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3,4-epoxy-1-butene and 1,3-butadiene

3,4-epoxy-1-butene has been researched along with 1,3-butadiene in 69 studies

Research

Studies (69)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (10.14)	18.7374
1990's	43 (62.32)	18.2507
2000's	14 (20.29)	29.6817
2010's	4 (5.80)	24.3611
2020's	1 (1.45)	2.80

Authors

Authors	Studies
Duescher, RJ; Elfarra, AA	1
Bond, JA; Csanády, GA; Guengerich, FP	1
Chichłowska-Sliwińska, M; Sasiadek, M	1
Duescher, RJ; Elfarra, AA; Pasch, CM	1
Norppa, H; Sasiadek, M; Sorsa, M	1
Järventaus, H; Sasiadek, M; Sorsa, M	1
Bolt, HM; Filser, JG; Kreiling, R; Laib, RJ; Vangala, RR	1
Bolt, HM; Filser, JG; Kreiling, R; Laib, RJ	2
Loeser, E; Schmidt, U	1
Bolt, HM; Filser, JG	1
Bolt, HM; Filser, JG; Lieser, K; Rolzhäuser, HP; Schmiedel, G; Schurig, V; Wistuba, D	1
Malvoisin, E; Roberfroid, M	1
Malvoisin, E; Mercier, M; Roberfroid, M	1
Colagiovanni, DB; Irons, RD; Stillman, WS	1
Tates, AD; Xiao, Y	1
Bechtold, WE; Dahl, AR; Griffith, WC; Henderson, RF; Pei, L; Thornton-Manning, JR	1
Cheng, X; Maniglier-Poulet, C; Ross, D; Ruth, JA	1
Kaltia, S; Koivisto, P; Kostiainen, R; Neagu, C; Neagu, I; Peltonen, K	1
Asgharian, B; Bond, JA; Himmelstein, MW; Turner, MJ	2
Bond, JA; Legator, MS; Osterman-Golkar, SM; Ward, JB	1
Cochrane, JE; Skopek, TR	1
Bolt, HM	1
Bond, JA; Csanády, GA; Leavens, T; Medinsky, MA	1
Bechtold, WE; Dahl, AR; Henderson, RF; Maples, KR; Sabourin, PJ	1
Kohn, MC; Melnick, RL	2
Adler, ID; Koivisto, P; Peltonen, K; Sorsa, M	1
Elfarra, AA; Krause, RJ; Selzer, RR	1
Filser, JG; Johanson, G	1
Baur, C; Csanády, GA; Filser, JG; Kreuzer, PE	1
Bond, JA; Plopper, CG; Seaton, MJ	1
Bechtold, WE; Dahl, AR; Henderson, RF; Thornton-Manning, JR	1
Lähdetie, J; Sjöblom, T	1
Bond, JA; Janszen, DB; Leavens, TL; Moss, OR; Turner, MJ	1
Bond, JA; Medinsky, MA; Schlosser, PM; Sweeney, LM	1
Lähdetie, J; Peltonen, K; Sjöblom, T	1
Bond, JA; Farris, GM; James, RA; Leavens, TL; Marshall, MW; Shah, R; Wong, VA	1
Anderson, D; Brinkworth, MH; Dobrzyńka, MM; Jackson, LI; Yu, TW	1
Kilpeläinen, I; Koivisto, P; Lähdetie, J; Landin, H; Osterman-Golkar, S; Peltonen, K; Pérez, HL	1
Smith, MT; Wang, Y; Xi, L; Zhang, L	1
Bechtold, WE; Dahl, AR; Griffith, WC; Henderson, RF; Thornton-Manning, JR	1
Adler, ID; Kliesch, U; Nylund, L; Peltonen, K	1
Adler, ID; Koivisto, P; Pacchierotti, F; Peltonen, K	1
de Zwart, FA; Tates, AD; van Dam, FJ; van Teylingen, CM; Zwinderman, AH	1
Adler, ID; Anderson, D; Brinkworth, M; Demopoulos, NA; Lähdetie, J; Osterman-Golkar, S; Pacchierotti, F; Peltonen, K; Russo, A; Tates, A; Waters, R	1
Allen, ML; Bechtold, WE; Dahl, AR; Griffith, WC; Henderson, RF; Thornton-Manning, JR	1
Chiang, SY; Swenberg, JA; Walker, VE	1
Chen, W; Claffey, DJ; Koop, DR; Nelson, SD; Nieusma, JL; Peter, RM; Ross, D; Ruth, JA	1
DeMarini, DM; Doerr, CL; Hanley, NM; Kligerman, AD; Milholland, VS; Tennant, AH	1
Jackson, MA; Rice, JM; Stack, HF; Waters, MD	1
Erexson, GL; Tindall, KR	1
Begemann, P; Neumann, HG; Srám, RJ	1
Elfarra, AA; Kemper, RA; Krause, RJ	1
Bhowmik, S; Csanády, GA; Faller, TH; Filser, JG; Kessler, W; Pütz, C; Schuster, A	1
Gargas, ML; Himmelstein, MW; Sweeney, LM	1
Meyer, KG; Pluta, LJ; Recio, L; Saranko, CJ; Steen, AM	1
Boogaard, PJ; de Kloe, KP; van Sittert, NJ; Watson, WP	1
Elfarra, AA; Kemper, RA; Krause, RJ; Moll, TS; Selzer, RR	1
Booth, ED; Kilgour, JD; Robinson, SA; Watson, WP	1
Boogaard, PJ; Booth, ED; de Kloe, KP; Watson, WP	1
Dean, SM; Harris, CM; Harris, TM; Kowalcyzk, A; Lloyd, RS; Merritt, WK; Rizzo, CJ; Scholdberg, TA; Stone, MP	1
Boysen, G; Georgieva, NI; Gold, A; Jayaraj, K; Swenberg, JA; Upton, PB	1
An, J; Wen, Y; Wu, MH; Yu, YX; Zhang, PP; Zhang, XY	1
Sangaraju, D; Swenberg, J; Tretyakova, N; Villalta, PW; Wickramaratne, S	1
Fabiani, R; Fuccelli, R; Morozzi, G; Rosignoli, P; Sepporta, MV; Servili, M	1
Esades, A; Kotapati, S; Le, C; Matter, B; Tretyakova, N	1
Jokipii Krueger, CC; Le Marchand, L; Madugundu, G; Park, SL; Patel, Y; Stram, DO; Tretyakova, N	1

Reviews

3 review(s) available for 3,4-epoxy-1-butene and 1,3-butadiene

Article	Year
[Genotoxic properties of 1,3-butadiene and its derivatives]. Medycyna pracy, 1991, Volume: 42, Issue:3 Topics: Animals; Butadienes; Chromosome Aberrations; DNA Damage; Epoxy Compounds; In Vitro Techniques; Mice; Mutagenesis; Mutagenicity Tests; Mutagens; Neoplasms, Experimental; Rats; Sister Chromatid Exchange	1991
A review of the genetic and related effects of 1,3-butadiene in rodents and humans. Mutation research, 2000, Volume: 463, Issue:3 Topics: Air Pollutants, Occupational; Alkylating Agents; Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Biotransformation; Butadienes; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; DNA Damage; Epoxy Compounds; Female; Glycols; Hemoglobins; Humans; Inactivation, Metabolic; Male; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Mutagenesis; Mutagenicity Tests; Mutagens; Neoplasms, Experimental; Occupational Exposure; Organ Specificity; Oxidation-Reduction; Proteins; Rats; Rats, Sprague-Dawley; Single-Blind Method; Sister Chromatid Exchange; Species Specificity	2000
Reactive metabolites of 1,3-butadiene: DNA and hemoglobin adduct formation and potential roles in carcinogenicity. Advances in experimental medicine and biology, 2001, Volume: 500 Topics: Animals; Butadienes; Carcinogens; Cytochrome P-450 Enzyme System; DNA; Epoxy Compounds; Hemoglobins; Humans; Mutagens; Nucleosides; Peroxidase	2001

Other Studies

66 other study(ies) available for 3,4-epoxy-1-butene and 1,3-butadiene

Article	Year
1,3-Butadiene oxidation by human myeloperoxidase. Role of chloride ion in catalysis of divergent pathways. The Journal of biological chemistry, 1992, Oct-05, Volume: 267, Issue:28 Topics: Aldehydes; Anions; Butadienes; Butanols; Catalysis; Chlorides; Chromatography, Gas; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Oxidation-Reduction; Peroxidase; Potassium Chloride	1992
Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice. Carcinogenesis, 1992, Volume: 13, Issue:7 Topics: Animals; Biotransformation; Butadienes; Carcinogens; Cytosol; Epoxy Compounds; Humans; Kinetics; Liver; Lung; Male; Mathematics; Mice; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Models, Biological; Organ Specificity; Rats; Rats, Inbred Strains; Species Specificity	1992
Mechanisms of 1,3-butadiene oxidations to butadiene monoxide and crotonaldehyde by mouse liver microsomes and chloroperoxidase. Archives of biochemistry and biophysics, 1991, Volume: 286, Issue:1 Topics: Aldehydes; Animals; Biotransformation; Butadienes; Chloride Peroxidase; Chromatography, High Pressure Liquid; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Kinetics; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; NADP; Oxidation-Reduction	1991
1,3-Butadiene and its epoxides induce sister-chromatid exchanges in human lymphocytes in vitro. Mutation research, 1991, Volume: 261, Issue:2 Topics: Butadienes; Dose-Response Relationship, Drug; Epoxy Compounds; Humans; In Vitro Techniques; Mutagenicity Tests; Mutagens; Sister Chromatid Exchange	1991
Sister-chromatid exchanges induced by 1.3-butadiene and its epoxides in CHO cells. Mutation research, 1991, Volume: 263, Issue:1 Topics: Animals; Butadienes; Cells, Cultured; Cricetinae; Cricetulus; Epoxy Compounds; Mutagens; Sister Chromatid Exchange	1991
Inhalation pharmacokinetics of 1,3-butadiene and 1,2-epoxybutene-3 in rats and mice. Environmental health perspectives, 1990, Volume: 86 Topics: Administration, Inhalation; Alkylation; Animals; Butadienes; Carcinogens; DNA; Epoxy Compounds; Ethers, Cyclic; Liver; Male; Mice; Nuclear Proteins; Rats; Rats, Inbred Strains; Sulfhydryl Compounds	1990
Inhalation pharmacokinetics of 1,2-epoxybutene-3 reveal species differences between rats and mice sensitive to butadiene-induced carcinogenesis. Archives of toxicology, 1987, Volume: 61, Issue:1 Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Chromatography, Gas; Epoxy Compounds; Ethers, Cyclic; Glutathione; Liver; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Species Specificity	1987
Species differences in butadiene metabolism between mice and rats evaluated by inhalation pharmacokinetics. Archives of toxicology, 1986, Volume: 58, Issue:4 Topics: Animals; Biotransformation; Butadienes; Carcinogens; Epoxy Compounds; Kinetics; Male; Metabolic Clearance Rate; Mice; Rats; Species Specificity	1986
Species differences in the formation of butadiene monoxide from 1,3-butadiene. Archives of toxicology, 1985, Volume: 57, Issue:4 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Butadienes; Epoxide Hydrolases; Epoxy Compounds; Ethers, Cyclic; Humans; In Vitro Techniques; Liver; Lung; Macaca mulatta; Mice; Mitochondria; Oxygenases; Rats; Rats, Inbred Strains; Species Specificity	1985
Inhalation pharmacokinetics based on gas uptake studies. VI. Comparative evaluation of ethylene oxide and butadiene monoxide as exhaled reactive metabolites of ethylene and 1,3-butadiene in rats. Archives of toxicology, 1984, Volume: 55, Issue:4 Topics: Animals; Butadienes; Epoxy Compounds; Ethers, Cyclic; Ethylene Oxide; Ethylenes; Kinetics; Male; Rats; Rats, Inbred Strains	1984
Biological activation of 1,3-butadiene to vinyl oxirane by rat liver microsomes and expiration of the reactive metabolite by exposed rats. Journal of cancer research and clinical oncology, 1983, Volume: 106, Issue:2 Topics: Acetone; Animals; Biotransformation; Butadienes; Epoxy Compounds; Ethers, Cyclic; In Vitro Techniques; Male; Microsomes, Liver; Mutagens; Rats; Rats, Inbred Strains; Stereoisomerism	1983
Hepatic microsomal metabolism of 1,3-butadiene. Xenobiotica; the fate of foreign compounds in biological systems, 1982, Volume: 12, Issue:2 Topics: Animals; Biotransformation; Butadienes; Epoxy Compounds; Glycols; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains	1982
Enzymatic hydration of butadiene monoxide and its importance in the metabolism of butadiene. Advances in experimental medicine and biology, 1981, Volume: 136 Pt A Topics: Animals; Butadienes; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Epoxy Compounds; Ethers, Cyclic; Kinetics; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains	1981
Toxicity of 1,3-butadiene to bone marrow mimics haematopoietic defects observed in mice bearing white spotted or steel mutations. IARC scientific publications, 1993, Issue:127 Topics: Animals; Bone Marrow; Butadienes; Cells, Cultured; Colony-Forming Units Assay; Epoxy Compounds; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Cell Growth Factors; Interleukin-3; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagens; Recombinant Proteins; Stem Cell Factor	1993
Clastogenic effects of 1,3-butadiene and its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in splenocytes and germ cells of rats and mice in vivo. Environmental and molecular mutagenesis, 1995, Volume: 26, Issue:2 Topics: Administration, Inhalation; Animals; Body Weight; Butadienes; Chromosomes; Epoxy Compounds; Germ Cells; Golgi Apparatus; Male; Mice; Micronucleus Tests; Mutagens; Organ Size; Rats; Rats, Inbred Lew; Species Specificity; Spermatids; Spermatozoa; Spleen; Testis	1995
Gender differences in the metabolism of 1,3-butadiene in Sprague-Dawley rats following a low level inhalation exposure. Carcinogenesis, 1995, Volume: 16, Issue:11 Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Female; Male; Rats; Rats, Sprague-Dawley; Sex Factors; Species Specificity	1995
Metabolism of 1,3-butadiene to butadiene monoxide in mouse and human bone marrow cells. Chemico-biological interactions, 1995, Jul-14, Volume: 97, Issue:2 Topics: Animals; Bone Marrow; Bone Marrow Cells; Butadienes; Chromatography, Gas; Epoxy Compounds; Humans; Hydrogen Peroxide; Liver; Male; Mice; Mice, Inbred Strains; Microsomes; NADP; Peroxidase; Rats; Rats, Sprague-Dawley	1995
Alkylation of purine bases with 3,4-epoxy-1-butene, a reactive metabolite of 1,3-butadiene. IARC scientific publications, 1994, Issue:125 Topics: Adenine; Alkylation; Butadienes; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Electrochemistry; Epoxy Compounds; Guanine; Heating; Hydrolysis; Magnetic Resonance Spectroscopy; Mutagens; Purines; Sensitivity and Specificity	1994
Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation. Carcinogenesis, 1994, Volume: 15, Issue:8 Topics: Administration, Inhalation; Animals; Butadienes; Epoxy Compounds; In Vitro Techniques; Male; Mice; Rats; Rats, Sprague-Dawley; Respiration; Species Specificity	1994
Use of haemoglobin adducts for biomonitoring exposure to 1,3-butadiene. IARC scientific publications, 1993, Issue:127 Topics: Adult; Animals; Butadienes; Dose-Response Relationship, Drug; Epoxy Compounds; Hemoglobins; Humans; Male; Mice; Mice, Inbred Strains; Mutagens; Occupational Exposure; Rats; Rats, Sprague-Dawley	1993
Mutagenicity of 1,3-butadiene and its epoxide metabolites in human TK6 cells and in splenic T cells isolated from exposed B6C3F1 mice. IARC scientific publications, 1993, Issue:127 Topics: Animals; Butadienes; Cells, Cultured; Epoxy Compounds; Male; Mice; Mice, Inbred Strains; Mutagens; Mutation; T-Lymphocytes	1993
Interspecies differences in metabolism and kinetics of 1,3-butadiene, isobutene and styrene. IARC scientific publications, 1993, Issue:127 Topics: Alkenes; Alkylation; Animals; Butadienes; Epoxy Compounds; Humans; Mice; Mice, Inbred Strains; Mutagens; Rats; Rats, Sprague-Dawley; Species Specificity; Styrene; Styrenes	1993
Research strategy for assessing target tissue dosimetry of 1,3-butadiene in laboratory animals and humans. IARC scientific publications, 1993, Issue:127 Topics: Animals; Butadienes; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Epoxy Compounds; Glutathione; Glutathione Transferase; Humans; Hydrolysis; Lung; Mice; Mice, Inbred Strains; Microsomes, Liver; Mutagens; Rats; Rats, Sprague-Dawley; Species Specificity	1993
Species differences in the metabolism of 1,3-butadiene in vivo. IARC scientific publications, 1993, Issue:127 Topics: Administration, Inhalation; Animals; Butadienes; Epoxy Compounds; Macaca fascicularis; Mice; Mice, Inbred Strains; Mutagens; Rats; Rats, Sprague-Dawley; Species Specificity	1993
Species differences in the production and clearance of 1,3-butadiene metabolites: a mechanistic model indicates predominantly physiological, not biochemical, control. Carcinogenesis, 1993, Volume: 14, Issue:4 Topics: Adsorption; Animals; Body Burden; Butadienes; Epoxy Compounds; Humans; Mice; Models, Biological; Mutagens; Rats; Species Specificity; Time Factors	1993
Inhalation exposure of rats and mice to 1,3-butadiene induces N6-adenine adducts of epoxybutene detected by 32P-postlabeling and HPLC. Environmental health perspectives, 1996, Volume: 104 Suppl 3 Topics: Adenine; Administration, Inhalation; Alkylation; Animals; Butadienes; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA Adducts; Epoxy Compounds; Guanine; In Vitro Techniques; Mice; Phosphorus Radioisotopes; Rats	1996
Biochemistry of 1,3-butadiene metabolism and its relevance to 1,3-butadiene-induced carcinogenicity. Toxicology, 1996, Oct-28, Volume: 113, Issue:1-3 Topics: Animals; Butadienes; Carcinogens; Epoxy Compounds; Glutathione; Humans; Mice; Microsomes, Liver; Nucleosides; Oxidation-Reduction; Peroxidase; Rats; Rats, Sprague-Dawley	1996
PBPK model for butadiene metabolism to epoxides: quantitative species differences in metabolism. Toxicology, 1996, Oct-28, Volume: 113, Issue:1-3 Topics: Animals; Butadienes; Carcinogens; Epoxy Compounds; Glutathione; Humans; Male; Mice; Models, Biological; Rats; Rats, Sprague-Dawley; Species Specificity	1996
A physiological toxicokinetic model for 1,3-butadiene in rodents and man: blood concentrations of 1,3-butadiene, its metabolically formed epoxides, and of haemoglobin adducts--relevance of glutathione depletion. Toxicology, 1996, Oct-28, Volume: 113, Issue:1-3 Topics: Animals; Body Burden; Butadienes; Carcinogens; Epoxy Compounds; Female; Glutathione; Hemoglobins; Humans; Male; Mice; Models, Biological; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity	1996
Metabolism of 1,3-butadiene: inhalation pharmacokinetics and tissue dosimetry of butadiene epoxides in rats and mice. Toxicology, 1996, Oct-28, Volume: 113, Issue:1-3 Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Glutathione; Male; Mice; Rats; Rats, Sprague-Dawley; Species Specificity	1996
1,3-Butadiene metabolism by lung airways isolated from mice and rats. Toxicology, 1996, Oct-28, Volume: 113, Issue:1-3 Topics: Animals; Butadienes; Carcinogens; Epoxy Compounds; Lung; Male; Mice; Rats; Rats, Sprague-Dawley; Species Specificity	1996
Gender and species differences in the metabolism of 1,3-butadiene to butadiene monoepoxide and butadiene diepoxide in rodents following low-level inhalation exposures. Toxicology, 1996, Oct-28, Volume: 113, Issue:1-3 Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Female; Male; Mice; Rats; Rats, Sprague-Dawley; Sex Factors; Species Specificity	1996
Micronuclei are induced in rat spermatids in vitro by 1,2,3,4-diepoxybutane but not by 1,2-epoxy-3-butene and 1,2-dihydroxy-3,4-epoxybutane. Mutagenesis, 1996, Volume: 11, Issue:5 Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Epoxy Compounds; Glycols; Male; Meiosis; Micronucleus Tests; Mutagens; Rats; Rats, Sprague-Dawley; Spermatids	1996
Metabolic interactions of 1,3-butadiene and styrene in male B6C3F1 mice. Toxicology and applied pharmacology, 1996, Volume: 141, Issue:2 Topics: Animals; Butadienes; Epoxy Compounds; Male; Mice; Mutagens; Styrene; Styrenes	1996
Physiologically based pharmacokinetic modeling of 1,3-butadiene, 1,2-epoxy-3-butene, and 1,2:3,4-diepoxybutane toxicokinetics in mice and rats. Carcinogenesis, 1997, Volume: 18, Issue:4 Topics: Administration, Inhalation; Animals; Butadienes; Epoxy Compounds; Injections, Intravenous; Mice; Models, Biological; Rats; Species Specificity	1997
Germ cell mutagenicity of three metabolites of 1,3-butadiene in the rat: induction of spermatid micronuclei by butadiene mono-, di-, and diolepoxides in vivo. Environmental and molecular mutagenesis, 1997, Volume: 29, Issue:3 Topics: Animals; Body Weight; Butadienes; Cell Survival; DNA Replication; Epoxy Compounds; Glycols; Male; Micronucleus Tests; Mutagens; Organ Size; Rats; Rats, Sprague-Dawley; Spermatids; Testis	1997
Genotoxicity and cytotoxicity in male B6C3F1 mice following exposure to mixtures of 1,3-butadiene and styrene. Environmental and molecular mutagenesis, 1997, Volume: 29, Issue:4 Topics: Animals; Bone Marrow; Butadienes; Carcinogens; Dose-Response Relationship, Drug; Drug Synergism; Epoxy Compounds; Erythrocytes; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Spleen; Styrene; Styrenes; Thymus Gland; Toxicity Tests	1997
Somatic and germ cell effects in rats and mice after treatment with 1,3-butadiene and its metabolites, 1,2-epoxybutene and 1,2,3,4-diepoxybutane. Mutation research, 1997, Jul-14, Volume: 391, Issue:3 Topics: Administration, Inhalation; Animals; Bone Marrow; Butadienes; DNA; Dose-Response Relationship, Drug; Electrophoresis; Epoxy Compounds; Liver; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Rats; Rats, Sprague-Dawley; Species Specificity; Spermatozoa; Testis	1997
Haemoglobin adducts of epoxybutanediol from exposure to 1,3-butadiene or butadiene epoxides. Chemico-biological interactions, 1997, Aug-01, Volume: 105, Issue:3 Topics: Air Pollutants, Occupational; Animals; Butadienes; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Glycols; Hemoglobins; Humans; Magnetic Resonance Spectroscopy; Male; Micronucleus Tests; Rats; Rats, Sprague-Dawley; Rats, Wistar; Valine	1997
Induction of chromosome-specific aneuploidy and micronuclei in human lymphocytes by metabolites of 1,3-butadiene. Carcinogenesis, 1997, Volume: 18, Issue:9 Topics: Aneuploidy; Butadienes; Carcinogens; Cells, Cultured; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 7; Diploidy; Epoxy Compounds; Genotype; Glutathione Transferase; Humans; Interphase; Lymphocytes; Male; Metaphase; Micronuclei, Chromosome-Defective; Micronucleus Tests	1997
Comparison of the disposition of butadiene epoxides in Sprague-Dawley rats and B6C3F1 mice following a single and repeated exposures to 1,3-butadiene via inhalation. Toxicology, 1997, Nov-21, Volume: 123, Issue:1-2 Topics: Adipose Tissue; Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Female; Femur; Lung; Mammary Glands, Animal; Mice; Rats; Rats, Sprague-Dawley	1997
In vitro and in vivo mutagenicity of the butadiene metabolites butadiene diolepoxide, butadiene monoepoxide and diepoxybutane. Mutagenesis, 1997, Volume: 12, Issue:5 Topics: Animals; Bone Marrow Cells; Butadienes; Crosses, Genetic; Epoxy Compounds; Female; Fetal Death; Genes, Lethal; Glycols; Litter Size; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Pregnancy; Salmonella typhimurium; Structure-Activity Relationship	1997
DNA adducts in mouse testis and lung after inhalation exposure to 1,3-butadiene. Mutation research, 1998, Jan-16, Volume: 397, Issue:1 Topics: Alkylation; Animals; Biomarkers; Butadienes; Chromatography, High Pressure Liquid; DNA Adducts; DNA Repair; Environmental Pollution; Epoxy Compounds; Germ Cells; Guanine; Lung; Male; Mice; Molecular Structure; Mutagens; Stereoisomerism; Testis	1998
Comparison of induction of hprt mutations by 1,3-butadiene and/or its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in lymphocytes from spleen of adult male mice and rats in vivo. Mutation research, 1998, Jan-16, Volume: 397, Issue:1 Topics: Age Factors; Animals; Butadienes; Cells, Cultured; Clone Cells; Enzyme Induction; Epoxy Compounds; Ethylnitrosourea; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Male; Mice; Mice, Inbred Strains; Mutagens; Mutation; Rats; Rats, Inbred Lew; Spleen	1998
Genetic effects of 1,3-butadiene and associated risk for heritable damage. Mutation research, 1998, Jan-16, Volume: 397, Issue:1 Topics: Animals; Butadienes; DNA Adducts; Embryo, Mammalian; Epoxy Compounds; Germ Cells; Humans; Mice; Mutagenicity Tests; Mutagens; Rats; Risk Factors; Translocation, Genetic	1998
Disposition of butadiene epoxides in Sprague-Dawley rats following exposures to 8000 ppm 1,3-butadiene: comparisons with tissue epoxide concentrations following low-level exposures. Toxicological sciences : an official journal of the Society of Toxicology, 1998, Volume: 41, Issue:2 Topics: Animals; Biotransformation; Butadienes; Carcinogens; Epoxy Compounds; Female; Inhalation Exposure; Mutagens; Rats; Rats, Sprague-Dawley	1998
Quantitative analysis of 1,3-butadiene-induced DNA adducts in vivo and in vitro using liquid chromatography electrospray ionization tandem mass spectrometry. Journal of mass spectrometry : JMS, 1998, Volume: 33, Issue:4 Topics: Animals; Butadienes; Cattle; Cells, Cultured; Chromatography, Gas; Chromatography, Liquid; DNA; DNA Adducts; Epoxy Compounds; Humans; Hydrolysis; Lymphocytes; Mass Spectrometry; Mice; Mice, Inbred Strains; Mutagens; Rats; Rats, Inbred F344	1998
Oxidation of 1,3-butadiene to (R)- and (S)-butadiene monoxide by purified recombinant cytochrome P450 2E1 from rabbit, rat and human. Toxicology letters, 1998, Mar-31, Volume: 95, Issue:2 Topics: Animals; Butadienes; Carcinogens; Cytochrome P-450 CYP2E1; Epoxy Compounds; Humans; In Vitro Techniques; Liver; Oxidation-Reduction; Rabbits; Rats; Stereoisomerism	1998
Comparison of cytogenetic effects of 3,4-epoxy-1-butene and 1,2:3, 4-diepoxybutane in mouse, rat and human lymphocytes following in vitro G0 exposures. Mutation research, 1999, Feb-02, Volume: 439, Issue:1 Topics: Animals; Butadienes; Carcinogens; Cell Cycle; Chromosome Aberrations; Epoxy Compounds; Erythrocytes; Genotype; Glutathione Transferase; Humans; Interphase; Lymphocytes; Mice; Mutagenicity Tests; Rats; Regression Analysis; Sister Chromatid Exchange	1999
Micronuclei and gene mutations in transgenic big Blue((R)) mouse and rat fibroblasts after exposure to the epoxide metabolites of 1, 3-butadiene. Mutation research, 2000, Dec-20, Volume: 472, Issue:1-2 Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Apoptosis; Biotransformation; Butadienes; Cell Survival; Cells, Cultured; Epoxy Compounds; Fibroblasts; Glycols; Humans; Mice; Mice, Transgenic; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenicity Tests; Rats; Rats, Mutant Strains	2000
Hemoglobin adducts of epoxybutene in workers occupationally exposed to 1,3-butadiene. Archives of toxicology, 2001, Volume: 74, Issue:11 Topics: Air Pollutants, Occupational; Butadienes; Carcinogens; Environmental Monitoring; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Hemoglobins; Humans; Inhalation Exposure; Occupational Exposure; Smoking	2001
Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism. Chemico-biological interactions, 2001, Jun-01, Volume: 135-136 Topics: Animals; Biotransformation; Butadienes; Carcinogens; Cytochrome P-450 Enzyme System; Epoxy Compounds; Female; Glutathione; Inactivation, Metabolic; Kidney; Liver; Lung; Male; Mice; Rats; Rats, Sprague-Dawley; Sex Characteristics; Tissue Distribution	2001
First-pass metabolism of 1,3-butadiene in once-through perfused livers of rats and mice. Chemico-biological interactions, 2001, Jun-01, Volume: 135-136 Topics: Aldehydes; Animals; Biotransformation; Butadienes; Epoxy Compounds; Glycols; Kinetics; Liver; Male; Mice; Perfusion; Rats; Rats, Sprague-Dawley; Species Specificity	2001
Physiological modeling of butadiene disposition in mice and rats. Chemico-biological interactions, 2001, Jun-01, Volume: 135-136 Topics: Animals; Butadienes; Cytochrome P-450 Enzyme System; DNA Adducts; Epoxide Hydrolases; Epoxy Compounds; Kinetics; Male; Mice; Models, Biological; Oxidation-Reduction; Rats; Tissue Distribution	2001
Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment. Chemico-biological interactions, 2001, Jun-01, Volume: 135-136 Topics: Animals; Butadienes; Epoxy Compounds; Female; Humans; Mice; Models, Biological; Rats; Risk Assessment; Sensitivity and Specificity; Species Specificity	2001
Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms. Chemico-biological interactions, 2001, Jun-01, Volume: 135-136 Topics: Air Pollutants; Animals; Bacterial Proteins; Butadienes; Cell Line; Epoxy Compounds; Escherichia coli Proteins; Female; Humans; Lac Repressors; Male; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Rats; Repressor Proteins; Spleen	2001
A novel DNA adduct, originating from 1,2-epoxy-3,4-butanediol, is the major DNA adduct after exposure to [2,3-(14)C]-1,3-butadiene,[4-(14)C]-1,2-epoxy-3-butane. Chemico-biological interactions, 2001, Jun-01, Volume: 135-136 Topics: Animals; Butadienes; Carbon Radioisotopes; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Epoxy Compounds; Humans; In Vitro Techniques; Liver; Lung; Male; Mice; Rats; Rats, Sprague-Dawley	2001
Dose responses for DNA adduct formation in tissues of rats and mice exposed by inhalation to low concentrations of 1,3-[2,3-[(14)C]-butadiene. Chemico-biological interactions, 2004, Mar-15, Volume: 147, Issue:2 Topics: Administration, Inhalation; Animals; Butadienes; Carbon Radioisotopes; Carcinogens, Environmental; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Epoxy Compounds; Guanine; Liver; Lung; Male; Mice; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley; Scintillation Counting; Species Specificity; Testis	2004
DNA adducts in rats and mice following exposure to [4-14C]-1,2-epoxy-3-butene and to [2,3-14C]-1,3-butadiene. Chemico-biological interactions, 2004, Jun-30, Volume: 148, Issue:1-2 Topics: Animals; Butadienes; Carbon Radioisotopes; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Dose-Response Relationship, Drug; Epoxy Compounds; Guanine; Injections, Intraperitoneal; Liver; Lung; Male; Mice; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley	2004
Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence. Biochemistry, 2005, Mar-08, Volume: 44, Issue:9 Topics: Alkylating Agents; Base Sequence; Butadienes; Codon; DNA Adducts; Epoxy Compounds; Genes, ras; Humans; Inosine; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protons; Thermodynamics	2005
Quantitative analysis of N-terminal valine peptide adducts specific for 1,2-epoxy-3-butene. Chemico-biological interactions, 2007, Mar-20, Volume: 166, Issue:1-3 Topics: Animals; Butadienes; Calibration; Epoxy Compounds; Female; Hemoglobins; Humans; Male; Peptides; Rats; Rats, Sprague-Dawley; Reference Standards; Sex Characteristics; Valine	2007
DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells. Mutation research, 2012, Sep-18, Volume: 747, Issue:2 Topics: Butadienes; Butylene Glycols; Carcinogens; Cell Line, Transformed; Comet Assay; DNA Breaks, Single-Stranded; DNA Damage; Epoxy Compounds; Hepatocytes; Humans; Mutagens	2012
NanoLC/ESI+ HRMS3 quantitation of DNA adducts induced by 1,3-butadiene. Journal of the American Society for Mass Spectrometry, 2014, Volume: 25, Issue:7 Topics: Adult; Animals; Butadienes; Cell Line, Tumor; DNA Adducts; Environmental Exposure; Epoxy Compounds; Female; Humans; Liver; Male; Middle Aged; Rats; Rats, Inbred F344; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Young Adult	2014
Preventive activity of olive oil phenolic compounds on alkene epoxides induced oxidative DNA damage on human peripheral blood mononuclear cells. Nutrition and cancer, 2014, Volume: 66, Issue:8 Topics: Acetylcysteine; Butadienes; Catalase; Comet Assay; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Epoxy Compounds; Humans; Leukocytes, Mononuclear; Olive Oil; Oxidative Stress; Phenols; Plant Oils	2014
High throughput HPLC-ESI(-)-MS/MS methodology for mercapturic acid metabolites of 1,3-butadiene: Biomarkers of exposure and bioactivation. Chemico-biological interactions, 2015, Nov-05, Volume: 241 Topics: Acetylcysteine; Biomarkers; Butadienes; Butanones; Carcinogens; Chromatography, High Pressure Liquid; Elastomers; Epoxy Compounds; Humans; Occupational Exposure; Styrenes; Tandem Mass Spectrometry; Urine	2015
Ethnic differences in excretion of butadiene-DNA adducts by current smokers. Carcinogenesis, 2021, 05-28, Volume: 42, Issue:5 Topics: Acetylcysteine; Adult; Aged; Asian; Butadienes; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2E1; DNA Adducts; Epoxy Compounds; Ethnicity; Female; Glutathione Transferase; Humans; Male; Middle Aged; Native Hawaiian or Other Pacific Islander; Smoke; Smokers; Spectrometry, Mass, Electrospray Ionization; Tobacco Products; Vehicle Emissions; White People	2021