Compounds > 3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan
Page last updated: 2024-09-03

3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan and enkephalin, ala(2)-mephe(4)-gly(5)-

3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 7 studies

Compound Research Comparison

Studies
(3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan)		Trials
(3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan)		Recent Studies (post-2010)
(3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan)		Studies
(enkephalin, ala(2)-mephe(4)-gly(5)-)		Trials
(enkephalin, ala(2)-mephe(4)-gly(5)-)		Recent Studies (post-2010) (enkephalin, ala(2)-mephe(4)-gly(5)-)
75024151071

Protein Interaction Comparison

ProteinTaxonomy3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan (IC50)enkephalin, ala(2)-mephe(4)-gly(5)- (IC50)
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.003
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.003
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.003
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.003
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.003
Delta-type opioid receptorMus musculus (house mouse)1.2415
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0132
Mu-type opioid receptorHomo sapiens (human)0.004
Delta-type opioid receptorHomo sapiens (human)0.0014
Mu-type opioid receptorMus musculus (house mouse)0.0048
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0283

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (71.43)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davis, P; Hruby, VJ; Lai, J; Ma, SW; Moye, S; Nair, P; Navratilova, E; Porreca, F; Tumati, S; Vanderah, TW; Yamamoto, T; Yamamura, HI1
Davis, P; Hruby, VJ; Lai, J; Largent-Milnes, T; Ma, SW; Moye, S; Nair, P; Navratilova, E; Porreca, F; Tumati, S; Vagner, J; Vanderah, TW; Yamamoto, T; Yamamura, HI1
Davis, P; Hruby, VJ; Jacobsen, NE; Lai, J; Ma, SW; Moye, S; Nair, P; Navratilova, E; Porreca, F; Vanderah, TW; Yamamoto, T; Yamamura, HI1
Davis, P; Hruby, VJ; Lai, J; Ma, SW; Nair, P; Porreca, F; Vanderah, TW; Yamamoto, T; Yamamura, HI1
Davis, P; Hruby, VJ; Jacobsen, NE; Kulkarni, V; Lai, J; Ma, SW; Nair, P; Navratilova, E; Porreca, F; Vagner, J; Vanderah, TW; Yamamoto, T; Yamamura, HI1
Davis, P; Hruby, VJ; Jacobsen, NE; Kulkarni, V; Lai, J; Ma, SW; Nair, P; Navratilova, E; Porreca, F; Vanderah, TW; Yamamoto, T; Yamamura, HI1
Davis, P; Hruby, VJ; Jacobsen, NE; Lai, J; Largent-Milnes, TM; Ma, SW; Nair, P; Porreca, F; Vanderah, TW; Yamamoto, T; Yamamura, HI1

Other Studies

7 other study(ies) available for 3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan and enkephalin, ala(2)-mephe(4)-gly(5)-

ArticleYear
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
    Journal of medicinal chemistry, 2007, Jun-14, Volume: 50, Issue:12

    Topics: Analgesics; Animals; Cell Line; Drug Design; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens

2007
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
    Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5

    Topics: Animals; Cell Line; Cell Line, Tumor; Combinatorial Chemistry Techniques; Cricetinae; Cricetulus; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens

2008
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
    Journal of medicinal chemistry, 2008, Oct-23, Volume: 51, Issue:20

    Topics: Amino Acid Sequence; Cell Line, Tumor; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ligands; Micelles; Models, Molecular; Neurokinin-1 Receptor Antagonists; Nuclear Magnetic Resonance, Biomolecular; Opioid Peptides; Protein Structure, Secondary; Receptors, Neurokinin-1; Receptors, Opioid, delta; Receptors, Opioid, mu; Spectrometry, Fluorescence

2008
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
    Bioorganic & medicinal chemistry, 2009, Oct-15, Volume: 17, Issue:20

    Topics: Animals; Cystine; Half-Life; In Vitro Techniques; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Receptors, Opioid

2009
Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.
    Journal of medicinal chemistry, 2009, Aug-27, Volume: 52, Issue:16

    Topics: Analgesics; Animals; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Glycosylation; Guinea Pigs; Hydrogen Bonding; Ileum; Ligands; Magnetic Resonance Spectroscopy; Male; Mice; Models, Molecular; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Protein Structure, Secondary; Radioligand Assay; Rats; Receptors, Neurokinin-1; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens

2009
Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.
    Journal of medicinal chemistry, 2010, Aug-12, Volume: 53, Issue:15

    Topics: Analgesics, Opioid; Animals; Guinea Pigs; Humans; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Neurokinin-1 Receptor Antagonists; Penicillamine; Peptides, Cyclic; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship

2010
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
    Journal of medicinal chemistry, 2011, Apr-14, Volume: 54, Issue:7

    Topics: Amino Acid Sequence; Analgesics; Animals; Drug Discovery; Drug Stability; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; Magnetic Resonance Spectroscopy; Male; Mice; Micelles; Molecular Conformation; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Receptors, Neurokinin-1; Receptors, Opioid, mu; Receptors, sigma; Structure-Activity Relationship; Tyrosine; Vas Deferens

2011