Compounds > 3,5-dihydroxyphenylglycine
Page last updated: 2024-09-02

3,5-dihydroxyphenylglycine and ly 341495

3,5-dihydroxyphenylglycine has been researched along with ly 341495 in 8 studies

Compound Research Comparison

Studies
(3,5-dihydroxyphenylglycine)		Trials
(3,5-dihydroxyphenylglycine)		Recent Studies (post-2010)
(3,5-dihydroxyphenylglycine)		Studies
(ly 341495)		Trials
(ly 341495)		Recent Studies (post-2010) (ly 341495)
3011612470106
220101705

Protein Interaction Comparison

ProteinTaxonomy3,5-dihydroxyphenylglycine (IC50)ly 341495 (IC50)
Metabotropic glutamate receptor 8Homo sapiens (human)0.17
NADH-cytochrome b5 reductase 3 Homo sapiens (human)8.2
Metabotropic glutamate receptor 1Rattus norvegicus (Norway rat)8.99
Metabotropic glutamate receptor 2Rattus norvegicus (Norway rat)0.1116
Metabotropic glutamate receptor 3Rattus norvegicus (Norway rat)0.0168
Metabotropic glutamate receptor 4Rattus norvegicus (Norway rat)2.65
Metabotropic glutamate receptor 6Rattus norvegicus (Norway rat)1.14
Metabotropic glutamate receptor 5Homo sapiens (human)8.2
Metabotropic glutamate receptor 1Homo sapiens (human)7.8
Metabotropic glutamate receptor 2Homo sapiens (human)0.0469
Metabotropic glutamate receptor 7Homo sapiens (human)0.99
Metabotropic glutamate receptor 3Homo sapiens (human)0.0086

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's6 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bortolotto, ZA; Collingridge, GL; Doherty, AJ; Fitzjohn, SM; Kingston, AE; Lodge, D; Ornstein, PL; Palmer, MJ; Schoepp, DD1
Chamberlain, M; Johnson, MP; Kelly, GM1
Chamberlain, M; Johnson, MP; Kelly, G1
Bear, MF; Dong, X; Fallon, JR; Huber, KM; Philpot, BD; Snyder, EM1
Frondaroli, A; Grassi, S; Pettorossi, VE1
Duvoisin, RM; Grandes, P; Kushmerick, C; Price, GD; Puente, N; Renden, R; Taschenberger, H; von Gersdorff, H; Wadiche, JI1
Lu, Y1
Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO1

Reviews

1 review(s) available for 3,5-dihydroxyphenylglycine and ly 341495

ArticleYear
Ligands for glutamate receptors: design and therapeutic prospects.
    Journal of medicinal chemistry, 2000, Jul-13, Volume: 43, Issue:14

    Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses

2000

Other Studies

7 other study(ies) available for 3,5-dihydroxyphenylglycine and ly 341495

ArticleYear
The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
    Neuropharmacology, 1998, Volume: 37, Issue:12

    Topics: Aging; Amino Acids; Animals; Binding, Competitive; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Neuronal Plasticity; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Resorcinols; Transfection; Xanthenes

1998
Phosphoinositide hydrolysis in vivo with group I metabotropic glutamate receptor agonists.
    Brain research, 1999, Mar-13, Volume: 821, Issue:2

    Topics: Amino Acids; Animals; Brain Chemistry; Cerebellum; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Hydrolysis; Injections, Intraventricular; Male; Neuroprotective Agents; Phenylacetates; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Tritium; Type C Phospholipases; Xanthenes

1999
Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.
    Journal of neuroendocrinology, 2001, Volume: 13, Issue:8

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Amino Acids; Animals; Benzoates; Bridged Bicyclo Compounds; Corticosterone; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Neuroprotective Agents; Paraventricular Hypothalamic Nucleus; Phenylacetates; Propionates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Xanthenes

2001
Internalization of ionotropic glutamate receptors in response to mGluR activation.
    Nature neuroscience, 2001, Volume: 4, Issue:11

    Topics: Amino Acids; Animals; Cells, Cultured; Cycloheximide; Dendrites; Electrophysiology; Endocytosis; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Immunohistochemistry; In Vitro Techniques; Methoxyhydroxyphenylglycol; Neurons; Protein Synthesis Inhibitors; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Synapses; Synapsins; Synaptic Transmission; Xanthenes

2001
Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei.
    The Journal of physiology, 2002, Sep-15, Volume: 543, Issue:Pt 3

    Topics: Amino Acids; Animals; Chromones; Excitatory Amino Acid Antagonists; Glycine; Membrane Potentials; Neuronal Plasticity; Organ Culture Techniques; Phenylacetates; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Vestibular Nuclei; Xanthenes

2002
Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jun-30, Volume: 24, Issue:26

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Benzoxazines; Brain Stem; Calcium Signaling; Cannabinoid Receptor Modulators; Endocannabinoids; Evoked Potentials, Auditory, Brain Stem; Glycine; Ion Transport; Morpholines; Naphthalenes; Nerve Endings; Patch-Clamp Techniques; Picrotoxin; Piperidines; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Resorcinols; Scopolamine; Synaptic Transmission; Xanthenes

2004
Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.
    Journal of neurophysiology, 2007, Volume: 97, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Chickens; Cochlear Nucleus; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kinetics; Membrane Potentials; Models, Neurological; Neurons; Patch-Clamp Techniques; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Resorcinols; Synapses; Synaptic Transmission; Xanthenes

2007