3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan has been researched along with biphalin in 7 studies
| Studies (3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan) | Trials (3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan) | Recent Studies (post-2010) (3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan) | Studies (biphalin) | Trials (biphalin) | Recent Studies (post-2010) (biphalin) |
|---|---|---|---|---|---|
| 75 | 0 | 24 | 84 | 0 | 38 |
| Protein | Taxonomy | 3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan (IC50) | biphalin (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.0104 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.006 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0014 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.0022 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0025 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, P; Hruby, VJ; Lai, J; Ma, SW; Moye, S; Nair, P; Navratilova, E; Porreca, F; Tumati, S; Vanderah, TW; Yamamoto, T; Yamamura, HI | 1 |
| Davis, P; Hruby, VJ; Lai, J; Largent-Milnes, T; Ma, SW; Moye, S; Nair, P; Navratilova, E; Porreca, F; Tumati, S; Vagner, J; Vanderah, TW; Yamamoto, T; Yamamura, HI | 1 |
| Davis, P; Hruby, VJ; Jacobsen, NE; Lai, J; Ma, SW; Moye, S; Nair, P; Navratilova, E; Porreca, F; Vanderah, TW; Yamamoto, T; Yamamura, HI | 1 |
| Davis, P; Hruby, VJ; Lai, J; Ma, SW; Nair, P; Porreca, F; Vanderah, TW; Yamamoto, T; Yamamura, HI | 1 |
| Davis, P; Hruby, VJ; Jacobsen, NE; Kulkarni, V; Lai, J; Ma, SW; Nair, P; Navratilova, E; Porreca, F; Vagner, J; Vanderah, TW; Yamamoto, T; Yamamura, HI | 1 |
| Davis, P; Hruby, VJ; Jacobsen, NE; Kulkarni, V; Lai, J; Ma, SW; Nair, P; Navratilova, E; Porreca, F; Vanderah, TW; Yamamoto, T; Yamamura, HI | 1 |
| Davis, P; Hruby, VJ; Jacobsen, NE; Lai, J; Largent-Milnes, TM; Ma, SW; Nair, P; Porreca, F; Vanderah, TW; Yamamoto, T; Yamamura, HI | 1 |
7 other study(ies) available for 3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan and biphalin
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Topics: Analgesics; Animals; Cell Line; Drug Design; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 2007 |
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Topics: Animals; Cell Line; Cell Line, Tumor; Combinatorial Chemistry Techniques; Cricetinae; Cricetulus; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 2008 |
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Topics: Amino Acid Sequence; Cell Line, Tumor; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ligands; Micelles; Models, Molecular; Neurokinin-1 Receptor Antagonists; Nuclear Magnetic Resonance, Biomolecular; Opioid Peptides; Protein Structure, Secondary; Receptors, Neurokinin-1; Receptors, Opioid, delta; Receptors, Opioid, mu; Spectrometry, Fluorescence | 2008 |
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Topics: Animals; Cystine; Half-Life; In Vitro Techniques; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Receptors, Opioid | 2009 |
Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.
Topics: Analgesics; Animals; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Glycosylation; Guinea Pigs; Hydrogen Bonding; Ileum; Ligands; Magnetic Resonance Spectroscopy; Male; Mice; Models, Molecular; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Protein Structure, Secondary; Radioligand Assay; Rats; Receptors, Neurokinin-1; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 2009 |
Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.
Topics: Analgesics, Opioid; Animals; Guinea Pigs; Humans; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Neurokinin-1 Receptor Antagonists; Penicillamine; Peptides, Cyclic; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 2010 |
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Topics: Amino Acid Sequence; Analgesics; Animals; Drug Discovery; Drug Stability; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; Magnetic Resonance Spectroscopy; Male; Mice; Micelles; Molecular Conformation; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Receptors, Neurokinin-1; Receptors, Opioid, mu; Receptors, sigma; Structure-Activity Relationship; Tyrosine; Vas Deferens | 2011 |