phenols; Quaternary Ammonium Compounds; Rats; Regression Analysis; Rifamycins; Sarcina; Staphylococcus aureus; Structure-Activity Relationship; Thyronines; Thyroxine

1976
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor.
    Chemistry & biology, 1998, Volume: 5, Issue:6

    Topics: Animals; Cell Line; Drug Design; HeLa Cells; Humans; Ligands; Phenols; Rats; Receptors, Thyroid Hormone; Structure-Activity Relationship; Substrate Specificity; Transcription, Genetic; Triiodothyronine

1998
Structural determinants of selective thyromimetics.
    Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14

    Topics: Acetates; Binding, Competitive; Humans; Ligands; Phenols; Structure-Activity Relationship; Thyroid Hormone Receptors beta

2003
Differential effects of triiodothyronine and 3,5-dimethyl-3'-isopropyl-L-thyronine treatment of maternal rats upon hepatic L-triiodothyronine aminotransferase activity in fetal rats.
    Endocrinology, 1978, Volume: 102, Issue:2

    Topics: Animals; Female; Fetus; Gestational Age; Liver; Maternal-Fetal Exchange; Pregnancy; Rats; Thyronines; Transaminases; Triiodothyronine; Triiodothyronine, Reverse

1978
[Metabolic effects of 3,5-dimethyl-3'-isopropyl-L-thyronine and 3,5,3'-triiodo-L-thyronine in the brain and liver of hypothyroid rats. Similarities and differences].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1987, Volume: 181, Issue:4

    Topics: Animals; Brain; Cell Nucleus; Hypothyroidism; Liver; Male; Mitochondria; Mitochondria, Liver; Rats; Rats, Inbred Strains; Thyronines; Triiodothyronine

1987
Comparative effects of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) and 3,5-diiodo-3'-isopropylthyroacetic acid (IpTA2) on body weight gain and lipid metabolism in genetically obese Zucker rats.
    Biochemical pharmacology, 1986, May-15, Volume: 35, Issue:10

    Topics: Animals; Body Weight; DNA-Directed RNA Polymerases; Female; Lipid Metabolism; Liver; Obesity; Rats; Rats, Zucker; Structure-Activity Relationship; Thyronines; Thyroxine; Triiodothyronine

1986
Prenatal exposure of the fetal rat to excessive L-thyroxine or 3,5-dimethyl-3'-isopropyl-thyronine produces persistent changes in the thyroid control system.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1985, Volume: 17, Issue:12

    Topics: Animals; Body Weight; Female; Fetus; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Thyroid Gland; Thyronines; Thyroxine; Time Factors; Triiodothyronine

1985
Preferential binding of 3,5-dimethyl-3'-isopropylthyroinine (DIMIT) to brain nuclear receptors for thyroid hormones.
    Journal of neurochemistry, 1980, Volume: 34, Issue:4

    Topics: Animals; Binding, Competitive; Brain; Cell Nucleus; Kidney; Kinetics; Liver; Organ Specificity; Rats; Receptors, Cell Surface; Thyroid Hormones; Thyronines; Triiodothyronine

1980
Effect of chromatin associated factors on the activity of thyroid hormone receptors in rat liver and brain.
    Biochemical and biophysical research communications, 1981, Jan-15, Volume: 98, Issue:1

    Topics: Animals; Binding, Competitive; Brain; Cell Nucleus; Chromatin; Kinetics; Liver; Organ Specificity; Rats; Receptors, Cell Surface; Receptors, Thyroid Hormone; Thyronines; Triiodothyronine

1981
Identification and characterization of nuclear 3,5,3'-triiodothyronine-binding sites in fetal human lung.
    The Journal of clinical endocrinology and metabolism, 1981, Volume: 53, Issue:1

    Topics: Cell Nucleus; Humans; Kinetics; Lung; Receptors, Cell Surface; Receptors, Thyroid Hormone; Temperature; Thyronines; Triiodothyronine

1981
A radioimmunoassay of 3,5-dimethyl-3'-isopropyl-L-thyronine.
    Endocrinology, 1984, Volume: 114, Issue:4

    Topics: Animals; Cross Reactions; Female; Pregnancy; Radioimmunoassay; Rats; Rats, Inbred Strains; Thyronines; Thyrotropin; Thyroxine; Triiodothyronine

1984
Thyromimetic effects of 3,5-dimethyl,3'-isopropyl thyronine (DIMIT) and 3,5-diethyl,3'-isopropyl thyronine (DIET) in various tissues of the rat.
    Metabolism: clinical and experimental, 1984, Volume: 33, Issue:7

    Topics: Animals; Biotransformation; Cerebral Cortex; Diiodothyronines; Liver; Male; Myocardium; Rats; Thyroid Hormones; Thyronines; Thyrotropin; Thyroxine; Triiodothyronine

1984
Transplacental effects of 3,5-dimethyl-3'-isopropyl-L-thyronine on fetal hypothyroidism in primates.
    Endocrinology, 1983, Volume: 112, Issue:6

    Topics: Animals; Female; Fetus; Hypothyroidism; Iodine Radioisotopes; Macaca mulatta; Maternal-Fetal Exchange; Pregnancy; Thyronines; Thyrotropin; Thyroxine; Triiodothyronine

1983
Hormone maturative effect on perinatal rat colon glycosidases.
    Journal of pediatric gastroenterology and nutrition, 1983, Volume: 2, Issue:1

    Topics: Acetylglucosaminidase; alpha-L-Fucosidase; Animals; Animals, Newborn; Colon; Cortisone; Glucuronidase; Glycoside Hydrolases; Rats; Rats, Inbred Strains; Thyroid Hormones; Thyronines; Thyroxine; Triiodothyronine

1983
Treatment of ovine cretinism in utero with 3,5-dimethyl-3'-isopropyl-L-thyronine.
    Endocrinology, 1982, Volume: 111, Issue:1

    Topics: Animals; Congenital Hypothyroidism; Dose-Response Relationship, Drug; Female; Fetal Diseases; Kinetics; Pregnancy; Sheep; Thyroidectomy; Thyronines; Thyroxine; Triiodothyronine

1982
Maturational effect of triiodothyronine and its analog 3,5-dimethyl-3'-isopropyl-L-thyronine on sucrase activity in the small intestine of the developing rat.
    Journal of pediatric gastroenterology and nutrition, 1982, Volume: 1, Issue:3

    Topics: Animals; Animals, Suckling; Fetus; Intestine, Small; Proteins; Rats; Rats, Inbred Strains; Sucrase; Thyronines; Thyrotropin; Triiodothyronine

1982
Suppression of thyrotropin by 3,5-dimethyl-3'-isopropyl-L-thyronine in euthyroid and hypothyroid rats.
    Endocrinology, 1980, Volume: 107, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Hypothyroidism; Male; Pituitary Gland; Rats; Thyroid Gland; Thyronines; Thyrotropin; Thyroxine; Triiodothyronine

1980
Influence of 3,5-dimethyl-3'-isopropyl-L-thyronine on thyroid state and gestational outcome in the Wistar rat.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:10

    Topics: Animals; Female; Fetal Death; Iodine; Male; Organ Size; Pituitary Gland; Pregnancy; Pregnancy Outcome; Rats; Rats, Wistar; Thyroid Function Tests; Thyroid Gland; Thyronines; Thyrotropin; Triiodothyronine

1993
Rabbit skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase activity: stimulation in vitro by thyroid hormone analogues and bipyridines.
    Biochimica et biophysica acta, 1993, Dec-12, Volume: 1153, Issue:2

    Topics: Animals; Calcium-Transporting ATPases; Cardiotonic Agents; Kinetics; Microsomes; Milrinone; Muscles; Pyridones; Rabbits; Sarcoplasmic Reticulum; Stereoisomerism; Structure-Activity Relationship; Thyronines; Thyroxine; Triiodothyronine

1993
Effect of dexamethasone, triiodothyronine and dimethyl-isopropyl-thyronine on lung maturation of the fetal rat lung.
    Journal of perinatal medicine, 1999, Volume: 27, Issue:4

    Topics: Animals; Blotting, Northern; Dexamethasone; Female; Fetal Organ Maturity; Glucocorticoids; Humans; Infant, Newborn; Lung; Microscopy, Electron; Phosphatidylcholines; Pregnancy; Proteolipids; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Rats; Rats, Wistar; Respiratory Distress Syndrome, Newborn; Thyronines; Triiodothyronine

1999