Page last updated: 2024-09-04

3,5-diiodothyropropionic acid and triiodothyronine

3,5-diiodothyropropionic acid has been researched along with triiodothyronine in 11 studies

Compound Research Comparison

Studies
(3,5-diiodothyropropionic acid)
Trials
(3,5-diiodothyropropionic acid)
Recent Studies (post-2010)
(3,5-diiodothyropropionic acid)
Studies
(triiodothyronine)
Trials
(triiodothyronine)
Recent Studies (post-2010) (triiodothyronine)
4741226,2478613,473

Protein Interaction Comparison

ProteinTaxonomy3,5-diiodothyropropionic acid (IC50)triiodothyronine (IC50)
Thyroid hormone receptor alphaHomo sapiens (human)0.0006
Thyroid hormone receptor betaHomo sapiens (human)0.0006
Proliferating cell nuclear antigenHomo sapiens (human)3.6
Thyroid hormone receptor betaRattus norvegicus (Norway rat)0.0031
Adenosine receptor A1Homo sapiens (human)0.4109

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (27.27)18.2507
2000's3 (27.27)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Actis, M; Evison, B; Fujii, N; Inoue, A; Perry, S; Punchihewa, C1
Bahl, JJ; Goldman, S; Morkin, E; Pennock, GD; Raya, TE2
Drvota, V1
Carlsson, B; Faergemann, J; Hedner, T; Sun, XY; Yazdanparast, P; Zhao, XH1
Gerdes, AM; Hora, M; Liu, Y; Morkin, E; Redetzke, RA; Schlenker, EH1
Gerdes, AM; Liu, Y; Redetzke, RA; Sherer, BA; Wang, D1
Davis, FB; Davis, PJ; Mousa, SA; Mousa, SS1
Anand, I; Barnhill, JG; Churby, L; Dunlap, M; Edson, RG; Erikson, J; Goldman, S; Hattler, B; Ladenson, PW; McCarren, M; Morkin, E; O'Brien, T; Shih, MC; Thai, H; Warner, A; Warren, SR1
Gerdes, AM; Iervasi, G1
Bonagura, JD; Chen, CA; Kalyanasundaram, A; Mahamud, SD; Nishijima, Y; Periasamy, M; Talukder, MA; Xie, L; Yang, F; Zweier, JL1

Reviews

2 review(s) available for 3,5-diiodothyropropionic acid and triiodothyronine

ArticleYear
Development of a thyroid hormone analogue for the treatment of congestive heart failure.
    Thyroid : official journal of the American Thyroid Association, 1996, Volume: 6, Issue:5

    Topics: Animals; Cardiotonic Agents; Diiodothyronines; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Heart Failure; Humans; Myocardial Contraction; Myocardial Infarction; Propionates; Rabbits; Rats; Triiodothyronine; Ventricular Function, Left

1996
Thyroid replacement therapy and heart failure.
    Circulation, 2010, Jul-27, Volume: 122, Issue:4

    Topics: Animals; Cardiovascular Diseases; Diiodothyronines; Disease Models, Animal; Glomerular Filtration Rate; Heart Failure; Homeostasis; Humans; Hyperthyroidism; Hypothyroidism; Kidney Tubules; Muscle Cells; Myocardial Contraction; Myocardial Infarction; Natriuretic Peptides; Propionates; Thyroid Hormones; Thyroxine; Triiodothyronine; Vasodilation

2010

Trials

1 trial(s) available for 3,5-diiodothyropropionic acid and triiodothyronine

ArticleYear
Effects of the thyromimetic agent diiodothyropropionic acid on body weight, body mass index, and serum lipoproteins: a pilot prospective, randomized, controlled study.
    The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:3

    Topics: Aged; Body Mass Index; Body Weight; Chronic Disease; Diiodothyronines; Dose-Response Relationship, Drug; Double-Blind Method; Heart Failure; Humans; Lipoproteins; Middle Aged; Osteogenesis; Patient Selection; Pilot Projects; Propionates; Prospective Studies; Thyrotropin; Thyroxine; Time Factors; Treatment Outcome; Triiodothyronine

2010

Other Studies

8 other study(ies) available for 3,5-diiodothyropropionic acid and triiodothyronine

ArticleYear
Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis.
    Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7

    Topics: Amino Acid Sequence; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cisplatin; DNA; DNA Damage; DNA Replication; HeLa Cells; Humans; Neoplasms; Proliferating Cell Nuclear Antigen; Protein Interaction Maps; Small Molecule Libraries; Structure-Activity Relationship

2013
Studies on the use of thyroid hormone and a thyroid hormone analogue in the treatment of congestive heart failure.
    The Annals of thoracic surgery, 1993, Volume: 56, Issue:1 Suppl

    Topics: Animals; Captopril; Cardiac Output; Cattle; Diiodothyronines; Heart Failure; Hemodynamics; Humans; Propionates; Rats; Receptors, Thyroid Hormone; Triiodothyronine

1993
Downregulation of thyroid hormone receptor subtype mRNA levels by retinoic acid in cultured cardiomyocytes.
    Biochemical and biophysical research communications, 1998, Jan-26, Volume: 242, Issue:3

    Topics: Diiodothyronines; DNA Probes; Down-Regulation; Heart Diseases; Humans; Myocardium; Propionates; Receptors, Thyroid Hormone; RNA, Messenger; Tretinoin; Triiodothyronine; Tumor Cells, Cultured

1998
Action of topical thyroid hormone analogues on glucocorticoid-induced skin atrophy in mice.
    Thyroid : official journal of the American Thyroid Association, 2006, Volume: 16, Issue:3

    Topics: Acetates; Animals; Atrophy; Betamethasone Valerate; Diiodothyronines; Female; Glucocorticoids; Male; Mice; Mice, Inbred BALB C; Propionates; Skin; Tretinoin; Triiodothyronine

2006
Effects of thyroidectomy, T4, and DITPA replacement on brain blood vessel density in adult rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:5

    Topics: Animals; Blood Vessels; Body Temperature; Body Weight; Cerebrovascular Circulation; Diiodothyronines; Echocardiography; Heart Function Tests; Immunohistochemistry; Male; Platelet Endothelial Cell Adhesion Molecule-1; Propionates; Rats; Rats, Sprague-Dawley; Thyroidectomy; Thyroxine; Triiodothyronine

2008
Thyroid hormone analog 3,5-diiodothyropropionic acid promotes healthy vasculature in the adult myocardium independent of thyroid effects on cardiac function.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:5

    Topics: Angiogenesis Inducing Agents; Animals; Body Temperature; Coronary Vessels; Diiodothyronines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Implants; Heart Diseases; Hemodynamics; Hypothyroidism; Male; Neovascularization, Physiologic; Propionates; Rats; Rats, Sprague-Dawley; Thyroidectomy; Thyroxine; Triiodothyronine; Ultrasonography; Ventricular Function, Left

2009
Human platelet aggregation and degranulation is induced in vitro by L-thyroxine, but not by 3,5,3'-triiodo-L-thyronine or diiodothyropropionic acid (DITPA).
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2010, Volume: 16, Issue:3

    Topics: Acetates; Adenosine Triphosphate; Adolescent; Blood Platelets; Collagen; Cytoplasmic Granules; Diiodothyronines; Female; Humans; Imidazoles; Male; Phenols; Platelet Activation; Platelet Aggregation; Propionates; Receptors, Thyroid Hormone; Substrate Specificity; Thyroxine; Triiodothyronine; Young Adult

2010
Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Blotting, Western; Cardiotonic Agents; Data Interpretation, Statistical; Diiodothyronines; Dose-Response Relationship, Drug; Echocardiography; Electrocardiography; Heart; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Propionates; Sympathomimetics; Thyroxine; Triiodothyronine; Ventricular Function, Left

2011