Compounds > 3-4-dihydroxyphenylpropionic-acid

3-4-dihydroxyphenylpropionic-acid and fosmidomycin

3-4-dihydroxyphenylpropionic-acid has been researched along with fosmidomycin* in 1 studies

Other Studies

1 other study(ies) available for 3-4-dihydroxyphenylpropionic-acid and fosmidomycin

Article	Year
Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Journal of medicinal chemistry, 2009, Nov-12, Volume: 52, Issue:21 1-Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) in the non-mevalonate pathway found in most bacteria is a validated anti-infective drug target. Fosmidomycin, a potent DXR inhibitor, is active against Gram-negative bacteria. A coordination chemistry and structure based approach was used to discover a novel, lipophilic DXR inhibitor with an IC(50) of 1.4 microM. It exhibited a broad spectrum of activity against Gram-negative and -positive bacteria with minimal inhibition concentrations of 20-100 microM (or 3.7-19 microg/mL). Topics: Aldose-Ketose Isomerases; Anti-Bacterial Agents; Cell Line; Cell Membrane Permeability; Chelating Agents; Drug Resistance, Bacterial; Fosfomycin; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Magnesium; Microbial Sensitivity Tests; Models, Molecular; Multienzyme Complexes; Oxidoreductases; Pyridones; Structure-Activity Relationship	2009

Article

Year

Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Journal of medicinal chemistry, 2009, Nov-12, Volume: 52, Issue:21

1-Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) in the non-mevalonate pathway found in most bacteria is a validated anti-infective drug target. Fosmidomycin, a potent DXR inhibitor, is active against Gram-negative bacteria. A coordination chemistry and structure based approach was used to discover a novel, lipophilic DXR inhibitor with an IC(50) of 1.4 microM. It exhibited a broad spectrum of activity against Gram-negative and -positive bacteria with minimal inhibition concentrations of 20-100 microM (or 3.7-19 microg/mL).

Topics: Aldose-Ketose Isomerases; Anti-Bacterial Agents; Cell Line; Cell Membrane Permeability; Chelating Agents; Drug Resistance, Bacterial; Fosfomycin; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Magnesium; Microbial Sensitivity Tests; Models, Molecular; Multienzyme Complexes; Oxidoreductases; Pyridones; Structure-Activity Relationship

2009