Compounds > 3,4-methylenedioxyamphetamine

3,4-methylenedioxyamphetamine and alpha-methyldopamine

3,4-methylenedioxyamphetamine has been researched along with alpha-methyldopamine in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (38.46)18.2507
2000's5 (38.46)29.6817
2010's3 (23.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hsu, FL; Yeh, SY1
McCann, UD; Ricaurte, GA1
Bourquin, D; Bracher, K; Brenneisen, R; Helmlin, HJ; Vonlanthen, D1
Ensslin, HK; Kovar, KA; Maurer, HH1
Lau, SS; Miller, RT; Monks, TJ1
Easton, N; Fry, J; Kingston, S; Marsden, CA; O'Shea, E; Watkins, A1
Amado, F; Bastos, ML; Borges, F; Carvalho, F; Carvalho, M; Fernandes, E; Milhazes, N; Monks, TJ; Remião, F1
Amado, F; Bastos, ML; Borges, F; Carvalho, F; Carvalho, M; Fernandes, E; Gonçalves, MJ; Milhazes, N; Monteiro, Mdo C; Remião, F; Seabra, V1
Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Dirnagl, U; Fernandes, E; Ferreira, LM; Lobo, AM; Macedo, C; Meisel, A; Remião, F1
Banks, ML; Czoty, PW; Kisor, DF; Nader, MA; Nichols, DE; Sprague, JE1
Barbosa, DJ; Branco, PS; Capela, JP; Carvalho, F; de Lourdes Bastos, M; Duarte, JA; Fernandes, E; Ferreira, LM; Oliveira, JM; Silva, R; Siopa, F1
Carmo, H; Carvalho, F; da Silva, DD; Silva, E1
Barbosa, DJ; Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R1

Trials

1 trial(s) available for 3,4-methylenedioxyamphetamine and alpha-methyldopamine

ArticleYear
Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS.
    Journal of analytical toxicology, 1996, Volume: 20, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Deoxyepinephrine; Female; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Hydrolysis; Ion Exchange Resins; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reference Standards

1996

Other Studies

12 other study(ies) available for 3,4-methylenedioxyamphetamine and alpha-methyldopamine

ArticleYear
The neurochemical and stimulatory effects of putative metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in rats.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Central Nervous System Stimulants; Cerebral Cortex; Deoxyepinephrine; Dopamine; Epinephrine; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nordefrin; Rats; Rats, Inbred Strains; Serotonin

1991
Major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons.
    Brain research, 1991, Apr-05, Volume: 545, Issue:1-2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Cerebral Cortex; Cerebral Ventricles; Corpus Striatum; Deoxyepinephrine; Dopamine; Functional Laterality; Hippocampus; Injections, Intraventricular; Male; Neurons; Organ Specificity; Rats; Rats, Inbred Strains; Serotonin

1991
Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, "Eve") and its metabolites in urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay.
    Journal of chromatography. B, Biomedical applications, 1996, Aug-30, Volume: 683, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Amphetamines; Deoxyepinephrine; Designer Drugs; Dopamine; Fluorescence Polarization Immunoassay; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Time Factors

1996
2,5-Bis-(glutathion-S-yl)-alpha-methyldopamine, a putative metabolite of (+/-)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations.
    European journal of pharmacology, 1997, Apr-04, Volume: 323, Issue:2-3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Brain; Cerebral Cortex; Corpus Striatum; Deoxyepinephrine; Depression, Chemical; Glutathione; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents

1997
Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy).
    Brain research, 2003, Oct-17, Volume: 987, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Cytochrome P-450 CYP2D6; Deoxyepinephrine; Female; Glutathione; Humans; Male; Microsomes, Liver; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Stereoisomerism

2003
Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates.
    Archives of toxicology, 2004, Volume: 78, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Biotransformation; Cell Survival; Cells, Cultured; Deoxyepinephrine; Dose-Response Relationship, Drug; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hallucinogens; Hepatocytes; Lipid Peroxidation; Male; Rats; Rats, Wistar

2004
Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro.
    Chemical research in toxicology, 2004, Volume: 17, Issue:5

    Topics: 3,4-Methylenedioxyamphetamine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cell Survival; Cells, Cultured; Deoxyepinephrine; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Metabolism; Myocytes, Cardiac; Rats; Serotonin Agents; Time Factors

2004
Neurotoxicity mechanisms of thioether ecstasy metabolites.
    Neuroscience, 2007, Jun-08, Volume: 146, Issue:4

    Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Adenosine Triphosphate; Animals; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Deoxyepinephrine; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Free Radical Scavengers; Glutathione; Hallucinogens; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Rats; Rats, Wistar; Temperature; Time Factors

2007
Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:10

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Body Temperature; Deoxyepinephrine; Fever; Hallucinogens; Macaca fascicularis; Male; Serotonin Agents; Temperature

2007
Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes.
    British journal of pharmacology, 2012, Volume: 165, Issue:4b

    Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Antioxidants; Brain; Deoxyepinephrine; Dopamine; Glutathione; Hallucinogens; Hydrogen Peroxide; Levodopa; Male; Membrane Potential, Mitochondrial; Mice; Oxidative Stress; Protein Carbonylation; Serotonin; Synaptosomes

2012
Mixtures of 3,4-methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non-cytotoxic concentrations.
    Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Biotransformation; Cell Survival; Chemical and Drug Induced Liver Injury; Deoxyepinephrine; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Nonlinear Dynamics; Risk Assessment; Temperature; Time Factors

2014
"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.
    Archives of toxicology, 2014, Volume: 88, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Caspase 3; Cell Death; Cell Differentiation; Cell Line; Deoxyepinephrine; Fever; Glutathione; Humans; Mitochondria; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxicity Syndromes; Temperature

2014