Compounds > 3,5-dihydroxyphenylglycine
Page last updated: 2024-09-02

3,5-dihydroxyphenylglycine and glutamic acid

3,5-dihydroxyphenylglycine has been researched along with glutamic acid in 46 studies

Compound Research Comparison

Studies
(3,5-dihydroxyphenylglycine)		Trials
(3,5-dihydroxyphenylglycine)		Recent Studies (post-2010)
(3,5-dihydroxyphenylglycine)		Studies
(glutamic acid)		Trials
(glutamic acid)		Recent Studies (post-2010) (glutamic acid)
30116141,75745212,876
2201041,75745212,876

Protein Interaction Comparison

ProteinTaxonomy3,5-dihydroxyphenylglycine (IC50)glutamic acid (IC50)
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2Rattus norvegicus (Norway rat)0.821
Chain A, Glutamate Receptor Subunit 2Rattus norvegicus (Norway rat)0.821
Chain B, Glutamate Receptor Subunit 2Rattus norvegicus (Norway rat)0.821
Metabotropic glutamate receptor 8Homo sapiens (human)0.0057
Glutamate receptor ionotropic, NMDA 2DHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 3BHomo sapiens (human)0.07
Glutamate receptor 1Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 2Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 3Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 4Rattus norvegicus (Norway rat)0.5885
Glutamate receptor ionotropic, kainate 1Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 2Rattus norvegicus (Norway rat)0.38
Glutamate receptor 1Homo sapiens (human)0.613
Glutamate receptor 2Homo sapiens (human)0.613
Glutamate receptor 3Homo sapiens (human)0.613
Glutamate receptor ionotropic, kainate 3Rattus norvegicus (Norway rat)0.38
Excitatory amino acid transporter 1Homo sapiens (human)207
Glutamate receptor 4Homo sapiens (human)0.613
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 4Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2CHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 5Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 3AHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.1533

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (30.43)18.2507
2000's27 (58.70)29.6817
2010's4 (8.70)24.3611
2020's1 (2.17)2.80

Authors

AuthorsStudies
Adam, G; Bleuel, Z; Chaboz, S; Ellis, GJ; Faull, RL; Malherbe, P; Messer, J; Metzler, V; Mutel, V; Nilly, A; Richards, JG; Roughley, BS; Schlaeger, EJ1
Bischoff, F; Janssen, C; Langlois, X; Lavreysen, H; Lesage, AS; Leysen, JE1
Alexander, SP; Kendall, DA; Neil, KE1
Herrero, I; Miras-Portugal, MT; Sánchez-Prieto, J1
Bleuel, Z; Cartmell, J; Goepfert, F; Kemp, JA; Knoflach, F; Mutel, V; Pink, JR; Richards, JG; Schaffhauser, H; Wichmann, J1
Carfì, M; Cozzi, A; Leonardi, P; Lombardi, G; Moroni, F; Pellicciari, R; Sourtcheva, S1
Lerma, J; Rodríguez-Moreno, A; Sánchez-Prieto, J; Sistiaga, A1
Bortolotto, ZA; Collingridge, GL; Doherty, AJ; Fitzjohn, SM; Kingston, AE; Lodge, D; Ornstein, PL; Palmer, MJ; Schoepp, DD1
Conquet, F; Herrero, I; Sánchez-Prieto, J; Sistiaga, A1
Collingridge, GL; Doherty, AJ; Jane, DE1
Aggleton, JP; Bashir, ZI; Bortolotto, ZA; Brown, MW; Cho, K; Collingridge, GL; Conquet, F; McCaffery, B1
Beart, PM; Jones, NM; Monn, JA; Widdop, RE1
Herrero, I; Manahan-Vaughan, D; Reymann, KG; Sánchez-Prieto, J1
Hirate, K; Nishikawa, T; Ohnishi, Y; Sato, T; Tanaka, K; Teramoto, T1
Sánchez-Prieto, J; Sistiaga, A2
Croucher, MJ; Harris, JR; Jane, DE; Thomas, LS1
Barbanel, G; Cambonie, G; Kamenka, JM; Laplanche, L1
Barbanel, G; Cambonie, G; Kamenka, JM1
Chamberlain, M; Johnson, MP; Kelly, G1
Croucher, MJ; Gasparini, F; Jane, DE; Thomas, LS1
Angehagen, M; Björklund, U; Hansson, E; Muyderman, H; Nilsson, M; Olsson, T; Sandberg, M1
Bernardi, G; Bonsi, P; Calabresi, P; Centonze, D; Conquet, F; Gubellini, P; Picconi, B; Pisani, A1
Baker, DA; Carson, D; Kalivas, PW; Swanson, CJ; Worley, PF1
Bibbig, A; Buhl, EH; Kopell, N; LeBeau, FE; Traub, RD; Whittington, MA1
Anderson, J; Correa, L; Lorrain, DS; Varney, M1
Sulzer, D; Zhang, H1
Canales, JJ; Cauli, O; Elayadi, A; Errami, M; Felipo, V; Llansola, M1
Artola, A; de Graan, PN; Gispen, WH; Kamal, A; Ramakers, GM; van Dam, EJ1
Nistri, A; Ostroumov, K; Sharifullina, E1
de Hemptinne, I; Hermans, E; Maloteaux, JM; Najimi, M; Tilleux, S; Vanhoutte, N; Vermeiren, C1
Cauli, O; Felipo, V; Llansola, M; Mlili, N1
Carroll, FI; Dewey, WL; Gabra, BH; Navarro, HA; Smith, FL1
Battaglia, G; Conti, V; Diaspro, A; Feligioni, M; Henley, JM; Musante, V; Neri, E; Pedrazzi, M; Pittaluga, A; Puliti, A; Ravazzolo, R; Usai, C1
Kalivas, PW; Pacchioni, AM; Vallone, J; Worley, PF1
Beart, PM; Farso, MC; O'Shea, RD1
Bezprozvanny, I; Herndon, E; Huynh, DP; Liu, J; Nelson, O; Pulst, SM; Tang, TS; Tu, H1
Beltramo, M; Brusa, R; Lozza, G; Mancini, I; Petrò, R; Reggiani, A; Scandroglio, P1
Anna Rossi, PI; Bonanno, G; Bonifacino, T; Di Prisco, S; Giribaldi, F; Milanese, M; Pittaluga, A; Puliti, A; Tacchetti, C; Usai, C1
Johnson, SW; Shen, KZ1
Han, YE; Ho, WK; Kim, HH; Lee, D; Lee, KH; Lee, SH; Sohn, JW1
Huang, H; Li, D; Lu, Y; Peng, K; Wang, X; Wang, Y1
Acher, FC; Brabet, I; Jullian, N; Pin, JP1
Costantino, G; Macchiarulo, A; Pellicciari, R1
Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO1
Acher, FC; Bertrand, HO; Bessis, AS; Pin, JP1

Reviews

1 review(s) available for 3,5-dihydroxyphenylglycine and glutamic acid

ArticleYear
Ligands for glutamate receptors: design and therapeutic prospects.
    Journal of medicinal chemistry, 2000, Jul-13, Volume: 43, Issue:14

    Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses

2000

Other Studies

45 other study(ies) available for 3,5-dihydroxyphenylglycine and glutamic acid

ArticleYear
Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections.
    Journal of neurochemistry, 2000, Volume: 75, Issue:6

    Topics: Animals; Binding, Competitive; Brain; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Humans; Imidazoles; Indans; Intracellular Fluid; Kainic Acid; Male; Organ Specificity; Quinazolines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Proteins; Spinal Cord; Transfection

2000
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
    Molecular pharmacology, 2003, Volume: 63, Issue:5

    Topics: Adamantane; Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Brain; Cell Line; Cell Membrane; CHO Cells; Chromones; Cricetinae; Humans; Naphthalenes; Pyrans; Quinolines; Quinoxalines; Quisqualic Acid; Radioligand Assay; Rats; Receptors, Metabotropic Glutamate; Transfection; Tritium

2003
Coupling of metabotropic glutamate receptors to phosphoinositide mobilisation and inhibition of cyclic AMP generation in the guinea-pig cerebellum.
    British journal of pharmacology, 1996, Volume: 118, Issue:2

    Topics: 2-Chloroadenosine; Animals; Cerebellum; Colforsin; Cyclic AMP; Cycloleucine; Female; Glutamic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Resorcinols

1996
Functional switch from facilitation to inhibition in the control of glutamate release by metabotropic glutamate receptors.
    The Journal of biological chemistry, 1998, Jan-23, Volume: 273, Issue:4

    Topics: Animals; Calcium; Cerebral Cortex; Diglycerides; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine

1998
Effect of metabotropic glutamate receptor activation on receptor-mediated cyclic AMP responses in primary cultures of rat striatal neurones.
    Brain research, 1998, Apr-27, Volume: 791, Issue:1-2

    Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Autoradiography; Cells, Cultured; Corpus Striatum; Cyclic AMP; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glutamic Acid; Glycine; Hydrolysis; In Situ Hybridization; Neurons; Phosphatidylinositols; Rats; Receptors, Metabotropic Glutamate; Resorcinols

1998
Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex.
    European journal of pharmacology, 1998, Apr-24, Volume: 347, Issue:2-3

    Topics: Animals; Benzoates; Bridged Bicyclo Compounds; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indans; Microdialysis; Parietal Lobe; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Resorcinols

1998
Switch from facilitation to inhibition of excitatory synaptic transmission by group I mGluR desensitization.
    Neuron, 1998, Volume: 21, Issue:6

    Topics: Animals; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; GTP-Binding Proteins; Hippocampus; In Vitro Techniques; Male; Models, Neurological; Nerve Endings; Neurons; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission; Synaptosomes

1998
The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
    Neuropharmacology, 1998, Volume: 37, Issue:12

    Topics: Aging; Amino Acids; Animals; Binding, Competitive; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Neuronal Plasticity; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Resorcinols; Transfection; Xanthenes

1998
The metabotropic glutamate receptor 1 is not involved in the facilitation of glutamate release in cerebrocortical nerve terminals.
    Neuropharmacology, 1998, Volume: 37, Issue:12

    Topics: Adenosine; Animals; Cerebral Cortex; Diglycerides; Glutamic Acid; Glycine; Mice; Mice, Knockout; Nerve Endings; Phosphatidylinositols; Purinergic P1 Receptor Agonists; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reference Values; Resorcinols; Synaptosomes; Time Factors

1998
Antagonist activity of alpha-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells.
    British journal of pharmacology, 1999, Volume: 126, Issue:1

    Topics: Animals; Benzoates; Binding, Competitive; Calcium; CHO Cells; Cricetinae; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Phenylacetates; Receptors, Metabotropic Glutamate; Resorcinols

1999
Synaptic depression induced by pharmacological activation of metabotropic glutamate receptors in the perirhinal cortex in vitro.
    Neuroscience, 1999, Volume: 93, Issue:3

    Topics: Animals; Cycloleucine; Cyclopropanes; Electric Stimulation; Entorhinal Cortex; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Glycine; Hippocampus; Male; Neocortex; Neuronal Plasticity; Organ Culture Techniques; Propionates; Rats; Rats, Inbred Strains; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission; Temporal Lobe

1999
Type I and II metabotropic glutamate receptors mediate depressor and bradycardic actions in the nucleus of the solitary tract of anaesthetized rats.
    European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3

    Topics: Anesthesia; Animals; Blood Pressure; Bradycardia; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Heart Rate; Indans; Male; Microinjections; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Solitary Nucleus

1999
Presynaptic group 1 metabotropic glutamate receptors may contribute to the expression of long-term potentiation in the hippocampal CA1 region.
    Neuroscience, 1999, Volume: 94, Issue:1

    Topics: Animals; Azetidinecarboxylic Acid; Calcium; Cycloleucine; Dicarboxylic Acids; Diglycerides; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; Long-Term Potentiation; Male; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Presynaptic Terminals; Pyrrolidines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Synaptosomes

1999
[The ameliorating effects of a novel NC-1900 on impairments of learning/memory caused by glutamic acid].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1999, Volume: 114 Suppl 1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine Vasopressin; Avoidance Learning; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kainic Acid; Learning Disabilities; Male; Memory Disorders; Mice; Mice, Inbred Strains; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oligopeptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Resorcinols

1999
Protein phosphatase 2B inhibitors mimic the action of arachidonic acid and prolong the facilitation of glutamate release by group I mGlu receptors.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: 4-Aminopyridine; Animals; Arachidonic Acid; Calcineurin; Calcineurin Inhibitors; Calcium; Cyclosporine; Diglycerides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Membrane Potentials; Protein Phosphatase 1; Pyrethrins; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Synaptosomes; Time Factors

2000
Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Animals; Aspartic Acid; Autoreceptors; Benzoates; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Indans; Male; Neurons; Phenylacetates; Prosencephalon; Quisqualic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Tetrodotoxin; Tritium

2000
Protein phosphatase 1 and 2A inhibitors prolong the switch in the control of glutamate release by group I metabotropic glutamate receptors: characterization of the inhibitory pathway.
    Journal of neurochemistry, 2000, Volume: 75, Issue:4

    Topics: 4-Aminopyridine; Animals; Brain Chemistry; Calcium Channels, N-Type; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; GTP-Binding Proteins; Male; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Potassium; Potassium Channel Blockers; Protein Kinase C; Protein Phosphatase 1; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Synaptosomes; Virulence Factors, Bordetella

2000
N-methyl-D-aspartate but not glutamate induces the release of hydroxyl radicals in the neonatal rat: modulation by group I metabotropic glutamate receptors.
    Journal of neuroscience research, 2000, Oct-01, Volume: 62, Issue:1

    Topics: Animals; Animals, Newborn; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hydroxybenzoates; Hydroxyl Radical; Hypoxia-Ischemia, Brain; Ibotenic Acid; Indans; Microdialysis; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols

2000
Glutamate inhibition of NMDA-induced hydroxyl radical release: an ontogenic study in rat.
    Neuroreport, 2001, Jul-03, Volume: 12, Issue:9

    Topics: Aging; Animals; Animals, Newborn; Brain; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hydroxyl Radical; Microdialysis; N-Methylaspartate; Neurons; Neurotoxins; Oxidative Stress; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Salicylates

2001
Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.
    Journal of neuroendocrinology, 2001, Volume: 13, Issue:8

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Amino Acids; Animals; Benzoates; Bridged Bicyclo Compounds; Corticosterone; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Neuroprotective Agents; Paraventricular Hypothalamic Nucleus; Phenylacetates; Propionates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Xanthenes

2001
Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence.
    Neuropharmacology, 2001, Volume: 41, Issue:4

    Topics: Animals; Brain Chemistry; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Male; Microdialysis; Pyridines; Rats; Rats, Wistar; Receptors, Kainic Acid; Resorcinols

2001
Alpha 1-adrenergic modulation of metabotropic glutamate receptor-induced calcium oscillations and glutamate release in astrocytes.
    The Journal of biological chemistry, 2001, Dec-07, Volume: 276, Issue:49

    Topics: Animals; Astrocytes; Calcium; Calcium Signaling; Cells, Cultured; Chromatography, High Pressure Liquid; Glutamic Acid; Glycine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Metabotropic Glutamate; Resorcinols

2001
Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
    Neuroscience, 2001, Volume: 106, Issue:3

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Anticonvulsants; Benzoates; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Mice; Mice, Knockout; Muscarine; Muscarinic Agonists; N-Methylaspartate; Neostriatum; Neurons; Phenylacetates; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Synaptic Transmission

2001
Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Nov-15, Volume: 21, Issue:22

    Topics: Animals; Brain Chemistry; Calcium Channel Blockers; Carrier Proteins; Cocaine; Drug Administration Schedule; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glycine; Homer Scaffolding Proteins; Male; Microdialysis; Motor Activity; Neuropeptides; Nucleus Accumbens; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Resorcinols; Tetrodotoxin

2001
Gap junctions between interneuron dendrites can enhance synchrony of gamma oscillations in distributed networks.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Dec-01, Volume: 21, Issue:23

    Topics: Animals; Biological Clocks; Carbenoxolone; Computer Simulation; Dendrites; Electric Stimulation; Gap Junctions; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Male; Models, Neurological; Nerve Net; Neural Networks, Computer; Potassium; Rats; Rats, Wistar; Receptors, GABA-A; Resorcinols; Sensory Thresholds; Stimulation, Chemical

2001
Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment.
    Neuroscience letters, 2002, Jul-26, Volume: 327, Issue:3

    Topics: Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glycine; Male; Microdialysis; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Time Factors

2002
Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Nov-19, Volume: 23, Issue:33

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glycine; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Symporters; Synaptic Transmission

2003
Chronic hyperammonemia alters motor and neurochemical responses to activation of group I metabotropic glutamate receptors in the nucleus accumbens in rats in vivo.
    Neurobiology of disease, 2003, Volume: 14, Issue:3

    Topics: Animals; Chromones; Chronic Disease; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamic Acid; Glycine; Hepatic Encephalopathy; Hyperammonemia; Immunohistochemistry; Microdialysis; Microinjections; Motor Activity; Nucleus Accumbens; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols

2003
Group I metabotropic glutamate receptors regulate the frequency-response function of hippocampal CA1 synapses for the induction of LTP and LTD.
    The European journal of neuroscience, 2004, Volume: 19, Issue:1

    Topics: Animals; Electric Stimulation; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Neural Pathways; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Synapses; Synaptic Transmission

2004
Activation of group I metabotropic glutamate receptors enhances efficacy of glutamatergic inputs to neonatal rat hypoglossal motoneurons in vitro.
    The European journal of neuroscience, 2004, Volume: 20, Issue:5

    Topics: Action Potentials; Animals; Animals, Newborn; Glutamic Acid; Glycine; Hypoglossal Nerve; In Vitro Techniques; Motor Neurons; Neural Pathways; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols

2004
Acute up-regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes.
    Journal of neurochemistry, 2005, Volume: 94, Issue:2

    Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biotinylation; Blotting, Western; Calcium; Carbachol; Cells, Cultured; Cholinergic Agonists; Chromones; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Glycine; Immunohistochemistry; Methoxyhydroxyphenylglycol; Phorbol Esters; Protein Kinase C; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium; Tritium; Type C Phospholipases

2005
Motor activity is modulated via different neuronal circuits in rats with chronic liver failure than in normal rats.
    The European journal of neuroscience, 2007, Volume: 25, Issue:7

    Topics: Animals; Behavior, Animal; Brain; Chronic Disease; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Liver Failure; Male; Microdialysis; Motor Activity; Neural Pathways; Neurons; Portacaval Shunt, Surgical; Rats; Rats, Wistar; Resorcinols

2007
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
    Brain research, 2008, Jan-02, Volume: 1187

    Topics: Analgesics, Opioid; Animals; Calcium Signaling; Central Nervous System; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hyperalgesia; Male; Mice; Morphine; Nociceptors; Pain; Placebo Effect; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission

2008
Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings.
    Neuropharmacology, 2008, Volume: 55, Issue:4

    Topics: Animals; Aspartic Acid; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agents; Exocytosis; Gene Expression; Glutamic Acid; Glycine; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Potassium Chloride; Presynaptic Terminals; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Synaptosomes; Syntaxin 1; Tritium; Vesicular Glutamate Transport Protein 1

2008
Neuronal pentraxins modulate cocaine-induced neuroadaptations.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; C-Reactive Protein; Cocaine; Conditioning, Psychological; Crosses, Genetic; Extracellular Matrix; Gene Deletion; Glutamic Acid; Glycine; Locomotion; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Motor Activity; Nerve Tissue Proteins; Neurons; Receptors, AMPA; Resorcinols; Synapses

2009
Evidence group I mGluR drugs modulate the activation profile of lipopolysaccharide-exposed microglia in culture.
    Neurochemical research, 2009, Volume: 34, Issue:10

    Topics: Animals; Animals, Newborn; Cells, Cultured; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ligands; Lipopolysaccharides; Microglia; Nitrites; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Tumor Necrosis Factor-alpha

2009
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jul-22, Volume: 29, Issue:29

    Topics: Animals; Ataxins; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Death; Cells, Cultured; Chlorocebus aethiops; COS Cells; Dantrolene; Excitatory Amino Acid Agents; Glutamic Acid; Glycine; Inositol 1,4,5-Trisphosphate Receptors; Mice; Mice, Transgenic; Motor Activity; Nerve Degeneration; Nerve Tissue Proteins; Purkinje Cells; Resorcinols; Ryanodine; Spinocerebellar Ataxias

2009
Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology.
    Journal of biomolecular screening, 2010, Volume: 15, Issue:10

    Topics: Analgesics; Animals; Benzimidazoles; Biological Assay; Calcium; Cannabinoids; CHO Cells; Chromones; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Cycloleucine; Electric Impedance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indoles; Naphthalenes; Neuroprotective Agents; Quinolines; Quisqualic Acid; Receptor, Cannabinoid, CB2; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Thiazoles

2010
Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis.
    Neuropharmacology, 2013, Volume: 66

    Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Autoreceptors; Calcium; Disease Models, Animal; Excitatory Amino Acid Antagonists; Exocytosis; Female; Glutamic Acid; Glycine; Humans; Inositol Phosphates; Lumbar Vertebrae; Male; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Synaptosomes

2013
Group I mGluRs evoke K-ATP current by intracellular Ca2+ mobilization in rat subthalamus neurons.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:1

    Topics: Animals; Calcium; Glutamic Acid; Glycine; In Vitro Techniques; Ion Channel Gating; KATP Channels; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Subthalamic Nucleus

2013
Costimulation of AMPA and metabotropic glutamate receptors underlies phospholipase C activation by glutamate in hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Apr-22, Volume: 35, Issue:16

    Topics: Animals; Calcium; Calcium Channels, L-Type; Enzyme Activation; Glutamic Acid; Glycine; Hippocampus; Long-Term Synaptic Depression; Male; Rats; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Type C Phospholipases

2015
Mechanisms Underlying Enhancement of Spontaneous Glutamate Release by Group I mGluRs at a Central Auditory Synapse.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020, 09-09, Volume: 40, Issue:37

    Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Glycine; Male; Mice; Mice, Inbred C57BL; Receptors, Metabotropic Glutamate; Resorcinols; Sodium Channel Blockers; Sound Localization; Synapses; Tetrodotoxin; Trapezoid Body

2020
Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation.
    Journal of medicinal chemistry, 1999, May-06, Volume: 42, Issue:9

    Topics: Animals; Binding Sites; Cell Line; CHO Cells; Cricetinae; Glutamates; Ligands; Models, Molecular; Molecular Conformation; Receptors, Metabotropic Glutamate; Structure-Activity Relationship

1999
Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity.
    Journal of medicinal chemistry, 1999, Jul-29, Volume: 42, Issue:15

    Topics: Excitatory Amino Acid Agonists; Ligands; Molecular Conformation; Receptors, Metabotropic Glutamate; Structure-Activity Relationship

1999
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.
    Journal of medicinal chemistry, 2002, Jul-18, Volume: 45, Issue:15

    Topics: Binding Sites; Crystallography, X-Ray; Excitatory Amino Acid Agonists; Glutamic Acid; Ligands; Models, Molecular; Receptors, Metabotropic Glutamate; Sequence Homology, Amino Acid; Structure-Activity Relationship

2002