3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan has been researched along with aprepitant in 3 studies
| Studies (3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan) | Trials (3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan) | Recent Studies (post-2010) (3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan) | Studies (aprepitant) | Trials (aprepitant) | Recent Studies (post-2010) (aprepitant) |
|---|---|---|---|---|---|
| 75 | 0 | 24 | 769 | 229 | 521 |
| Protein | Taxonomy | 3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan (IC50) | aprepitant (IC50) |
|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.046 | |
| Substance-P receptor | Homo sapiens (human) | 0.0002 | |
| Substance-P receptor | Meriones unguiculatus (Mongolian gerbil) | 0.0001 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coveñas, R; González-Ortega, A; Muñoz, M | 1 |
| Carranza, A; Coveñas, R; González-Ortega, A; Muñoz, M; Robles-Frias, MJ; Rosso, M; Salinas-Martín, MV | 1 |
| Almendro, V; Carranza, A; Coveñas, R; Garcia-Recio, S; González-Ortega, A; Muñoz, M; Salinas-Martín, MV | 1 |
3 other study(ies) available for 3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan and aprepitant
| Article | Year |
|---|---|
The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines.
Topics: Antineoplastic Agents; Apoptosis; Aprepitant; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Real-Time Polymerase Chain Reaction; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Substance P; Tryptophan | 2012 |
The substance P/neurokinin-1 receptor system in lung cancer: focus on the antitumor action of neurokinin-1 receptor antagonists.
Topics: Antineoplastic Agents; Apoptosis; Aprepitant; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Tryptophan; Tumor Cells, Cultured | 2012 |
The neurokinin-1 receptor antagonist aprepitant is a promising candidate for the treatment of breast cancer.
Topics: Antineoplastic Agents; Aprepitant; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; MCF-7 Cells; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Tryptophan | 2014 |