Page last updated: 2024-09-02

3,5-dihydroxyphenylglycine and 6-methyl-2-(phenylethynyl)pyridine

3,5-dihydroxyphenylglycine has been researched along with 6-methyl-2-(phenylethynyl)pyridine in 32 studies

Compound Research Comparison

Studies
(3,5-dihydroxyphenylglycine)
Trials
(3,5-dihydroxyphenylglycine)
Recent Studies (post-2010)
(3,5-dihydroxyphenylglycine)
Studies
(6-methyl-2-(phenylethynyl)pyridine)
Trials
(6-methyl-2-(phenylethynyl)pyridine)
Recent Studies (post-2010) (6-methyl-2-(phenylethynyl)pyridine)
3011615430185
220105430185

Protein Interaction Comparison

ProteinTaxonomy3,5-dihydroxyphenylglycine (IC50)6-methyl-2-(phenylethynyl)pyridine (IC50)
Luciferin 4-monooxygenasePhotinus pyralis (common eastern firefly)6.2333
Metabotropic glutamate receptor 5Rattus norvegicus (Norway rat)0.0129
Metabotropic glutamate receptor 5Homo sapiens (human)0.0199
Amine oxidase [flavin-containing] AMus musculus (house mouse)8

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.13)18.2507
2000's20 (62.50)29.6817
2010's10 (31.25)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Chapman, AG; Meldrum, BS; Nanan, K; Williams, M1
Hermans, E; Maloteaux, JM; Najimi, M; Page, G; Peeters, M1
Ahmadi, H; Croucher, MJ; Harris, JR; Lawrence, V; Thomas, LS1
Conn, PJ; Mannaioni, G; Marino, MJ; Traynelis, SF; Valenti, O1
Chamberlain, M; Johnson, MP; Kelly, G1
Croucher, MJ; Gasparini, F; Jane, DE; Thomas, LS1
Bernardi, G; Bonsi, P; Calabresi, P; Centonze, D; Conquet, F; Gubellini, P; Picconi, B; Pisani, A1
Merlin, LR1
Anderson, J; Correa, L; Lorrain, DS; Varney, M1
Frondaroli, A; Grassi, S; Pettorossi, VE1
Conn, PJ; Mannaioni, G; Poisik, OV; Smith, Y; Traynelis, S1
Berrino, L; Bianchi, R; de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rodella, L; Rossi, F1
Hou, L; Klann, E1
Andree, TH; Gong, X; Liu, F; Marquis, K; Reinhart, P; Zhang, G1
Azzi, M; Kougioumoutzakis, A; Lacaille, JC; Morin, F; Topolnik, L1
Chen, Y; Conn, PJ; de Paulis, T; Goudet, C; Hemstapat, K; Nong, Y; Pin, JP1
Carroll, FI; Dewey, WL; Gabra, BH; Navarro, HA; Smith, FL1
Baker, S; Brioni, JD; Chang, R; EI-Kouhen, O; Gauvin, DM; Hernandez, G; Hollingsworth, PR; Honore, P; Lehto, SG; Moreland, RB; Stewart, AO; Zheng, G; Zhu, CZ1
Chongthammakun, S; Viwatpinyo, K1
Araque, A; Navarrete, M1
Kullmann, DM; Le Duigou, C1
Huang, JQ; Lou, YJ; Pan, X; Zhang, YY; Zhou, LM; Zhu, DY1
Dell'anno, MT; Fisone, G; Pallottino, S1
Boccella, S; De Chiaro, M; de Novellis, V; Gatta, L; Giordano, C; Guida, F; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Siniscalco, D; Vita, D1
Arreola, AC; Kimmey, BA; Pierce, RC; Schmidt, HD1
Hsu, KS; Huang, CC; Lee, CC; Liang, YC1
Chen, A; Hu, WW; Jiang, XL; Li, H; Potegal, M1
Seki, K; Yashiro, S1
Chen, SR; Pan, HL; Xie, JD1
Berardo, C; Cagna, M; Di Pasqua, LG; Ferrigno, A; Richelmi, P; Siciliano, V; Vairetti, M1
Costantino, G; Macchiarulo, A; Pellicciari, R1
Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO1

Reviews

1 review(s) available for 3,5-dihydroxyphenylglycine and 6-methyl-2-(phenylethynyl)pyridine

ArticleYear
Ligands for glutamate receptors: design and therapeutic prospects.
    Journal of medicinal chemistry, 2000, Jul-13, Volume: 43, Issue:14

    Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses

2000

Other Studies

31 other study(ies) available for 3,5-dihydroxyphenylglycine and 6-methyl-2-(phenylethynyl)pyridine

ArticleYear
Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893).
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred DBA; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Seizures; Sound; Time Factors

2000
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
    Journal of neurochemistry, 2001, Volume: 76, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Indoles; Isoquinolines; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine; Sulfonamides; Synaptosomes; Tetradecanoylphorbol Acetate

2001
Endogenous sulphur-containing amino acids: potent agonists at presynaptic metabotropic glutamate autoreceptors in the rat central nervous system.
    British journal of pharmacology, 2001, Volume: 133, Issue:6

    Topics: Amino Acids, Sulfur; Animals; Aspartic Acid; Autoreceptors; Calcium; Central Nervous System; Cysteic Acid; Cysteine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Male; Neurotransmitter Agents; Presynaptic Terminals; Prosencephalon; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Tetrodotoxin; Tritium

2001
Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Aug-15, Volume: 21, Issue:16

    Topics: Animals; Benzoates; Calcium; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Neural Inhibition; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Synaptic Transmission

2001
Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.
    Journal of neuroendocrinology, 2001, Volume: 13, Issue:8

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Amino Acids; Animals; Benzoates; Bridged Bicyclo Compounds; Corticosterone; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Neuroprotective Agents; Paraventricular Hypothalamic Nucleus; Phenylacetates; Propionates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Xanthenes

2001
Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence.
    Neuropharmacology, 2001, Volume: 41, Issue:4

    Topics: Animals; Brain Chemistry; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Male; Microdialysis; Pyridines; Rats; Rats, Wistar; Receptors, Kainic Acid; Resorcinols

2001
Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
    Neuroscience, 2001, Volume: 106, Issue:3

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Anticonvulsants; Benzoates; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Mice; Mice, Knockout; Muscarine; Muscarinic Agonists; N-Methylaspartate; Neostriatum; Neurons; Phenylacetates; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Synaptic Transmission

2001
Differential roles for mGluR1 and mGluR5 in the persistent prolongation of epileptiform bursts.
    Journal of neurophysiology, 2002, Volume: 87, Issue:1

    Topics: Animals; Benzoates; Convulsants; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Picrotoxin; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Time Factors

2002
Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment.
    Neuroscience letters, 2002, Jul-26, Volume: 327, Issue:3

    Topics: Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glycine; Male; Microdialysis; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Time Factors

2002
Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei.
    The Journal of physiology, 2002, Sep-15, Volume: 543, Issue:Pt 3

    Topics: Amino Acids; Animals; Chromones; Excitatory Amino Acid Antagonists; Glycine; Membrane Potentials; Neuronal Plasticity; Organ Culture Techniques; Phenylacetates; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Vestibular Nuclei; Xanthenes

2002
Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jan-01, Volume: 23, Issue:1

    Topics: Animals; Cells, Cultured; Central Nervous System; Electric Conductivity; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Globus Pallidus; Glycine; Neurons; Parkinson Disease; Patch-Clamp Techniques; Phenotype; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols

2003
Group I metabotropic glutamate receptors modulate glutamate and gamma-aminobutyric acid release in the periaqueductal grey of rats.
    European journal of pharmacology, 2003, Feb-21, Volume: 462, Issue:1-3

    Topics: Animals; Chromones; Dendrites; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamates; Glycine; Male; Microdialysis; Microscopy, Electron; Periaqueductal Gray; Phenylacetates; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Tetrodotoxin

2003
Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jul-14, Volume: 24, Issue:28

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Animals; Benzoates; Chromones; Dendrites; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyramidal Cells; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Sirolimus; Synaptosomes; Tacrolimus; TOR Serine-Threonine Kinases; Wortmannin

2004
The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides.
    Journal of neurochemistry, 2005, Volume: 95, Issue:5

    Topics: Amyloid beta-Peptides; Animals; Benzoates; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; In Vitro Techniques; Indoles; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Morpholines; Neurons; Oncogene Protein v-akt; Peptide Fragments; Phosphorylation; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Serine; Signal Transduction

2005
mGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneurones.
    The Journal of physiology, 2006, Aug-15, Volume: 575, Issue:Pt 1

    Topics: Animals; Benzoates; Calcium; Calcium Signaling; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Long-Term Potentiation; Membrane Potentials; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; src-Family Kinases; Synapses; Synaptic Transmission; TRPC Cation Channels

2006
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
    Molecular pharmacology, 2007, Volume: 71, Issue:5

    Topics: Allosteric Regulation; Allosteric Site; Animals; Benzamides; Binding, Competitive; Cell Line; Drug Synergism; Glycine; Humans; Male; Mutation; Neurons; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Substantia Nigra; Substrate Specificity; Subthalamic Nucleus

2007
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
    Brain research, 2008, Jan-02, Volume: 1187

    Topics: Analgesics, Opioid; Animals; Calcium Signaling; Central Nervous System; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hyperalgesia; Male; Mice; Morphine; Nociceptors; Pain; Placebo Effect; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission

2008
Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats.
    European journal of pharmacology, 2008, Feb-12, Volume: 580, Issue:3

    Topics: Analgesics, Non-Narcotic; Animals; Calcium; Cell Membrane; Cerebellum; Dimethylamines; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Fluorometry; Glycine; Heterocyclic Compounds, 3-Ring; Hindlimb; Male; Molecular Structure; Morphine; Pain, Postoperative; Pyridines; Pyrimidinones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Rotarod Performance Test; Thiophenes; Tritium

2008
Activation of group I metabotropic glutamate receptors leads to brain-derived neurotrophic factor expression in rat C6 cells.
    Neuroscience letters, 2009, Dec-25, Volume: 467, Issue:2

    Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Chromones; Glycine; Protein Kinase C; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; RNA, Messenger; Signal Transduction

2009
Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes.
    Neuron, 2010, Oct-06, Volume: 68, Issue:1

    Topics: Animals; Animals, Newborn; Astrocytes; Benzoates; Biophysics; Calcium; Cannabinoid Receptor Modulators; Chelating Agents; Drug Interactions; Egtazic Acid; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Photolysis; Piperidines; Pyramidal Cells; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Resorcinols; Synaptic Transmission; Thapsigargin

2010
Group I mGluR agonist-evoked long-term potentiation in hippocampal oriens interneurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Apr-13, Volume: 31, Issue:15

    Topics: Animals; Benzoates; Electric Stimulation; Electrodes, Implanted; Electrophysiological Phenomena; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Interneurons; Long-Term Potentiation; Male; Phenylacetates; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Resorcinols

2011
Involvement of metabotropic glutamate receptor 5 in cardiomyocyte differentiation from mouse embryonic stem cells.
    Stem cells and development, 2012, Aug-10, Volume: 21, Issue:12

    Topics: Animals; Calcium Channels, L-Type; Calcium Channels, T-Type; Calcium Signaling; Carrier Proteins; Cell Differentiation; Cell Line; Cell Survival; Coculture Techniques; Embryoid Bodies; Female; Gene Expression; Gene Knockdown Techniques; Glycine; GTP Phosphohydrolases; Homer Scaffolding Proteins; Male; Mice; Mice, Inbred ICR; Myocytes, Cardiac; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; RNA Interference

2012
mGlu5R promotes glutamate AMPA receptor phosphorylation via activation of PKA/DARPP-32 signaling in striatopallidal medium spiny neurons.
    Neuropharmacology, 2013, Volume: 66

    Topics: Animals; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phosphorylation; Purinergic P1 Receptor Antagonists; Pyridines; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Triazines; Triazoles

2013
Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat.
    Neuropharmacology, 2013, Volume: 66

    Topics: Action Potentials; Amygdala; Animals; Bicuculline; Carrageenan; Chromones; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; GABA Antagonists; Gene Expression; Glycine; Male; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Pain; Physical Stimulation; Prefrontal Cortex; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols

2013
Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking.
    Addiction biology, 2015, Volume: 20, Issue:2

    Topics: Animals; Benzimidazoles; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Nucleus Accumbens; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Thiazoles

2015
Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways.
    Molecular neurobiology, 2015, Volume: 52, Issue:3

    Topics: Animals; Benzamides; Chromones; Cocaine; Cocaine-Related Disorders; Dopaminergic Neurons; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genes, Reporter; Glycine; Imidazoles; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nucleus Accumbens; Pyrazoles; Pyridazines; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D1; Receptors, Dopamine D2; Resorcinols; Substance Withdrawal Syndrome

2015
Molecular mechanisms of group I metabotropic glutamate receptor mediated LTP and LTD in basolateral amygdala in vitro.
    Psychopharmacology, 2017, Volume: 234, Issue:4

    Topics: Animals; Basolateral Nuclear Complex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols

2017
Association of social defeat stress-induced anhedonia-like symptoms with mGluR1-dependent decrease in membrane-bound AMPA-GluR1 in the mouse ventral midbrain.
    Stress (Amsterdam, Netherlands), 2017, Volume: 20, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anhedonia; Animals; Glycine; Male; Mesencephalon; Methoxyhydroxyphenylglycol; Mice; Prefrontal Cortex; Pyridines; Receptors, AMPA; Receptors, Metabotropic Glutamate; Resorcinols; Social Dominance; Stress, Psychological

2017
Presynaptic mGluR5 receptor controls glutamatergic input through protein kinase C-NMDA receptors in paclitaxel-induced neuropathic pain.
    The Journal of biological chemistry, 2017, 12-15, Volume: 292, Issue:50

    Topics: Animals; Antineoplastic Agents, Phytogenic; Behavior, Animal; Cells, Cultured; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Injections, Spinal; Male; Nerve Tissue Proteins; Neuralgia; Neurons, Afferent; Paclitaxel; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Resorcinols; Spinal Cord Dorsal Horn; Synaptosomes

2017
The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an in vitro model of benign steatosis.
    European journal of histochemistry : EJH, 2020, Nov-10, Volume: 64, Issue:4

    Topics: Fatty Liver; Glycine; Hep G2 Cells; Humans; PPAR alpha; Pyridines; Receptor, Metabotropic Glutamate 5; Resorcinols; Sterol Regulatory Element Binding Protein 1; Triglycerides

2020
Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity.
    Journal of medicinal chemistry, 1999, Dec-30, Volume: 42, Issue:26

    Topics: Amino Acid Sequence; Binding Sites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ligands; Models, Molecular; Molecular Sequence Data; Protein Conformation; Receptors, Metabotropic Glutamate; Sequence Homology, Amino Acid

1999