Page last updated: 2024-09-03

3,5-diiodothyronine and thyroxine

3,5-diiodothyronine has been researched along with thyroxine in 32 studies

Compound Research Comparison

Studies
(3,5-diiodothyronine)
Trials
(3,5-diiodothyronine)
Recent Studies (post-2010)
(3,5-diiodothyronine)
Studies
(thyroxine)
Trials
(thyroxine)
Recent Studies (post-2010) (thyroxine)
126158502
12615838,9891,4106,550

Protein Interaction Comparison

ProteinTaxonomy3,5-diiodothyronine (IC50)thyroxine (IC50)
TransthyretinHomo sapiens (human)2.1939
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)5.25
Solute carrier organic anion transporter family member 4C1Homo sapiens (human)8
Bile acid receptorHomo sapiens (human)7.86

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199013 (40.63)18.7374
1990's5 (15.63)18.2507
2000's4 (12.50)29.6817
2010's8 (25.00)24.3611
2020's2 (6.25)2.80

Authors

AuthorsStudies
Bolger, MB; Dietrich, SW; Jorgensen, EC; Kollman, PA1
Kehrhahn, OH; Kubinyi, H1
Kvetny, J1
Horst, C; Rokos, H; Seitz, HJ1
Földes, O; Gschendtová, K; Langer, P1
Ong, RL; Pittman, CS1
Burger, AG; Engler, D1
Faber, J; Friis, T; Heaf, J; Kirkegaard, C; Kølendorf, K; Lumholtz, IB; Siersbaek-Nielsen, K1
Imura, H; Inada, M; Ishii, H; Mashio, Y; Naito, K; Nishikawa, M; Tanaka, K1
Chopra, IJ; Huang, TS; Hurd, RE; Solomon, DH2
Brozmanová, H; Földes, O; Gschwendtová, K; Langer, P; Straussová, K1
Davis, FB; Davis, PJ; Lin, HY; Thacore, HR1
Craik, DJ; Duggan, BM1
Baumgartner, A; Brödel, O; Eravci, M; Finke, R; Gräf, KJ; Hiedra, L; Hoell, T; Meinhold, H; Pinna, G; Prengel, H; Stoltenburg-Didinger, G; Thoma, R1
Davis, FB; Davis, PJ; Gordinier, JK; Lin, HY; Martino, LJ; Wilcox, BD1
Folkers, G; Hagenbuch, B; Klenk, U; Meier, PJ; Pizzagalli, F; Stieger, B1
JORGENSEN, EC; REID, JA1
García-G, C; Jeziorski, MC; Orozco, A; Valverde-R, C1
GEMMILL, CL1
Kabadi, UM1
Alvarez, RM; Marti, MA; Petruk, AA1
Ehrenkranz, JR; Goldberg, IJ; Huang, LS; Huggins, LA; Nagareddy, PR; Scanlan, TS; Yu, S1
Cioffi, F; de Lange, P; Goglia, F; Lanni, A; Senese, R1
Araujo, RL; da Silva Leandro, M; de Andrade, BM; de Carvalho, DP; de Castro, JP; de Souza dos Santos, MC; Ferreira, AC; Neto, RA; Padron, AS; Pantaleão, TU1
Brabant, G; Dörr, M; Friedrich, N; Homuth, G; Ittermann, T; Köhrle, J; Laqua, R; Lehmphul, I; Nauck, M; Pietzner, M; Schurmann, C; Völker, U; Völzke, H; Wallaschofski, H1
Hernández-Puga, G; Lazcano, I; Olvera, A; Orozco, A1
Damiano, F; Gnoni, A; Rochira, A; Siculella, L1
De Angelis, M; Feldt-Rasmussen, U; Giesert, F; Kiviranta, H; Li, ZM; Main, KM; Schramm, KW; Shen, H; Skakkebæk, NE; Toppari, J; Vogt-Weisenhorn, D1
Rutigliano, G; Saponaro, F; Zucchi, R1
Fröhlich, E; Wahl, R1
Buisine, N; Lazcano, I; Olvera, A; Orozco, A; Pech-Pool, SM; Sachs, L1

Reviews

7 review(s) available for 3,5-diiodothyronine and thyroxine

ArticleYear
Thyroxine analogues. 23. Quantitative structure-activity correlation studies of in vivo and in vitro thyromimetic activities.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:7

    Topics: Animals; Cell Nucleus; Goiter; In Vitro Techniques; Liver; Mathematics; Molecular Conformation; Protein Binding; Rats; Receptors, Cell Surface; Structure-Activity Relationship; Thyroxine; Thyroxine-Binding Proteins

1977
The deiodination of the iodothyronines and of their derivatives in man.
    Endocrine reviews, 1984,Spring, Volume: 5, Issue:2

    Topics: Chemical Phenomena; Chemistry; Diiodothyronines; Diiodotyrosine; Glucuronates; Humans; Hyperthyroidism; Iodine; Kinetics; Phenyl Ethers; Radioimmunoassay; Sulfates; Thyronines; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse

1984
Thyroid: biological actions of 'nonclassical' thyroid hormones.
    The Journal of endocrinology, 2014, Volume: 221, Issue:2

    Topics: Animals; Diiodothyronines; Humans; Signal Transduction; Thyroid Gland; Thyroid Hormones; Thyronines; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse

2014
Non-mammalian models reveal the role of alternative ligands for thyroid hormone receptors.
    Molecular and cellular endocrinology, 2017, Dec-25, Volume: 459

    Topics: Animals; Biological Evolution; Diiodothyronines; Fishes; Gene Expression Regulation; Invertebrates; Iodide Peroxidase; Ligands; Phylogeny; Receptors, Thyroid Hormone; Signal Transduction; Species Specificity; Thyroid Epithelial Cells; Thyroxine; Triiodothyronine

2017
Action of Thyroid Hormones, T3 and T2, on Hepatic Fatty Acids: Differences in Metabolic Effects and Molecular Mechanisms.
    International journal of molecular sciences, 2017, Mar-31, Volume: 18, Issue:4

    Topics: Animals; Diiodothyronines; Fatty Acids; Humans; Lipid Metabolism; Liver; Mitochondria; Models, Biological; Thyroxine; Triiodothyronine

2017
Novel thyroid hormones.
    Endocrine, 2019, Volume: 66, Issue:1

    Topics: Animals; Diiodothyronines; Humans; Thyronines; Thyroxine; Triiodothyronine

2019
Physiological Role and Use of Thyroid Hormone Metabolites - Potential Utility in COVID-19 Patients.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Comorbidity; COVID-19; Diiodothyronines; Humans; Iodide Peroxidase; SARS-CoV-2; Thyroid Diseases; Thyroid Hormones; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse

2021

Other Studies

25 other study(ies) available for 3,5-diiodothyronine and thyroxine

ArticleYear
Quantitative structure-activity relationships. 1. The modified Free-Wilson approach.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:5

    Topics: Animals; Antifungal Agents; Cholinesterase Inhibitors; Epinephrine; Glycerol; Hypnotics and Sedatives; Kinetics; Models, Chemical; Phenethylamines; Phenyl Ethers; Piperidines; Propylene Glycols; Regression Analysis; Structure-Activity Relationship; Thyroxine; Urea

1976
3,5-T2 stimulates oxygen consumption, but not glucose uptake in human mononuclear blood cells.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1992, Volume: 24, Issue:7

    Topics: Adult; Blood Glucose; Diiodothyronines; DNA; Humans; In Vitro Techniques; Middle Aged; Neutrophils; Oxygen Consumption; Thyroxine; Triiodothyronine

1992
Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-L-thyronine.
    The Biochemical journal, 1989, Aug-01, Volume: 261, Issue:3

    Topics: Animals; Diiodothyronines; Hypothyroidism; Male; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Inbred Strains; Stimulation, Chemical; Thyronines; Thyroxine; Triiodothyronine, Reverse

1989
Effect of ethanol and linoleic acid on changes in biliary excretion of iodothyronines possibly related to thyroxine deiodination in rat liver.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1988, Volume: 20, Issue:4

    Topics: Animals; Bile; Diiodothyronines; Ethanol; Linoleic Acids; Liver; Male; Rats; Rats, Inbred Strains; Thyroxine; Triiodothyronine

1988
Proton nuclear magnetic resonance assignments of thyroid hormone and its analogues.
    Biochemistry international, 1985, Volume: 10, Issue:5

    Topics: Diiodothyronines; Magnetic Resonance Spectroscopy; Thyroid Hormones; Thyronines; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse

1985
Simultaneous turnover studies of thyroxine, 3,5,3' and 3,3',5'-triiodothyronine, 3,5-, 3,3'-, and 3',5'- diiodothyronine, and 3'-monoiodothyronine in chronic renal failure.
    The Journal of clinical endocrinology and metabolism, 1983, Volume: 56, Issue:2

    Topics: Adult; Aged; Diiodothyronines; Female; Humans; Iodine Radioisotopes; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Serum Albumin; Thyroid Hormones; Thyronines; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse

1983
Serum concentrations of 3, 3'-diiodothyronine, 3', 5'-diiodothyronine, and 3, 5-diiodothyronine in altered thyroid states.
    Endocrinologia japonica, 1983, Volume: 30, Issue:2

    Topics: Adult; Diiodothyronines; Humans; Hyperthyroidism; Hypothyroidism; Middle Aged; Thyronines; Thyroxine; Triiodothyronine

1983
Effect of 3,5,3'-triiodothyronine-induced hyperthyroidism on iodothyronine metabolism in the rat: evidence for tissue differences in metabolic responses.
    Endocrinology, 1984, Volume: 114, Issue:4

    Topics: Animals; Diiodothyronines; Hyperthyroidism; Kinetics; Male; Rats; Rats, Inbred Strains; Thyronines; Thyroxine; Triiodothyronine

1984
Thyromimetic effects of 3,5-dimethyl,3'-isopropyl thyronine (DIMIT) and 3,5-diethyl,3'-isopropyl thyronine (DIET) in various tissues of the rat.
    Metabolism: clinical and experimental, 1984, Volume: 33, Issue:7

    Topics: Animals; Biotransformation; Cerebral Cortex; Diiodothyronines; Liver; Male; Myocardium; Rats; Thyroid Hormones; Thyronines; Thyrotropin; Thyroxine; Triiodothyronine

1984
In vivo study of iodothyronine deiodination in rat liver: effect of salicylate on biliary excretion of several iodothyronines.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1983, Volume: 15, Issue:3

    Topics: Animals; Bile; Biliary Tract; Diiodothyronines; Iodide Peroxidase; Liver; Male; Rats; Rats, Inbred Strains; Salicylates; Thyroid Hormones; Thyroxine; Triiodothyronine

1983
Thyroid hormone analogues potentiate the antiviral action of interferon-gamma by two mechanisms.
    Journal of cellular physiology, 1996, Volume: 167, Issue:2

    Topics: Antiviral Agents; Cycloheximide; Diiodothyronines; Drug Synergism; HeLa Cells; Humans; Interferon-gamma; Protein Biosynthesis; Sensitivity and Specificity; Thyroid Hormones; Thyroxine; Triiodothyronine

1996
1H and 13C NMR relaxation studies of molecular dynamics of the thyroid hormones thyroxine, 3,5,3'-triiodothyronine, and 3,5-diiodothyronine.
    Journal of medicinal chemistry, 1996, Sep-27, Volume: 39, Issue:20

    Topics: Alanine; Chemical Phenomena; Chemistry, Physical; Diiodothyronines; Fourier Analysis; Magnetic Resonance Spectroscopy; Mathematics; Molecular Conformation; Molecular Structure; Protons; Thyroxine; Triiodothyronine

1996
Elevated 3,5-diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors.
    The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:5

    Topics: Astrocytoma; Brain Injuries; Brain Neoplasms; Craniocerebral Trauma; Diiodothyronines; Glioblastoma; Humans; Liver Diseases; Radioimmunoassay; Reference Values; Sensitivity and Specificity; Sepsis; Thyroxine; Triiodothyronine

1997
Potentiation by thyroid hormone of human IFN-gamma-induced HLA-DR expression.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Jul-15, Volume: 161, Issue:2

    Topics: Biological Transport; Cell Nucleus; Dextrothyroxine; Diiodothyronines; Drug Synergism; Genistein; HeLa Cells; HLA-DR Antigens; Humans; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Nuclear Proteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger; Thyroxine; Time Factors; Trans-Activators; Transcription Factors; Triiodothyronine; Triiodothyronine, Reverse; Tyrosine

1998
Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.
    Molecular endocrinology (Baltimore, Md.), 2002, Volume: 16, Issue:10

    Topics: Amino Acid Sequence; Animals; Brain; CHO Cells; Chromosomes, Human, Pair 12; Cloning, Molecular; Cricetinae; Diiodothyronines; Estradiol; Estrone; Female; Humans; Leydig Cells; Male; Membrane Proteins; Molecular Sequence Data; Oocytes; Organ Specificity; Organic Anion Transporters; Sequence Homology, Amino Acid; Sulfobromophthalein; Testis; Thyroxine; Triiodothyronine; Xenopus

2002
THYROXINE ANALOGS. SYNTHESIS AND ANTIGOITROGENIC ACTIVITY OF 3'-CHLORO- AND 3',5'-DICHLORO-3,5-DIIODO-L-THYRONINES IN THE RAT.
    Endocrinology, 1965, Volume: 76

    Topics: Antithyroid Agents; Biological Assay; Chemical Phenomena; Chemistry; Chromatography; Diiodothyronines; Goiter; Pharmacology; Rats; Research; Thyroid Hormones; Thyronines; Thyroxine

1965
Effects of iodothyronines on the hepatic outer-ring deiodinating pathway in killifish.
    General and comparative endocrinology, 2004, Jan-15, Volume: 135, Issue:2

    Topics: Animals; Diiodothyronines; Enzyme Activation; Fundulidae; Gene Expression Regulation, Enzymologic; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Liver; Male; Polymerase Chain Reaction; RNA, Messenger; Thyroid Gland; Thyroxine; Triiodothyronine

2004
Effects of thyroxine, 3,5-diiodothyronine and thyronine on ascorbic acid oxidation.
    The American journal of physiology, 1951, Volume: 167, Issue:2

    Topics: Ascorbic Acid; Carbohydrate Metabolism; Dehydroascorbic Acid; Diiodothyronines; Thyronines; Thyroxine

1951
Role of thyrotropin in metabolism of thyroid hormones in nonthyroidal tissues.
    Metabolism: clinical and experimental, 2006, Volume: 55, Issue:6

    Topics: Animals; Diiodothyronines; Dogs; Female; Kinetics; Thyroid Hormones; Thyrotropin; Thyroxine; Triiodothyronine

2006
Thyroid hormone interactions with DMPC bilayers. A molecular dynamics study.
    The journal of physical chemistry. B, 2009, Oct-08, Volume: 113, Issue:40

    Topics: Computer Simulation; Diiodothyronines; Dimyristoylphosphatidylcholine; Lipid Bilayers; Lipids; Models, Molecular; Molecular Structure; Static Electricity; Thyroxine; Triiodothyronine; Water

2009
Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway.
    Endocrinology, 2012, Volume: 153, Issue:11

    Topics: Animals; Apolipoproteins B; Cholesterol; Diiodothyronines; Liver; Mice; Mice, Knockout; Receptors, LDL; Scavenger Receptors, Class B; Thyroxine; Triiodothyronine

2012
Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues.
    The Journal of endocrinology, 2014, Volume: 221, Issue:3

    Topics: Animals; Basal Metabolism; Diiodothyronines; Dual Oxidases; Flavoproteins; Hypothalamo-Hypophyseal System; Hypothyroidism; Immunoblotting; Iodide Peroxidase; Iodides; Iodothyronine Deiodinase Type II; Kidney; Liver; Male; NADPH Oxidase 4; NADPH Oxidases; Oxygen Consumption; Rats; Rats, Wistar; Receptors, Thyrotropin; Reverse Transcriptase Polymerase Chain Reaction; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

2014
Translating pharmacological findings from hypothyroid rodents to euthyroid humans: is there a functional role of endogenous 3,5-T2?
    Thyroid : official journal of the American Thyroid Association, 2015, Volume: 25, Issue:2

    Topics: Adult; Aged; Diiodothyronines; Female; Humans; Hypothyroidism; Leptin; Male; Middle Aged; Thyrotropin; Thyroxine; Triiodothyronine; Young Adult

2015
Determination of thyroid hormones in placenta using isotope-dilution liquid chromatography quadrupole time-of-flight mass spectrometry.
    Journal of chromatography. A, 2018, Jan-26, Volume: 1534

    Topics: Animals; Chromatography, Liquid; Diiodothyronines; Female; Humans; Isotope Labeling; Isotopes; Limit of Detection; Liquid-Liquid Extraction; Mass Spectrometry; Mice; Placenta; Pregnancy; Reference Standards; Solid Phase Extraction; Thyroid Hormones; Thyroxine; Triiodothyronine

2018
Differential effects of 3,5-T2 and T3 on the gill regeneration and metamorphosis of the
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Ambystoma mexicanum; Animals; Gills; Mammals; Thyroid Hormones; Thyroxine

2023