3,4-methylenedioxyamphetamine and 4-hydroxy-3-methoxymethamphetamine

3,4-methylenedioxyamphetamine has been researched along with 4-hydroxy-3-methoxymethamphetamine in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (16.67)18.2507
2000's16 (66.67)29.6817
2010's4 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chei, DM; Foltz, RL; Lim, HK; Zeng, S1
Bourquin, D; Bracher, K; Brenneisen, R; Helmlin, HJ; Vonlanthen, D1
Kikura, R; Mieczkowski, T; Nakahara, Y; Tagliaro, F1
Brenneisen, R; Lanz, M; Thormann, W1
Brenneisen, R; Camí, J; de la Torre, R; Farré, M; Mas, M; Ortuño, J; Roset, PN; Segura, J1
Camí, J; de la Torre, R; Farré, M; Hernández-López, C; Joglar, J; Llebaria, A; Mas, M; Ortuño, J; Pizarro, N; Pujadas, M; Roset, PN; Segura, J1
Cano, S; de la Torre, R; Farré, M; Joglar, J; Llebaria, A; Pizarro, N; Segura, J1
de la Torre, R; Farré, M; Joglar, J; Peiró, AM; Pizarro, N; Pujadas, M; Roset, PN1
Abraham, TT; Huestis, MA; Pirnay, SO1
Abraham, TT; Huestis, MA; Lowe, RH; Pirnay, SO1
Cody, JT; Phelix, CF; Valtier, S1
Kamata, H; Katagi, M; Nemoto, N; Sakuma, T; Shima, N; Tsuchihashi, H1
Maurer, HH; Mueller, M; Peters, FT; Ricaurte, GA2
Huestis, MA; Kolbrich, EA; Lowe, RH1
Kamata, H; Kamata, T; Katagi, M; Miki, A; Nemoto, N; Nishikawa, M; Sakuma, T; Shima, N; Tsuchihashi, H; Zaitsu, K1
Aasim, WR; Gan, SH; Tan, SC1
Huestis, MA; Maurer, HH; Mueller, M; Peters, FT; Ricaurte, GA1
Fukuhara, K; Goda, Y; Okuda, H; Shoda, T1
Abraham, TT; Barnes, AJ; Goodwin, RS; Gorelick, DA; Huestis, MA; Kolbrich Spargo, EA; Lowe, RH; Milman, G; Pirnay, SO1
Bastos, ML; Branco, P; Carmo, H; Carvalho, F; da Silva, DG; de Pinho, PG; Ferreira, L; Pontes, H; Remião, F1
Baumann, MH; Concheiro, M; Huestis, MA; Marrone, GF; Rothman, RB; Scheidweiler, KB1
Baumann, MH; Blough, BE; Goldberg, SR; Schindler, CW; Tella, SR; Thorndike, EB1
Kraemer, T; Liechti, ME; Rickli, A; Schmid, Y; Schmidhauser, C; Steuer, AE1

Trials

4 trial(s) available for 3,4-methylenedioxyamphetamine and 4-hydroxy-3-methoxymethamphetamine

ArticleYear
Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS.
    Journal of analytical toxicology, 1996, Volume: 20, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Deoxyepinephrine; Female; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Hydrolysis; Ion Exchange Resins; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reference Standards

1996
Non-linear pharmacokinetics of MDMA ('ecstasy') in humans.
    British journal of clinical pharmacology, 2000, Volume: 49, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Adult; Area Under Curve; Blood Pressure; Cross-Over Studies; Deoxyepinephrine; Diastole; Dose-Response Relationship, Drug; Double-Blind Method; Hallucinogens; Humans; Hydrogen-Ion Concentration; Male; Metabolic Clearance Rate; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Pilot Projects; Time Factors

2000
Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis.
    Journal of analytical toxicology, 2002, Volume: 26, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Deoxyepinephrine; Electrophoresis, Capillary; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Substance Abuse Detection

2002
Chiral Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine and its Phase I and II Metabolites following Controlled Administration to Humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:12

    Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Methamphetamine; Stereoisomerism; Young Adult

2015

Other Studies

20 other study(ies) available for 3,4-methylenedioxyamphetamine and 4-hydroxy-3-methoxymethamphetamine

ArticleYear
Comparative investigation of disposition of 3,4-(methylenedioxy)methamphetamine (MDMA) in the rat and the mouse by a capillary gas chromatography-mass spectrometry assay based on perfluorotributylamine-enhanced ammonia positive ion chemical ionization.
    Journal of pharmaceutical and biomedical analysis, 1992, Volume: 10, Issue:9

    Topics: 3,4-Methylenedioxyamphetamine; Ammonia; Animals; Dopamine; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Male; Methamphetamine; Mice; Mice, Inbred Strains; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Species Specificity

1992
Hair analysis for drug abuse. XV. Disposition of 3, 4-methylenedioxymethamphetamine (MDMA) and its related compounds into rat hair and application to hair analysis for MDMA abuse.
    Forensic science international, 1997, Jan-17, Volume: 84, Issue:1-3

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Gas Chromatography-Mass Spectrometry; Hair; Hallucinogens; Humans; Lactates; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Substance Abuse Detection; Substance-Related Disorders

1997
Enantioselective determination of 3,4-methylene-dioxymethamphetamine and two of its metabolites in human urine by cyclodextrin-modified capillary zone electrophoresis.
    Electrophoresis, 1997, Volume: 18, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Cyclodextrins; Dopamine; Electrophoresis, Capillary; Humans; Methamphetamine; Molecular Conformation; N-Methyl-3,4-methylenedioxyamphetamine

1997
Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites by gas chromatography/mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2003, Volume: 17, Issue:4

    Topics: 3,4-Methylenedioxyamphetamine; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Male; Methamphetamine; Molecular Conformation; Reference Values; Reproducibility of Results; Substance Abuse Detection

2003
Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites in human samples including the catechol-type metabolite (3,4-dihydroxymethamphetamine).
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9

    Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Area Under Curve; Catechol O-Methyltransferase; Cytochrome P-450 CYP2D6; Deoxyepinephrine; Half-Life; Humans; Male; Methamphetamine; Methods; Phenotype; Polymorphism, Genetic; Stereoisomerism

2004
Sensitive gas chromatography-mass spectrometry method for simultaneous measurement of MDEA, MDMA, and metabolites HMA, MDA, and HMMA in human urine.
    Clinical chemistry, 2006, Volume: 52, Issue:9

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Calibration; Central Nervous System Stimulants; Dopamine; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Sensitivity and Specificity; Substance Abuse Detection

2006
Selection and optimization of hydrolysis conditions for the quantification of urinary metabolites of MDMA.
    Journal of analytical toxicology, 2006, Volume: 30, Issue:8

    Topics: 3,4-Methylenedioxyamphetamine; Dopamine; Forensic Toxicology; Glucuronidase; Hallucinogens; Humans; Hydrochloric Acid; Hydrolysis; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Substance Abuse Detection

2006
Analysis of MDMA and its metabolites in urine and plasma following a neurotoxic dose of MDMA.
    Journal of analytical toxicology, 2007, Volume: 31, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Biotransformation; Calibration; Dopamine; Gas Chromatography-Mass Spectrometry; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Psychotropic Drugs; Rats; Reproducibility of Results; Toxicology

2007
Direct determination of glucuronide and sulfate of 4-hydroxy-3-methoxymethamphetamine, the main metabolite of MDMA, in human urine.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Sep-15, Volume: 857, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamine-Related Disorders; Calibration; Designer Drugs; Gas Chromatography-Mass Spectrometry; Glucuronides; Hallucinogens; Humans; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection; Sulfates

2007
Validated liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxym
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Aug-15, Volume: 855, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Calibration; Chromatography, Liquid; Deoxyepinephrine; Hallucinogens; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Saimiri; Spectrometry, Mass, Electrospray Ionization

2007
Two-dimensional gas chromatography/electron-impact mass spectrometry with cryofocusing for simultaneous quantification of MDMA, MDA, HMMA, HMA, and MDEA in human plasma.
    Clinical chemistry, 2008, Volume: 54, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Calibration; Central Nervous System Stimulants; Dopamine; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reproducibility of Results; Substance Abuse Detection

2008
Urinary excretion of the main metabolites of 3,4-methylenedioxymethamphetamine (MDMA), including the sulfate and glucuronide of 4-hydroxy-3-methoxymethamphetamine (HMMA), in humans and rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 2008, Volume: 38, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Glucuronides; Humans; Male; Mass Spectrometry; Methamphetamine; Rats; Rats, Wistar; Sulfates

2008
Development of a simultaneous liquid-liquid extraction and chiral derivatization method for stereospecific GC-MS analysis of amphetamine-type stimulants in human urine using fractional factorial design.
    Biomedical chromatography : BMC, 2008, Volume: 22, Issue:9

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Gas Chromatography-Mass Spectrometry; Humans; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reproducibility of Results; Substance Abuse Detection

2008
Liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxymethampheta
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Oct-15, Volume: 874, Issue:1-2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Brain Chemistry; Chromatography, Liquid; Deoxyepinephrine; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization

2008
Simultaneous liquid chromatographic-electrospray ionization mass spectrometric quantification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its metabolites 3,4-dihydroxymethamphetamine, 4-hydroxy-3-methoxymethamphetamine and 3,4-methylenedioxya
    Forensic science international, 2009, Jan-30, Volume: 184, Issue:1-3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Chromatography, Liquid; Deoxyepinephrine; Forensic Toxicology; Hallucinogens; Humans; Hydrolysis; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Saimiri; Spectrometry, Mass, Electrospray Ionization

2009
4-Hydroxy-3-methoxymethamphetamine glucuronide as a phase II metabolite of 3,4-methylenedioxymethamphetamine: enzyme-assisted synthesis and involvement of human hepatic uridine 5'-diphosphate-glucuronosyltransferase 2B15 in the glucuronidation.
    Chemical & pharmaceutical bulletin, 2009, Volume: 57, Issue:5

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Chromatography, High Pressure Liquid; Glucuronates; Glucuronides; Glucuronosyltransferase; Humans; Methamphetamine; Microsomes, Liver; Molecular Structure; Rats

2009
Urinary MDMA, MDA, HMMA, and HMA excretion following controlled MDMA administration to humans.
    Journal of analytical toxicology, 2009, Volume: 33, Issue:8

    Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Adult; Female; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Substance Abuse Detection; Young Adult

2009
Gas chromatography-ion trap mass spectrometry method for the simultaneous measurement of MDMA (ecstasy) and its metabolites, MDA, HMA, and HMMA in plasma and urine.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Mar-15, Volume: 878, Issue:9-10

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Dopamine; Gas Chromatography-Mass Spectrometry; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Wistar; Sensitivity and Specificity

2010
Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA) and its pharmacodynamic consequences in the rat.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Area Under Curve; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin

2014
Effects of 3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites on cardiovascular function in conscious rats.
    British journal of pharmacology, 2014, Volume: 171, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiovascular System; Consciousness; Deoxyepinephrine; Dopamine; Dose-Response Relationship, Drug; Hallucinogens; Heart Rate; Male; Metabolic Detoxication, Phase I; Methamphetamine; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Telemetry; Time Factors

2014