3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan and cp 99994

3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan has been researched along with cp 99994 in 2 studies

Compound Research Comparison

Studies (3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan)	Trials (3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan)	Recent Studies (post-2010) (3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan)	Studies (cp 99994)	Trials (cp 99994)	Recent Studies (post-2010) (cp 99994)
75	0	24	231	2	19

Protein Interaction Comparison

Protein	Taxonomy	cp 99994 (IC50)
Glutamate receptor 1	Rattus norvegicus (Norway rat)	0.0006
Glutamate receptor 2	Rattus norvegicus (Norway rat)	0.0006
Glutamate receptor 3	Rattus norvegicus (Norway rat)	0.0006
Glutamate receptor 4	Rattus norvegicus (Norway rat)	0.0006
Substance-P receptor	Homo sapiens (human)	0.0004

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cascieri, MA; Fong, TM; Hardwicke, S; Lewis, RT; MacIntyre, DE; MacLeod, AM; Merchant, KJ; Metzger, JM; Sadowski, S; Shepheard, S	1
Beusen, DD; Marshall, GR; Shands, EF; Takeuchi, Y	1

Other Studies

2 other study(ies) available for 3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan and cp 99994

Article	Year
Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan. Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6 Topics: Amines; Amino Acid Sequence; Animals; Binding Sites; Biphenyl Compounds; Cardiovascular System; CHO Cells; Cricetinae; Esters; Extravasation of Diagnostic and Therapeutic Materials; Female; Ferrets; Guinea Pigs; Heterocyclic Compounds; Humans; Hypnotics and Sedatives; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Solubility; Structure-Activity Relationship; Substance P; Tryptophan	1995
Derivation of a three-dimensional pharmacophore model of substance P antagonists bound to the neurokinin-1 receptor. Journal of medicinal chemistry, 1998, Sep-10, Volume: 41, Issue:19 Topics: Binding Sites; Biphenyl Compounds; Crystallography, X-Ray; Ligands; Models, Molecular; Molecular Conformation; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P	1998

Article

Year

Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan.

Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6

Topics: Amines; Amino Acid Sequence; Animals; Binding Sites; Biphenyl Compounds; Cardiovascular System; CHO Cells; Cricetinae; Esters; Extravasation of Diagnostic and Therapeutic Materials; Female; Ferrets; Guinea Pigs; Heterocyclic Compounds; Humans; Hypnotics and Sedatives; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Solubility; Structure-Activity Relationship; Substance P; Tryptophan

1995

Derivation of a three-dimensional pharmacophore model of substance P antagonists bound to the neurokinin-1 receptor.

Journal of medicinal chemistry, 1998, Sep-10, Volume: 41, Issue:19

Topics: Binding Sites; Biphenyl Compounds; Crystallography, X-Ray; Ligands; Models, Molecular; Molecular Conformation; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P

1998