3-4-methylenedioxy-beta-nitrostyrene has been researched along with pterostilbene* in 1 studies
1 other study(ies) available for 3-4-methylenedioxy-beta-nitrostyrene and pterostilbene
| Article | Year |
|---|---|
Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis.
Studies have shown that the abnormal activation of the NLRP3 inflammasome is involved in a variety of inflammatory-based diseases. In this study, a high content screening model targeting the activation of inflammasome was first established and pterostilbene was discovered as the active scaffold. Based on this finding, total of 50 pterostilbene derivatives were then designed and synthesized. Among them, compound Topics: Animals; Anti-Inflammatory Agents; Cell Line; Colitis; Dextran Sulfate; Female; Humans; Inflammasomes; Interleukin-1beta; Macrophages; Male; Mice, Inbred C57BL; Molecular Structure; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Stilbenes; Structure-Activity Relationship | 2021 |