Compounds > 3,4-methylenedioxyamphetamine

3,4-methylenedioxyamphetamine and deoxyepinephrine

3,4-methylenedioxyamphetamine has been researched along with deoxyepinephrine in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (34.48)18.2507
2000's13 (44.83)29.6817
2010's6 (20.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brewster, WK; Johnson, MP; Nichols, DE; Steele, TD; Yim, GK1
Hsu, FL; Yeh, SY1
McCann, UD; Ricaurte, GA1
Cho, AK; Hiramatsu, M; Kumagai, Y; Unger, SE1
Cho, AK; Chu, TY; Ellis, SW; Hiratsuka, A; Lennard, MS; Lin, LY; Schmitz, DA; Tucker, GT; Woods, HF1
Bourquin, D; Bracher, K; Brenneisen, R; Helmlin, HJ; Vonlanthen, D1
Ensslin, HK; Kovar, KA; Maurer, HH1
Lau, SS; Miller, RT; Monks, TJ1
Atterwill, CK; Davenport-Jones, JE; Fox, RM; Walker, TM1
Bai, F; Lau, SS; Monks, TJ1
Brenneisen, R; Camí, J; de la Torre, R; Farré, M; Mas, M; Ortuño, J; Roset, PN; Segura, J1
Bai, F; Lau, SS; Miller, RT; Monks, TJ1
Camí, J; de la Torre, R; Farré, M; Hernández-López, C; Joglar, J; Llebaria, A; Mas, M; Ortuño, J; Pizarro, N; Pujadas, M; Roset, PN; Segura, J1
Easton, N; Fry, J; Kingston, S; Marsden, CA; O'Shea, E; Watkins, A1
Amado, F; Bastos, ML; Borges, F; Carvalho, F; Carvalho, M; Fernandes, E; Milhazes, N; Monks, TJ; Remião, F1
Amado, F; Bastos, ML; Borges, F; Carvalho, F; Carvalho, M; Fernandes, E; Gonçalves, MJ; Milhazes, N; Monteiro, Mdo C; Remião, F; Seabra, V1
de la Torre, R; Farré, M; Joglar, J; Peiró, AM; Pizarro, N; Pujadas, M; Roset, PN1
Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Dirnagl, U; Fernandes, E; Ferreira, LM; Lobo, AM; Macedo, C; Meisel, A; Remião, F1
Banks, ML; Czoty, PW; Kisor, DF; Nader, MA; Nichols, DE; Sprague, JE1
Maurer, HH; Mueller, M; Peters, FT; Ricaurte, GA2
Huestis, MA; Maurer, HH; Mueller, M; Peters, FT; Ricaurte, GA1
Felim, A; Largeron, M; Maurer, HH; McCann, UD; Mueller, M; Neudörffer, A; Peters, FT; Ricaurte, GA; Yuan, J1
Maldonado Adrian, C; McCann, UD; Mueller, M; Ricaurte, GA; Yuan, J1
Barbosa, DJ; Branco, PS; Capela, JP; Carvalho, F; de Lourdes Bastos, M; Duarte, JA; Fernandes, E; Ferreira, LM; Oliveira, JM; Silva, R; Siopa, F1
Almeida, B; Barenys, M; Boix, N; Flick, B; Joglar, J; Klug, S; Llobet, JM1
Carmo, H; Carvalho, F; da Silva, DD; Silva, E1
Barbosa, DJ; Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R1
Baumann, MH; Blough, BE; Goldberg, SR; Schindler, CW; Tella, SR; Thorndike, EB1

Reviews

1 review(s) available for 3,4-methylenedioxyamphetamine and deoxyepinephrine

ArticleYear
Serotonergic neurotoxicity of methylenedioxyamphetamine and methylenedioxymetamphetamine.
    Advances in experimental medicine and biology, 2001, Volume: 500

    Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Animals; Behavior, Animal; Brain; Deoxyepinephrine; Glutathione; Hallucinogens; Humans; Molecular Structure; N-Methyl-3,4-methylenedioxyamphetamine; Neurotransmitter Agents; Rats; Serotonin Agents

2001

Trials

3 trial(s) available for 3,4-methylenedioxyamphetamine and deoxyepinephrine

ArticleYear
Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS.
    Journal of analytical toxicology, 1996, Volume: 20, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Deoxyepinephrine; Female; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Hydrolysis; Ion Exchange Resins; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reference Standards

1996
Non-linear pharmacokinetics of MDMA ('ecstasy') in humans.
    British journal of clinical pharmacology, 2000, Volume: 49, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Adult; Area Under Curve; Blood Pressure; Cross-Over Studies; Deoxyepinephrine; Diastole; Dose-Response Relationship, Drug; Double-Blind Method; Hallucinogens; Humans; Hydrogen-Ion Concentration; Male; Metabolic Clearance Rate; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Pilot Projects; Time Factors

2000
Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis.
    Journal of analytical toxicology, 2002, Volume: 26, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Deoxyepinephrine; Electrophoresis, Capillary; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Substance Abuse Detection

2002

Other Studies

25 other study(ies) available for 3,4-methylenedioxyamphetamine and deoxyepinephrine

ArticleYear
Assessment of the role of alpha-methylepinine in the neurotoxicity of MDMA.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Amines; Brain Chemistry; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deoxyepinephrine; Electrochemistry; Injections, Intraventricular; Male; Mice; Microsomes, Liver; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Species Specificity

1991
The neurochemical and stimulatory effects of putative metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in rats.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Central Nervous System Stimulants; Cerebral Cortex; Deoxyepinephrine; Dopamine; Epinephrine; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nordefrin; Rats; Rats, Inbred Strains; Serotonin

1991
Major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons.
    Brain research, 1991, Apr-05, Volume: 545, Issue:1-2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Cerebral Cortex; Cerebral Ventricles; Corpus Striatum; Deoxyepinephrine; Dopamine; Functional Laterality; Hippocampus; Injections, Intraventricular; Male; Neurons; Organ Specificity; Rats; Rats, Inbred Strains; Serotonin

1991
Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyepinephrine; Glutathione; Male; Microsomes, Liver; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains

1990
The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6).
    Biochemical pharmacology, 1994, Mar-29, Volume: 47, Issue:7

    Topics: 3,4-Methylenedioxyamphetamine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Deoxyepinephrine; Humans; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; N-Methyl-3,4-methylenedioxyamphetamine; NADP; Saccharomyces cerevisiae; Transfection

1994
Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, "Eve") and its metabolites in urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay.
    Journal of chromatography. B, Biomedical applications, 1996, Aug-30, Volume: 683, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Amphetamines; Deoxyepinephrine; Designer Drugs; Dopamine; Fluorescence Polarization Immunoassay; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Time Factors

1996
2,5-Bis-(glutathion-S-yl)-alpha-methyldopamine, a putative metabolite of (+/-)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations.
    European journal of pharmacology, 1997, Apr-04, Volume: 323, Issue:2-3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Brain; Cerebral Cortex; Corpus Striatum; Deoxyepinephrine; Depression, Chemical; Glutathione; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents

1997
The neurotoxic effects of methylenedioxymethamphetamine (MDMA) and its metabolites on rat brain spheroids in culture.
    Cell biology and toxicology, 1999, Volume: 15, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Biomarkers; Brain; Brain Diseases; Cytosol; Deoxyepinephrine; Dose-Response Relationship, Drug; Fetus; Glial Fibrillary Acidic Protein; Glutathione; L-Lactate Dehydrogenase; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Serotonin; Serotonin Agents; Spheroids, Cellular

1999
Glutathione and N-acetylcysteine conjugates of alpha-methyldopamine produce serotonergic neurotoxicity: possible role in methylenedioxyamphetamine-mediated neurotoxicity.
    Chemical research in toxicology, 1999, Volume: 12, Issue:12

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Deoxyepinephrine; Glutathione; Hydroxyindoleacetic Acid; Male; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents

1999
Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy).
    Brain research, 2003, Oct-17, Volume: 987, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Cytochrome P-450 CYP2D6; Deoxyepinephrine; Female; Glutathione; Humans; Male; Microsomes, Liver; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Stereoisomerism

2003
Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates.
    Archives of toxicology, 2004, Volume: 78, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Biotransformation; Cell Survival; Cells, Cultured; Deoxyepinephrine; Dose-Response Relationship, Drug; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hallucinogens; Hepatocytes; Lipid Peroxidation; Male; Rats; Rats, Wistar

2004
Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro.
    Chemical research in toxicology, 2004, Volume: 17, Issue:5

    Topics: 3,4-Methylenedioxyamphetamine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cell Survival; Cells, Cultured; Deoxyepinephrine; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Metabolism; Myocytes, Cardiac; Rats; Serotonin Agents; Time Factors

2004
Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites in human samples including the catechol-type metabolite (3,4-dihydroxymethamphetamine).
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9

    Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Area Under Curve; Catechol O-Methyltransferase; Cytochrome P-450 CYP2D6; Deoxyepinephrine; Half-Life; Humans; Male; Methamphetamine; Methods; Phenotype; Polymorphism, Genetic; Stereoisomerism

2004
Neurotoxicity mechanisms of thioether ecstasy metabolites.
    Neuroscience, 2007, Jun-08, Volume: 146, Issue:4

    Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Adenosine Triphosphate; Animals; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Deoxyepinephrine; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Free Radical Scavengers; Glutathione; Hallucinogens; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Rats; Rats, Wistar; Temperature; Time Factors

2007
Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:10

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Body Temperature; Deoxyepinephrine; Fever; Hallucinogens; Macaca fascicularis; Male; Serotonin Agents; Temperature

2007
Validated liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxym
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Aug-15, Volume: 855, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Calibration; Chromatography, Liquid; Deoxyepinephrine; Hallucinogens; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Saimiri; Spectrometry, Mass, Electrospray Ionization

2007
Liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxymethampheta
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Oct-15, Volume: 874, Issue:1-2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Brain Chemistry; Chromatography, Liquid; Deoxyepinephrine; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization

2008
Simultaneous liquid chromatographic-electrospray ionization mass spectrometric quantification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its metabolites 3,4-dihydroxymethamphetamine, 4-hydroxy-3-methoxymethamphetamine and 3,4-methylenedioxya
    Forensic science international, 2009, Jan-30, Volume: 184, Issue:1-3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Chromatography, Liquid; Deoxyepinephrine; Forensic Toxicology; Hallucinogens; Humans; Hydrolysis; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Saimiri; Spectrometry, Mass, Electrospray Ionization

2009
Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:10

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Deoxyepinephrine; Disease Models, Animal; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Serotonin

2009
Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity.
    Synapse (New York, N.Y.), 2011, Volume: 65, Issue:10

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Deoxyepinephrine; Dextromethorphan; Excitatory Amino Acid Antagonists; Hydroxyindoleacetic Acid; Male; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Sprague-Dawley; Serotonin; Sulfides

2011
Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes.
    British journal of pharmacology, 2012, Volume: 165, Issue:4b

    Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Antioxidants; Brain; Deoxyepinephrine; Dopamine; Glutathione; Hallucinogens; Hydrogen Peroxide; Levodopa; Male; Membrane Potential, Mitochondrial; Mice; Oxidative Stress; Protein Carbonylation; Serotonin; Synaptosomes

2012
Effects of MDMA (ecstasy) and two of its metabolites on rat embryos in vitro.
    Reproductive toxicology (Elmsford, N.Y.), 2012, Volume: 34, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Deoxyepinephrine; Embryo, Mammalian; Embryonic Development; Female; Hallucinogens; In Vitro Techniques; N-Methyl-3,4-methylenedioxyamphetamine; Pregnancy; Rats; Rats, Sprague-Dawley

2012
Mixtures of 3,4-methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non-cytotoxic concentrations.
    Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Biotransformation; Cell Survival; Chemical and Drug Induced Liver Injury; Deoxyepinephrine; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Nonlinear Dynamics; Risk Assessment; Temperature; Time Factors

2014
"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.
    Archives of toxicology, 2014, Volume: 88, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Caspase 3; Cell Death; Cell Differentiation; Cell Line; Deoxyepinephrine; Fever; Glutathione; Humans; Mitochondria; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxicity Syndromes; Temperature

2014
Effects of 3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites on cardiovascular function in conscious rats.
    British journal of pharmacology, 2014, Volume: 171, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiovascular System; Consciousness; Deoxyepinephrine; Dopamine; Dose-Response Relationship, Drug; Hallucinogens; Heart Rate; Male; Metabolic Detoxication, Phase I; Methamphetamine; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Telemetry; Time Factors

2014