3,4-dihydroxyphenylethanol has been researched along with phenylethyl alcohol in 790 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (2.03) | 18.7374 |
| 1990's | 16 (2.03) | 18.2507 |
| 2000's | 156 (19.75) | 29.6817 |
| 2010's | 441 (55.82) | 24.3611 |
| 2020's | 161 (20.38) | 2.80 |
| Authors | Studies |
|---|---|
| de Vries, JA; Fremouw-Ottevangers, DC; Muskiet, FA; van der Meulen, J; Wolthers, BG | 1 |
| Edwards, GA; Graham, PE; Lazarus, L; Smythe, GA | 1 |
| Clezy, PS; Duncan, MW; Smythe, GA | 1 |
| Cassis, L; Grohmann, M; Henseling, M; Trendelenburg, U | 1 |
| Deitrich, RA; Tank, AW; Weiner, H | 1 |
| Mårdh, G; Vallee, BL | 1 |
| Sharman, DF | 1 |
| Helander, A; Tottmar, O | 1 |
| Edwards, DJ; Knopf, S; Ravitch, J; Sedlock, ML | 1 |
| Blum, K; Calhoun, W; Merritt, JH; Wallace, JE | 1 |
| Edwards, DJ; Rizk, M | 1 |
| Edwards, DJ; Rizk, M; Spiker, DG | 1 |
| Baker, CA; Johnson, GA | 1 |
| Honda, K; Kamiya, HO; Kohjimoto, Y; Sakurai, Y; Takano, Y | 1 |
| Debus, G; Kehr, W; Thiede, HM | 1 |
| Chen, YJ; Liu, SQ; Sun, JY; Wang, DD; Wu, LJ; Zhu, TR | 1 |
| Kelly, MJ; Loncar-Stevanović, H; Sharman, DF | 1 |
| De Angelis, L; Galli, C; Salami, M; Visioli, F | 1 |
| Blasevich, M; Galli, C; Montedoro, GF; Papini, N; Petroni, A; Salami, M | 1 |
| Sim, MK; Xu, CL | 1 |
| Aeschbach, R; Aruoma, OI; Butler, J; Halliwell, B; Löliger, J; Murcia, A; Scott, BC | 1 |
| Catapano, AL; Galli, C; Grignaffini, P; Roma, P | 1 |
| Blasevich, M; Galli, C; Montedoro, GF; Petroni, A; Salami, M; Servili, M | 1 |
| Cucciolla, V; Galletti, P; Leone, A; Manna, C; Moltedo, O; Zappia, V | 1 |
| Fujimoto, S; Kohyama, N; Nagata, T; Sekiya, K | 1 |
| Blasevich, M; Galli, C; Papini, N; Petroni, A; Sala, A; Salami, M | 1 |
| de la Puerta, R; Hoult, JR; Ruiz Gutierrez, V | 1 |
| Gatlin, CL; Hopkins, TL; Kerwin, JL; Kramer, KJ; Turecek, F; Xu, R; Yates, JR | 1 |
| Aeschbach, R; Aruoma, OI; Banni, S; Bianchi, ML; Corongiu, FP; Deiana, M; Dessi, MA; Halliwell, B; Kaur, H; Spencer, JP | 1 |
| Bisignano, G; Crisafi, G; Lo Cascio, R; Saija, A; Tomaino, A; Uccella, N | 1 |
| Avolio, S; Capasso, R; Evidente, A; Solla, F | 1 |
| Bornet, F; Caruso, D; Galli, C; Galli, G; Mattei, A; Patelli, R; Visioli, F | 1 |
| Borriello, A; Cucciolla, V; D'Angelo, S; Della Ragione, F; Galletti, P; Manna, C; Zappia, V | 1 |
| Cucciolla, V; D'Angelo, S; Galletti, P; Maisto, G; Manna, C; Zappia, V | 1 |
| Eisenhofer, G; Harvey-White, J; Hayakawa, Y; Kirk, K; Kopin, IJ; Lamensdorf, I | 1 |
| Eisenhofer, G; Harvey-White, J; Kirk, K; Kopin, IJ; Lamensdorf, I; Nechustan, A | 1 |
| Hayball, PJ; Tan, HW; Tuck, KL | 1 |
| Berra, B; Bonanome, A; Caruso, D; Fedeli, E; Galli, G; Pagnan, A; Toia, A; Ursini, F; Xamin, A; Zamburlini, A | 1 |
| Cert, A; Juan, ME; Planas, JM; Ruiz-Gutiérrez, V | 1 |
| Colombo, C; Galli, C; Hernandez, A; Plasmati, E; Sala, A; Viappiani, S; Visioli, F | 1 |
| Borriello, A; Cucciolla, V; Galletti, P; Manna, C; Pietra, VD; Pontoni, G; Racioppi, L; Ragione, FD; Zappia, V | 1 |
| Caruso, D; Galli, C; Galli, G; Mulinacci, N; Patelli, R; Plasmati, E; Romani, A; Visioli, F | 1 |
| Catalá, A; de la Puerta, R; Gutierrez, VR | 1 |
| Cantos, E; Espín, JC; Soler-Rivas, C; Tomás-Barberán, FA; Wichers, HJ | 1 |
| Almeida, M; Gordon, MH; Paiva-Martins, F | 1 |
| Covas, MI; de la Torre, R; Farré Albaladejo, M; Lamuela Raventós, RM; Menoyo Colomer, E; Miró-Casas, E; Rodriguez, JO | 1 |
| Freeman, MP; Hayball, PJ; Stretch, GL; Stupans, I; Tuck, KL | 1 |
| de la Puerta, R; Flavill, JA; Hoult, JR; Martínez Domínguez, ME; Ruíz-Gutíerrez, V | 1 |
| Agradi, E; Cillo, F; Fico, G; Francisci, C; Tomè, F | 1 |
| Capasso, G; D'Angelo, S; Galletti, P; Manna, C; Mazzoni, O; Migliardi, V; Morrica, P; Pontoni, G; Zappia, V | 1 |
| Caruso, D; Galli, C; Galli, G; Patelli, R; Visioli, F | 1 |
| Briante, R; Febbraio, F; La Cara, F; Nucci, R; Patumi, M | 1 |
| Katan, MB; Leenen, R; Roodenburg, AJ; Vissers, MN; Zock, PL | 1 |
| Hayball, PJ; Stupans, I; Tuck, KL | 1 |
| Hayball, PJ; Kirlich, A; Stupans, I; Tuck, KL | 1 |
| Galli, C; Visioli, F | 1 |
| Blekas, G; Boskou, DG; Harizanis, C; Tsimidou, M; Vassilakis, C | 1 |
| Brenes, M; García, P; Garrido, A; Romero, C | 1 |
| Bismuto, E; Briante, R; Febbraio, F; Nucci, R; Patumi, M; Terenziani, S | 1 |
| De Bartolomeo, A; Fabiani, R; Montedoro, GF; Morozzi, G; Rosignoli, P; Servili, M | 1 |
| Farquharson, AJ; Grant, I; Quiles, JL; Simpson, DK; Wahle, KW | 1 |
| Brenes, M; Dobarganes, MC; García, A; Romero, C; Velasco, J | 1 |
| Fernández-Bolaños, J; Guillén, R; Heredia, A; Jiménez, A; Rodríguez, G; Rodríguez, R | 1 |
| Fregapane, G; Gómez-Alonso, S; Salvador, MD | 1 |
| Calzaretti, G; Casalino, E; Felice Tecce, M; Landriscina, C; Landriscina, V; Sblano, C | 1 |
| Borriello, A; Criniti, V; Cucciolla, V; Della Ragione, F; Indaco, S; Zappia, V | 1 |
| Celli, N; De Curtis, A; Del Boccio, P; Di Deo, A; Iacoviello, L; Rotilio, D | 1 |
| Hayball, PJ; Stupans, I; Tan, HW; Tuck, KL | 1 |
| Fregapane, G; Gómez-Alonso, S; Gordon, MH; Salvador, MD | 1 |
| Covas, MI; de la Torre, R; Farré-Albadalejo, M; Fitó, M; Marrugat, J; Miró-Casas, E | 1 |
| Ancora, MA; Carluccio, MA; De Caterina, R; Distante, A; Massaro, M; Scoditti, E; Siculella, L; Storelli, C; Visioli, F | 1 |
| Covas, MI; de la Torre, R; Farre, M; Fito, M; Miro-Casas, E; Ortuño, J; Roset, P; Weinbrenner, T | 1 |
| Caruso, D; Colonnelli, K; Galli, C; Galli, G; Grande, S; Patelli, C; Visioli, F | 1 |
| Bonoli, M; Gallina Toschi, T; Lercker, G; Montanucci, M | 1 |
| Burke, WJ; Li, SW; Nonneman, R; Williams, EA; Zahm, DS | 1 |
| Allouche, N; Fki, I; Sayadi, S | 1 |
| Brenes, M; García, A; García, P; Garrido, A; Romero, C; Yousfi, K | 1 |
| Hashimoto, T; Ibi, M; Matsuno, K; Nakashima, S; Tanigawa, T; Yabe-Nishimura, C; Yoshikawa, T | 1 |
| Allouche, N; Damak, M; Ellouz, R; Sayadi, S | 1 |
| Feng, WS; Li, J; Liu, YB; Zheng, XK | 1 |
| Covas, MI; de la Torre, R; Farré, M; Fitó, M; Gimeno, E; López-Sabater, MC; Marrugat, J; Miró-Casas, E; Schröder, H | 1 |
| Dang, PM; Driss, F; El-Benna, J; Elbim, C; Gougerot-Pocidalo, MA; O'Dowd, Y; Pasquier, C | 1 |
| d'Ischia, M; Giudicianni, I; Napolitano, A; Panzella, L; Paolillo, L; Sacchi, R; Savarese, M | 1 |
| Bisignano, G; Furneri, PM; Piperno, A; Sajia, A | 1 |
| Nenadis, N; Tsimidou, MZ; Wang, LF; Zhang, HY | 1 |
| Arienti, G; Carlini, E; Montedoro, G; Palmerini, CA; Saccardi, C; Servili, M | 1 |
| Baroni, A; D'Angelo, S; Donnarumma, G; Galletti, P; Ingrosso, D; Masella, L; Migliardi, V; Sorrentino, A; Tufano, MA; Zappia, M | 1 |
| Gordon, MH; Paiva-Martins, F | 1 |
| Carbonneau, MA; Cristol, JP; Descomps, B; Léger, CL; Mas, E; Michel, F; Monnier, L | 1 |
| Alonso, MG; de Pascual-Teresa, S; Etienne, N; Minihane, AM; Rimbach, G; Turner, R; Weinberg, PD | 1 |
| Capasso, G; Chiodini, P; Della Ragione, F; Di Gennaro, CI; Galletti, P; Indaco, S; Manna, C; Migliardi, V; Zappia, V | 1 |
| Cert, A; Mateos, R; Moreda, W; Pérez-Camino, MC; Trujillo, M | 1 |
| He, DX; Kong, LZ; Li, S; Ran, GL; Shi, JG; Wang, SJ; Xue, Z; Yang, YC | 1 |
| Carnuccio, R; Cinelli, MP; De Stefano, D; Di Meglio, P; Irace, C; Maiuri, MC; Sacchi, R; Savarese, M | 1 |
| Agalias, A; Aligiannis, N; Bazios, D; Doulias, PT; Galaris, D; Mitakou, S; Nousis, L | 1 |
| Bazoti, FN; Coxam, V; Gikas, E; Puel, C; Tsarbopoulos, A | 1 |
| Allouche, N; Sayadi, S | 1 |
| Isidori, M; Lavorgna, M; Nardelli, A; Parrella, A | 1 |
| Baró, L; Bartolomé, MV; Carrero, JJ; Fonollá, J; Gil-Loyzaga, P; González-Santiago, M; López-Huertas, E; Martín-Bautista, E | 1 |
| Capasso, R; De Martino, A; Manna, C; Migliardi, V; Sannino, F | 1 |
| Bravo, L; Goya, L; Mateos, R | 2 |
| Alonso, A; Fernández-Bolaños, J; Medina, I; Pazos, M; Torres, JL | 1 |
| Covas, MI; de la Torre, K; de la Torre, R; Farré-Albaladejo, M; Fitó, M; Joglar, J; Kaikkonen, J; Lamuela-Raventós, RM; López-Sabater, C; Pujadas-Bastardes, MA; Weinbrenner, T | 1 |
| Braut-Boucher, F; Chastre, E; Daniel, F; Driss, F; Fay, M; Gougerot-Pocidalo, MA; Grodet, A; Guichard, C; Kotelevets, L; Lizard, G; Marie, JC; Ogier-Denis, E; Pedruzzi, E; Vandewalle, A | 1 |
| Covas, MI; de la Torre, R; Farré, M; Fitó, M; Pujadas, MA | 1 |
| Bosisio, E; Caruso, D; Crestani, M; De Fabiani, E; Dell'Agli, M; Fagnani, R; Galli, GV; Masciadri, M; Mitro, N; Mussoni, L; Scurati, S; Tremoli, E | 1 |
| Alcudia, F; Bautista, J; Cert, A; Cert, R; Collantes de Teran, L; Espartero, JL; Jover, M; Mateos, R; Parrado, J; Trujillo, M | 1 |
| Corsetti, A; Esposto, S; Massitti, O; Montedoro, GF; Servili, M; Settanni, L; Taticchi, A; Urbani, S; Veneziani, G | 1 |
| Lois, S; Medina, I; Pazos, M; Torres, JL | 1 |
| Acín, S; Arbonés-Mainar, JM; Carnicer, R; Covas, MI; Fernández-Bolaños, J; Guillén, N; Navarro, MA; Orman, I; Osada, J; Ruiz-Gutiérrez, V; Sarría, AJ; Segovia, JC; Surra, JC; Torre, Rde L | 1 |
| Diniz, YS; Ebaid, GM; Faine, LA; Galhardi, CM; Novelli, EL; Padovani, CR; Rodrigues, HG | 1 |
| Bäumler, H; Covas, MI; de la Torre, R; Fitó, M; Gaddi, A; Kaikkonen, J; Kiesewetter, H; Marrugat, J; Mursu, J; Nascetti, S; Nyyssönen, K; Poulsen, HE; Salonen, JT; Virtanen, J; Zunft, HJ | 1 |
| Grasso, S; Renis, M; Siracusa, L; Spatafora, C; Tringali, C | 1 |
| Bast, A; de Vente, J; Haenen, GR; Rietjens, SJ | 1 |
| Bouallagui, Z; Sayadi, S | 2 |
| Fernandez-Bolaños, J; Guillén, R; Jiménez, A; Rodríguez, G; Rodríguez, R | 1 |
| Bao, J; Chang, YT; Huang, PL; Lee, JW; Lee-Huang, S; Sun, Y; Zhang, D; Zhang, J | 2 |
| Fki, I; Sahnoun, Z; Sayadi, S | 1 |
| Agalias, A; Gikas, E; Magiatis, P; Manios, T; Mikros, E; Skaltsounis, AL; Spanos, I; Tsarbopoulos, A | 1 |
| Dirsch, VM; Erker, T; Handler, N; Heiss, EH; Schmitt, CA | 1 |
| Agalias, A; Coxam, V; Davicco, MJ; Horcajada, MN; Kati-Coulibaly, S; Lebecque, P; Mardon, J; Obled, C; Puel, C; Rock, E; Skaltsounis, LA | 1 |
| Bernini, R; Gambacorta, A; Migliorini, A; Tofani, D | 1 |
| Japón-Luján, R; Luque de Castro, MD | 1 |
| Iwai, K; Kawada, T; Koyama, F; Oi-Kano, Y; Senbongi, R; Watanabe, K; Watanabe, T | 1 |
| Azabou, S; Ghorbel, A; Najjar, W; Sayadi, S | 1 |
| Bogani, P; Eckert, GP; Müller, WE; Podstawa, M; Schaffer, S; Visioli, F | 1 |
| Bao, J; Huang, PL; Lee-Huang, S; Zhang, DW; Zhang, JZ | 1 |
| Ancora, MA; Carluccio, M; Carluccio, MA; De Caterina, R; Distante, A; Massaro, M; Scoditti, E; Storelli, C | 1 |
| Bast, A; Haenen, GR; Rietjens, SJ | 1 |
| Amouric, A; Casalot, L; Labat, M; Liebgott, PP; Lorquin, J | 1 |
| Esposto, S; Gill, CI; Hashim, YZ; Kaisalo, L; McGlynn, H; Montedoro, G; Rowland, IR; Selvaggini, R; Servili, M; Taticchi, A; Wähälä, K | 1 |
| Gambacorta, A; Migliorini, A; Tofani, D | 1 |
| Brenes, M; de Castro, A; García, A; Medina, E; Romero, C | 1 |
| Boyle, SP; Wahle, KW; Young, J | 1 |
| Bovicelli, P | 1 |
| Capasso, G; Ciarcia, R; Damiano, S; Della Ragione, F; Di Gennaro, CI; Florio, S; Galletti, P; Manna, C; Mazzoni, O; Perna, A; Pollastro, RM; Zappia, V | 1 |
| De Bartolomeo, A; Fabiani, R; Fuccelli, R; Morozzi, G; Rosignoli, P | 1 |
| Geng, C; Hu, C; Jiang, L; Yoshimura, H; Zhang, X; Zhong, L | 1 |
| Bouallagui, Z; Bouaziz, M; El Feki, A; Fki, I; Isoda, H; Jemai, H; Sayadi, S | 1 |
| Alonso, A; Medina, I; Pazos, M; Sánchez, I | 1 |
| Ben Othman, N; Hamdi, M; Roblain, D; Thonart, P | 1 |
| Andjelkovic, M; Pedra, M; Renders, K; Socaciu, C; Van Camp, J; Verhé, R | 1 |
| Assunta Dessì, M; Atzeri, A; Corona, G; Deiana, M; Incani, A; Loru, D; Paola Melis, M; Rosa, A | 2 |
| Bernini, R; Cacchi, S; Fabrizi, G; Filisti, E | 1 |
| De Bartolomeo, A; Fabiani, R; Fuccelli, R; Montedoro, GF; Morozzi, G; Rosignoli, P; Servili, M | 1 |
| de la Cruz, JP; Fernández-Bolaños, J; González-Correa, JA; Muñoz-Marín, J; Navas, MD; Trujillo, M | 1 |
| Geng, C; Jiang, L; Yoshimura, H; Zhang, X; Zhong, L | 1 |
| Barontini, M; Bernini, R; Crisante, F; Mincione, E | 1 |
| Asensi, R; Correa, JA; De La Cruz, JP; Espartero, JL; López-Villodres, JA; Rodríguez-Gutiérez, G | 1 |
| Cornwell, DG; Ma, J | 1 |
| Japón-Luján, R; Luque de Castro, MD; Pérez-Serradilla, JA | 1 |
| Agalias, A; Coxam, V; Davicco, MJ; Horcajada, MN; Lebecque, P; Mardon, J; Mazur, A; Puel, C; Skaltsounis, AL | 1 |
| De La Cruz, JP; Espartero, JL; González-Correa, JA; Lopez-Villodres, JA; Navas, MD; Trujillo, M | 1 |
| de la Torre, R | 1 |
| Bertelli, AA; Das, DK; Das, M; Dudley, JI; Lekli, I; Mukherjee, S | 1 |
| Bouaziz, M; El Feki, A; Fki, I; Jemai, H; Sayadi, S | 1 |
| Geerlings, A; Hilfiker, S; Luzón-Toro, B | 1 |
| Cert, A; Espartero, JL; Madrona, A; Mateos, R; Pereira-Caro, G; Trujillo, M | 1 |
| Lin, LC; Tsai, TH; Wu, YT | 1 |
| Cao, J; Geng, C; Gong, D; Jiang, L; Yoshimura, H; Zhong, L | 1 |
| Bertelli, AA; Das, DK; Gurusamy, N; Lekli, I; Mukherjee, S | 1 |
| Konczak, I; Obied, HK; Prenzler, PD; Rehman, AU; Robards, K | 1 |
| Ehara, H; Jinno, M; Kawaminami, M; Kurusu, S; Yonezawa, T | 1 |
| Cao, J; Zhang, X; Zhong, L | 1 |
| Papoti, VT; Tsimidou, MZ | 1 |
| Cao, J; Jiang, L; Zhang, X; Zhong, L | 1 |
| Fregapane, G; Gómez-Rico, A; Inarejos-García, AM; Salvador, MD | 1 |
| Amado, F; Belo, L; Borges, F; Fernandes, J; Nascimento, H; Paiva-Martins, F; Rocha, S; Santos-Silva, A; Vitorino, R | 1 |
| Anderson, DG; Doorn, JA; Florang, VR; Jinsmaa, Y; Rees, JN; Strack, S | 1 |
| Allouche, N; Damak, M; Elfeki, A; Hamden, K | 1 |
| Anglada, R; Covas, MI; de la Torre, R; Farré, M; Fito, M; Khymenets, O; Konstantinidou, V; Muñoz-Aguayo, D | 1 |
| Cao, J; Geng, C; Jiang, L; Zhang, X; Zhong, L | 1 |
| Espartero, JL; Fernández-Bolaños, J; Madrona, A; Mateos, R; Pereira-Caro, G; Rodríguez, G; Trujillo, M | 1 |
| Hara, A; Imai, K; Karibe, K; Nakamura, K; Nghia, VB; Ogawa, H; Yamada, K; Yamada, M; Yamamoto, Y; Yonezawa, Y; Yoshida, Y; Yoshimura, H | 1 |
| De Bartolomeo, A; Fabiani, R; Fuccelli, R; Morozzi, G; Pieravanti, F | 1 |
| Alcantara, D; Lucas, R; Morales, JC | 1 |
| Fernández-Bolaños, J; Fuentes-Alventosa, JM; Guillén, R; Jaramillo, S; Jiménez-Araujo, A; Lama, A; Rodríguez, G; Rodríguez-Arcos, R | 1 |
| Battino, M; Bullon, P; Goteri, G; Granados-Principal, S; Morillo, JM; Quiles, JL; Ramirez-Tortosa, M; Rubini, C | 1 |
| d'Ischia, M; De Lucia, M; Napolitano, A; Panzella, L; Pezzella, A | 1 |
| Feng, Z; Hao, J; Jia, H; Li, X; Liu, J; Sharman, E; Shen, W; Wang, Y; Weber, P; Wertz, K; Yu, G | 1 |
| An, Y; Geng, C; Guo, W; Jiang, L; Zhong, L | 1 |
| Corona, G; Deiana, M; Dessì, MA; Incani, A; Spencer, JP; Vauzour, D | 1 |
| El Feki, A; Jemai, H; Sayadi, S | 1 |
| Arós, F; Civit, E; Corella, D; Covas, MI; de la Torre, R; Estruch, R; Farré, M; Fernandez-Crehuet, J; Fiol, M; Flores, G; Lapetra, J; Martínez-González, MA; Ros, E; Ruiz-Gutiérrez, V; Sáez, G; Salas-Salvadó, J; Schröder, H; Vila, J | 1 |
| Alcántara, D; Lois, S; Lucas, R; Medina, I; Morales, JC | 1 |
| Amouric, A; Comte, A; Liebgott, PP; Lorquin, J; Tholozan, JL | 1 |
| Gikas, E; Magiatis, P; Melliou, E; Skaltsounis, AL; Tsarbopoulos, A; Zoidou, E | 1 |
| Andò, S; Casaburi, I; Chimento, A; De Luca, A; Iacopetta, D; Maggiolini, M; Onofrio, A; Pezzi, V; Puoci, F; Rizza, P; Sirianni, R | 1 |
| Corona, G; Deiana, M; Dessì, MA; Incani, A; Spencer, JP; Vafeiadou, K; Vauzour, D | 1 |
| Fonollá, J; González-Santiago, M; Lopez-Huertas, E | 1 |
| Feng, Z; Hao, J; Li, X; Liu, J; Liu, Z; Sharman, E; Shen, W; Shi, X; Sun, L; Wang, Y; Weber, P; Wertz, K; Zhu, L | 1 |
| Bravo, L; Goya, L; Granado-Serrano, AB; Martín, MA; Ramos, S; Rodríguez-Ramiro, I; Trujillo, M | 1 |
| Brown, L; Campbell, F; Poudyal, H | 1 |
| Granados-Principal, S; Quiles, JL; Ramirez-Tortosa, CL; Ramirez-Tortosa, MC; Sanchez-Rovira, P | 1 |
| Fu, LZ; Li, HM; Li, HZ; Li, RT; Pan, YY; Song, HJ; Wang, WG | 1 |
| Covas, MI; de la Torre, R; Farré, M; Fitó, M; Joglar, J; Khymenets, O; Muñoz-Aguayo, D; Pujadas, M; Torres, JL; Touriño, S | 1 |
| Alcántara, D; Comelles, F; Curcuroze, M; Lucas, R; Maldonado, OS; Morales, JC; Parra, JL | 1 |
| Halliwell, B; Hoi, A; Long, LH | 1 |
| Eckert, GP; Müller, WE; Schaffer, S | 1 |
| Ortega-García, F; Peragón, J | 1 |
| Brouk, M; Fishman, A; Nov, Y | 1 |
| Bouallagui, Z; Bouaziz, M; Engasser, JM; Ghoul, M; Lassoued, S; Sayadi, S | 1 |
| Bravo, L; Espartero, JL; Kroon, PA; Madrona, A; Mateos, R; Pereira-Caro, G; Saha, S | 1 |
| Jia, H; Jia, X; Li, X; Liu, J; Liu, Z; Long, J; Sun, L; Wang, Y; Weber, P; Zhu, L | 1 |
| Calheiros, R; Marques, MP; Paiva-Martins, F; Rodrigues, V | 1 |
| Bouallagui, Z; Han, J; Isoda, H; Sayadi, S | 1 |
| Bernini, R; Crisante, F; Merendino, N; Molinari, R; Soldatelli, MC; Velotti, F | 1 |
| Camacho-Corencia, P; Granados-Principal, S; Quiles, JL; Ramirez-Tortosa, C; Ramirez-Tortosa, MC; Sanchez-Rovira, P; Vera-Ramirez, L | 1 |
| Bastida, S; Esperanza Díaz, L; Gómez-Martínez, S; Lucas, R; Marcos, A; Sánchez-Muniz, FJ; Vázquez-Velasco, M | 1 |
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| Chamkha, M; Geißen, SU; Hadrich, F; Sayadi, S | 1 |
| Binou, P; Karathanos, VT; Kosta, O; Stergiou, A; Tentolouris, N | 1 |
| Chatzikonstantinou, AV; Chochos, CL; Giannakopoulou, A; Houhoula, D; Stamatis, H; Tsakni, A | 1 |
| Guo, Z; Li, M; Li, X; Liu, T; Tian, X; Wang, P; Wang, W | 1 |
| Cappelletto, E; Fongaro, B; Polverino de Laureto, P; Sosic, A; Spolaore, B | 1 |
| Cáceres, D; Giménez, B; Holgado, F; Márquez-Ruiz, G; Robert, P; Romero-Hasler, P; Soto-Bustamante, E; Vergara, C | 1 |
| Cao, K; Cao, W; Feng, Z; Liu, J; Xiong, Y; Xu, J; Zhang, J | 1 |
| Apetrei, C; Bounegru, AV | 1 |
| Anzar, M; Benson, JD; Blondin, P; Sharafi, M; Vincent, P | 1 |
| Alisi, A; Bianchi, M; Braghini, MR; Comparcola, D; Condorelli, AG; Conti, LA; Crudele, A; De Stefanis, C; Gurrado, F; Lioci, G; Mosca, A; Nobili, R; Panera, N; Sartorelli, MR; Scoppola, V; Smeriglio, A; Svegliati-Baroni, G; Trombetta, D | 1 |
| Fang, Z; Han, S; Jin, Q; Karrar, E; Wang, X; Wang, Y; Wu, G; Zeng, W; Zhang, H; Zhang, Y | 1 |
| Bermúdez-Oria, A; Espejo-Calvo, JA; Fernández-Bolaños, J; Fernández-Prior, Á; López-Maestro, F; Rodríguez-Gutiérrez, G | 1 |
| Brocchini, S; Nardi, M; Procopio, A; Somavarapu, S | 1 |
| Accardi, G; Aiello, A; Allegra, M; Calabrò, A; Candore, G; Caruso, C; Gervasi, F; Ligotti, ME; Pojero, F; Procopio, A | 1 |
| Bender, C; Golz, C; Strassmann, S | 1 |
| Arangia, A; Cuzzocrea, S; D'Amico, R; Di Paola, R; Impellizzeri, D; Marino, Y | 1 |
| Idrus, RBH; Lokanathan, Y; Razali, RA; Saim, A; Yazid, MD | 1 |
| Azman, SS; Haizum Abdullah, NA; Heng, JW; Shanmugam, J; Sulaiman, N; Vijakumaran, U; Yazid, MD | 1 |
| Chen, X; Liu, C; Peplowski, L; Qi, L; Shen, W; Xia, Y; Yang, H | 1 |
| Goyal, B; Goyal, D; Kaur, G; Mankoo, OK | 1 |
| Bai, Y; Cai, Y; Yan, Y; Zheng, X | 1 |
| Accardi, G; Aiello, A; Allegra, M; Attanzio, A; Bonacci, S; Caldarella, R; Candore, G; Caruso, C; Fiore, SD; Gervasi, F; Ligotti, ME; Pojero, F; Procopio, A; Restivo, I; Tesoriere, L | 1 |
| Arroyo-López, FN; Benítez-Cabello, A; Caballero-Guerrero, B; Cubero-Cardoso, J; Fermoso, FG; Fernández-Prior, MÁ; Garrido-Fernández, A; López-García, E; Nyström, L; Reinhard, C | 1 |
| Ding, Z; Mei, X; Rong, X; Xia, M; Zhu, B | 1 |
46 review(s) available for 3,4-dihydroxyphenylethanol and phenylethyl alcohol
| Article | Year |
|---|---|
Biological effects of hydroxytyrosol, a polyphenol from olive oil endowed with antioxidant activity.
Topics: Antioxidants; Humans; Neoplasms; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Reactive Oxygen Species | 1999 |
Biological properties of olive oil phytochemicals.
Topics: Antioxidants; Coronary Disease; Diet; Diet, Mediterranean; Dietary Fats, Unsaturated; Humans; Neoplasms; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Squalene | 2002 |
Radical-scavenging polyphenols: new strategies for their synthesis.
Topics: Animals; Chemistry, Pharmaceutical; Flavonoids; Free Radical Scavengers; Humans; Models, Chemical; Molecular Structure; Phenols; Phenylethyl Alcohol; Polyphenols; Ubiquinone | 2007 |
Nutritional benefit of olive oil: the biological effects of hydroxytyrosol and its arylating quinone adducts.
Topics: Animals; Antioxidants; Diet, Mediterranean; Health Promotion; Humans; Inflammation; Neoplasms; Olive Oil; Phenylethyl Alcohol; Plant Oils; Quinones | 2008 |
Bioavailability of olive oil phenolic compounds in humans.
Topics: Biological Availability; Biotransformation; Dopamine; Flavonoids; Humans; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols | 2008 |
Hydroxytyrosol: from laboratory investigations to future clinical trials.
Topics: Anti-Infective Agents; Antioxidants; Cardiovascular Diseases; Diet, Mediterranean; Humans; Neoplasms; Olive Oil; Phenylethyl Alcohol; Plant Oils; Platelet Aggregation Inhibitors | 2010 |
Extra virgin olive oil's polyphenols: biological activities.
Topics: Animals; Cardiotonic Agents; Drug Evaluation, Preclinical; Flavonoids; Humans; Industrial Waste; Models, Biological; Molecular Structure; Neoplasms; Neuroprotective Agents; Olive Oil; Patents as Topic; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols | 2011 |
Mechanisms of action of phenolic compounds in olive.
Topics: Antioxidants; Cardiovascular Diseases; Cell Adhesion Molecules; Diet, Mediterranean; Humans; Lipid Peroxidation; Neoplasms; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils | 2012 |
Factors influencing phenolic compounds in table olives (Olea europaea).
Topics: Antioxidants; Diet, Mediterranean; Drug Stability; Flavonoids; Food Handling; Fruit; Health Promotion; Hot Temperature; Humans; Iridoid Glucosides; Iridoids; Olea; Phenol; Phenylethyl Alcohol; Pyrans; Seeds; Species Specificity | 2012 |
Naturally occurring hydroxytyrosol: synthesis and anticancer potential.
Topics: Animals; Humans; Neoplasms; Phenylethyl Alcohol | 2013 |
Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus; Humans; Iridoid Glucosides; Iridoids; Metabolic Diseases; Olive Oil; Phenylethyl Alcohol; Plant Oils | 2014 |
The antioxidant hydroxytyrosol: biotechnological production challenges and opportunities.
Topics: Antioxidants; Biotechnology; Phenylethyl Alcohol; Technology, Pharmaceutical | 2015 |
Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Diet, Mediterranean; Humans; In Vitro Techniques; Neurodegenerative Diseases; Olive Oil; Phenylethyl Alcohol | 2015 |
Cardioprotective Effects of the Polyphenol Hydroxytyrosol from Olive Oil.
Topics: Animals; Biological Availability; Cardiovascular Diseases; Humans; Molecular Structure; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Platelet Aggregation Inhibitors | 2017 |
The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents; Biological Availability; Cyclopentane Monoterpenes; Dietary Supplements; Humans; Iridoid Glucosides; Iridoids; Olive Oil; Phenols; Phenylethyl Alcohol | 2016 |
Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders.
Topics: Adiposity; Animals; Antioxidants; Body Weight; Diet, Mediterranean; Disease Models, Animal; Homeostasis; Humans; Hyperglycemia; Lipid Metabolism; Metabolic Syndrome; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Polyphenols | 2017 |
Antimicrobial activity of Olea europaea Linné extracts and their applicability as natural food preservative agents.
Topics: Aldehydes; Anti-Infective Agents; Food Preservatives; Fruit; Iridoid Glucosides; Iridoids; Olea; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Pyrans | 2017 |
Hydroxytyrosol and Cytoprotection: A Projection for Clinical Interventions.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Autophagy; Cytoprotection; Humans; Mitochondria; Olive Oil; Oxidative Stress; Phenylethyl Alcohol | 2017 |
Liver Protective Effects of Extra Virgin Olive Oil: Interaction between Its Chemical Composition and the Cell-signaling Pathways Involved in Protection.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Autophagy; Dietary Fats, Unsaturated; Dietary Supplements; Endoplasmic Reticulum Stress; Food Quality; Functional Food; Humans; Lipogenesis; Liver; Non-alcoholic Fatty Liver Disease; Olive Oil; Phenylethyl Alcohol; Signal Transduction | 2018 |
Hydroxytyrosol: Bioavailability, toxicity, and clinical applications.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Diet, Healthy; Diet, Mediterranean; Dietary Supplements; Humans; Olive Oil; Phenylethyl Alcohol | 2018 |
Hydroxytyrosol: Emerging Trends in Potential Therapeutic Applications.
Topics: Animals; Cardiovascular Diseases; Humans; Neoplasms; Neurodegenerative Diseases; Phenylethyl Alcohol | 2018 |
Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates.
Topics: Animals; Antineoplastic Agents; Cell Movement; Cell Proliferation; Coronary Disease; DNA Damage; Humans; Iridoid Glucosides; Iridoids; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Olea; Olive Oil; Phenylethyl Alcohol; Pyrans | 2018 |
Olive Oil Nutraceuticals in the Prevention and Management of Diabetes: From Molecules to Lifestyle.
Topics: Diabetes Mellitus, Type 2; Dietary Fats; Dietary Supplements; Humans; Iridoid Glucosides; Iridoids; Life Style; Olive Oil; Phenylethyl Alcohol | 2018 |
Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Autophagy; Diet, Mediterranean; Humans; Metabolic Syndrome; Neoplasms; Neurodegenerative Diseases; Osteoporosis; Phenylethyl Alcohol; Protective Agents | 2019 |
Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health.
Topics: Antineoplastic Agents; Cardiotonic Agents; Health; Humans; Neuroprotective Agents; Phenylethyl Alcohol | 2019 |
Chemical, physical and biotechnological approaches to the production of the potent antioxidant hydroxytyrosol.
Topics: Antioxidants; Biotechnology; Olea; Phenylethyl Alcohol; Technology, Pharmaceutical | 2019 |
Effects of Olive Oil and Its Minor Components on Cardiovascular Diseases, Inflammation, and Gut Microbiota.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Diet, Mediterranean; Gastrointestinal Microbiome; Humans; Inflammation; Lipoproteins, LDL; Oleic Acid; Olive Oil; Phenols; Phenylethyl Alcohol | 2019 |
Molecular pathways involved in lymphedema: Hydroxytyrosol as a candidate natural compound for treating the effects of lymph accumulation.
Topics: Animals; Antioxidants; Gene Expression Regulation; Hemostasis; Humans; Leukotriene B4; Lymphedema; Metabolic Networks and Pathways; Olea; Oxidative Stress; Phenylethyl Alcohol; Plant Extracts | 2020 |
Hydroxytyrosol: A natural compound with promising pharmacological activities.
Topics: Anti-Inflammatory Agents; Antioxidants; Humans; Olea; Olive Oil; Oxidative Stress; Phenols; Phenylethyl Alcohol; Plant Leaves | 2020 |
Extra Virgin Olive Oil Polyphenols: Modulation of Cellular Pathways Related to Oxidant Species and Inflammation in Aging.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Humans; Inflammation; Mice; NF-E2-Related Factor 2; NF-kappa B; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Polyphenols; Signal Transduction | 2020 |
Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet.
Topics: Antioxidants; Diet, Healthy; Diet, Mediterranean; Eating; Epigenomics; Female; Food Analysis; Gene Expression; Health Status; Humans; Isothiocyanates; Male; MicroRNAs; Nutrigenomics; Phenylethyl Alcohol; Sulfoxides; Xanthine | 2020 |
Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases.
Topics: Adult; Aged; Animals; Antioxidants; Cardiovascular Diseases; Female; Humans; Male; Metabolic Syndrome; Mice; Middle Aged; Oxidative Stress; Phenylethyl Alcohol; Rabbits; Rats | 2020 |
Molecular Action of Hydroxytyrosol in Wound Healing: An In Vitro Evidence-Based Review.
Topics: Anti-Inflammatory Agents; Antioxidants; Humans; Olea; Phenols; Phenylethyl Alcohol; Wound Healing | 2020 |
Food supplements based on palmitoylethanolamide plus hydroxytyrosol from olive tree or Bacopa monnieri extracts for neurological diseases.
Topics: Amides; Bacopa; Dietary Supplements; Ethanolamines; Humans; Nervous System Diseases; Olea; Palmitic Acids; Phenylethyl Alcohol; Plant Extracts | 2020 |
Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review.
Topics: Aldehydes; Cyclopentane Monoterpenes; Iridoid Glucosides; Iridoids; Olea; Olive Oil; Phenols; Phenylethyl Alcohol | 2021 |
Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Cyclopentane Monoterpenes; Diet, Mediterranean; Glucosides; Humans; Iridoid Glucosides; Iridoids; Neoplasms; Olive Oil; Phenols; Phenylethyl Alcohol; Pyrans | 2021 |
The mechanism and prevention of mitochondrial injury after exercise.
Topics: Apoptosis; Athletic Injuries; Calcium; Dietary Supplements; DNA Damage; Exercise; Fatigue; Free Radicals; Humans; Lipid Peroxidation; Mitochondria; Nitric Oxide; Phenylethyl Alcohol; Resveratrol; Thioctic Acid; Ubiquinone | 2021 |
Graphene-Based Sensors for the Detection of Bioactive Compounds: A Review.
Topics: Antioxidants; Ascorbic Acid; Biosensing Techniques; Curcumin; Electric Conductivity; Electrodes; Free Radicals; Gallic Acid; Graphite; Humans; Iridoid Glucosides; Melatonin; Metals; Nanocomposites; Nanostructures; Oxides; Phenylethyl Alcohol; Quantum Dots; Resveratrol; Tannins; Tocopherols | 2021 |
Beneficial effects of natural compounds on experimental liver ischemia-reperfusion injury.
Topics: Animals; Ascorbic Acid; Biological Products; Fatty Acids, Unsaturated; Humans; Liver; Phenylethyl Alcohol; Reperfusion Injury; Vitamin E; Vitamins | 2021 |
Beneficial effects of dietary supplementation with olive oil, oleic acid, or hydroxytyrosol in metabolic syndrome: Systematic review and meta-analysis.
Topics: Dietary Supplements; Humans; Metabolic Syndrome; Oleic Acid; Olive Oil; Phenylethyl Alcohol | 2021 |
Protective Effects and Benefits of Olive Oil and Its Extracts on Women's Health.
Topics: Animals; Diet, Healthy; Diet, Mediterranean; Female; Humans; Iridoid Glucosides; Olea; Olive Oil; Phenylethyl Alcohol; Plant Oils; Polyphenols; Protective Agents; Women's Health | 2021 |
Progress in Colloid Delivery Systems for Protection and Delivery of Phenolic Bioactive Compounds: Two Study Cases-Hydroxytyrosol and Curcumin.
Topics: Colloids; Curcumin; Drug Carriers; Hydrophobic and Hydrophilic Interactions; Phenylethyl Alcohol | 2022 |
Hydroxytyrosol oleate: A promising neuroprotective nanocarrier delivery system of oleuropein and derivatives.
Topics: Antioxidants; Humans; Male; Neuroblastoma; Olea; Oleic Acid; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils | 2023 |
Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging.
Topics: Antioxidants; Humans; Inflammation; Inflammation Mediators; Iridoid Glucosides; Iridoids; Olive Oil; Phenylethyl Alcohol | 2022 |
Hydroxytyrosol and Its Potential Uses on Intestinal and Gastrointestinal Disease.
Topics: Animals; Antioxidants; Gastrointestinal Diseases; Humans; Nuts; Olive Oil; Phenylethyl Alcohol | 2023 |
Effects of Hydroxytyrosol in Endothelial Functioning: A Comprehensive Review.
Topics: Antioxidants; Endothelial Cells; Olea; Olive Oil; Phenylethyl Alcohol | 2023 |
31 trial(s) available for 3,4-dihydroxyphenylethanol and phenylethyl alcohol
| Article | Year |
|---|---|
Evidence of postprandial absorption of olive oil phenols in humans.
Topics: Adolescent; Adult; Antioxidants; Arteriosclerosis; Diet; Dietary Fats, Unsaturated; Fasting; Female; Humans; Intestinal Absorption; Lipid Peroxidation; Lipids; Lipoproteins; Longitudinal Studies; Male; Olive Oil; Phenylethyl Alcohol; Plant Oils; Postprandial Period; Time Factors; Vitamin E | 2000 |
Tyrosol and hydroxytyrosol are absorbed from moderate and sustained doses of virgin olive oil in humans.
Topics: Adult; Antioxidants; Biomarkers; Diet Records; Dose-Response Relationship, Drug; Female; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Middle Aged; Nutritive Value; Olive Oil; Phenylethyl Alcohol; Plant Oils | 2003 |
Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation--a randomized controlled trial.
Topics: Antioxidants; Cholesterol, HDL; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lipoproteins, LDL; Male; Middle Aged; Olive Oil; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Plant Oils | 2004 |
Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans.
Topics: Adult; Antioxidants; Cross-Over Studies; Diet; Humans; Lipid Peroxidation; Lipoproteins, LDL; Male; Olive Oil; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Postprandial Period | 2006 |
Is dopamine behind the health benefits of red wine?
Topics: Adolescent; Adult; Biological Availability; Cross-Over Studies; Diet, Mediterranean; Dopamine; Dose-Response Relationship, Drug; Humans; Male; Olive Oil; Phenylethyl Alcohol; Plant Oils; Wine | 2006 |
The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial.
Topics: Adult; Antioxidants; Cholesterol; Cholesterol, HDL; Cross-Over Studies; Dietary Fats, Unsaturated; Flavonoids; Heart Diseases; Humans; Male; Middle Aged; Olive Oil; Patient Compliance; Patient Dropouts; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols; Risk Factors; Triglycerides | 2006 |
Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans.
Topics: Adult; Antioxidants; Atherosclerosis; CD40 Ligand; Cross-Over Studies; Down-Regulation; Humans; Leukocytes, Mononuclear; Lipoproteins, LDL; Male; Middle Aged; Olive Oil; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Polyphenols; Receptors, Adrenergic, beta-2; Receptors, Interleukin-8; Signal Transduction; Young Adult | 2012 |
Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis.
Topics: Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Olea; Osteoarthritis, Knee; Pain Measurement; Phenylethyl Alcohol; Phytotherapy; Plant Extracts | 2013 |
Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract.
Topics: Absorption; Adult; Antioxidants; Chromatography, Liquid; Dose-Response Relationship, Drug; Female; Humans; Iridoid Glucosides; Iridoids; Male; Middle Aged; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Polyphenols; Pyrans; Tandem Mass Spectrometry | 2013 |
Moderate consumption of wine, through both its phenolic compounds and alcohol content, promotes hydroxytyrosol endogenous generation in humans. A randomized controlled trial.
Topics: Adult; Animals; Biological Availability; Blood Pressure; Cross-Over Studies; Dopamine; Double-Blind Method; Ethanol; Healthy Volunteers; Humans; Male; Phenols; Phenylethyl Alcohol; Rats; Tyramine; Wine | 2015 |
Anti-inflammatory effect of white wine in CKD patients and healthy volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; C-Reactive Protein; Case-Control Studies; Cross-Over Studies; Female; Humans; Interleukin-6; Interleukin-8; Male; Middle Aged; Olive Oil; Phenylethyl Alcohol; Prospective Studies; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha; Wine | 2015 |
Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans.
Topics: Animals; Cell Line; Cells, Cultured; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Humans; Intestinal Mucosa; Intestine, Small; Leukocytes, Mononuclear; Male; Mice, Inbred C57BL; MicroRNAs; Organ Specificity; Organoids; Phenylethyl Alcohol; Tissue Culture Techniques | 2016 |
Melatonin and hydroxytyrosol-rich wines influence the generation of DNA oxidation catabolites linked to mutagenesis after the ingestion of three types of wine by healthy volunteers.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Cross-Over Studies; DNA; Double-Blind Method; Female; Humans; Melatonin; Mutation; Oxidation-Reduction; Phenylethyl Alcohol; Wine; Young Adult | 2016 |
Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers.
Topics: Adolescent; Adult; Antioxidants; Central Nervous System; Ethanol; F2-Isoprostanes; Female; Healthy Volunteers; Humans; Melatonin; Oxidative Stress; Phenylethyl Alcohol; Protective Agents; Wine; Young Adult | 2017 |
Hydroxytyrosol supplementation increases vitamin C levels in vivo. A human volunteer trial.
Topics: Adult; Ascorbic Acid; Blood Pressure; Body Mass Index; Dietary Supplements; Female; Folic Acid; Healthy Volunteers; Humans; Iron; Kidney Function Tests; Lipid Metabolism; Lipids; Liver Function Tests; Male; Olive Oil; Phenylethyl Alcohol | 2017 |
Antioxidant Effects of a Hydroxytyrosol-Based Pharmaceutical Formulation on Body Composition, Metabolic State, and Gene Expression: A Randomized Double-Blinded, Placebo-Controlled Crossover Trial.
Topics: Adult; Antioxidants; Body Composition; Double-Blind Method; Drug Compounding; Eating; Erythrocyte Membrane; Fatty Acids, Unsaturated; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Phenylethyl Alcohol; Placebos; Young Adult | 2017 |
Effect of the dietary intake of melatonin- and hydroxytyrosol-rich wines by healthy female volunteers on the systemic lipidomic-related oxylipins.
Topics: Adolescent; Adult; Female; Healthy Volunteers; Humans; Melatonin; Oxidative Stress; Oxylipins; Phenols; Phenylethyl Alcohol; Wine; Young Adult | 2017 |
Potential treatment of atopic dermatitis: tolerability and safety of cream containing nanoparticles loaded with hydrocortisone and hydroxytyrosol in human subjects.
Topics: Administration, Cutaneous; Adolescent; Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Dermatitis, Atopic; Double-Blind Method; Female; Glucocorticoids; Humans; Hydrocortisone; Middle Aged; Nanoparticles; Phenylethyl Alcohol; Skin; Skin Cream; Young Adult | 2019 |
A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients receiving adjuvant hormonal therapy: results of a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; C-Reactive Protein; Chemotherapy, Adjuvant; Curcumin; Drug Combinations; Fatty Acids, Omega-3; Female; Humans; Inflammation; Middle Aged; Musculoskeletal Pain; Phenylethyl Alcohol; Pilot Projects; Postmenopause; Prospective Studies | 2019 |
The Antioxidant Effects of Hydroxytyrosol and Vitamin E on Pediatric Nonalcoholic Fatty Liver Disease, in a Clinical Trial: A New Treatment?
Topics: Administration, Oral; Adolescent; Child; Double-Blind Method; Female; Glycation End Products, Advanced; Humans; Male; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phenylethyl Alcohol; Protein Carbonylation; Treatment Outcome; Vitamin E | 2019 |
Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial.
Topics: Aged; Cardiovascular System; Case-Control Studies; Cross-Over Studies; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6; Female; Gene Expression Regulation; Humans; Leukocytes, Mononuclear; Male; Phenylethyl Alcohol; Wine | 2019 |
Generation of the Antioxidant Hydroxytyrosol from Tyrosol Present in Beer and Red Wine in a Randomized Clinical Trial.
Topics: Adult; Antioxidants; Beer; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Male; Phenylethyl Alcohol; Wine; Young Adult | 2019 |
Assessing Validity of Self-Reported Dietary Intake within a Mediterranean Diet Cluster Randomized Controlled Trial among US Firefighters.
Topics: Biomarkers; Cross-Over Studies; Diet, Mediterranean; Fatty Acids; Firefighters; Humans; Phenylethyl Alcohol; Pilot Projects; Reproducibility of Results; Surveys and Questionnaires; United States | 2019 |
Effects of postprandial hydroxytyrosol and derivates on oxidation of LDL, cardiometabolic state and gene expression: a nutrigenomic approach for cardiovascular prevention.
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Catalase; Diet, Healthy; Diet, Mediterranean; Double-Blind Method; Female; Humans; Inflammation Mediators; Lipoproteins, LDL; Male; Middle Aged; Nutrigenomics; Olive Oil; Oxidative Stress; Phenols; Phenylethyl Alcohol; Postprandial Period; Protective Factors; Risk Factors; Rome; Superoxide Dismutase-1; Upstream Stimulatory Factors; Young Adult | 2019 |
Chondroprotective Properties of Human-Enriched Serum Following Polyphenol Extract Absorption: Results from an Exploratory Clinical Trial.
Topics: Absorption, Physicochemical; Adult; Anti-Inflammatory Agents; Cells, Cultured; Chondrocytes; Grape Seed Extract; Healthy Volunteers; Humans; Interleukin-1beta; Male; NF-kappa B; Phenylethyl Alcohol; Plant Extracts; Polyphenols; Proanthocyanidins; Young Adult | 2019 |
Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans.
Topics: Biological Availability; Female; Humans; Male; Olea; Olive Oil; Phenylethyl Alcohol; Plant Oils; Tandem Mass Spectrometry | 2021 |
Antioxidant activity of Hydroxytyrosol and Vitamin E reduces systemic inflammation in children with paediatric NAFLD.
Topics: Antioxidants; Biomarkers; Child; Drug Combinations; Female; Humans; Interleukin-10; Male; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phenylethyl Alcohol; Vitamin E | 2021 |
A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration.
Topics: Aged; Aged, 80 and over; Dietary Supplements; Docosahexaenoic Acids; Female; Humans; Lutein; Macular Degeneration; Male; Middle Aged; Nutrients; Phenylethyl Alcohol; Resveratrol; Treatment Outcome; Visual Acuity; Xanthophylls; Zeaxanthins | 2021 |
Effect of Long-Term Hydroxytyrosol Administration on Body Weight, Fat Mass and Urine Metabolomics: A Randomized Double-Blind Prospective Human Study.
Topics: Body Weight; Double-Blind Method; Female; Humans; Metabolomics; Obesity; Overweight; Phenylethyl Alcohol; Prospective Studies | 2022 |
Oral Supplement Containing Hydroxytyrosol and Punicalagin Improves Dyslipidemia in an Adult Population without Co-Adjuvant Treatment: A Randomized, Double-Blind, Controlled and Crossover Trial.
Topics: Adult; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Double-Blind Method; Dyslipidemias; Humans; Hydrolyzable Tannins; Phenylethyl Alcohol; Triglycerides | 2022 |
Oral Bioavailability and Metabolism of Hydroxytyrosol from Food Supplements.
Topics: Antioxidants; Biological Availability; Cross-Over Studies; Dietary Supplements; Humans; Olea; Olive Oil; Phenylethyl Alcohol; Plant Oils; Tandem Mass Spectrometry | 2023 |
713 other study(ies) available for 3,4-dihydroxyphenylethanol and phenylethyl alcohol
| Article | Year |
|---|---|
Determination of some L-3,4-dihydroxyphenylalanine and dopamine metabolites in urine by means of mass fragmentography.
Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; Adult; Aging; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Flavoring Agents; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Humans; Infant; Infant, Newborn; Lactates; Levodopa; Middle Aged; Neuroblastoma; Phenylethyl Alcohol | 1978 |
The impact of recent advances in diagnostic technology on the clinical presentation of phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Epinephrine; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Norepinephrine; Phenylethyl Alcohol; Pheochromocytoma; Retrospective Studies; Tomography, X-Ray Computed | 1992 |
Gas chromatographic/mass spectrometric methodology for simultaneous assay of salsolinol, dopamine, norepinephrine, dihydroxyphenylacetic acid and dihydroxyphenylethanol.
Topics: 3,4-Dihydroxyphenylacetic Acid; Beverages; Dopamine; Food Analysis; Gas Chromatography-Mass Spectrometry; Isoquinolines; Norepinephrine; Phenylethyl Alcohol | 1985 |
Errors introduced by a tritium label in position 8 of catecholamines.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; 3,4-Dihydroxyphenylacetic Acid; Animals; Aorta, Thoracic; Catecholamines; Deamination; In Vitro Techniques; Isotope Labeling; Male; Mandelic Acids; Methoxyhydroxyphenylglycol; Monoamine Oxidase Inhibitors; Muscle, Smooth; Myocardium; Neurons; Norepinephrine; Phenylethyl Alcohol; Rabbits; Rats; Vas Deferens | 1986 |
Effects of induction of rat liver cytosolic aldehyde dehydrogenase on the oxidation of biogenic aldehydes.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aldehyde Dehydrogenase; Aldehydes; Animals; Cytosol; Dopamine; Enzyme Induction; Ethanol; Isoenzymes; Liver; Norepinephrine; Phenobarbital; Phenylethyl Alcohol; Polychlorinated Dibenzodioxins; Rats | 1986 |
Human class I alcohol dehydrogenases catalyze the interconversion of alcohols and aldehydes in the metabolism of dopamine.
Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; Acetaldehyde; Alcohol Dehydrogenase; Catechols; Dopamine; Ethanol; Humans; Isoenzymes; Kinetics; Liver; Phenylacetates; Phenylethyl Alcohol; Substrate Specificity | 1986 |
The metabolism of dopamine in the blood of ruminant animals: formation of 3,4-dihydroxyphenylacetaldehyde.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biotransformation; Chromatography, High Pressure Liquid; Dopamine; Female; Monoamine Oxidase; Oxidation-Reduction; Phenylacetates; Phenylethyl Alcohol; Ruminants | 1987 |
Effects of ethanol, acetaldehyde and disulfiram on the metabolism of biogenic aldehydes in isolated human blood cells and platelets.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetaldehyde; Blood Platelets; Cells, Cultured; Disulfiram; Dopamine; Erythrocytes; Ethanol; Humans; Hydroxyindoleacetic Acid; Leukocytes; Phenylacetates; Phenylethyl Alcohol; Serotonin | 1987 |
Effects of intraventricular injections of 6-hydroxydopamine on amine metabolites in rat brain and urine.
Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; Adrenal Glands; Animals; Biogenic Amines; Brain Chemistry; Dopamine; Ethylene Glycols; Gas Chromatography-Mass Spectrometry; Heart; Homovanillic Acid; Hydroxydopamines; Injections, Intraventricular; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Organ Size; Oxidopamine; Phenols; Phenylethyl Alcohol; Rats; Rats, Inbred Strains; Spleen | 1985 |
Synergy of ethanol and alcohol-like metabolites: tryptophol and 3,4-dihydroxyphenylethanol.
Topics: Animals; Brain; Catechols; Dopamine; Drug Synergism; Ethanol; Indoles; Male; Mice; Phenylethyl Alcohol; Serotonin; Sleep; Time Factors | 1973 |
Conversion of 3, 4-dihydroxyphenylalanine and deuterated 3, 4-dihydroxyphenylalanine to alcoholic metabolites of catecholamines in rat brain.
Topics: 3-Methoxy-4-hydroxyphenylethanol; Animals; Brain; Deuterium; Dopamine; Levodopa; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Phenylethyl Alcohol; Rats | 1981 |
Effects of L-DOPA on the excretion of alcoholic metabolites of catecholamines and trace amines in rat and human urine.
Topics: 3-Methoxy-4-hydroxyphenylethanol; Amines; Animals; Dopamine; Gas Chromatography-Mass Spectrometry; Humans; Levodopa; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Parkinson Disease; Phenylethyl Alcohol; Rats | 1981 |
Radioenzymatic assay of dihydroxyphenylglycol (DOPEG) and dihydroxyphenylethanol (DOPET) in plasma and cerebrospinal fluid.
Topics: Adult; Aged; Animals; Cats; Dogs; Ethanol; Female; Glycols; Humans; Infant; Male; Methoxyhydroxyphenylglycol; Middle Aged; Phenylethyl Alcohol; Radioisotope Dilution Technique; Rats; S-Adenosylmethionine; Tritium | 1981 |
Enhancement of [3H]dopamine release and its [3H]metabolites in rat striatum by nicotinic drugs.
Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; 5-Methoxytryptamine; Animals; Corpus Striatum; Dopamine; Ganglionic Stimulants; Male; Phenylethyl Alcohol; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Synaptosomes | 1982 |
Catecholamine metabolism in rat brain following the intracerebroventricular administration of cyclic nucleotides.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Chemistry; Bucladesine; Catecholamines; Cyclic GMP; Dibutyryl Cyclic GMP; Dopamine; Homovanillic Acid; Male; Normetanephrine; Phenylethyl Alcohol; Rats; Rats, Inbred Strains | 1982 |
[Studies on the active constituents of Syringa oblata Lindl].
Topics: Anti-Infective Agents; Chemical Phenomena; Chemistry; Cholagogues and Choleretics; Coumaric Acids; Glycosides; Hydroxybenzoates; Phenylethyl Alcohol; Plant Extracts; Propionates | 1982 |
The metabolism of dopamine in the blood of ruminant animals: an enzyme system to metabolize dopamine released from the mast cells in these species?
Topics: 3-Methoxy-4-hydroxyphenylethanol; Animals; Artiodactyla; Cattle; Deer; Dopamine; Female; Goats; Guinea Pigs; Horses; Humans; Male; Mast Cells; Phenylethyl Alcohol; Rabbits; Sheep; Species Specificity; Swine | 1983 |
Formation of F2-isoprostanes in oxidized low density lipoprotein: inhibitory effect of hydroxytyrosol.
Topics: Antioxidants; Lipid Peroxidation; Lipoproteins, LDL; Phenylethyl Alcohol; Prostaglandins, Synthetic; Time Factors | 1995 |
Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adenosine Diphosphate; Antioxidants; Collagen; Eicosanoids; Flavonoids; Humans; Hydroxyeicosatetraenoic Acids; Iridoid Glucosides; Iridoids; Olive Oil; Phenylethyl Alcohol; Plant Extracts; Plant Oils; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrans; Thromboxane B2 | 1995 |
Reduction of dihydroxyphenylacetic acid by a novel enzyme in the rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Edetic Acid; Enzyme Inhibitors; Mass Spectrometry; Oxidation-Reduction; Oxidoreductases; Phenylethyl Alcohol; Rats | 1995 |
Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol.
Topics: Antioxidants; Ascorbic Acid; Bleomycin; Catechols; Cymenes; Deoxyribose; DNA Damage; Fatty Alcohols; Ferric Compounds; Food Preservation; Guaiacol; Hydroxyl Radical; Lipid Peroxidation; Liposomes; Monoterpenes; Phenylethyl Alcohol; Pulse Radiolysis; Terpenes; Thymol | 1994 |
Protection of low-density lipoprotein from oxidation by 3,4-dihydroxyphenylethanol.
Topics: Animals; Antioxidants; Humans; Lipoproteins, LDL; Oxidation-Reduction; Phenylethyl Alcohol; Rabbits | 1994 |
A phenolic antioxidant extracted from olive oil inhibits platelet aggregation and arachidonic acid metabolism in vitro.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Antioxidants; Arachidonic Acid; Blood Platelets; Collagen; Humans; Hydroxyeicosatetraenoic Acids; Olive Oil; Phenylethyl Alcohol; Plant Oils; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1994 |
The protective effect of the olive oil polyphenol (3,4-dihydroxyphenyl)-ethanol counteracts reactive oxygen metabolite-induced cytotoxicity in Caco-2 cells.
Topics: Antioxidants; Caco-2 Cells; Cell Survival; Dietary Fats, Unsaturated; Humans; Hydrogen Peroxide; Intestinal Mucosa; Intestines; Inulin; Lipid Peroxidation; Malondialdehyde; Olive Oil; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Reactive Oxygen Species; Xanthine; Xanthine Oxidase; Xanthines | 1997 |
Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Blood Platelets; Cells, Cultured; Enzyme Inhibitors; Fruit; Molecular Structure; Neutrophils; Phenylethyl Alcohol; Plant Extracts; Rats; Rats, Wistar | 1997 |
Inhibition of leukocyte leukotriene B4 production by an olive oil-derived phenol identified by mass-spectrometry.
Topics: Antioxidants; Arachidonate 5-Lipoxygenase; Calcium; Chromatography, High Pressure Liquid; Depression, Chemical; Gas Chromatography-Mass Spectrometry; Humans; Ionophores; Leukocytes; Leukotriene B4; Olive Oil; Phenylethyl Alcohol; Plant Oils | 1997 |
Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil.
Topics: Animals; Antioxidants; Caffeic Acids; Dietary Fats, Unsaturated; Eicosanoids; Iridoid Glucosides; Iridoids; Leukocytes; Lipoxygenase Inhibitors; Male; Olive Oil; Phenylethyl Alcohol; Plant Oils; Pyrans; Rats; Rats, Wistar; Reactive Oxygen Species | 1999 |
Mass spectrometric analysis of catechol-histidine adducts from insect cuticle.
Topics: Animals; Catechols; Evaluation Studies as Topic; Histidine; Manduca; Mass Spectrometry; Phenylethyl Alcohol | 1999 |
Inhibition of peroxynitrite dependent DNA base modification and tyrosine nitration by the extra virgin olive oil-derived antioxidant hydroxytyrosol.
Topics: Animals; Antioxidants; Cattle; Chronic Disease; DNA; DNA Damage; Humans; Hybrid Cells; Mice; Neuroblastoma; Neurons; Nitrates; Nitric Oxide; Olive Oil; Oxidants; Phenylethyl Alcohol; Plant Oils; Rats; Retina; Superoxides; Tyrosine | 1999 |
On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol.
Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; In Vitro Techniques; Iridoid Glucosides; Iridoids; Microbial Sensitivity Tests; Phenylethyl Alcohol; Pyrans | 1999 |
A highly convenient synthesis of hydroxytyrosol and its recovery from agricultural waste waters.
Topics: Agriculture; Antioxidants; Chromatography, High Pressure Liquid; Food Handling; Olive Oil; Phenylethyl Alcohol; Plant Oils; Waste Disposal, Fluid | 1999 |
Olive oil phenolics are dose-dependently absorbed in humans.
Topics: Adult; Antioxidants; Dietary Fats, Unsaturated; Humans; Intestinal Absorption; Male; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils | 2000 |
Transport mechanism and metabolism of olive oil hydroxytyrosol in Caco-2 cells.
Topics: Antioxidants; Biological Availability; Caco-2 Cells; Catechol O-Methyltransferase; Cell Differentiation; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Diffusion; Enterocytes; Humans; Kinetics; Methylation; Olive Oil; Phenylethyl Alcohol; Plant Oils | 2000 |
Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cell Differentiation; Cell Line; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Electron Transport; Glucose; Homovanillic Acid; Humans; L-Lactate Dehydrogenase; Mitochondria; Nerve Growth Factor; Neurons; Neurotoxins; Oxidation-Reduction; PC12 Cells; Phenylethyl Alcohol; Rats; Rotenone; Stress, Physiological; Uncoupling Agents | 2000 |
3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Antioxidants; Dopamine; Energy Metabolism; Enzyme Inhibitors; Estrogens, Non-Steroidal; Fluorenes; Hydantoins; Isoflavones; Mitochondria; Neurons; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; PC12 Cells; Phenylethyl Alcohol; Rats; Rotenone | 2000 |
Synthesis of tritium-labeled hydroxytyrosol, a phenolic compound found in olive Oil.
Topics: Biological Availability; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Radiometry; Tritium | 2000 |
Determination of hydroxytyrosol in plasma by HPLC.
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Phenylethyl Alcohol; Rats; Reproducibility of Results; Spectrophotometry, Ultraviolet | 2000 |
Olive phenol hydroxytyrosol prevents passive smoking-induced oxidative stress.
Topics: Animals; Antioxidants; Creatinine; Dinoprost; F2-Isoprostanes; Inhalation Exposure; Lipid Peroxidation; Male; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Tobacco Smoke Pollution; Trees | 2000 |
Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis.
Topics: Annexin A5; Antioxidants; Apoptosis; Cell Differentiation; Cell Division; Cell Line, Transformed; Cholecalciferol; Cytochrome c Group; HL-60 Cells; Homogentisic Acid; Humans; Kinetics; Olive Oil; Phenylethyl Alcohol; Plant Oils; Structure-Activity Relationship | 2000 |
Hydroxytyrosol, as a component of olive mill waste water, is dose- dependently absorbed and increases the antioxidant capacity of rat plasma.
Topics: Animals; Antioxidants; Biological Availability; Blood; Dose-Response Relationship, Drug; Food Industry; Male; Olive Oil; Phenylethyl Alcohol; Plant Oils; Rats; Rats, Sprague-Dawley; Waste Disposal, Fluid | 2001 |
The effect of tyrosol, hydroxytyrosol and oleuropein on the non-enzymatic lipid peroxidation of rat liver microsomes.
Topics: Animals; Cholesterol; Fatty Acids; Iridoid Glucosides; Iridoids; Lipid Peroxidation; Microsomes, Liver; Oxidation-Reduction; Phenylethyl Alcohol; Phospholipids; Pyrans; Rats; Rats, Wistar | 2001 |
Synthesis of the antioxidant hydroxytyrosol using tyrosinase as biocatalyst.
Topics: Agaricales; Antioxidants; Catalysis; Kinetics; Monophenol Monooxygenase; Olive Oil; Phenylethyl Alcohol; Plant Oils | 2001 |
Antioxidant activity of hydroxytyrosol acetate compared with that of other olive oil polyphenols.
Topics: Acetates; Antioxidants; Emulsions; Free Radical Scavengers; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Time Factors | 2001 |
Capillary gas chromatography-mass spectrometry quantitative determination of hydroxytyrosol and tyrosol in human urine after olive oil intake.
Topics: Adult; Aged; Biological Availability; Calibration; Dietary Fats, Unsaturated; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Olive Oil; Phenylethyl Alcohol; Plant Oils; Reference Values; Reproducibility of Results; Sensitivity and Specificity | 2001 |
The in vivo fate of hydroxytyrosol and tyrosol, antioxidant phenolic constituents of olive oil, after intravenous and oral dosing of labeled compounds to rats.
Topics: Administration, Oral; Animals; Antioxidants; Biological Availability; Free Radical Scavengers; Injections, Intravenous; Intestinal Absorption; Isotope Labeling; Male; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Rats; Rats, Sprague-Dawley; Tritium | 2001 |
Effects of virgin olive oil phenolics on scavenging of reactive nitrogen species and upon nitrergic neurotransmission.
Topics: Animals; Antioxidants; Caffeic Acids; Dose-Response Relationship, Drug; Free Radical Scavengers; Iridoid Glucosides; Iridoids; Male; Muscle Relaxation; Muscle, Smooth; Neural Conduction; Nitrates; Nitric Oxide; Nitroprusside; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Pyrans; Rats; Rats, Wistar | 2001 |
Estrogenic activity of phenolic compounds from Nigella damascena evaluated using a recombinant yeast screen.
Topics: Colony-Stimulating Factors; Estrogens; Humans; Lac Operon; Magnoliopsida; Phenylacetates; Phenylethyl Alcohol; Plant Extracts; Plants, Medicinal; Receptors, Estrogen; Recombinant Fusion Proteins; Recombinant Proteins; Saccharomyces cerevisiae | 2001 |
Pharmacokinetics and metabolism of hydroxytyrosol, a natural antioxidant from olive oil.
Topics: Administration, Oral; Animals; Antioxidants; Female; Gastrointestinal Contents; Humans; Male; Olive Oil; Phenylethyl Alcohol; Plant Oils; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2001 |
Urinary excretion of olive oil phenols and their metabolites in humans.
Topics: Biological Availability; Catechol O-Methyltransferase; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Humans; Male; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils | 2001 |
Bioactive derivatives from oleuropein by a biotransformation on Olea europaea leaf extracts.
Topics: Antioxidants; Bioreactors; Biotransformation; Chromatography, Gas; Chromatography, High Pressure Liquid; Colorimetry; Iridoid Glucosides; Iridoids; Lipid Peroxidation; Oleaceae; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Pyrans | 2002 |
Olive oil phenols are absorbed in humans.
Topics: Absorption; Adult; Colon; Dietary Supplements; Drug Stability; Female; Humans; Ileostomy; Iridoid Glucosides; Iridoids; Male; Olive Oil; Phenols; Phenylethyl Alcohol; Placebos; Plant Oils; Pyrans | 2002 |
Structural characterization of the metabolites of hydroxytyrosol, the principal phenolic component in olive oil, in rats.
Topics: Animals; Antioxidants; Free Radical Scavengers; Glucuronides; Homovanillic Acid; Magnetic Resonance Spectroscopy; Molecular Structure; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Rats | 2002 |
Comparison of radical scavenging effect, inhibition of microsomal oxygen free radical generation, and serum lipoprotein oxidation of several natural antioxidants.
Topics: Animals; Antioxidants; Aryl Hydrocarbon Hydroxylases; Bepridil; Biphenyl Compounds; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Free Radical Scavengers; Gallic Acid; Humans; Iridoid Glucosides; Iridoids; Lipid Peroxidation; Lipoproteins, LDL; Male; Microsomes, Liver; Olive Oil; Oxidoreductases, N-Demethylating; Phenylethyl Alcohol; Picrates; Plant Oils; Pyrans; Rats; Rats, Wistar; Reactive Oxygen Species; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 2002 |
Biophenols in table olives.
Topics: Antioxidants; Chromatography, High Pressure Liquid; Flavonoids; Fruit; Greece; Indicators and Reagents; Luteolin; Oleaceae; Phenols; Phenylethyl Alcohol | 2002 |
Hydroxytyrosol 4-beta-D-glucoside, an important phenolic compound in olive fruits and derived products.
Topics: Chromatography, High Pressure Liquid; Flavonoids; Fruit; Glucosides; Magnetic Resonance Spectroscopy; Oleaceae; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Polymers; Polyphenols; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2002 |
Olea europaea L. leaf extract and derivatives: antioxidant properties.
Topics: Antioxidants; Chromatography, Gas; Enzymes, Immobilized; Gas Chromatography-Mass Spectrometry; Glycoside Hydrolases; Oleaceae; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Plant Oils | 2002 |
Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis.
Topics: Adenocarcinoma; Antioxidants; Apoptosis; Cell Division; Colonic Neoplasms; DNA, Neoplasm; G1 Phase; Humans; Leukemia, Promyelocytic, Acute; Olive Oil; Phenylethyl Alcohol; Plant Oils; Tumor Cells, Cultured | 2002 |
Olive oil phenolics: effects on DNA oxidation and redox enzyme mRNA in prostate cells.
Topics: Antioxidants; Caffeic Acids; Cell Survival; Dietary Fats, Unsaturated; DNA Damage; Glutathione Peroxidase; Humans; Lipid Peroxidation; Male; Olive Oil; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Plant Oils; Prostate; RNA, Messenger; Tumor Cells, Cultured | 2002 |
Influence of thermal treatments simulating cooking processes on the polyphenol content in virgin olive oil.
Topics: alpha-Tocopherol; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Flavonoids; Food Handling; Glycerides; Hot Temperature; Lignans; Microwaves; Olive Oil; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Plant Oils; Polymers; Polyphenols; Pressure | 2002 |
Production in large quantities of highly purified hydroxytyrosol from liquid-solid waste of two-phase olive oil processing or "Alperujo".
Topics: Chromatography, High Pressure Liquid; Drug Stability; Food Handling; Hot Temperature; Hydrogen-Ion Concentration; Industrial Waste; Magnetic Resonance Spectroscopy; Olive Oil; Oxidation-Reduction; Phenylethyl Alcohol; Plant Oils; Solubility; Steam | 2002 |
Phenolic compounds profile of cornicabra virgin olive oil.
Topics: Chromatography, High Pressure Liquid; Colorimetry; Drug Stability; Flavonoids; Iridoid Glucosides; Iridoids; Olive Oil; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Plant Oils; Polymers; Polyphenols; Pyrans; Seasons | 2002 |
Antioxidant effect of hydroxytyrosol (DPE) and Mn2+ in liver of cadmium-intoxicated rats.
Topics: Animals; Antioxidants; Cadmium; Liver; Male; Manganese; Phenylethyl Alcohol; Rats; Rats, Wistar | 2002 |
Antioxidants induce different phenotypes by a distinct modulation of signal transduction.
Topics: Antioxidants; Apoptosis; DNA-Binding Proteins; DNA, Complementary; Early Growth Response Protein 1; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Imidazoles; Immediate-Early Proteins; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Models, Chemical; Phenotype; Phenylethyl Alcohol; Phosphorylation; Proto-Oncogene Proteins c-jun; Pyridines; Pyrrolidines; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stilbenes; Thiocarbamates; Time Factors; Transcription Factors; Up-Regulation | 2002 |
Liquid chromatography-tandem mass spectrometry analysis of oleuropein and its metabolite hydroxytyrosol in rat plasma and urine after oral administration.
Topics: Administration, Oral; Animals; Calibration; Iridoid Glucosides; Iridoids; Phenylethyl Alcohol; Pyrans; Rats; Sensitivity and Specificity | 2003 |
Simultaneous determination of oleuropein and hydroxytyrosol in rat plasma using liquid chromatography with fluorescence detection.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Iridoid Glucosides; Iridoids; Phenylethyl Alcohol; Pyrans; Rats; Sensitivity and Specificity; Spectrometry, Fluorescence | 2003 |
Changes in phenolic composition and antioxidant activity of virgin olive oil during frying.
Topics: Antioxidants; Hot Temperature; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Pyrans | 2003 |
Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals.
Topics: Animals; Antioxidants; Arteriosclerosis; Cattle; Cell Adhesion; Cells, Cultured; Diet; Endothelium, Vascular; Flavonoids; Gene Expression Regulation; Humans; Iridoid Glucosides; Iridoids; NF-kappa B; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols; Pyrans; Resveratrol; RNA, Messenger; Stilbenes; Transcription Factor AP-1; Transcription, Genetic; U937 Cells; Vascular Cell Adhesion Molecule-1; Wine | 2003 |
Hydroxytyrosol disposition in humans.
Topics: Adult; Antioxidants; Female; Gas Chromatography-Mass Spectrometry; Humans; Iridoid Glucosides; Iridoids; Male; Middle Aged; Olive Oil; Phenylethyl Alcohol; Plant Oils; Pyrans | 2003 |
Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administration.
Topics: Animals; Antioxidants; Drug Combinations; Humans; Hydrolysis; Iridoid Glucosides; Iridoids; Olive Oil; Pharmaceutical Vehicles; Phenylethyl Alcohol; Plant Oils; Pyrans; Rats; Species Specificity; Yogurt | 2003 |
Fast separation and determination of tyrosol, hydroxytyrosol and other phenolic compounds in extra-virgin olive oil by capillary zone electrophoresis with ultraviolet-diode array detection.
Topics: Electrophoresis, Capillary; Hydrogen-Ion Concentration; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Reproducibility of Results; Spectrophotometry, Ultraviolet; Temperature | 2003 |
3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Homovanillic Acid; Immunohistochemistry; Male; Neurons; Parkinson Disease; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2003 |
Toward a high yield recovery of antioxidants and purified hydroxytyrosol from olive mill wastewaters.
Topics: Antioxidants; Flavonoids; Food Handling; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols; Waste Disposal, Fluid | 2004 |
Effect of cultivar and processing method on the contents of polyphenols in table olives.
Topics: Chromatography, High Pressure Liquid; Flavonoids; Food Handling; Fruit; Olea; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Polyphenols; Species Specificity | 2004 |
An endogenous metabolite of dopamine, 3,4-dihydroxyphenylethanol, acts as a unique cytoprotective agent against oxidative stress-induced injury.
Topics: Amitrole; Animals; Catalase; Cell Death; Cell Survival; Dopamine; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Iron; L-Lactate Dehydrogenase; Nitroso Compounds; Oxidative Stress; PC12 Cells; Phenylethyl Alcohol; Rats; Superoxides | 2004 |
Use of whole cells of Pseudomonas aeruginosa for synthesis of the antioxidant hydroxytyrosol via conversion of tyrosol.
Topics: Antioxidants; Biotransformation; Kinetics; Phenylethyl Alcohol; Pseudomonas aeruginosa; Soil Microbiology | 2004 |
[Isolation and structural identification of C-glycosylflavones from Corallodiscus flabellata].
Topics: Acetophenones; Flavonoids; Glucosides; Glycosides; Magnoliopsida; Molecular Conformation; Molecular Structure; Phenylethyl Alcohol; Plants, Medicinal | 2004 |
Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils.
Topics: Acridines; Adult; Flavonoids; Flow Cytometry; Fluoresceins; Free Radical Scavengers; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Luminescent Measurements; Luminol; Neutrophils; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols; Superoxides | 2004 |
Acid-induced structural modifications of unsaturated Fatty acids and phenolic olive oil constituents by nitrite ions: a chemical assessment.
Topics: Acids; Alkenes; Antineoplastic Agents; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Ions; Iridoid Glucosides; Iridoids; Isomerism; Magnetic Resonance Spectroscopy; Nitrites; Nitrosation; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Pyrans | 2004 |
Antimycoplasmal activity of hydroxytyrosol.
Topics: Antiprotozoal Agents; Flavonoids; Fruit; Mycoplasma fermentans; Mycoplasma hominis; Mycoplasma Infections; Mycoplasma pneumoniae; Olea; Phenols; Phenylethyl Alcohol; Plant Leaves; Polyphenols | 2004 |
Radical scavenging potential of phenolic compounds encountered in O. europaea products as indicated by calculation of bond dissociation enthalpy and ionization potential values.
Topics: Chemical Phenomena; Chemistry, Physical; Free Radical Scavengers; Olea; Phenols; Phenylethyl Alcohol; Thermodynamics | 2005 |
Activity of olive oil phenols on lymphomonocyte cytosolic calcium.
Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Cytosol; Humans; Kinetics; Lymphocytes; Monocytes; Nifedipine; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils | 2005 |
Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells.
Topics: Antioxidants; Apoptosis; Humans; Isoaspartic Acid; Lipid Peroxidation; Melanoma; Methylation; Olive Oil; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Proteins; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Tumor Cells, Cultured; Ultraviolet Rays | 2005 |
Interactions of ferric ions with olive oil phenolic compounds.
Topics: Drug Stability; Ferric Compounds; Hydrogen-Ion Concentration; Iridoid Glucosides; Iridoids; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Pyrans | 2005 |
A thromboxane effect of a hydroxytyrosol-rich olive oil wastewater extract in patients with uncomplicated type I diabetes.
Topics: Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Dinoprost; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Olive Oil; Phenylethyl Alcohol; Plant Oils; Platelet Aggregation; Thromboxane B2; Time Factors; Waste Disposal, Fluid; Waste Products | 2005 |
Antioxidant and anti-atherogenic activities of olive oil phenolics.
Topics: Antioxidants; Arteriosclerosis; Cell Adhesion Molecules; Cells, Cultured; Chemokine CCL2; Endothelium; Homovanillic Acid; Hydrogen Peroxide; In Vitro Techniques; Intercellular Adhesion Molecule-1; Iridoid Glucosides; Iridoids; Lipoproteins, LDL; Macrophages; Nitric Oxide; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Platelet Aggregation; Pyrans; Vascular Cell Adhesion Molecule-1 | 2005 |
Diverse effects of natural antioxidants on cyclosporin cytotoxicity in rat renal tubular cells.
Topics: Animals; Antioxidants; Cell Survival; Cells, Cultured; Cyclosporine; Epithelium; Fluoresceins; Glutathione; Kidney Diseases; Kidney Tubules, Proximal; Lipid Peroxides; Phenylethyl Alcohol; Rats; Rats, Inbred WKY; Reactive Oxygen Species; Resveratrol; Stilbenes; Thiobarbituric Acid Reactive Substances; Vitamin E | 2005 |
Relationships between oxidative stability, triacylglycerol composition, and antioxidant content in olive oil matrices.
Topics: alpha-Tocopherol; Antioxidants; Drug Stability; Olive Oil; Oxidation-Reduction; Phenylethyl Alcohol; Plant Oils; Triglycerides | 2005 |
[Studies on chemical constituents from the corm of Cremastra appendiculata].
Topics: Orchidaceae; Phenylethyl Alcohol; Plants, Medicinal; Sitosterols | 2005 |
Hydroxytyrosol, a phenolic compound from virgin olive oil, prevents macrophage activation.
Topics: Animals; Antioxidants; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Interferon Regulatory Factor-1; Interferon-Stimulated Gene Factor 3; Lipopolysaccharides; Macrophage Activation; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Olive Oil; Phenylethyl Alcohol; Plant Oils; Reactive Oxygen Species; RNA, Messenger | 2005 |
DNA protecting and genotoxic effects of olive oil related components in cells exposed to hydrogen peroxide.
Topics: Caffeic Acids; Chromatography, High Pressure Liquid; Comet Assay; DNA; DNA Damage; Humans; Hydrogen Peroxide; Iridoid Glucosides; Iridoids; Jurkat Cells; Nuclear Magnetic Resonance, Biomolecular; Olea; Olive Oil; Phenylethyl Alcohol; Plant Extracts; Plant Oils; Pyrans | 2005 |
Development of a sensitive and specific solid phase extraction--gas chromatography-tandem mass spectrometry method for the determination of elenolic acid, hydroxytyrosol, and tyrosol in rat urine.
Topics: Animals; Female; Gas Chromatography-Mass Spectrometry; Mass Spectrometry; Phenylethyl Alcohol; Pyrans; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Synthesis of hydroxytyrosol, 2-hydroxyphenylacetic acid, and 3-hydroxyphenylacetic acid by differential conversion of tyrosol isomers using Serratia marcescens strain.
Topics: Kinetics; Phenylacetates; Phenylethyl Alcohol; Serratia marcescens; Soil Microbiology | 2005 |
Model study on the effect of 15 phenolic olive mill wastewater constituents on seed germination and Vibrio fischeri metabolism.
Topics: Aliivibrio fischeri; Catechols; Cucumis; Flavonoids; Germination; Herbicides; Industrial Waste; Lepidium sativum; Olea; Phenols; Phenylethyl Alcohol; Polyphenols; Seeds; Sorghum | 2005 |
One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development.
Topics: Animals; Antioxidants; Aortic Diseases; Atherosclerosis; Diet; Fatty Acids; Hyperlipidemias; Lipids; Male; Olive Oil; Phenylethyl Alcohol; Plant Oils; Rabbits | 2006 |
Protective effects of synthetic hydroxytyrosol acetyl derivatives against oxidative stress in human cells.
Topics: Acetylation; Antioxidants; Erythrocytes; Humans; Oxidative Stress; Phenylethyl Alcohol | 2005 |
Metabolism of the olive oil phenols hydroxytyrosol, tyrosol, and hydroxytyrosyl acetate by human hepatoma HepG2 cells.
Topics: Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Glucuronides; Humans; In Vitro Techniques; Mass Spectrometry; Methylation; Microsomes, Liver; Olive Oil; Phenylethyl Alcohol; Plant Oils; Rats; Rats, Wistar; Sulfates | 2005 |
Physicochemical properties of natural phenolics from grapes and olive oil byproducts and their antioxidant activity in frozen horse mackerel fillets.
Topics: Animals; Antioxidants; Chemical Phenomena; Chemistry, Physical; Food Preservation; Freezing; Fruit; Olive Oil; Perciformes; Phenols; Phenylethyl Alcohol; Plant Oils; Proanthocyanidins; Propyl Gallate; Vitis | 2006 |
Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells.
Topics: Apoptosis; Carcinoma; Caspase 3; Caspases; Cell Line, Tumor; Colonic Neoplasms; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Humans; Models, Biological; NF-kappa B; Phenylethyl Alcohol; Phosphoprotein Phosphatases; Protein Phosphatase 2; Signal Transduction; Tumor Necrosis Factor-alpha | 2006 |
Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation.
Topics: Cell Adhesion Molecules; E-Selectin; Endothelium, Vascular; Gene Expression; Humans; Intercellular Adhesion Molecule-1; Iridoid Glucosides; Iridoids; Olive Oil; Phenylethyl Alcohol; Plant Oils; Pyrans; RNA, Messenger; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2006 |
Lipophilic hydroxytyrosyl esters. Antioxidant activity in lipid matrices and biological systems.
Topics: Acetates; alpha-Tocopherol; Animals; Antioxidants; Brain; Butylated Hydroxytoluene; Esters; Linoleic Acid; Lipid Peroxidation; Oleic Acid; Palmitates; Phenylethyl Alcohol; Proteins; Rats; Rats, Wistar | 2006 |
The use of Lactobacillus pentosus 1MO to shorten the debittering process time of black table olives (Cv. Itrana and Leccino): a pilot-scale application.
Topics: Fermentation; Food Handling; Fruit; Hydrogen-Ion Concentration; Iridoid Glucosides; Iridoids; Lactobacillus; Olea; Phenols; Phenylethyl Alcohol; Pyrans; Taste | 2006 |
Inhibition of hemoglobin- and iron-promoted oxidation in fish microsomes by natural phenolics.
Topics: Animals; Antioxidants; Chemical Phenomena; Chemistry, Physical; Fruit; Gadiformes; Hemoglobins; Iron; Lipid Peroxidation; Microsomes; Olive Oil; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Plant Oils; Proanthocyanidins; Propyl Gallate; Vitis | 2006 |
Hydroxytyrosol administration enhances atherosclerotic lesion development in apo E deficient mice.
Topics: Animals; Apolipoprotein A-I; Apolipoproteins B; Apolipoproteins E; Aryldialkylphosphatase; Cholesterol, HDL; Coronary Artery Disease; DNA Primers; Macrophage-1 Antigen; Male; Mice; Monocytes; Phenylethyl Alcohol; Reverse Transcriptase Polymerase Chain Reaction; Triglycerides | 2006 |
Effects of olive oil and its minor constituents on serum lipids, oxidative stress, and energy metabolism in cardiac muscle.
Topics: Animals; Antioxidants; Dietary Fats, Unsaturated; Energy Metabolism; Flavonoids; Lipids; Male; Myocardium; Oleic Acid; Olive Oil; Oxidative Stress; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols; Rats; Rats, Wistar | 2006 |
Hydroxytyrosol lipophilic analogues: enzymatic synthesis, radical scavenging activity and DNA oxidative damage protection.
Topics: Acetylation; Bacteria; Biphenyl Compounds; Chemical Phenomena; Chemistry, Physical; Comet Assay; DNA; DNA Damage; Free Radical Scavengers; Fungi; Humans; In Vitro Techniques; Indicators and Reagents; Lipase; Mutagens; Oxidative Stress; Phenylethyl Alcohol; Picrates; Solubility | 2007 |
The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NObullet response of isolated rat aorta.
Topics: Animals; Antioxidants; Aorta; Benzene Derivatives; Cyclic GMP; Diet, Mediterranean; Free Radical Scavengers; Hydroxyl Radical; In Vitro Techniques; Male; Olive Oil; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Rats; Rats, Inbred Lew | 2007 |
Production of high hydroxytyrosol yields via tyrosol conversion by Pseudomonas aeruginosa immobilized resting cells.
Topics: Catalysis; Cells, Immobilized; Kinetics; Phenylethyl Alcohol; Pseudomonas aeruginosa | 2006 |
Effect of steam treatment of alperujo on the composition, enzymatic saccharification, and in vitro digestibility of alperujo.
Topics: Cellulase; Cellulose; Food Handling; Hydrogen-Ion Concentration; Hydrolysis; Olive Oil; Pepsin A; Phenylethyl Alcohol; Plant Oils; Steam | 2007 |
Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide.
Topics: Antioxidants; Biological Availability; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Humans; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver Neoplasms; Malondialdehyde; Olive Oil; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Reactive Oxygen Species; tert-Butylhydroperoxide; Time Factors | 2007 |
Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: part II. integrase inhibition.
Topics: Catalytic Domain; HIV Integrase; HIV Integrase Inhibitors; Iridoid Glucosides; Iridoids; Models, Molecular; Phenylethyl Alcohol; Pyrans; Structure-Activity Relationship | 2007 |
Hypocholesterolemic effects of phenolic extracts and purified hydroxytyrosol recovered from olive mill wastewater in rats fed a cholesterol-rich diet.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Catalase; Cholesterol, Dietary; Industrial Waste; Lipids; Liver; Male; Olea; Phenols; Phenylethyl Alcohol; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2007 |
Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. fusion [corrected] inhibition.
Topics: Chromatography, Liquid; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; HIV Envelope Protein gp41; HIV Integrase Inhibitors; HIV-1; Iridoid Glucosides; Iridoids; Mass Spectrometry; Models, Molecular; Phenylethyl Alcohol; Pyrans | 2007 |
A new process for the management of olive oil mill waste water and recovery of natural antioxidants.
Topics: Antioxidants; Flavonoids; Industrial Waste; Lactones; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols; Waste Management; Water | 2007 |
No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells.
Topics: Cardiovascular Diseases; Cell Line; Citrulline; Endothelial Cells; Flavonoids; Genes, Reporter; Humans; Inflammation; Luciferases; Nitric Oxide; Nitric Oxide Synthase Type III; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols; Transcriptional Activation; Wine | 2007 |
Black Lucques olives prevented bone loss caused by ovariectomy and talc granulomatosis in rats.
Topics: Animals; Antioxidants; Body Weight; Bone Density; Calcium; Disease Models, Animal; Female; Fruit; Humans; Inflammation; Olea; Organ Size; Osteoporosis; Osteoporosis, Postmenopausal; Ovariectomy; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Wistar; Talc; Uterus; Vitamin E | 2007 |
High-yielding preparation of a stable precursor of hydroxytyrosol by total synthesis and from the natural glycoside oleuropein.
Topics: Antioxidants; Drug Stability; Food Additives; Iridoid Glucosides; Iridoids; Phenylethyl Alcohol; Pyrans | 2007 |
Static-dynamic superheated liquid extraction of hydroxytyrosol and other biophenols from alperujo (a semisolid residue of the olive oil industry).
Topics: Hot Temperature; Industrial Waste; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Sensitivity and Specificity | 2007 |
Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats.
Topics: Adipose Tissue, Brown; Animals; Corn Oil; Dietary Fats, Unsaturated; Epinephrine; Ion Channels; Male; Mitochondrial Proteins; Norepinephrine; Olive Oil; Phenylethyl Alcohol; Plant Oils; Rats; Rats, Sprague-Dawley; Uncoupling Protein 1 | 2007 |
Mild photochemical synthesis of the antioxidant hydroxytyrosol via conversion of tyrosol.
Topics: Antioxidants; Catalysis; Kinetics; Phenylethyl Alcohol; Photochemistry; Thermodynamics; Ultraviolet Rays | 2007 |
Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo.
Topics: Adenosine Triphosphate; Animals; Brain; Cell Death; Diet; Female; Industrial Waste; Mice; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Plant Oils | 2007 |
Computational study of bindings of olive leaf extract (OLE) to HIV-1 fusion protein gp41.
Topics: Antiviral Agents; Computer Simulation; HIV Envelope Protein gp41; HIV-1; Humans; Hydrogen Bonding; Iridoid Glucosides; Iridoids; Models, Molecular; Molecular Structure; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Protein Binding; Pyrans; Thermodynamics | 2007 |
Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants.
Topics: Antioxidants; Cell Adhesion; Cells, Cultured; Diet, Mediterranean; Dose-Response Relationship, Drug; Endothelial Cells; Flavonoids; Homocysteine; Humans; Hyperhomocysteinemia; I-kappa B Proteins; Monocytes; Mutation; NADPH Oxidases; Phenols; Phenylethyl Alcohol; Phosphorylation; Polyphenols; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Protein Transport; Reactive Oxygen Species; Resveratrol; RNA, Messenger; Stilbenes; Transcription Factor RelA; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2007 |
New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol.
Topics: Antioxidants; Diet; Free Radical Scavengers; Humans; Lipid Peroxidation; Lipoproteins, LDL; Olive Oil; Phenylethyl Alcohol; Plant Oils | 2007 |
Bioconversion of tyrosol into hydroxytyrosol and 3,4-dihydroxyphenylacetic acid under hypersaline conditions by the new Halomonas sp. strain HTB24.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aldehydes; Base Composition; Biotransformation; DNA, Bacterial; DNA, Ribosomal; Food Microbiology; Halomonas; Industrial Waste; Molecular Sequence Data; Phenylacetates; Phenylethyl Alcohol; Phylogeny; Pyruvic Acid; RNA, Ribosomal, 16S; Salinity; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Succinic Acid; Water Microbiology | 2007 |
Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Caffeic Acids; Cell Survival; Collagen; Colonic Neoplasms; Drug Combinations; Humans; Laminin; Neoplasm Invasiveness; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Proteoglycans; Tumor Cells, Cultured | 2008 |
High-yielding synthesis of methyl orthoformate-protected hydroxytyrosol and its use in preparation of hydroxytyrosyl acetate.
Topics: Acetates; Benzodioxoles; Catechols; Phenylethyl Alcohol | 2007 |
Main antimicrobial compounds in table olives.
Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Fermentation; Iridoid Glucosides; Iridoids; Lactobacillus; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Olea; Phenylethyl Alcohol; Pyrans; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2007 |
Cytoprotective effects of phenolic antioxidants and essential fatty acids in human blood monocyte and neuroblastoma cell lines: surrogates for neurological damage in vivo.
Topics: Antioxidants; Ascorbic Acid; Cell Line, Tumor; Cytoprotection; DNA Damage; Fatty Acids, Essential; Fatty Acids, Unsaturated; Humans; Hydrogen Peroxide; Monocytes; Neurons; Oxidants; Oxidative Stress; Phenols; Phenylethyl Alcohol; Vitamin E | 2008 |
In vivo effect of the natural antioxidant hydroxytyrosol on cyclosporine nephrotoxicity in rats.
Topics: Animals; Antioxidants; Aorta, Abdominal; Cyclosporine; Disease Models, Animal; Ethidium; Gene Expression; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glutathione; Heme Oxygenase-1; Immunosuppressive Agents; Kidney Glomerulus; Lipid Peroxidation; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; Thiobarbituric Acid Reactive Substances; Treatment Outcome | 2008 |
Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells.
Topics: Apoptosis; Cell Cycle; Cell Differentiation; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; HL-60 Cells; Humans; Intracellular Signaling Peptides and Proteins; Phenylethyl Alcohol; Up-Regulation | 2008 |
Inhibition of Sudan I genotoxicity in human liver-derived HepG2 cells by the antioxidant hydroxytyrosol.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Antioxidants; Cell Line, Tumor; Deoxyguanosine; DNA Damage; Glutathione; Humans; Lipid Peroxidation; Micronucleus Tests; Mutagens; Naphthols; Phenylethyl Alcohol; Reactive Oxygen Species | 2008 |
Lipid-lowering and antioxidant effects of hydroxytyrosol and its triacetylated derivative recovered from olive tree leaves in cholesterol-fed rats.
Topics: Acetylation; Animals; Antioxidants; Catalase; Cholesterol, Dietary; Hypolipidemic Agents; Lipids; Liver; Male; Olea; Phenylethyl Alcohol; Plant Leaves; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2008 |
Hydroxytyrosol prevents oxidative deterioration in foodstuffs rich in fish lipids.
Topics: Animals; Antioxidants; Cod Liver Oil; Emulsions; Fish Oils; Food Preservation; Lipid Peroxidation; Muscles; Oxidation-Reduction; Perciformes; Phenylethyl Alcohol | 2008 |
Tunisian table olive phenolic compounds and their antioxidant capacity.
Topics: Antioxidants; Chromans; Diet; Fruit; Nutritive Value; Olea; Phenols; Phenylethyl Alcohol; Species Specificity; Tunisia; Vanillic Acid | 2008 |
Correlations of the phenolic compounds and the phenolic content in some Spanish and French olive oils.
Topics: alpha-Tocopherol; Chromatography, Liquid; France; Mass Spectrometry; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Regression Analysis; Spain | 2008 |
Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H(2)O(2) induced lipid peroxidation in renal tubular epithelial cells.
Topics: alpha-Tocopherol; Animals; Antioxidants; Cholesterol; Epithelial Cells; Fatty Acids, Nonesterified; Homovanillic Acid; Hydrogen Peroxide; Kidney Tubules; Lipid Peroxidation; LLC-PK1 Cells; Malondialdehyde; Membrane Lipids; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Protective Agents; Serotonin; Swine | 2008 |
2-Arylhydroxytyrosol derivatives via Suzuki-Miyaura cross-coupling.
Topics: Molecular Structure; Phenylethyl Alcohol; Stereoisomerism | 2008 |
Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells.
Topics: Antioxidants; DNA Damage; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Hydrogen Peroxide; Leukocytes, Mononuclear; Olea; Olive Oil; Oxidative Stress; Phenols; Phenylethyl Alcohol; Plant Oils | 2008 |
Effects of hydroxytyrosol and hydroxytyrosol acetate administration to rats on platelet function compared to acetylsalicylic acid.
Topics: Acetates; Animals; Aspirin; Blood Platelets; Catechols; Collagen; Eicosanoids; Male; Nitric Oxide; Phenylethyl Alcohol; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar | 2008 |
Inhibition of acrylamide genotoxicity in human liver-derived HepG2 cells by the antioxidant hydroxytyrosol.
Topics: Acrylamide; Antioxidants; Blotting, Western; Cell Line, Tumor; Dose-Response Relationship, Drug; Fluoresceins; Fluorescent Dyes; Glutamate-Cysteine Ligase; Glutathione; Humans; Liver; Micronucleus Tests; Phenylethyl Alcohol; Reactive Oxygen Species | 2008 |
Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol.
Topics: Chromatography, High Pressure Liquid; Dithionite; Esterification; Homovanillic Acid; Hydrolysis; Iodobenzenes; Iodobenzoates; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Phenylethyl Alcohol | 2008 |
Virgin olive oil polyphenol hydroxytyrosol acetate inhibits in vitro platelet aggregation in human whole blood: comparison with hydroxytyrosol and acetylsalicylic acid.
Topics: 6-Ketoprostaglandin F1 alpha; Acetates; Adult; Aspirin; Blood Platelets; Catechols; Dose-Response Relationship, Drug; Female; Humans; Leukocytes; Male; Nitric Oxide; Olive Oil; Phenylethyl Alcohol; Plant Oils; Platelet Aggregation; Thromboxane B2 | 2009 |
Static-dynamic sequential superheated liquid extraction of phenols and fatty acids from alperujo.
Topics: Acetonitriles; Antioxidants; Biotechnology; Chloroform; Chromatography, High Pressure Liquid; Fatty Acids; Formates; Gas Chromatography-Mass Spectrometry; Hot Temperature; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Solvents; Time Factors; Water | 2008 |
Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model.
Topics: Animals; Bone Density; Bone Density Conservation Agents; Disease Models, Animal; Female; Flavonoids; Humans; Inflammation; Olive Oil; Osteoporosis; Ovariectomy; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols; Random Allocation; Rats; Rats, Wistar | 2008 |
Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia-reoxygenation.
Topics: Acetates; Animals; Antioxidants; Brain; Catechols; Diet, Mediterranean; Dose-Response Relationship, Drug; Energy Metabolism; Hypoxia-Ischemia, Brain; L-Lactate Dehydrogenase; Male; Nerve Degeneration; Neuroprotective Agents; Olive Oil; Organ Culture Techniques; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Rats; Rats, Wistar; Reperfusion Injury | 2008 |
Does white wine qualify for French paradox? Comparison of the cardioprotective effects of red and white wines and their constituents: resveratrol, tyrosol, and hydroxytyrosol.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cardiotonic Agents; Heart; Humans; In Vitro Techniques; Male; Mitochondrial Swelling; Myocardial Ischemia; Myocardium; Peroxides; Phenylethyl Alcohol; Random Allocation; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Wine | 2008 |
Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves.
Topics: Animals; Antioxidants; beta-Glucosidase; Catalase; Cholesterol, Dietary; Enzyme Activation; Heart; Hydrochloric Acid; Hydrolysis; Hypercholesterolemia; Iridoid Glucosides; Iridoids; Lipid Peroxidation; Lipids; Liver; Male; Molecular Structure; Olea; Organ Size; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Pyrans; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2008 |
Hydroxytyrosol increases norepinephrine transporter function in pheochromocytoma cells.
Topics: 3-Iodobenzylguanidine; Animals; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; PC12 Cells; Phenylethyl Alcohol; Rats; Tritium | 2008 |
New lipophilic tyrosyl esters. Comparative antioxidant evaluation with hydroxytyrosyl esters.
Topics: Antioxidants; Benzenesulfonates; Benzothiazoles; Candida; Drug Stability; Esters; Ferric Compounds; Lipase; Phenylethyl Alcohol; Structure-Activity Relationship; Sulfonic Acids | 2008 |
Measurement of free hydroxytyrosol in microdialysates from blood and brain of anesthetized rats by liquid chromatography with fluorescence detection.
Topics: Anesthesia; Animals; Brain; Chromatography, High Pressure Liquid; Chromatography, Liquid; Fluorescence; Male; Microdialysis; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Time Factors | 2009 |
Effects of hydroxytyrosol-20 on carrageenan-induced acute inflammation and hyperalgesia in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Hyperalgesia; Inflammation; Interleukin-10; Interleukin-1beta; Male; Olea; Pain Measurement; Phenylethyl Alcohol; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha | 2009 |
Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol.
Topics: Aging; Animals; Apoptosis; Cardiotonic Agents; Forkhead Transcription Factors; In Situ Nick-End Labeling; Myocytes, Cardiac; Nerve Tissue Proteins; Nicotinamide Phosphoribosyltransferase; Oncogene Protein v-akt; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Resveratrol; Signal Transduction; Sirtuins; Stilbenes; Transcriptional Activation; Wine | 2009 |
Chemistry and bioactivity of olive biophenols in some antioxidant and antiproliferative in vitro bioassays.
Topics: Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Free Radical Scavengers; Humans; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Pyrans | 2009 |
Inhibition of ovulation by a lipoxygenase inhibitor involves reduced cyclooxygenase-2 expression and prostaglandin E2 production in gonadotropin-primed immature rats.
Topics: Animals; Chorionic Gonadotropin; Cyclooxygenase 2; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Female; Gonadotropins, Equine; Immunohistochemistry; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Models, Animal; Ovary; Ovulation; Ovulation Induction; Phenylethyl Alcohol; Progesterone; Protein Isoforms; Rats; Rats, Wistar; Time Factors | 2009 |
Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells.
Topics: Cyclooxygenase 2; Cytokines; Gene Expression Regulation; Humans; Inflammation Mediators; Monocytes; Nitric Oxide Synthase Type II; Phenylethyl Alcohol | 2009 |
Impact of sampling parameters on the radical scavenging potential of olive (Olea europaea L.) leaves.
Topics: Flavonoids; Free Radical Scavengers; Iridoid Glucosides; Iridoids; Olea; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Pyrans; Species Specificity; Time Factors | 2009 |
Suppressive effects of hydroxytyrosol on oxidative stress and nuclear Factor-kappaB activation in THP-1 cells.
Topics: Antioxidants; Blotting, Western; Cell Line; Cell Nucleus; Free Radical Scavengers; Glutathione; Humans; Lipopolysaccharides; NF-kappa B; Nitric Oxide; Oxidative Stress; Phenylethyl Alcohol; Reactive Oxygen Species; Stimulation, Chemical | 2009 |
Effect of malaxation conditions on phenol and volatile profiles in olive paste and the corresponding virgin olive oils (Olea europaea L. Cv. Cornicabra).
Topics: Aldehydes; Consumer Behavior; Food Handling; Fruit; Iridoid Glucosides; Iridoids; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Pyrans; Temperature; Volatilization | 2009 |
Effects of olive oil polyphenols on erythrocyte oxidative damage.
Topics: Adult; Amino Acid Sequence; Erythrocytes; Female; Flavonoids; Humans; Iridoid Glucosides; Iridoids; Male; Membrane Proteins; Middle Aged; Molecular Sequence Data; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols; Pyrans | 2009 |
Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aldehyde Reductase; Aldehydes; Animals; Dopamine; Lipid Peroxidation; Malondialdehyde; Oxidation-Reduction; Oxidative Stress; PC12 Cells; Phenylethyl Alcohol; Rats | 2009 |
Hypoglycemic and antioxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats.
Topics: Animals; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Flavonoids; Glutathione Peroxidase; Hypoglycemic Agents; Kidney; Liver; Liver Function Tests; Male; Olea; Pancreas; Phenols; Phenylethyl Alcohol; Plant Extracts; Polyphenols; Rats; Rats, Wistar; Superoxide Dismutase | 2009 |
Time course of changes in the expression of insulin sensitivity-related genes after an acute load of virgin olive oil.
Topics: Adult; Antioxidants; Blood Glucose; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Insulin; Insulin Resistance; Leukocytes, Mononuclear; Lipids; Male; Nutrigenomics; Oligonucleotide Array Sequence Analysis; Olive Oil; Phenylethyl Alcohol; Plant Oils; Time Factors; Young Adult | 2009 |
Protective effect of hydroxytyrosol against acrylamide-induced cytotoxicity and DNA damage in HepG2 cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrylamide; Antioxidants; Cell Line; Deoxyguanosine; DNA Breaks; DNA Damage; Glutathione; Humans; Mutagens; Phenylethyl Alcohol; Reactive Oxygen Species | 2009 |
Synthesis of hydroxytyrosyl alkyl ethers from olive oil waste waters.
Topics: Alkylation; Antioxidants; Ethers; Industrial Waste; Lipids; Molecular Structure; Olive Oil; Oxidation-Reduction; Phenylethyl Alcohol; Plant Oils; Refuse Disposal | 2009 |
Mechanism of the antiviral effect of hydroxytyrosol on influenza virus appears to involve morphological change of the virus.
Topics: Adenoviridae; Animals; Antiviral Agents; Cell Line; Cytoplasm; Dogs; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza A Virus, H5N1 Subtype; Influenza A Virus, H9N2 Subtype; Newcastle disease virus; Phenylethyl Alcohol; RNA, Viral; Rotavirus; Viral Proteins; Virion; Virus Assembly; Virus Attachment; Virus Replication | 2009 |
Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Apoptosis; Caffeic Acids; HL-60 Cells; Humans; Hydrogen Peroxide; Phenylethyl Alcohol | 2009 |
A concise synthesis of glucuronide metabolites of urolithin-B, resveratrol, and hydroxytyrosol.
Topics: Coumarins; Glucuronides; Glycosylation; Phenylethyl Alcohol; Resveratrol; Stereoisomerism; Stilbenes | 2009 |
3,4-Dihydroxyphenylglycol (DHPG): an important phenolic compound present in natural table olives.
Topics: Antioxidants; Chromatography, High Pressure Liquid; Fruit; Glucosides; Methoxyhydroxyphenylglycol; Olea; Phenols; Phenylethyl Alcohol | 2009 |
Gingival vascular damage in atherosclerotic rabbits: hydroxytyrosol and squalene benefits.
Topics: Animals; Antioxidants; Arteries; Atherosclerosis; Collagen; Diet, Atherogenic; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Fibrosis; Gingiva; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mouth Mucosa; Olive Oil; Periodontal Diseases; Phenylethyl Alcohol; Plant Oils; Rabbits; Squalene; Ubiquinone | 2009 |
Plant catechols and their S-glutathionyl conjugates as antinitrosating agents: expedient synthesis and remarkable potency of 5-S-glutathionylpiceatannol.
Topics: 2-Naphthylamine; Caffeic Acids; Catechols; Chlorogenic Acid; Free Radical Scavengers; Glutathione; Nitrosation; Phenylethyl Alcohol; Plant Extracts; Reactive Nitrogen Species; Stilbenes | 2008 |
Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; AMP-Activated Protein Kinases; Animals; Cardiovascular Diseases; Cell Respiration; DNA-Binding Proteins; DNA, Mitochondrial; Enzyme Activation; Fatty Acids, Nonesterified; Gene Expression Regulation; Mice; Mitochondria; Mitochondrial Proteins; Nuclear Respiratory Factors; Osmolar Concentration; Oxidative Phosphorylation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Peroxisome Proliferator-Activated Receptors; Phenylethyl Alcohol; RNA, Messenger; RNA, Small Interfering; Trans-Activators; Transcription Factors | 2010 |
The protective effects of hydroxytyrosol against UVB-induced DNA damage in HaCaT cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Cell Line; Comet Assay; Deoxyguanosine; DNA Damage; Humans; NF-kappa B; Oxidative Stress; Phenylethyl Alcohol; Reactive Oxygen Species; Tumor Suppressor Protein p53; Ultraviolet Rays | 2010 |
Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phenylethyl Alcohol; Phosphorylation | 2009 |
Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Iridoid Glucosides; Iridoids; Liver; Male; Olea; Oxidative Stress; Phenylethyl Alcohol; Phytotherapy; Plant Extracts; Plant Leaves; Pyrans; Rats; Rats, Wistar | 2009 |
Alcohol consumption is associated with high concentrations of urinary hydroxytyrosol.
Topics: Aged; Alcohol Drinking; Cardiovascular Diseases; Cross-Sectional Studies; Diet, Mediterranean; Energy Intake; Exercise; Female; Health Status; Humans; Life Style; Male; Middle Aged; Multicenter Studies as Topic; Olive Oil; Phenylethyl Alcohol; Plant Oils; Randomized Controlled Trials as Topic; Risk Assessment; Socioeconomic Factors; Spain; Surveys and Questionnaires; Wine | 2009 |
Effect of lipophilization of hydroxytyrosol on its antioxidant activity in fish oils and fish oil-in-water emulsions.
Topics: Animals; Antioxidants; Emulsions; Fish Oils; Gadus morhua; Humans; Molecular Structure; Oxidation-Reduction; Phenylethyl Alcohol; Taste | 2009 |
Hydroxytyrosol from tyrosol using hydroxyphenylacetic acid-induced bacterial cultures and evidence of the role of 4-HPA 3-hydroxylase.
Topics: Bacteria; Biotransformation; Culture Media; Escherichia coli; Halomonas; Micrococcus luteus; Mixed Function Oxygenases; Phenylacetates; Phenylethyl Alcohol; Pseudomonas aeruginosa; Serratia marcescens; Water Pollutants, Chemical | 2009 |
Identification of Throuba Thassos, a traditional Greek table olive variety, as a nutritional rich source of oleuropein.
Topics: Food Handling; Greece; Humans; Iridoid Glucosides; Iridoids; Nutritive Value; Olea; Phenylethyl Alcohol; Pyrans | 2010 |
Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Estradiol; Estrogen Receptor alpha; Female; Humans; Iridoid Glucosides; Iridoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phenylethyl Alcohol; Protein Kinase Inhibitors; Pyrans; Transcriptional Activation | 2010 |
Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol.
Topics: Animals; Cell Survival; Cells, Cultured; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Homovanillic Acid; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Phenylethyl Alcohol; Proto-Oncogene Proteins c-akt; Signal Transduction; Swine | 2010 |
Human absorption of a supplement containing purified hydroxytyrosol, a natural antioxidant from olive oil, and evidence for its transient association with low-density lipoproteins.
Topics: Adult; Antioxidants; Female; Humans; Intestinal Absorption; Lipoproteins, LDL; Male; Olive Oil; Phenylethyl Alcohol; Plant Oils | 2010 |
Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells.
Topics: Acrolein; Antioxidants; Cell Line; Dietary Supplements; DNA-Binding Proteins; Flavonoids; Humans; Ion Channels; Macular Degeneration; Metabolic Detoxication, Phase II; Mitochondria; Mitochondrial Proteins; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Phenols; Phenylethyl Alcohol; Pigment Epithelium of Eye; Polyphenols; PPAR alpha; Transcription Factors; Uncoupling Protein 2 | 2010 |
Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Nucleus; Diet, Mediterranean; Enzyme Induction; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glutathione; Hep G2 Cells; Humans; Liver; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protective Agents; Protein Transport; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; tert-Butylhydroperoxide | 2010 |
Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats.
Topics: Animals; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Flavonoids; Glucose Intolerance; Heart; Hypertension; Inflammation; Liver; Male; Metabolic Syndrome; Myocardium; Obesity; Olea; Oxidative Stress; Phenols; Phenylethyl Alcohol; Phytotherapy; Plant Extracts; Plant Leaves; Polyphenols; Rats; Rats, Wistar | 2010 |
[Studies on the chemical constituents from Rhododendron delavayi].
Topics: Catechin; Chromatography, High Pressure Liquid; Flavonols; Molecular Structure; Phenylethyl Alcohol; Plant Leaves; Plant Stems; Plants, Medicinal; Quercetin; Rhododendron | 2009 |
Antioxidant activities of hydroxytyrosol main metabolites do not contribute to beneficial health effects after olive oil ingestion.
Topics: Antioxidants; Chromatography, High Pressure Liquid; Humans; Lipoproteins, LDL; Mass Spectrometry; Olive Oil; Phenylethyl Alcohol; Plant Oils | 2010 |
Surface-active properties of lipophilic antioxidants tyrosol and hydroxytyrosol fatty acid esters: a potential explanation for the nonlinear hypothesis of the antioxidant activity in oil-in-water emulsions.
Topics: Antioxidants; Emulsions; Esters; Oils; Phenylethyl Alcohol; Surface Properties; Surface-Active Agents | 2010 |
Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media.
Topics: Anthocyanins; Cell Culture Techniques; Cinnamates; Culture Media; Depsides; Drug Stability; Flavonoids; Hydrogen Peroxide; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Polyphenols; Rosmarinic Acid | 2010 |
Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells.
Topics: Animals; Antioxidants; Cytoprotection; Iron; Olea; Oxidative Stress; PC12 Cells; Phenylethyl Alcohol; Plant Extracts; Rats; Waste Disposal, Fluid | 2010 |
HPLC analysis of oleuropein, hydroxytyrosol, and tyrosol in stems and roots of Olea europaea L. cv. Picual during ripening.
Topics: Antioxidants; Chromatography, High Pressure Liquid; Fruit; Iridoid Glucosides; Iridoids; Olea; Phenylethyl Alcohol; Plant Leaves; Plant Roots; Plant Stems; Pyrans; Seasons; Spain; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells.
Topics: alpha-Tocopherol; Antioxidants; Caco-2 Cells; Cell Survival; Cholesterol; Fatty Acids; Free Radical Scavengers; Humans; Ketocholesterols; Linoleic Acid; Lipid Peroxidation; Malondialdehyde; Olive Oil; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Plant Oils | 2010 |
Improving biocatalyst performance by integrating statistical methods into protein engineering.
Topics: Biostatistics; Directed Molecular Evolution; Hydroxylation; Kinetics; Mutant Proteins; Oxygenases; Phenylethyl Alcohol; Protein Engineering | 2010 |
Hydroxytyrosol acyl esters: biosynthesis and activities.
Topics: Acetates; Catechols; Cell Proliferation; Enzymes, Immobilized; Esterification; Fungal Proteins; HeLa Cells; Humans; Lipase; Oxidative Stress; Phenylethyl Alcohol | 2011 |
Transepithelial transport and metabolism of new lipophilic ether derivatives of hydroxytyrosol by enterocyte-like Caco-2/TC7 cells.
Topics: Biological Transport; Caco-2 Cells; Enterocytes; Epithelial Cells; Ether; Humans; Phenylethyl Alcohol | 2010 |
Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction.
Topics: Acrolein; Antioxidants; Calcium; Cell Line; Cell Survival; Coloring Agents; DNA Damage; Glutathione; Glutathione Transferase; Humans; Indicators and Reagents; Macular Degeneration; Mitochondria; Neuroprotective Agents; NF-E2-Related Factor 1; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Protein Carbonylation; Retinal Pigment Epithelium; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2007 |
Characterization of antioxidant olive oil biophenols by spectroscopic methods.
Topics: Antioxidants; Iridoid Glucosides; Iridoids; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Pyrans; Spectrum Analysis, Raman | 2011 |
Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells.
Topics: Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Flow Cytometry; Humans; Olea; Phenylethyl Alcohol; Plant Leaves; Tandem Mass Spectrometry | 2011 |
Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells.
Topics: Cell Cycle; Cell Proliferation; Colonic Neoplasms; Esters; HT29 Cells; Humans; Phenylethyl Alcohol; Thioctic Acid | 2011 |
Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Microarray Analysis; Olive Oil; Phenylethyl Alcohol; Phytotherapy; Plant Oils; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Effects of hydroxytyrosol-enriched sunflower oil consumption on CVD risk factors.
Topics: Cardiovascular Diseases; Cholesterol; Cross-Over Studies; Enzyme-Linked Immunosorbent Assay; Humans; Phenylethyl Alcohol; Plant Oils; Risk Factors; Sunflower Oil | 2011 |
Anti-platelet effects of olive oil extract: in vitro functional and proteomic studies.
Topics: Antibodies; Blood Coagulation; Blood Platelets; Collagen; Female; Fibrinogen; Humans; Male; Methoxyhydroxyphenylglycol; Olive Oil; P-Selectin; Phenylethyl Alcohol; Phytotherapy; Plant Extracts; Plant Oils; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Polyphenols; Proteomics | 2011 |
Chemical and cellular antioxidant activity of phytochemicals purified from olive mill waste waters.
Topics: Antioxidants; Erythrocytes; Fruit; Humans; Industrial Waste; Olea; Phenols; Phenylethyl Alcohol; Pyrans; Reactive Oxygen Species | 2011 |
MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan.
Topics: Aging; Antioxidants; Fibroblasts; Humans; In Vitro Techniques; Longevity; Mitochondria; Phenylethyl Alcohol; Protein Kinases; Superoxide Dismutase | 2012 |
Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: regulatory effects of hydroxytyrosol.
Topics: Animals; Male; Mice; Mitochondria; Models, Biological; Muscle, Skeletal; Phenylethyl Alcohol; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley | 2011 |
Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction.
Topics: Animals; Cell Proliferation; Cells, Cultured; Endothelial Cells; Gene Expression; Heme Oxygenase-1; Hydrogen Peroxide; NF-E2-Related Factor 2; Phenylethyl Alcohol; Protective Agents; Swine | 2011 |
Hydroxytyrosol reduces intracellular reactive oxygen species levels in vascular endothelial cells by upregulating catalase expression through the AMPK-FOXO3a pathway.
Topics: Active Transport, Cell Nucleus; AMP-Activated Protein Kinases; Animals; Antioxidants; Catalase; Cell Nucleus; Endothelial Cells; Forkhead Transcription Factors; Gene Expression Regulation, Enzymologic; Intracellular Space; Phenylethyl Alcohol; Reactive Oxygen Species; Signal Transduction; Swine; Up-Regulation | 2011 |
Alkyl hydroxytyrosyl ethers show protective effects against oxidative stress in HepG2 cells.
Topics: Antioxidants; Carcinoma, Hepatocellular; Cell Survival; Ether; Hep G2 Cells; Humans; Malondialdehyde; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Protective Agents; Reactive Oxygen Species | 2011 |
Olive polyphenol hydroxytyrosol prevents bone loss.
Topics: 3T3 Cells; Animals; Female; Flavonoids; Humans; Iridoid Glucosides; Iridoids; Male; Mice; Olea; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Ovariectomy; Phenols; Phenylethyl Alcohol; Polyphenols; Pyrans | 2011 |
Hydroxytyrosol induces vascular smooth muscle cells apoptosis through NO production and PP2A activation with subsequent inactivation of Akt.
Topics: Animals; Apoptosis; Cell Movement; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; omega-N-Methylarginine; Phenylethyl Alcohol; Phosphorylation; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2011 |
New possibilities for the valorization of olive oil by-products.
Topics: Analysis of Variance; Antioxidants; Chromatography, High Pressure Liquid; Coumaric Acids; Ethanol; Flavonoids; Hot Temperature; Iridoids; Liquid-Liquid Extraction; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Leaves; Plant Oils; Pressure; Tandem Mass Spectrometry; Water | 2011 |
Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-β-induced toxicity. Involvement of the NF-κB signaling.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Blotting, Western; Cell Death; Cell Line, Tumor; Glutathione; Immunohistochemistry; Mice; NF-kappa B; Olive Oil; Phenylethyl Alcohol; Plant Oils; Protein Transport; Signal Transduction | 2011 |
Hydroxytyrosol, the phenolic compound of olive oil protects human PBMC against oxidative stress and DNA damage mediated by 2,3,7,8-TCDD.
Topics: Antioxidants; Catalase; Cell Survival; DNA Damage; Environmental Pollutants; Glutathione Peroxidase; Humans; Leukocytes, Mononuclear; Lipid Peroxidation; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Polychlorinated Dibenzodioxins; Reactive Oxygen Species; Superoxide Dismutase | 2011 |
Olive oil reduces oxidative damage in a 3-nitropropionic acid-induced Huntington's disease-like rat model.
Topics: Administration, Oral; Animals; Antioxidants; Corpus Striatum; Disease Models, Animal; Glutathione; Huntington Disease; Injections, Intraperitoneal; Lipid Peroxidation; Male; Nitro Compounds; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Propionates; Rats; Rats, Wistar; Succinate Dehydrogenase | 2011 |
In vivo prevention of bladder urotoxicity: purified hydroxytyrosol ameliorates urotoxic effects of cyclophosphamide and buthionine sulfoximine in mice.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Catalase; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyclophosphamide; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Industrial Waste; Lipid Peroxidation; Male; Mass Spectrometry; Mice; Olea; Phenylethyl Alcohol; Plant Extracts; Urinary Bladder; Urinary Bladder Diseases | 2011 |
Olive oil hydroxytyrosol reduces toxicity evoked by acrylamide in human Caco-2 cells by preventing oxidative stress.
Topics: Acrylamide; Antioxidants; Apoptosis; Caco-2 Cells; Caspase 3; Humans; JNK Mitogen-Activated Protein Kinases; Olive Oil; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Reactive Oxygen Species | 2011 |
Hydroxytyrosol glucuronides protect renal tubular epithelial cells against H(2)O(2) induced oxidative damage.
Topics: Animals; Antioxidants; Cell Line; Epithelial Cells; Glucuronides; Hydrogen Peroxide; Ketocholesterols; Kidney Tubules; Lipid Peroxides; Malondialdehyde; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Phenylethyl Alcohol; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Swine | 2011 |
Anti-proliferative and pro-apoptotic activities of hydroxytyrosol on different tumour cells: the role of extracellular production of hydrogen peroxide.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Proliferation; Culture Media, Conditioned; Culture Media, Serum-Free; Drug Resistance, Neoplasm; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Kinetics; Neoplasms; Oxidants; Oxidation-Reduction; Oxidoreductases; Oxygen; Phenylethyl Alcohol; Pyruvic Acid | 2012 |
[Study on the chemical constituents of endophytic fungus Fimetariella rabenhorstii isolated from Aquilaria sinensis].
Topics: Acetanilides; Ascomycota; Fermentation; Magnetic Resonance Spectroscopy; Molecular Structure; Niacin; Phenylethyl Alcohol; Thymelaeaceae | 2011 |
Hydroxytyrosol is the major anti-inflammatory compound in aqueous olive extracts and impairs cytokine and chemokine production in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chemokines; Cytokines; Dinoprostone; Gene Expression Regulation; Humans; Inhibitory Concentration 50; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Olea; Phenylethyl Alcohol; Plant Extracts; Polyphenols; RNA | 2011 |
Enzymatic hydrolysis of olive wastewater for hydroxytyrosol enrichment.
Topics: Acetates; Aspergillus niger; China; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hydrolysis; Olea; Phenols; Phenylethyl Alcohol; Soil; Waste Disposal, Fluid | 2011 |
Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Female; Food, Fortified; Intestinal Mucosa; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Olive Oil; Phenylethyl Alcohol; Plant Oils; Random Allocation | 2012 |
Reversed-phase dispersive liquid-liquid microextraction with multivariate optimization for sensitive HPLC determination of tyrosol and hydroxytyrosol in olive oil.
Topics: Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Limit of Detection; Liquid Phase Microextraction; Olive Oil; Phenylethyl Alcohol; Plant Oils; Solvents; Time Factors; Water | 2011 |
Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways.
Topics: Adaptor Proteins, Signal Transducing; Antioxidants; Apoptosis; Cell Line; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; NF-E2-Related Factor 2; Oxidative Stress; Phenylethyl Alcohol; Retinal Pigment Epithelium; Sequestosome-1 Protein; Signal Transduction | 2012 |
Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Antioxidants; Cell Differentiation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Iridoid Glucosides; Iridoids; Mice; Mitosis; Phenylethyl Alcohol; Pyrans; Reverse Transcriptase Polymerase Chain Reaction; Triglycerides | 2011 |
Direct liquid chromatography method for the simultaneous quantification of hydroxytyrosol and tyrosol in red wines.
Topics: Chromatography, High Pressure Liquid; Phenylethyl Alcohol; Wine | 2011 |
Lipophilic hydroxytyrosol esters: fatty acid conjugates for potential topical administration.
Topics: Anti-Inflammatory Agents; Antioxidants; Chromatography, High Pressure Liquid; Fatty Acids; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Olea; Phenylethyl Alcohol; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2011 |
Ultrasonic extraction of phenols from olive mill wastewater: comparison with conventional methods.
Topics: Anti-Infective Agents; Antioxidants; Food-Processing Industry; Industrial Waste; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Slovenia; Ultrasonics | 2011 |
Changes in the content of bioactive polyphenolic compounds of olive mill wastewater by the action of exogenous enzymes.
Topics: Aspergillus niger; beta-Glucosidase; Fungal Proteins; Hydrolysis; Industrial Waste; Olea; Phenols; Phenylethyl Alcohol; Sewage; Waste Disposal, Fluid | 2012 |
Enzymatic routes for the production of mono- and di-glucosylated derivatives of hydroxytyrosol.
Topics: alpha-Glucosidases; Animals; Aplysia; Biotechnology; Free Radical Scavengers; Glycosides; Glycosylation; Oxidation-Reduction; Phenylethyl Alcohol; Substrate Specificity | 2012 |
Oleuropein ameliorates acute colitis in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Colitis; Cytokines; Dextran Sulfate; Female; Iridoid Glucosides; Iridoids; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Nitric Oxide; Phenylethyl Alcohol; Pyrans | 2011 |
Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake.
Topics: Animals; Blood-Brain Barrier; Brain; Heart; Kidney; Liver; Male; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Spleen; Tandem Mass Spectrometry; Testis; Thymus Gland | 2012 |
Unsaturated fatty alcohol derivatives of olive oil phenolic compounds with potential low-density lipoprotein (LDL) antioxidant and antiobesity properties.
Topics: Animals; Anti-Obesity Agents; Antioxidants; Cerebellum; Eating; Fatty Alcohols; Lipid Peroxidation; Lipoproteins, LDL; Male; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; PPAR alpha; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2012 |
Hydroxytyrosol protects against oxidative DNA damage in human breast cells.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Breast; Breast Neoplasms; Cell Line; Cell Line, Tumor; DNA Damage; Female; Free Radical Scavengers; Humans; Olea; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Phytotherapy; Plant Oils | 2011 |
Digestive stability of hydroxytyrosol, hydroxytyrosyl acetate and alkyl hydroxytyrosyl ethers.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetates; Antioxidants; Bile Acids and Salts; Catechols; Ethers; Hydrolysis; Molecular Structure; Olive Oil; Pancreatin; Pepsin A; Phenylethyl Alcohol; Plant Oils | 2012 |
The olive compound 4-hydroxytyrosol inactivates Staphylococcus aureus bacteria and Staphylococcal Enterotoxin A (SEA).
Topics: Animals; Anti-Infective Agents; Antitoxins; Cell Proliferation; Cells, Cultured; Enterotoxins; Female; Mice; Mice, Inbred C57BL; Olea; Phenylethyl Alcohol; Proteolysis; Spleen; Staphylococcus aureus | 2011 |
Antiplatelet effect of new lipophilic hydroxytyrosol alkyl ether derivatives in human blood.
Topics: Adult; Anti-Inflammatory Agents; Dinoprostone; Ether; Female; Humans; Inflammation; Interleukin-1beta; Male; Nitric Oxide; Phenylethyl Alcohol; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2013 |
Hydroxytyrosol attenuates peripheral neuropathy in streptozotocin-induced diabetes in rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Male; Olive Oil; Phenylethyl Alcohol; Plant Oils; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Thiobarbituric Acid Reactive Substances | 2012 |
Characterization of refined edible oils enriched with phenolic extracts from olive leaves and pomace.
Topics: Antioxidants; Flavonoids; Furans; Iridoids; Lignans; Mass Spectrometry; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Plant Oils; Principal Component Analysis | 2012 |
Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages.
Topics: Antioxidants; Apoptosis; Atherosclerosis; CD36 Antigens; Cell Differentiation; Cell Proliferation; Cells, Cultured; Drug Evaluation, Preclinical; Humans; Lipoproteins, LDL; Macrophages; Monocytes; Olive Oil; Phenylethyl Alcohol; Plant Oils; Squalene; U937 Cells | 2012 |
Alperujo extract, hydroxytyrosol, and 3,4-dihydroxyphenylglycol are bioavailable and have antioxidant properties in vitamin E-deficient rats--a proteomics and network analysis approach.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Anticholesteremic Agents; Antioxidants; Diet; Dietary Supplements; Disease Models, Animal; Food-Processing Industry; Fruit; Hypolipidemic Agents; Industrial Waste; Intestinal Absorption; Liver; Male; Methoxyhydroxyphenylglycol; Mitochondrial Proteins; Olea; Oxidative Stress; Phenylethyl Alcohol; Plant Extracts; Random Allocation; Rats; Vitamin E Deficiency | 2012 |
Distribution of hydroxytyrosol and hydroxytyrosol acetate in olive oil emulsions and their antioxidant efficiency.
Topics: Acetates; Antioxidants; Catechols; Emulsions; Olive Oil; Phenylethyl Alcohol; Plant Oils; Solubility | 2012 |
Phenylpropanoid glycosides from plant cell cultures induce heme oxygenase 1 gene expression in a human keratinocyte cell line by affecting the balance of NRF2 and BACH1 transcription factors.
Topics: Antioxidants; Basic-Leucine Zipper Transcription Factors; Cell Line; Cytokines; Cytoprotection; Echinacea; Fanconi Anemia Complementation Group Proteins; Glycosides; Heme Oxygenase-1; Humans; Keratinocytes; NF-E2-Related Factor 2; Phenols; Phenylethyl Alcohol; Plant Extracts; RNA, Messenger; Syringa; Up-Regulation | 2012 |
Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters.
Topics: Animals; Antioxidants; Benzothiazoles; Catechols; Cell Line; Cell Survival; Esters; Fatty Acids; Iodobenzenes; Iodobenzoates; Myoblasts; Phenylethyl Alcohol; Rats; Structure-Activity Relationship; Sulfonic Acids | 2012 |
Bioconversion of oleuropein to hydroxytyrosol by lactic acid bacteria.
Topics: Iridoid Glucosides; Iridoids; Lactobacillus; Olea; Phenylethyl Alcohol; Pyrans | 2012 |
Effect of water deficit on leaf phenolic composition, gas exchange, oxidative damage and antioxidant activity of four Greek olive (Olea europaea L.) cultivars.
Topics: Agricultural Irrigation; Antioxidants; Chlorophyll; Chlorophyll A; Dehydration; Genotype; Iridoid Glucosides; Iridoids; Lipid Peroxidation; Malondialdehyde; Olea; Oxidative Stress; Phenols; Phenylethyl Alcohol; Photosynthesis; Plant Leaves; Plant Roots; Plant Transpiration; Pyrans; Stress, Physiological | 2012 |
Analysis of total contents of hydroxytyrosol and tyrosol in olive oils.
Topics: Chromatography, High Pressure Liquid; Liquid-Liquid Extraction; Olea; Olive Oil; Phenylethyl Alcohol; Plant Oils | 2012 |
Recovery of hydroxytyrosol rich extract from two-phase Chemlali olive pomace by chemical treatment.
Topics: Chromatography, High Pressure Liquid; Food Handling; Hot Temperature; Hydrogen-Ion Concentration; Industrial Waste; Olea; Phenylethyl Alcohol; Plant Oils | 2012 |
Engineering of L-tyrosine oxidation in Escherichia coli and microbial production of hydroxytyrosol.
Topics: Animals; Cloning, Molecular; Escherichia coli; Glucose; Mice; Oxidation-Reduction; Phenylethyl Alcohol; Protein Engineering; Recombinant Proteins; Tyrosine; Tyrosine 3-Monooxygenase | 2012 |
Assay of tyrosol and hydroxytyrosol in olive oil by tandem mass spectrometry and isotope dilution method.
Topics: Antioxidants; Isotope Labeling; Olive Oil; Phenylethyl Alcohol; Plant Oils; Tandem Mass Spectrometry | 2012 |
Novel, biocatalytically produced hydroxytyrosol dimer protects against ultraviolet-induced cell death in human immortalized keratinocytes.
Topics: Antioxidants; Apoptosis; Cell Death; Cell Line, Transformed; Gene Expression; Humans; Keratinocytes; Oxidative Stress; Phenylethyl Alcohol; Plant Extracts; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Ultraviolet Rays | 2012 |
Redox behaviour of verbascoside and rosmarinic acid.
Topics: Antioxidants; Cinnamates; Depsides; Electrochemical Techniques; Electrodes; Electrons; Glucosides; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Rosmarinic Acid | 2013 |
A new hydroxytyrosol metabolite identified in human plasma: hydroxytyrosol acetate sulphate.
Topics: Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Metabolic Networks and Pathways; Molecular Structure; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils | 2012 |
Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Culture Media; Female; Humans; Hydrogen Peroxide; Iridoid Glucosides; Iridoids; Mice; Olea; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Plant Extracts; Plant Oils; Pyrans; Reactive Oxygen Species | 2013 |
Antiproliferative, antioxidant and anti-inflammatory effects of hydroxytyrosol on human hepatoma HepG2 and Hep3B cell lines.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Line, Tumor; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Liver Neoplasms; Phenylethyl Alcohol | 2012 |
Synthesis and bioactivity profile of 5-s-lipoylhydroxytyrosol-based multidefense antioxidants with a sizeable (poly)sulfide chain.
Topics: Antioxidants; Cell Survival; Hep G2 Cells; Humans; Molecular Structure; Oxidation-Reduction; Phenylethyl Alcohol; Thioctic Acid | 2013 |
3,4 dihydroxyphenyl ethanol reduces secretion of angiogenin in human retinal pigment epithelial cells.
Topics: Antioxidants; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Humans; Macular Degeneration; Phenylethyl Alcohol; Retinal Pigment Epithelium; Ribonuclease, Pancreatic | 2013 |
Anti-apoptotic activity of hydroxytyrosol and hydroxytyrosyl laurate.
Topics: Animals; Apoptosis; Cell Line; Humans; Lauric Acids; Mice; Phenylethyl Alcohol; Reactive Oxygen Species | 2013 |
Enhanced chemopreventive activity of hydroxytyrosol on HL60 and HL60R cells by chemical conversion into thio derivatives.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; HL-60 Cells; Humans; Hydrogen Peroxide; Phenylethyl Alcohol; Sulfur Compounds | 2013 |
Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone/hydroxytyrosol: an ex vivo and in vivo study using an NC/Nga mouse model.
Topics: Animals; Anti-Inflammatory Agents; Chitosan; Dermatitis, Atopic; Dinitrofluorobenzene; Disease Models, Animal; Drug Carriers; Hydrocortisone; Mice; Nanoparticles; Phenylethyl Alcohol; Skin; Skin Absorption | 2013 |
Production of a chiral alcohol, 1-(3,4-dihydroxyphenyl) ethanol, by mushroom tyrosinase.
Topics: Agaricales; Biotransformation; Chromatography, High Pressure Liquid; Monophenol Monooxygenase; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Plant Proteins; Stereoisomerism | 2013 |
Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1α.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; HT29 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; I-kappa B Proteins; Iridoid Glucosides; Iridoids; NF-kappa B; NF-KappaB Inhibitor alpha; Olea; p38 Mitogen-Activated Protein Kinases; Phenylethyl Alcohol; PPAR gamma; Pyrans; Tumor Suppressor Protein p53 | 2013 |
Toxicological evaluation of pure hydroxytyrosol.
Topics: Animals; Body Weight; Feeding Behavior; Female; Locomotion; Male; No-Observed-Adverse-Effect Level; Organ Size; Phenylethyl Alcohol; Rats; Rats, Wistar; Toxicity Tests | 2013 |
Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.
Topics: Anticarcinogenic Agents; Apoptosis; Caco-2 Cells; Catechols; Cell Cycle Checkpoints; Colonic Neoplasms; Humans; Intestinal Mucosa; Intestines; Phenylethyl Alcohol; Transcriptome | 2013 |
Neuroprotective effect of alkyl hydroxytyrosyl ethers in rat brain slices subjected to a hypoxia-reoxygenation model.
Topics: Animals; Brain; Ethers; Glutathione; Hypoxia; In Vitro Techniques; Lipid Peroxidation; Male; Models, Biological; Neuroprotective Agents; Oxidative Stress; Oxygen; Phenylethyl Alcohol; Rats; Rats, Wistar | 2012 |
Effect of olive oil phenols on the production of inflammatory mediators in freshly isolated human monocytes.
Topics: Anti-Inflammatory Agents; Cell Survival; Cyclooxygenase 2; Dinoprostone; Humans; Monocytes; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Pyrans; Reactive Oxygen Species; RNA, Messenger; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2013 |
A new process for obtaining hydroxytyrosol using transformed Escherichia coli whole cells with phenol hydroxylase gene from Geobacillus thermoglucosidasius.
Topics: Bacterial Proteins; Biotransformation; Cloning, Molecular; Escherichia coli; Geobacillus; Industrial Microbiology; Mixed Function Oxygenases; Phenylethyl Alcohol; Transformation, Bacterial | 2013 |
Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-proliferation and apoptosis on human prostate cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Free Radical Scavengers; Fruit; Humans; Male; MAP Kinase Signaling System; Mitochondria; Olea; Olive Oil; Phenylethyl Alcohol; Plant Oils; Prostate; Prostatic Neoplasms; Protein Kinase Inhibitors; Superoxides; Up-Regulation | 2013 |
Selective cytotoxic activity of new lipophilic hydroxytyrosol alkyl ether derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cytotoxins; DNA Damage; Ether; Humans; Molecular Structure; Phenylethyl Alcohol | 2013 |
Antitumor activity of caffeic acid 3,4-dihydroxyphenethyl ester and its pharmacokinetic and metabolic properties.
Topics: Animals; Caffeic Acids; Cell Line, Tumor; Humans; Male; Mice; Mice, Inbred ICR; Phenylethyl Alcohol; Random Allocation; Xenograft Model Antitumor Assays | 2013 |
Protective effects of hydroxytyrosol on liver ischemia/reperfusion injury in mice.
Topics: Animals; Antioxidants; Apoptosis; Catalase; Cell Survival; Chemokine CXCL2; Disease Models, Animal; Hepatocytes; In Situ Nick-End Labeling; Interleukin-6; Liver; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Oxidative Stress; Phenylethyl Alcohol; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2013 |
An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function.
Topics: Administration, Oral; Aging; Animals; Antioxidants; Brain; Calcium; Chloride Channels; Gallic Acid; Homovanillic Acid; Male; Malondialdehyde; Muscle Strength; Muscle, Skeletal; Olive Oil; Patch-Clamp Techniques; Phenylethyl Alcohol; Plant Oils; Potassium Channels; Random Allocation; Rats; Rats, Wistar; Sarcolemma; Sarcoplasmic Reticulum | 2014 |
Hydroxytyrosol expresses antifungal activity in vitro.
Topics: Antifungal Agents; Arthrodermataceae; Candida albicans; Humans; Hydrophobic and Hydrophilic Interactions; Microbial Sensitivity Tests; Microbial Viability; Olive Oil; Phenylethyl Alcohol; Phytotherapy; Plant Extracts; Plant Leaves; Plant Oils; Plants, Medicinal; Yeasts | 2013 |
Kinetic study of hydroxytyrosol oxidation and its related compounds by Red Globe grape polyphenol oxidase.
Topics: Catechol Oxidase; Kinetics; Molecular Structure; Oxidation-Reduction; Phenylethyl Alcohol; Plant Proteins; Vitis | 2013 |
Hydroxytyrosol is not genotoxic in vitro.
Topics: Cells, Cultured; Chromosome Aberrations; DNA Damage; Escherichia coli; Food Safety; Humans; Lymphocytes; Mutagenicity Tests; Mutation; Phenylethyl Alcohol; Salmonella typhimurium | 2013 |
Protective activity of hydroxytyrosol metabolites on erythrocyte oxidative-induced hemolysis.
Topics: Adult; Antioxidants; Erythrocytes; Female; Hemolysis; Humans; Male; Middle Aged; Oxidative Stress; Phenylethyl Alcohol; Protective Agents | 2013 |
Recovery of antioxidants from olive mill wastewaters: a viable solution that promotes their overall sustainable management.
Topics: 2-Propanol; Acetates; Antioxidants; Chemical Fractionation; Chloroform; Conservation of Natural Resources; Ecosystem; Environment; Ether; Global Warming; Humans; Olea; Phenols; Phenylethyl Alcohol; Solvents; Waste Disposal, Fluid; Wastewater | 2013 |
A novel multi-commutated method for the determination of hydroxytyrosol in enriched foods using mercaptopropionic acid-capped CdTe quantum dots.
Topics: 3-Mercaptopropionic Acid; Anti-Infective Agents; Antioxidants; Automation, Laboratory; Cadmium Compounds; Chromatography, High Pressure Liquid; Food Inspection; Food, Fortified; High-Throughput Screening Assays; Indicators and Reagents; Limit of Detection; Phenylethyl Alcohol; Quality Control; Quantum Dots; Reproducibility of Results; Spectrometry, Fluorescence; Surface Properties; Tellurium | 2013 |
Hydroxytyrosol stimulates lipolysis via A-kinase and extracellular signal-regulated kinase activation in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes, White; Animals; Antioxidants; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Gene Expression Regulation, Enzymologic; Glycerol; Kinetics; Lipase; Lipolysis; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phenylethyl Alcohol; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Sterol Esterase; Triglycerides | 2014 |
Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Iridoid Glucosides; Iridoids; Phenylethyl Alcohol; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Tumor Cells, Cultured | 2014 |
Dose-dependent metabolic disposition of hydroxytyrosol and formation of mercapturates in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Dose-Response Relationship, Drug; Female; Glutathione; Glutathione Disulfide; Male; Phenylethyl Alcohol; Polyphenols; Rats | 2013 |
Combined treatment of hydroxytyrosol with carbon monoxide-releasing molecule-2 prevents TNF α-induced vascular endothelial cell dysfunction through NO production with subsequent NFκB inactivation.
Topics: Animals; Apoptosis; Carbon Monoxide; Caspase 3; Cell Survival; Endothelial Cells; NF-kappa B; Nitric Oxide; Olive Oil; Organometallic Compounds; Phenylethyl Alcohol; Phosphorylation; Plant Oils; Swine; Tumor Necrosis Factor-alpha | 2013 |
Application of dried spot cards as a rapid sample treatment method for determining hydroxytyrosol metabolites in human urine samples. Comparison with microelution solid-phase extraction.
Topics: Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Humans; Olive Oil; Phenylethyl Alcohol; Plant Oils; Solid Phase Extraction; Tandem Mass Spectrometry | 2013 |
Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation.
Topics: Administration, Oral; Animals; Brain; Dinoprostone; Glutathione; Hypoxia; Inflammation; Interleukin-1beta; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Neuroprotective Agents; Oxidative Stress; Phenylethyl Alcohol; Polyphenols; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2013 |
NF-κβ signaling and chronic inflammatory diseases: exploring the potential of natural products to drive new therapeutic opportunities.
Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Biological Products; Heart Failure; Humans; Inflammation; Metabolic Diseases; NF-kappa B; Phenylethyl Alcohol; Signal Transduction | 2014 |
Hydroxytyrosol inhibits cholangiocarcinoma tumor growth: an in vivo and in vitro study.
Topics: Animals; Antioxidants; Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Extracellular Signal-Regulated MAP Kinases; Gallbladder Neoplasms; Humans; M Phase Cell Cycle Checkpoints; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phenylethyl Alcohol; Xenograft Model Antitumor Assays | 2014 |
Simultaneous determination of phenylethanoid glycosides and aglycones by capillary zone electrophoresis with running buffer modifier.
Topics: beta-Cyclodextrins; Buffers; Caffeic Acids; Cinnamates; Cistanche; Electrophoresis, Capillary; Glycosides; Hydrogen-Ion Concentration; Lamiaceae; Limit of Detection; Phenylethyl Alcohol | 2014 |
Induction of hepatocyte growth factor production in human dermal fibroblasts by caffeic acid derivatives.
Topics: Caffeic Acids; Cells, Cultured; Fibroblasts; Glucosides; Hepatocyte Growth Factor; Humans; Monosaccharides; Phenols; Phenylethyl Alcohol; Quinic Acid; Succinates | 2013 |
Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice.
Topics: Animals; Antioxidants; Blood Glucose; Diet, High-Fat; Dietary Fats; Dynamins; fas Receptor; Gene Expression Regulation; Hyperglycemia; Hyperlipidemias; Insulin Resistance; Lipid Metabolism; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mitochondria; Obesity; Oxidative Stress; Phenylethyl Alcohol; Protein Carbonylation; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2014 |
Olive oil compounds inhibit vascular endothelial growth factor receptor-2 phosphorylation.
Topics: Cell Movement; Cell Proliferation; Cells, Cultured; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Neovascularization, Physiologic; Oleic Acid; Olive Oil; Phenylethyl Alcohol; Phosphorylation; Plant Extracts; Plant Oils; Protein Processing, Post-Translational; Quercetin; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells.
Topics: Antioxidants; Carcinoma, Hepatocellular; Endoplasmic Reticulum Stress; Glutathione; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Liver Neoplasms; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Oils; Risk Factors; Signal Transduction; Thioctic Acid; Tunicamycin; Unfolded Protein Response | 2014 |
Regulation of the biogenesis of OXPHOS complexes in cell transition from replicating to quiescent state: involvement of PKA and effect of hydroxytyrosol.
Topics: Adenosine Triphosphate; ATP Synthetase Complexes; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Electron Transport Complex I; Fibroblasts; Humans; Hydrogen Peroxide; Mitochondria; Nuclear Respiratory Factor 1; Oxidative Phosphorylation; Peroxisome Proliferator-Activated Receptors; Phenylethyl Alcohol; Signal Transduction | 2014 |
Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition.
Topics: Cyclooxygenase 2; Diet, Mediterranean; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; Inflammation; Leukocytes, Mononuclear; Macrophages; Matrix Metalloproteinase 9; Monocytes; NF-kappa B p50 Subunit; Olive Oil; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Phorbol Esters; Plant Oils; Polyphenols; Protein Kinase C beta; Protein Kinase C-alpha; Signal Transduction; U937 Cells | 2014 |
Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients.
Topics: Acetylcarnitine; Animals; Mitochondria; Mitochondrial Turnover; Muscular Atrophy; Muscular Disorders, Atrophic; Oxidative Stress; Phenylethyl Alcohol; Rats; Signal Transduction; Thioctic Acid; Ubiquinone | 2014 |
Antioxidant role of hydroxytyrosol on oxidative stress in cadmium-intoxicated rats: different effect in spleen and testes.
Topics: Animals; Antioxidants; Cadmium Chloride; Catalase; Cytosol; Lipid Peroxidation; Male; Mitochondria; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Wistar; Spleen; Superoxide Dismutase; Testis; Thiobarbituric Acid Reactive Substances | 2014 |
Directed evolution of nitrobenzene dioxygenase for the synthesis of the antioxidant hydroxytyrosol.
Topics: Amino Acid Substitution; Antioxidants; Dioxygenases; Directed Molecular Evolution; Kinetics; Mutant Proteins; Mutation, Missense; Nitrobenzenes; Phenylethyl Alcohol; Structure-Activity Relationship | 2014 |
Hydroxytyrosol and its potential therapeutic effects.
Topics: Drug Therapy; Humans; Olive Oil; Phenylethyl Alcohol; Plant Extracts; Plant Oils | 2014 |
Degradation of caffeic acid in subcritical water and online HPLC-DPPH assay of degradation products.
Topics: Antioxidants; Benzaldehydes; Caffeic Acids; Catechols; Chromatography, High Pressure Liquid; Hot Temperature; Kinetics; Phenylethyl Alcohol; Water | 2014 |
Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Enzyme Activation; Humans; Liver Neoplasms; Mice; Mice, Nude; NF-kappa B; Olive Oil; Phenylethyl Alcohol; Plant Oils; Proto-Oncogene Proteins c-akt | 2014 |
Characterization of poly(ε-caprolactone)-based nanocomposites containing hydroxytyrosol for active food packaging.
Topics: Antioxidants; Bentonite; Food Packaging; Microscopy, Electron, Transmission; Nanocomposites; Oxygen; Permeability; Phenylethyl Alcohol; Polyesters; X-Ray Diffraction | 2014 |
Addressing analytical requirements to support health claims on "olive oil polyphenols" (EC Regulation 432/2012).
Topics: Chromatography, High Pressure Liquid; Europe; Food Analysis; Food, Organic; Humans; Hydrolysis; Olive Oil; Phenylethyl Alcohol; Plant Oils; Polyphenols | 2014 |
Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Synuclein; Animals; Antioxidants; Ascorbic Acid; Cations, Divalent; Chelating Agents; Copper; Dopamine; Edetic Acid; Humans; Iron; Manganese; PC12 Cells; Phenylethyl Alcohol; Protein Aggregates; Protein Multimerization; Rats | 2014 |
Influence of olive-derived hydroxytyrosol on the toll-like receptor 4-dependent inflammatory response of mouse peritoneal macrophages.
Topics: Animals; Anti-Inflammatory Agents; Female; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Olea; Phenylethyl Alcohol; Toll-Like Receptor 4 | 2014 |
Hydroxytyrosol inhibits chemokine C-C motif ligand 5 mediated aged quiescent fibroblast-induced stimulation of breast cancer cell proliferation.
Topics: Aging; Antioxidants; Breast Neoplasms; Cell Proliferation; Chemokine CCL5; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Infant, Newborn; Phenylethyl Alcohol; Real-Time Polymerase Chain Reaction; RNA, Neoplasm; Tumor Cells, Cultured | 2014 |
Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.
Topics: Animals; Antioxidants; Apoptosis Inducing Factor; Doxorubicin; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex III; Electron Transport Complex IV; Fatty Acids; Female; Gas Chromatography-Mass Spectrometry; Heart Diseases; Immunoblotting; Mammary Neoplasms, Animal; Microscopy, Electron; Mitochondria, Heart; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley | 2014 |
Extra virgin olive oil phenols down-regulate lipid synthesis in primary-cultured rat-hepatocytes.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Cholesterol; Diacylglycerol O-Acyltransferase; Down-Regulation; Fatty Acids; Hepatocytes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iridoid Glucosides; Iridoids; Lipids; Lipogenesis; Male; Olive Oil; Phenylethyl Alcohol; Phosphorylation; Plant Oils; Rats, Wistar | 2014 |
Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats.
Topics: Acetates; Animals; Antioxidants; Blood Glucose; Catechols; Chemokine CCL2; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Diet, High-Fat; Hypercholesterolemia; Interleukin-1beta; Interleukin-6; Male; Malondialdehyde; Olive Oil; Phenols; Phenylethyl Alcohol; Phytochemicals; Plant Oils; Plasminogen Activator Inhibitor 1; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2014 |
Reduction of the nitro group to amine by hydroiodic acid to synthesize o-aminophenol derivatives as putative degradative markers of neuromelanin.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acids; Aminophenols; Chromatography, High Pressure Liquid; Iodine Compounds; Locus Coeruleus; Magnetic Resonance Spectroscopy; Melanins; Phenylethyl Alcohol; Substantia Nigra | 2014 |
Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Down-Regulation; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mitochondria; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Phosphatidylinositol 3-Kinases; Phosphorylation; Plant Oils; Polyphenols; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2014 |
Chronic hydroxytyrosol feeding modulates glutathione-mediated oxido-reduction pathways in adipose tissue: a nutrigenomic study.
Topics: 3T3-L1 Cells; Adipokines; Adipose Tissue; Animals; Antioxidants; Cardiovascular Diseases; Dietary Supplements; Glutathione; Hydrogen Peroxide; Leptin; Male; Mice; Mice, Inbred C57BL; Microarray Analysis; Nutrigenomics; Olive Oil; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Risk Factors; Transcriptome | 2014 |
Faecal microbial metabolism of olive oil phenolic compounds: in vitro and in vivo approaches.
Topics: Acetates; Catechols; Colon; Feces; Fermentation; Humans; In Vitro Techniques; Iridoid Glucosides; Iridoids; Kinetics; Microbiota; Nontherapeutic Human Experimentation; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils | 2014 |
In vivo and in vitro addition of dried olive extract in poultry.
Topics: Animals; Antioxidants; Chickens; Diet; Flavonoids; Food Additives; Freeze Drying; Fruit; Lipid Peroxidation; Meat; Olea; Phenylethyl Alcohol; Plant Extracts; Polyphenols; Poultry | 2014 |
Hydroxytyrosol and oleuropein of olive oil inhibit mast cell degranulation induced by immune and non-immune pathways.
Topics: Animals; beta-N-Acetylhexosaminidases; Cell Degranulation; Dose-Response Relationship, Drug; Iridoid Glucosides; Iridoids; Male; Mast Cells; Olive Oil; Phenylethyl Alcohol; Plant Oils; Rats, Wistar | 2014 |
In vivo striatal measurement of hydroxytyrosol, and its metabolite (homovanillic alcohol), compared with its derivative nitrohydroxytyrosol.
Topics: Animals; Biotransformation; Catechol O-Methyltransferase; Homovanillic Acid; Male; Neostriatum; Phenylethyl Alcohol; Rats; Rats, Wistar | 2014 |
Olive leaf extracts protect cardiomyocytes against 4-hydroxynonenal-induced toxicity in vitro: comparison with oleuropein, hydroxytyrosol, and quercetin.
Topics: Aldehydes; Animals; Antioxidants; Caspase 3; Cell Survival; In Vitro Techniques; Iridoid Glucosides; Iridoids; Mitochondria; Myocytes, Cardiac; Olea; Oxidative Stress; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Polyphenols; Protective Agents; Protein Serine-Threonine Kinases; Quercetin; Rats; Transcription Factors | 2014 |
Cell wall bound anionic peroxidases from asparagus byproducts.
Topics: Asparagus Plant; Biodegradation, Environmental; Cell Wall; Chlorophenols; Chromatography, Ion Exchange; Enzyme Stability; Hydrogen-Ion Concentration; Industrial Waste; Isoelectric Focusing; Kinetics; Peroxidases; Phenylethyl Alcohol; Wastewater | 2014 |
Phosphatidyl derivative of hydroxytyrosol. In vitro intestinal digestion, bioaccessibility, and its effect on antioxidant activity.
Topics: Antioxidants; Biological Availability; Hydrolysis; In Vitro Techniques; Intestinal Mucosa; Intestines; Phenylethyl Alcohol; Phosphatidic Acids; Phospholipids | 2014 |
Synthesis and antioxidant activity of nitrohydroxytyrosol and its acyl derivatives.
Topics: Antioxidants; Molecular Structure; Oxidation-Reduction; Phenylethyl Alcohol | 2014 |
3,4-dihydroxyphenylethanol attenuates spatio-cognitive deficits in an Alzheimer's disease mouse model: modulation of the molecular signals in neuronal survival-apoptotic programs.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cognition Disorders; Disease Models, Animal; Hippocampus; Ibotenic Acid; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Neuroprotective Agents; Peptide Fragments; Phenylethyl Alcohol; Signal Transduction | 2015 |
Determination of hydroxytyrosol and tyrosol by liquid chromatography for the quality control of cosmetic products based on olive extracts.
Topics: Chromatography, Liquid; Cosmetics; Limit of Detection; Olea; Phenylethyl Alcohol; Plant Extracts; Spectrophotometry, Ultraviolet | 2015 |
Hydroxytyrosol prevents increase of osteoarthritis markers in human chondrocytes treated with hydrogen peroxide or growth-related oncogene α.
Topics: Aged; Aged, 80 and over; Antioxidants; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Chemokine CXCL1; Chondrocytes; Humans; Hydrogen Peroxide; Hypertrophy; Inflammation Mediators; Middle Aged; Osteoarthritis; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2014 |
In vitro human fecal microbial metabolism of Forsythoside A and biological activities of its metabolites.
Topics: Adult; Animals; Anti-Infective Agents; Caffeic Acids; Chromatography, High Pressure Liquid; Complement Inactivating Agents; Feces; Female; Glycosides; Guinea Pigs; Humans; Male; Mass Spectrometry; Microbiota; Middle Aged; Molecular Structure; Phenylethyl Alcohol; Young Adult | 2014 |
Antioxidants in the prevention of UVB-induced keratynocyte apoptosis.
Topics: Antioxidants; Apoptosis; Caspases; Cell Line; Creatine; DNA Fragmentation; Humans; Intercellular Junctions; Keratinocytes; Melatonin; Microscopy, Fluorescence; Phenylethyl Alcohol; Poly(ADP-ribose) Polymerases; Ultraviolet Rays | 2014 |
Evaluation of potential antigenotoxic, cytotoxic and proapoptotic effects of the olive oil by-product "alperujo", hydroxytyrosol, tyrosol and verbascoside.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Cell Proliferation; DNA Damage; Drosophila melanogaster; Drosophila Proteins; Glucosides; HL-60 Cells; Humans; Hydrogen Peroxide; Olive Oil; Oxidants; Phenols; Phenylethyl Alcohol; Plant Oils | 2014 |
Efficient immuno-modulation of TH1/TH2 biomarkers in 2,4-dinitrofluorobenzene-induced atopic dermatitis: nanocarrier-mediated transcutaneous co-delivery of anti-inflammatory and antioxidant drugs.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cytokines; Dermatitis, Atopic; Dinitrofluorobenzene; Dinoprostone; Disease Models, Animal; Drug Carriers; Histamine; Hydrocortisone; Immunoglobulin E; Mice; Nanoparticles; Phenylethyl Alcohol; Skin; Th1 Cells; Th2 Cells; Vascular Endothelial Growth Factor A | 2014 |
Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring.
Topics: Animals; Antioxidants; Behavior, Animal; Cognition Disorders; Dietary Supplements; Female; Gene Expression Regulation, Developmental; Hippocampus; Male; Maternal Nutritional Physiological Phenomena; Mitochondria; Nerve Tissue Proteins; Neurogenesis; Neurons; Oxidative Stress; Phenylethyl Alcohol; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats, Sprague-Dawley; Restraint, Physical; Specific Pathogen-Free Organisms | 2015 |
Synthesis and antioxidant evaluation of isochroman-derivatives of hydroxytyrosol: structure-activity relationship.
Topics: Animals; Antioxidants; Brain; Malondialdehyde; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Rats; Rats, Wistar; Structure-Activity Relationship | 2015 |
Phenol esterase activity of porcine skin.
Topics: Animals; Decanoates; Emulsions; Esterases; Esters; Hydrolysis; Liposomes; Phenol; Phenylethyl Alcohol; Skin; Swine | 2015 |
Inhibitory and synergistic effects of natural olive phenols on human platelet aggregation and lipid peroxidation of microsomes from vitamin E-deficient rats.
Topics: Adult; Animals; Antioxidants; Disease Models, Animal; Female; Humans; Lipid Peroxidation; Male; Methoxyhydroxyphenylglycol; Microsomes; Middle Aged; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Extracts; Platelet Aggregation; Rats; Vitamin E; Vitamin E Deficiency | 2015 |
Hydroxytyrosol: lack of clastogenicity in a bone marrow chromosome aberration study in rats.
Topics: Administration, Oral; Animals; Antioxidants; Behavior, Animal; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; Female; Male; Mitotic Index; Mutagenicity Tests; Mutagens; Phenylethyl Alcohol; Rats; Rats, Wistar | 2014 |
Carbonyl trapping and antiglycative activities of olive oil mill wastewater.
Topics: Antioxidants; Benzothiazoles; Food Industry; Glucose; Glucosides; Glycation End Products, Advanced; Olive Oil; Oxidative Stress; Phenol; Phenols; Phenylethyl Alcohol; Pyruvaldehyde; Sulfonic Acids; Wastewater | 2015 |
Extravirgin olive oil up-regulates CB₁ tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms.
Topics: Animals; Caco-2 Cells; Cell Line; Cell Proliferation; Colon; Colonic Neoplasms; Dietary Fats, Unsaturated; DNA Methylation; Epigenesis, Genetic; Female; Fruit; Humans; Intestinal Mucosa; Neoplasm Proteins; Olea; Olive Oil; Phenylethyl Alcohol; Plant Extracts; Plant Oils; Promoter Regions, Genetic; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Up-Regulation | 2015 |
Mechanism of reactive carbonyl species trapping by hydroxytyrosol under simulated physiological conditions.
Topics: Chromatography, High Pressure Liquid; Glycation End Products, Advanced; Mass Spectrometry; Phenylethyl Alcohol; Pyruvaldehyde | 2015 |
Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Rheumatoid; Cyclooxygenase 2; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Inflammation; Male; Neutrophils; Nitric Oxide Synthase Type II; Olive Oil; Phenylethyl Alcohol; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2015 |
Skin delivery of antioxidant surfactants based on gallic acid and hydroxytyrosol.
Topics: Animals; Antioxidants; Caproates; Caprylates; Free Radical Scavengers; Gallic Acid; Oxidation-Reduction; Phenylethyl Alcohol; Skin; Skin Absorption; Surface-Active Agents; Swine | 2015 |
Enzymatic hydrolysis of oleuropein from Olea europea (olive) leaf extract and antioxidant activities.
Topics: Antioxidants; Biotransformation; Hydrolysis; Iridoid Glucosides; Iridoids; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Pyrans | 2015 |
Hydroxytyrosol and tyrosol esters partitioning into, location within, and effect on DOPC liposome bilayer behavior.
Topics: Antioxidants; Cuphea; Decanoic Acids; Esterification; Esters; Lipid Bilayers; Liposomes; Models, Chemical; Molecular Structure; Phenylethyl Alcohol; Phosphatidylcholines; Plant Oils; Time Factors | 2015 |
Investigations into the genotoxic potential of olive extracts.
Topics: Animals; Bone Marrow Cells; CHO Cells; Chromosome Aberrations; Cricetulus; Culture Media; DNA Damage; Homovanillic Acid; Humans; Hydrogen Peroxide; Lymphocytes; Mutagenicity Tests; Mutagens; Olea; Phenylethyl Alcohol; Plant Extracts; Rats | 2015 |
Hydroxytyrosol, a dietary phenolic compound forestalls the toxic effects of methylmercury-induced toxicity in IMR-32 human neuroblastoma cells.
Topics: bcl-2-Associated X Protein; Caspase 3; Catalase; Cell Line, Tumor; Cell Survival; Comet Assay; Cytochromes c; DNA Fragmentation; Glutathione; Humans; Methylmercury Compounds; Microscopy, Fluorescence; Neuroblastoma; NF-E2-Related Factor 2; Oxidative Stress; Phenylethyl Alcohol; Superoxide Dismutase; Tumor Suppressor Protein p53 | 2016 |
Dose effect on the uptake and accumulation of hydroxytyrosol and its metabolites in target tissues in rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Olive Oil; Phenylethyl Alcohol; Rats; Tandem Mass Spectrometry; Tissue Distribution | 2015 |
Protective Effect of Hydroxytyrosol Against Cardiac Remodeling After Isoproterenol-Induced Myocardial Infarction in Rat.
Topics: Animals; Cardiotonic Agents; Isoproterenol; Male; Myocardial Infarction; Phenylethyl Alcohol; Rats; Rats, Wistar; Ventricular Remodeling | 2016 |
The hydroxytyrosol-dependent increase of TNF-α in LPS-activated human monocytes is mediated by PGE2 and adenylate cyclase activation.
Topics: Adenylyl Cyclases; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Humans; Lipopolysaccharides; Monocytes; Phenylethyl Alcohol; Tumor Necrosis Factor-alpha | 2015 |
Role of Hydroxytyrosol-dependent Regulation of HO-1 Expression in Promoting Wound Healing of Vascular Endothelial Cells via Nrf2 De Novo Synthesis and Stabilization.
Topics: Animals; Cells, Cultured; Endothelial Cells; Heme Oxygenase-1; NF-E2-Related Factor 2; Olea; Oxidative Stress; Phenylethyl Alcohol; Signal Transduction; Swine; Up-Regulation; Wound Healing | 2015 |
Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinases; Animals; Brain; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Heat-Shock Proteins; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mitochondria; Neuroblastoma; NF-E2-Related Factor 2; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; PPAR gamma; Reactive Oxygen Species; Sequestosome-1 Protein; Sirtuin 1; Superoxide Dismutase; Superoxide Dismutase-1 | 2015 |
Effect of Saccharomyces cerevisiae and Candida zemplinina on quercetin, vitisin A and hydroxytyrosol contents in Sangiovese wines.
Topics: Benzofurans; Candida; Fermentation; Kinetics; Phenols; Phenylethyl Alcohol; Quercetin; Saccharomyces cerevisiae; Vitis; Wine | 2015 |
Olive oil and its phenolic compounds (hydroxytyrosol and tyrosol) ameliorated TCDD-induced heptotoxicity in rats via inhibition of oxidative stress and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Dietary Supplements; Lipid Peroxidation; Liver; Male; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Polychlorinated Dibenzodioxins; Polyphenols; Rats, Wistar | 2016 |
The protective role of olive oil hydroxytyrosol against oxidative alterations induced by mercury in human erythrocytes.
Topics: Antioxidants; Cell Shape; Cells, Cultured; Erythrocytes; Glutathione; Hemolysis; Humans; Mercury; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Reactive Oxygen Species | 2015 |
Microemulsion versus emulsion as effective carrier of hydroxytyrosol.
Topics: Drug Carriers; Electron Spin Resonance Spectroscopy; Emulsions; Phenylethyl Alcohol; Surface-Active Agents | 2016 |
Antioxidant activity of alkyl hydroxytyrosyl ethers in unsaturated lipids.
Topics: Alkylation; Antioxidants; Dietary Fats, Unsaturated; Ethers; Fats, Unsaturated; Fish Oils; Food Preservatives; Food Quality; Food Storage; Hot Temperature; Kinetics; Lipid Peroxides; Oxidation-Reduction; Phenylethyl Alcohol; Plant Oils; Soybean Oil; Sunflower Oil; Tocopherols | 2015 |
Additive regulation of adiponectin expression by the mediterranean diet olive oil components oleic Acid and hydroxytyrosol in human adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Diet, Mediterranean; Down-Regulation; Drug Synergism; Enzyme Activation; Gene Expression Regulation; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Oleic Acid; Olive Oil; Phenylethyl Alcohol; PPAR gamma; Tumor Necrosis Factor-alpha | 2015 |
Effect of intracerebral hydroxytyrosol and its nitroderivatives on striatal dopamine metabolism: A study by in vivo microdialysis.
Topics: Animals; Antioxidants; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dopamine; Male; Microdialysis; Phenylethyl Alcohol; Rats; Rats, Wistar | 2015 |
Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells.
Topics: Adrenergic Agents; Animals; Antioxidants; Apoptosis; Free Radical Scavengers; Hydrogen Peroxide; Kinetics; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Olive Oil; Oxidants; Oxidative Stress; Oxidopamine; PC12 Cells; Phenylethyl Alcohol; Rats; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction | 2015 |
Phenols and the antioxidant capacity of Mediterranean vegetables prepared with extra virgin olive oil using different domestic cooking techniques.
Topics: Antioxidants; Benzothiazoles; Chlorogenic Acid; Chromatography, High Pressure Liquid; Cluster Analysis; Cooking; Cucurbita; Dietary Fats; Furans; Iridoid Glucosides; Iridoids; Lignans; Multivariate Analysis; Olive Oil; Phenols; Phenylethyl Alcohol; Rutin; Solanum lycopersicum; Solanum melongena; Solanum tuberosum; Sulfonic Acids; Vegetables | 2015 |
Differences in the Neuroprotective Effect of Orally Administered Virgin Olive Oil (Olea europaea) Polyphenols Tyrosol and Hydroxytyrosol in Rats.
Topics: Animals; Antioxidants; Lipid Peroxidation; Male; Neuroprotective Agents; Olea; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Polyphenols; Rats; Rats, Wistar | 2015 |
Phenylethanoid glycosides in tepals of Magnolia salicifolia and their occurrence in flowers of Magnoliaceae.
Topics: Flowers; Glycosides; Magnoliaceae; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phenylethyl Alcohol; Xylose | 2015 |
3,4-dihydroxyphenylethanol suppresses irradiation-induced pulmonary fibrosis in adult rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Dexamethasone; Disease Models, Animal; Heme Oxygenase-1; Humans; Lung; Male; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Phenylethyl Alcohol; Pulmonary Fibrosis; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley | 2015 |
Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases.
Topics: DNA Cleavage; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Fruit; Glucosides; Humans; Iridoid Glucosides; Iridoids; Olea; Phenols; Phenylethyl Alcohol; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Topoisomerase II Inhibitors | 2015 |
Radical-scavenging Activity and Antioxidative Effects of Olive Leaf Components Oleuropein and Hydroxytyrosol in Comparison with Homovanillic Alcohol.
Topics: Antioxidants; Chromans; Free Radical Scavengers; Homovanillic Acid; Iridoid Glucosides; Iridoids; Linoleic Acids; Lipid Peroxidation; Micelles; Olea; Oxidation-Reduction; Phenylethyl Alcohol; Plant Leaves | 2015 |
Toxicological evaluation of an olive extract, H35: Subchronic toxicity in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Behavior, Animal; Dietary Supplements; Energy Intake; Female; Fruit; Heart; Kidney; Liver; Male; Olea; Organ Size; Phenylethyl Alcohol; Plant Extracts; Random Allocation; Rats, Wistar; Toxicity Tests, Subchronic; Weight Gain | 2015 |
Hydroxytyrosol Inhibits Cannabinoid CB1 Receptor Gene Expression in 3T3-L1 Preadipocyte Cell Line.
Topics: 3T3-L1 Cells; Adipocytes; alpha-Linolenic Acid; Animals; Cell Proliferation; fas Receptor; Gene Expression; Linoleic Acid; Lipoprotein Lipase; Mice; Phenylethyl Alcohol; PPAR gamma; Receptor, Cannabinoid, CB1; RNA, Messenger; Stem Cells | 2016 |
Chemical and Biological Investigation of Olive Mill Waste Water - OMWW Secoiridoid Lactones.
Topics: Antioxidants; Cell Line; Cell Survival; Fluoresceins; Humans; Iridoids; Lactones; Olea; Olive Oil; Phenylethyl Alcohol; Reactive Oxygen Species; Wastewater | 2015 |
Use of solar distillation for olive mill wastewater drying and recovery of polyphenolic compounds.
Topics: Antioxidants; Distillation; Equipment Design; Greece; Industrial Waste; Olea; Phenylethyl Alcohol; Polyphenols; Sewage; Sunlight; Temperature; Waste Disposal, Fluid; Wastewater | 2015 |
Hydroxytyrosol-Derived Compounds: A Basis for the Creation of New Pharmacological Agents for Cancer Prevention and Therapy.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Proliferation; Drug Discovery; Humans; Neoplasms; Olive Oil; Phenylethyl Alcohol | 2015 |
The α-Glucosidase and α-Amylase Enzyme Inhibitory of Hydroxytyrosol and Oleuropein.
Topics: alpha-Amylases; alpha-Glucosidases; Caco-2 Cells; Cell Survival; Dose-Response Relationship, Drug; Glycoside Hydrolase Inhibitors; Humans; Hyperglycemia; Iridoid Glucosides; Iridoids; Olea; Phenylethyl Alcohol; Phytotherapy; Plant Leaves | 2015 |
3-O-Hydroxytyrosol glucuronide and 4-O-hydroxytyrosol glucuronide reduce endoplasmic reticulum stress in vitro.
Topics: CCAAT-Enhancer-Binding Proteins; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glucuronides; Heat-Shock Proteins; Hep G2 Cells; Humans; Olive Oil; Phenylethyl Alcohol; Unfolded Protein Response | 2015 |
Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses.
Topics: Agaricus; Antiviral Agents; Catechols; DNA Virus Infections; DNA Viruses; Enzymes, Immobilized; Humans; Models, Molecular; Monophenol Monooxygenase; Nanotubes, Carbon; Phenylethyl Alcohol; RNA Virus Infections; RNA Viruses | 2015 |
Effect of hydroxytyrosol on quality of sulfur dioxide-free red wine.
Topics: Color; Odorants; Phenylethyl Alcohol; Sulfur Dioxide; Wine | 2016 |
Quercetin and hydroxytyrosol attenuates xanthine/xanthine oxidase-induced toxicity in H9c2 cardiomyocytes by regulation of oxidative stress and stress-sensitive signaling pathways.
Topics: Animals; Cardiotonic Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Myocytes, Cardiac; Oxidative Stress; Phenylethyl Alcohol; Quercetin; Rats; Reactive Oxygen Species; Signal Transduction; Xanthine; Xanthine Oxidase | 2015 |
Protective effect of hydroxytyrosol and its predominant plasmatic human metabolites against endothelial dysfunction in human aortic endothelial cells.
Topics: Aorta; Caco-2 Cells; Chemokine CCL2; Culture Media; E-Selectin; Endothelial Cells; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; P-Selectin; Phenylethyl Alcohol; Protective Agents; Vascular Cell Adhesion Molecule-1 | 2015 |
Differential partitioning of antioxidants, including hydroxytyrosol, in human plasma and LDL: implications for their antioxidant activity in vivo.
Topics: Antioxidants; Dietary Supplements; Humans; In Vitro Techniques; Lipoproteins, LDL; Olive Oil; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Plant Oils | 2012 |
Development and in vitro assessment of alginate bilayer films containing the olive compound hydroxytyrosol as an alternative for topical chemotherapy.
Topics: Administration, Cutaneous; Alginates; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Survival; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Liberation; Female; Glucuronic Acid; Hexuronic Acids; Humans; MCF-7 Cells; Olea; Phenylethyl Alcohol; Rheology; Skin Neoplasms | 2015 |
Minimization of Local and Systemic Adverse Effects of Topical Glucocorticoids by Nanoencapsulation: In Vivo Safety of Hydrocortisone-Hydroxytyrosol Loaded Chitosan Nanoparticles.
Topics: Animals; Chemistry, Pharmaceutical; Chitosan; Drug-Related Side Effects and Adverse Reactions; Female; Glucocorticoids; Hydrocortisone; Nanoparticles; Phenylethyl Alcohol; Rats; Rats, Wistar; Safety; Skin Cream; Skin Diseases | 2015 |
Development of a Sustainable Procedure for the Recovery of Hydroxytyrosol from Table Olive Processing Wastewater Using Adsorption Resin Technology and Centrifugal Partition Chromatography.
Topics: Adsorption; Centrifugation; Chromatography, High Pressure Liquid; Ion Exchange Resins; Molecular Structure; Olea; Phenylethyl Alcohol; Plant Extracts; Polystyrenes; Polyvinyls; Solvents; Wastewater; Water Purification | 2015 |
Gender differences in plasma and urine metabolites from Sprague-Dawley rats after oral administration of normal and high doses of hydroxytyrosol, hydroxytyrosol acetate, and DOPAC.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Biological Availability; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Male; Olive Oil; Phenols; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Sex Factors; Tandem Mass Spectrometry | 2017 |
In vitro chemo-preventive activities of hydroxytyrosol: the main phenolic compound present in extra-virgin olive oil.
Topics: Antioxidants; Cell Line, Tumor; Comet Assay; DNA Damage; Humans; Hydrogen Peroxide; Olive Oil; Phenols; Phenylethyl Alcohol | 2016 |
Obtainment and characterization of a potential functional ingredient from olive.
Topics: Antioxidants; Dietary Fiber; Fatty Acids; Fruit; Functional Food; Humans; Olea; Oleic Acid; Olive Oil; Phenols; Phenylethyl Alcohol; Polyphenols | 2015 |
Hydroxytyrosol and tyrosol sulfate metabolites protect against the oxidized cholesterol pro-oxidant effect in Caco-2 human enterocyte-like cells.
Topics: Caco-2 Cells; Cholesterol; Enterocytes; Humans; Malondialdehyde; Molecular Structure; Oxidants; Oxidation-Reduction; Phenylethyl Alcohol; Sulfates | 2016 |
A Convenient Synthesis of Hydroxytyrosol Monosulfate Metabolites.
Topics: Chemistry Techniques, Synthetic; Molecular Structure; Phenylethyl Alcohol; Polyphenols; Sulfates | 2015 |
Antioxidant Hydroxytyrosol-Based Polyacrylate with Antimicrobial and Antiadhesive Activity Versus Staphylococcus Epidermidis.
Topics: Anti-Bacterial Agents; Antioxidants; Bacterial Adhesion; Biofilms; Microbial Sensitivity Tests; Phenylethyl Alcohol; Staphylococcus epidermidis | 2016 |
Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Caco-2 Cells; Colonic Neoplasms; ErbB Receptors; Female; HT29 Cells; Humans; Lysosomes; Mice, Nude; Olive Oil; Phenylethyl Alcohol; Phosphorylation; Proteasome Endopeptidase Complex; Tyrosine; Xenograft Model Antitumor Assays | 2016 |
Optimization of parameters affecting signal intensity in an LTQ-orbitrap in negative ion mode: A design of experiments approach.
Topics: Iridoid Glucosides; Iridoids; Phenylethyl Alcohol; Spectrometry, Mass, Electrospray Ionization; Syringes | 2016 |
Hydroxytyrosol decreases the oxidative and nitrosative stress levels and promotes angiogenesis through HIF-1 independent mechanisms in renal hypoxic cells.
Topics: Cell Line, Tumor; DNA Damage; Gene Expression Regulation; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1; Leukocytes, Mononuclear; Neovascularization, Physiologic; Olive Oil; Oxidative Stress; Phenylethyl Alcohol | 2016 |
Factors influencing the formation of histaminol, hydroxytyrosol, tyrosol, and tryptophol in wine: Temperature, alcoholic degree, and amino acids concentration.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Fermentation; Histamine; Indoles; Phenylethyl Alcohol; Tandem Mass Spectrometry; Temperature; Wine | 2016 |
Antimicrobial activity of hydroxytyrosol: a current controversy.
Topics: Anti-Infective Agents; Chromatography, High Pressure Liquid; Culture Media; Escherichia coli; Microbial Sensitivity Tests; Phenylethyl Alcohol | 2016 |
Preparation, in vitro and in vivo evaluation of mPEG-PLGA nanoparticles co-loaded with syringopicroside and hydroxytyrosol.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Carriers; Drug Evaluation, Preclinical; Female; Glycosides; Hep G2 Cells; Humans; Male; Materials Testing; Mice; Nanoparticles; Particle Size; Phenylethyl Alcohol; Polyesters; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2016 |
Hydroxytyrosol inhibits phosphatidylserine exposure and suicidal death induced by mercury in human erythrocytes: Possible involvement of the glutathione pathway.
Topics: Apoptosis; Calcium; Environmental Exposure; Erythrocytes; Glutathione; Humans; In Vitro Techniques; Mercury; Phenylethyl Alcohol; Phosphatidylserines | 2016 |
TNF-α and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Foot; Inflammation; Interleukin-10; Male; Mice; Olea; Phenylethyl Alcohol; Polyphenols; Tumor Necrosis Factor-alpha | 2015 |
Effects of Silicon vs. Hydroxytyrosol-Enriched Restructured Pork on Liver Oxidation Status of Aged Rats Fed High-Saturated/High-Cholesterol Diets.
Topics: Aging; Animal Feed; Animals; Antioxidants; Body Weight; Catalase; Cholesterol, Dietary; Cholic Acid; Colloids; Dietary Fats; Drug Evaluation, Preclinical; Fatty Acids; Glutathione; Hypolipidemic Agents; Liver; Male; Meat; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Phenylethyl Alcohol; Rats; Rats, Wistar; Silicon Dioxide; Superoxide Dismutase; Sus scrofa; Swine | 2016 |
The Metabolic Fate of ortho-Quinones Derived from Catecholamine Metabolites.
Topics: Catecholamines; Fungal Proteins; Isomerism; Methoxyhydroxyphenylglycol; Monophenol Monooxygenase; Phenylethyl Alcohol; Quinones | 2016 |
Analysis of free hydroxytyrosol in human plasma following the administration of olive oil.
Topics: Biological Availability; Blood Chemical Analysis; Chromatography, Liquid; Dietary Fats, Unsaturated; Humans; Olea; Olive Oil; Phenylethyl Alcohol; Polyphenols; Solid Phase Extraction; Tandem Mass Spectrometry | 2016 |
Evaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models.
Topics: Biological Availability; Caco-2 Cells; Hep G2 Cells; Humans; Hydrolysis; Intestinal Mucosa; Liver; Models, Biological; Nitro Compounds; Phenylethyl Alcohol | 2016 |
Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation.
Topics: Analysis of Variance; Apigenin; Caffeic Acids; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Coumaric Acids; Dose-Response Relationship, Drug; Fruit; Humans; Luteolin; Mass Spectrometry; Olea; Olive Oil; Osteoblasts; Phenols; Phenylethyl Alcohol; Principal Component Analysis; Time Factors | 2016 |
Plant Phenols as Antibiotic Boosters: In Vitro Interaction of Olive Leaf Phenols with Ampicillin.
Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; Caffeic Acids; Drug Synergism; Escherichia coli; Flavones; Glucosides; Herb-Drug Interactions; Iridoid Glucosides; Iridoids; Medicine, Traditional; Olea; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Staphylococcus aureus | 2016 |
Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms.
Topics: Autophagy; Cells, Cultured; Chondrocytes; Cytoprotection; DNA Damage; Humans; Osteoarthritis; Oxidative Stress; Phenylethyl Alcohol; Sirtuin 1 | 2016 |
Hydroxytyrosol Protects against Myocardial Ischemia/Reperfusion Injury through a PI3K/Akt-Dependent Mechanism.
Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Phenylethyl Alcohol; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats | 2016 |
Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity.
Topics: Antioxidants; Cell Line, Tumor; Cell Survival; Cytotoxins; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Metabolic Detoxication, Phase II; NAD(P)H Dehydrogenase (Quinone); Neuroprotective Agents; Oxidopamine; Phenylethyl Alcohol | 2016 |
Antioxidant activity of olive wine, a byproduct of olive mill wastewater.
Topics: Administration, Oral; Animals; Antioxidants; Biomarkers; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Fermentation; Food-Processing Industry; Fruit; Glutathione; Hydroxyl Radical; Liver; Malondialdehyde; Mice; Olea; Oxidative Stress; Phenylethyl Alcohol; Phytotherapy; Picrates; Plants, Medicinal; Protein Carbonylation; Superoxide Dismutase; Wastewater; Wine | 2016 |
Hydroxytyrosol in functional hydroxytyrosol-enriched biscuits is highly bioavailable and decreases oxidised low density lipoprotein levels in humans.
Topics: Adult; Biological Availability; Female; Humans; Lipoproteins, LDL; Male; Olive Oil; Phenylethyl Alcohol; Plant Oils | 2016 |
Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD.
Topics: Animals; Disease Models, Animal; Duodenum; Hepatitis; Male; Non-alcoholic Fatty Liver Disease; Phenylethyl Alcohol; Rats | 2016 |
Oleic acid, hydroxytyrosol and n-3 fatty acids collectively modulate colitis through reduction of oxidative stress and IL-8 synthesis; in vitro and in vivo studies.
Topics: Animals; Caco-2 Cells; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Fatty Acids, Omega-3; Fish Oils; Humans; Interleukin-8; Male; Oleic Acid; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Wistar | 2016 |
Oleuropein hydrolysis in natural green olives: Importance of the endogenous enzymes.
Topics: beta-Glucosidase; Esterases; Food Handling; Food Storage; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Iridoid Glucosides; Iridoids; Olea; Phenols; Phenylethyl Alcohol; Pyrans; Salts; Taste | 2016 |
Pinoresinol of olive oil decreases vitamin D intestinal absorption.
Topics: Animals; Caco-2 Cells; Docosahexaenoic Acids; Female; Furans; Humans; Intestinal Absorption; Iridoid Glucosides; Iridoids; Lignans; Olive Oil; Phenylethyl Alcohol; Polyphenols; Rats; Rats, Wistar; Vitamin D | 2016 |
Effect of zinc formulations, sodium chloride, and hydroxytyrosol on the growth/no-growth boundaries of table olive related yeasts.
Topics: Candida; Fermentation; Hydrogen-Ion Concentration; Olea; Phenylethyl Alcohol; Pichia; Sodium Chloride; Zinc | 2016 |
Hydroxytyrosol and its complex forms (secoiridoids) modulate aorta and heart proteome in healthy rats: Potential cardio-protective effects.
Topics: Animals; Aorta; Cardiotonic Agents; Dietary Supplements; Female; Heart; Iridoids; Myocardium; Olive Oil; Phenylethyl Alcohol; Plant Extracts; Proteome; Rats, Wistar | 2016 |
Antioxidant effect of hydroxytyrosol on human sperm quality during in vitro incubation.
Topics: Adult; Antioxidants; Humans; Male; Middle Aged; Oxidative Stress; Phenylethyl Alcohol; Reactive Oxygen Species; Semen Analysis; Sperm Motility; Spermatozoa | 2017 |
In-vivo dermal pharmacokinetics, efficacy, and safety of skin targeting nanoparticles for corticosteroid treatment of atopic dermatitis.
Topics: Animals; Anti-Inflammatory Agents; Chitosan; Dermatitis, Atopic; Drug Delivery Systems; Hydrocortisone; Nanoparticles; Particle Size; Phenylethyl Alcohol; Rats; Skin; Skin Absorption | 2016 |
Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents.
Topics: Cell Line; Humans; Inhibitory Concentration 50; Leishmania donovani; Phenylethyl Alcohol; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2016 |
Interfacial Concentrations of Hydroxytyrosol and Its Lipophilic Esters in Intact Olive Oil-in-Water Emulsions: Effects of Antioxidant Hydrophobicity, Surfactant Concentration, and the Oil-to-Water Ratio on the Oxidative Stability of the Emulsions.
Topics: Antioxidants; Emulsions; Esters; Hydrophobic and Hydrophilic Interactions; Olive Oil; Oxidation-Reduction; Phenylethyl Alcohol; Surface-Active Agents; Water | 2016 |
Water-in-oil microemulsions versus emulsions as carriers of hydroxytyrosol: an in vitro gastrointestinal lipolysis study using the pHstat technique.
Topics: Animals; Chemistry, Pharmaceutical; Digestion; Dogs; Emulsifying Agents; Emulsions; Enzyme Assays; Fatty Acids; Fatty Acids, Nonesterified; Hydrogen-Ion Concentration; Lecithins; Lipase; Lipolysis; Monoglycerides; Olive Oil; Pharmaceutical Preparations; Phenylethyl Alcohol; Recombinant Proteins; Stomach; Surface-Active Agents; Triglycerides; Water | 2016 |
Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol.
Topics: Biological Availability; Dopamine; Humans; Phenylethyl Alcohol; Tissue Distribution; Tyramine | 2016 |
Synthesis and Antioxidant Activity of Alkyl Nitroderivatives of Hydroxytyrosol.
Topics: Antioxidants; Benzothiazoles; Carbon; Fluorescence Recovery After Photobleaching; Free Radical Scavengers; Humans; Nitrogen Dioxide; Oxidation-Reduction; Oxygen; Phenol; Phenols; Phenylethyl Alcohol; Reactive Oxygen Species; Sesame Oil; Sulfonic Acids | 2016 |
3,4-Dihydroxyphenylethanol (Hydroxytyrosol) Mitigates the Increase in Spontaneous Oxidation of Dopamine During Monoamine Oxidase Inhibition in PC12 Cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Dopamine Agents; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Parkinson Disease; PC12 Cells; Phenylethyl Alcohol; Rats | 2016 |
Original Research: Hydroxytyrosol, an ingredient of olive oil, reduces triglyceride accumulation and promotes lipolysis in human primary visceral adipocytes during differentiation.
Topics: Adipocytes; Apoptosis; Cell Differentiation; Cells, Cultured; Humans; Lipolysis; Olive Oil; Phenylethyl Alcohol; Transcriptome; Triglycerides | 2016 |
Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition; Diet, Mediterranean; Disease Models, Animal; Mice; Mice, Transgenic; Mitochondria; Olea; Oxidative Stress; Phenylethyl Alcohol | 2016 |
Synthesis and Antioxidant Activity of Hydroxytyrosol Alkyl-Carbonate Derivatives.
Topics: alpha-Tocopherol; Antioxidants; Carbonates; Molecular Structure; Olea; Oxidation-Reduction; Phenols; Phenylethyl Alcohol | 2016 |
Olive leaf extract activity against Candida albicans and C. dubliniensis - the in vitro viability study.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antioxidants; Candida; Candida albicans; Cell Nucleus; Cell Nucleus Shape; Chromatography, High Pressure Liquid; Coloring Agents; Fluorescent Dyes; Iridoid Glucosides; Iridoids; Microbial Sensitivity Tests; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Trypan Blue | 2016 |
Innovative method for recovery and valorization of hydroxytyrosol from olive mill wastewaters.
Topics: Chemistry Techniques, Analytical; Olea; Phenylethyl Alcohol; Polyphenols; Waste Products; Wastewater | 2016 |
Effect of Hydroxytyrosol on Human Mesenchymal Stromal/Stem Cell Differentiation into Adipocytes and Osteoblasts.
Topics: Adipocytes; Adipogenesis; Cell Differentiation; Humans; Mesenchymal Stem Cells; Osteoblasts; Phenylethyl Alcohol | 2016 |
Comparison of simple, double and gelled double emulsions as hydroxytyrosol and n-3 fatty acid delivery systems.
Topics: alpha-Linolenic Acid; Antioxidants; Emulsions; Fatty Acids, Omega-3; Gels; Hydrogen Peroxide; Oxidation-Reduction; Particle Size; Phenylethyl Alcohol; Plant Oils; Temperature | 2016 |
Application of dried blood spot cards to determine olive oil phenols (hydroxytyrosol metabolites) in human blood.
Topics: Blood Chemical Analysis; Chromatography, Liquid; Dried Blood Spot Testing; Humans; Olive Oil; Phenols; Phenylethyl Alcohol; Tandem Mass Spectrometry | 2016 |
Hydroxytyrosol modulates Par j 1-induced IL-10 production by PBMCs in healthy subjects.
Topics: Allergens; Anti-Inflammatory Agents; Antigens, Plant; Cells, Cultured; Diet; Humans; Hypersensitivity; Immunomodulation; Interleukin-10; Leukocytes, Mononuclear; Olive Oil; Phenylethyl Alcohol; Plant Proteins; Urticaceae | 2016 |
Investigations on the Reaction of C3 and C6 α-Dicarbonyl Compounds with Hydroxytyrosol and Related Compounds under Competitive Conditions.
Topics: Glycation End Products, Advanced; Kinetics; Molecular Structure; Phenylethyl Alcohol | 2016 |
Transdermal anti-inflammatory activity of bilayer film containing olive compound hydroxytyrosol: physical assessment, in vivo dermal safety and efficacy study in Freund's adjuvant-induced arthritic rat model.
Topics: Administration, Cutaneous; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Arthritis, Experimental; Drug Carriers; Freund's Adjuvant; Male; Olea; Organ Culture Techniques; Phenylethyl Alcohol; Plant Extracts; Rats; Rats, Wistar; Skin Absorption; Treatment Outcome | 2017 |
High doses of hydroxytyrosol induce apoptosis in papillary and follicular thyroid cancer cells.
Topics: Adenocarcinoma, Follicular; Antioxidants; Apoptosis; Blotting, Western; Carcinoma, Papillary; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; Humans; Phenylethyl Alcohol; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thyroid Neoplasms; Tumor Cells, Cultured | 2017 |
Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption.
Topics: Administration, Oral; Animals; Anterior Cruciate Ligament; Biflavonoids; Catechin; Cyclooxygenase 2; Diet; Dinoprostone; Disease Models, Animal; Female; Grape Seed Extract; Interleukin-1beta; Male; Mass Spectrometry; Matrix Metalloproteinase 13; Metabolome; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Olea; Osteoarthritis; Phenylethyl Alcohol; Proanthocyanidins; Rabbits; RNA, Messenger; Wounds and Injuries | 2016 |
Effects of hydroxytyrosol on cardiovascular biomarkers in experimental diabetes mellitus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aorta, Abdominal; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Cardiomyopathies; Dietary Supplements; Endothelium, Vascular; Inflammation Mediators; Lipid Peroxidation; Lipoproteins, LDL; Male; Muscle, Smooth, Vascular; Oxidative Stress; Phenylethyl Alcohol; Platelet Aggregation; Rats, Wistar; Reactive Nitrogen Species; Streptozocin | 2016 |
Effect of hydroxytyrosol and olive leaf extract on 1,2-dicarbonyl compounds, hydroxymethylfurfural and advanced glycation endproducts in a biscuit model.
Topics: Arginine; Chromatography, Liquid; Deoxyglucose; Flour; Food Handling; Furaldehyde; Gallic Acid; Glycation End Products, Advanced; Lysine; Maillard Reaction; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Pyruvaldehyde; Quercetin; Tandem Mass Spectrometry; Triticum | 2017 |
CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol.
Topics: Animals; Antioxidants; Biotransformation; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6; Humans; Male; Microsomes, Liver; Phenylethyl Alcohol; Rats; Rats, Wistar; Tyrosine | 2017 |
Hydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity.
Topics: Animals; Anti-Infective Agents; Cells, Cultured; Drug Synergism; Female; HIV-1; Human Activities; Humans; Leukocytes, Mononuclear; Microbial Sensitivity Tests; Phenylethyl Alcohol; Rabbits | 2016 |
Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetes Mellitus.
Topics: Animals; Brain; Diabetes Mellitus, Experimental; Humans; Male; Neuroprotective Agents; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Wistar | 2017 |
Influence of pH on the antioxidant phenols solubilised from hydrothermally treated olive oil by-product (alperujo).
Topics: Antioxidants; Chromatography, High Pressure Liquid; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Extracts | 2017 |
Hydroxytyrosol inhibits hydrogen peroxide-induced apoptotic signaling via labile iron chelation.
Topics: Antioxidants; Apoptosis; DNA Damage; Humans; Hydrogen Peroxide; Iron; Jurkat Cells; MAP Kinase Kinase 4; Olive Oil; p38 Mitogen-Activated Protein Kinases; Phenylethyl Alcohol; Phosphorylation | 2016 |
A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria.
Topics: Acylation; Bacteria; Biocatalysis; Biphenyl Compounds; Candida; Esterification; Free Radical Scavengers; Hydroxybenzoates; Lipase; Lipolysis; Methoxyhydroxyphenylglycol; Phenylethyl Alcohol; Phylogeny; Picrates; Polyphenols; Stereoisomerism | 2016 |
Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death.
Topics: Cell Death; Chondrocytes; Core Binding Factor Alpha 1 Subunit; Gene Expression; Humans; Hydrogen Peroxide; Matrix Metalloproteinase 13; MicroRNAs; Oxidants; Oxidative Stress; Phenylethyl Alcohol; RNA, Messenger; Sirtuin 1; Vascular Endothelial Growth Factor A | 2017 |
Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes in a rat model of diet-induced metabolic syndrome: Pharmacological and metabolism-based investigation.
Topics: Animals; Biomarkers; Cardiovascular System; Diet, High-Fat; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Liver; Male; Metabolic Syndrome; Obesity; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Wistar | 2017 |
Protective effects of hydroxytyrosol on gentamicin induced nephrotoxicity in mice.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Gentamicins; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Malondialdehyde; Mice; Oxidative Stress; Phenylethyl Alcohol; Sodium; Urination | 2017 |
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis.
Topics: Animals; Cattle; Endothelial Cells; Extracellular Matrix; Neovascularization, Physiologic; Phenylethyl Alcohol; Proteolysis | 2017 |
Phosphatidyl-hydroxytyrosol and phosphatidyl-tyrosol bilayer properties.
Topics: Lipid Bilayers; Molecular Structure; Particle Size; Phenylethyl Alcohol; Phospholipids; Quartz Crystal Microbalance Techniques; Surface Properties | 2017 |
Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages.
Topics: Animals; Anti-Inflammatory Agents; CD11b Antigen; Dinoprostone; Granulocytes; Humans; Inflammation Mediators; Lipopolysaccharides; Mice; MicroRNAs; Monocytes; NF-E2-Related Factor 2; Nitric Oxide; Phenylethyl Alcohol; RAW 264.7 Cells; Respiratory Burst; Resveratrol; Stilbenes | 2017 |
The LC-MS-based metabolomics of hydroxytyrosol administration in rats reveals amelioration of the metabolic syndrome.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolic Syndrome; Metabolome; Metabolomics; Olea; Phenylethyl Alcohol; Principal Component Analysis; Rats; Rats, Wistar | 2017 |
Hydroxytyrosol and the Colonic Metabolites Derived from Virgin Olive Oil Intake Induce Cell Cycle Arrest and Apoptosis in Colon Cancer Cells.
Topics: Apoptosis; Caco-2 Cells; Cell Cycle Checkpoints; Colon; Colonic Neoplasms; HT29 Cells; Humans; Olea; Olive Oil; Phenylethyl Alcohol | 2017 |
Biomethanization of olive mill solid waste after phenols recovery through low-temperature thermal pre-treatment.
Topics: Anaerobiosis; Biodegradation, Environmental; Food-Processing Industry; Industrial Waste; Methane; Olea; Phenols; Phenylethyl Alcohol; Spain; Temperature; Waste Management | 2017 |
Hydroxytyrosol extracts, olive oil and walnuts as functional components in chicken sausages.
Topics: Animals; Antioxidants; Chickens; Color; Cooking; Emulsions; Fat Substitutes; Fatty Acids, Unsaturated; Humans; Juglans; Lipid Peroxidation; Meat Products; Olive Oil; Phenylethyl Alcohol; Plant Extracts; Taste | 2017 |
Bioenergetic strategy of microalgae for the biodegradation of tyrosol and hydroxytyrosol.
Topics: Autotrophic Processes; Biodegradation, Environmental; Energy Metabolism; Industrial Waste; Microalgae; Olea; Phenylethyl Alcohol; Wastewater; Water Pollutants, Chemical; Water Purification | 2017 |
Protective effect of hydroxytyrosol in arsenic-induced mitochondrial dysfunction in rat brain.
Topics: Animals; Arsenic; Brain; Brain Diseases, Metabolic; Male; Mitochondria; Mitochondrial Proteins; Nerve Tissue Proteins; Phenylethyl Alcohol; Rats; Rats, Wistar | 2017 |
Olive leaf extract concentrated in hydroxytyrosol attenuates protein carbonylation and the formation of advanced glycation end products in a hepatic cell line (HepG2).
Topics: Antioxidants; Glycation End Products, Advanced; Hep G2 Cells; Hepatocytes; Humans; Iridoid Glucosides; Iridoids; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Protein Carbonylation | 2017 |
Complexation of hydroxytyrosol and 3,4-dihydroxyphenylglycol with pectin and their potential use for colon targeting.
Topics: Colon; Drug Delivery Systems; Drug Liberation; Methoxyhydroxyphenylglycol; Olea; Pectins; Phenylethyl Alcohol | 2017 |
Lipophilization of Hydroxytyrosol-Enriched Fractions from Olea europaea L. Byproducts and Evaluation of the in Vitro Effects on a Model of Colorectal Cancer Cells.
Topics: Cell Line, Tumor; Colorectal Neoplasms; Estrogen Receptor beta; Humans; Molecular Structure; Olea; Phenylethyl Alcohol; Plant Extracts; Waste Products | 2017 |
Evaluation of an olive leaf extract as a natural source of antiglycative compounds.
Topics: Chromatography, Liquid; Deoxyglucose; Fructosamine; Galactose; Glycation End Products, Advanced; Glycosylation; Glyoxal; Lysine; Olea; Ornithine; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Pyrimidines; Pyruvaldehyde; Tandem Mass Spectrometry | 2017 |
Hydroxytyrosol restores proper insulin signaling in an astrocytic model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Astrocytes; Blotting, Western; Cell Differentiation; Cell Line; Cell Survival; Insulin; Phenylethyl Alcohol; Rats; Signal Transduction | 2017 |
Micellization in vegetable oils: A structural characterisation.
Topics: Antioxidants; Benzhydryl Compounds; Cosmetics; Emulsifying Agents; Flavones; Glucosides; Glycerol; Humans; Iridoid Glucosides; Iridoids; Micelles; Phenylethyl Alcohol; Plant Oils; Solubility; Stearic Acids; Waxes | 2017 |
Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation.
Topics: Animals; Antioxidants; Diet, High-Fat; Down-Regulation; Liver; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Non-alcoholic Fatty Liver Disease; Phenylethyl Alcohol; PPAR alpha | 2017 |
Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice.
Topics: Animals; Antioxidants; Biomarkers; Delta-5 Fatty Acid Desaturase; Diet, High-Fat; Dietary Supplements; Fatty Acid Desaturases; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Hydroxylation; Insulin Resistance; Linoleoyl-CoA Desaturase; Liver; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Organ Specificity; Oxidative Stress; Phenylethyl Alcohol; Random Allocation; Weaning | 2017 |
Oleuropein, unexpected benefits!
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Pressure; Diet, Mediterranean; Humans; Hypertension; Iridoid Glucosides; Iridoids; Mice; Olea; Oxidative Stress; Parkinson Disease; Phenylethyl Alcohol; Rats | 2017 |
Hydroxytyrosol Attenuates LPS-Induced Acute Lung Injury in Mice by Regulating Autophagy and Sirtuin Expression.
Topics: Acute Lung Injury; Animals; Autophagy; Capillary Permeability; Chemokines; Cytokines; Disease Models, Animal; Gene Expression Regulation; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Mice; Models, Molecular; Molecular Conformation; Phenylethyl Alcohol; Sirtuins | 2017 |
Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylation.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Catechol O-Methyltransferase; Catechols; Cause of Death; Diet; Female; Genotype; Homovanillic Acid; Humans; Male; Methylation; Middle Aged; Myocardial Infarction; Olive Oil; Phenols; Phenylethyl Alcohol; Stroke; Wine | 2017 |
Bioactivity Improvement of Olea europaea Leaf Extract Biotransformed by Wickerhamomyces anomalus Enzymes.
Topics: beta-Glucosidase; Biotransformation; Caco-2 Cells; Coumaric Acids; Esterases; Humans; Hydrolysis; Iridoid Glucosides; Iridoids; Olea; Phenols; Phenylethyl Alcohol; Plant Leaves; Polyphenols; Saccharomycetales | 2017 |
Preparation, Characterization, and Antioxidant Activity Evaluation of Liposomes Containing Water-Soluble Hydroxytyrosol from Olive.
Topics: Antioxidants; Liposomes; Olea; Phenylethyl Alcohol; Water | 2017 |
Polyphenols and IUGR pregnancies: Maternal hydroxytyrosol supplementation improves prenatal and early-postnatal growth and metabolism of the offspring.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Birth Weight; Blood Glucose; Body Composition; Dietary Supplements; Female; Fetal Growth Retardation; Litter Size; Male; Phenylethyl Alcohol; Polyphenols; Postnatal Care; Pregnancy; Prenatal Nutritional Physiological Phenomena; Sex Factors; Swine; Weaning | 2017 |
Production of three phenylethanoids, tyrosol, hydroxytyrosol, and salidroside, using plant genes expressing in Escherichia coli.
Topics: Escherichia coli; Gene Expression Regulation, Enzymologic; Glucosides; Glycosyltransferases; Phenols; Phenylethyl Alcohol; Rhodiola | 2017 |
Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models.
Topics: Animals; Anti-Obesity Agents; Caffeic Acids; Models, Biological; Obesity; Oncorhynchus mykiss; Phenylethyl Alcohol; PPAR gamma; Rosiglitazone; Signal Transduction; Thiazolidinediones; Zebrafish | 2017 |
Proteomic evaluation of mouse adipose tissue and liver following hydroxytyrosol supplementation.
Topics: Adipose Tissue; Animals; Dietary Supplements; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Phenylethyl Alcohol; Proteins; Proteomics | 2017 |
Oleuropein and hydroxytyrosol inhibit the N-formyl-methionyl-leucyl-phenylalanine-induced neutrophil degranulation and chemotaxis via AKT, p38, and ERK1/2 MAP-Kinase inhibition.
Topics: Anti-Inflammatory Agents; Chemotaxis; Humans; Iridoid Glucosides; Iridoids; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenylethyl Alcohol; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction | 2017 |
Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea Europaea L.).
Topics: Acetates; Anti-Bacterial Agents; Catechols; Cell Membrane Permeability; DNA, Bacterial; Olea; Phenylethyl Alcohol; Plant Extracts; Vibrio | 2018 |
Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through the SIRT1-mediated signaling pathway.
Topics: Adventitia; Animals; Autophagy; Fibroblasts; Inflammation; Male; Models, Biological; Phenylethyl Alcohol; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Up-Regulation | 2018 |
Neurochemical evidence that cocaine- and amphetamine-regulated transcript (CART) 55-102 peptide modulates the dopaminergic reward system by decreasing the dopamine release in the mouse nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electric Stimulation; Extracellular Space; Homovanillic Acid; Humans; Male; Mice; Nerve Tissue Proteins; Norepinephrine; Nucleus Accumbens; Peptide Fragments; Phenylethyl Alcohol; Reward; Tissue Culture Techniques | 2017 |
Technological characteristics of cold-set gelled double emulsion enriched with n-3 fatty acids: Effect of hydroxytyrosol addition and chilling storage.
Topics: Antioxidants; Cold Temperature; Colony Count, Microbial; Dietary Fats; Emulsions; Fatty Acids, Omega-3; Food Handling; Food Microbiology; Food Storage; Gels; Hydrogen-Ion Concentration; Phenylethyl Alcohol; Thiobarbituric Acid Reactive Substances; Viscosity | 2017 |
Plasma Catechols After Eating Olives.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Catechols; Diet, Mediterranean; Eating; Female; Fruit; Healthy Volunteers; Humans; Liver; Male; Olea; Phenylethyl Alcohol | 2018 |
A new multifunctional hydroxytyrosol-fenofibrate with antidiabetic, antihyperlipidemic, antioxidant and antiinflammatory action.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemistry, Pharmaceutical; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Design; Fenofibrate; Hypoglycemic Agents; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Phenylethyl Alcohol | 2017 |
Effect of superoxide dismutase supplementation on sperm DNA fragmentation.
Topics: Abietanes; Adult; Antioxidants; Chromatin; DNA Fragmentation; Humans; Infertility, Male; Male; Multivariate Analysis; Phenylethyl Alcohol; Retrospective Studies; Semen; Semen Analysis; Spermatozoa; Superoxide Dismutase | 2017 |
Hydroxytyrosol contributes to cell proliferation and inhibits apoptosis in pulsed electromagnetic fields treated human umbilical vein endothelial cells in vitro.
Topics: Apoptosis; Biomarkers; Cell Movement; Cell Proliferation; Electromagnetic Fields; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Mitochondria; Phenylethyl Alcohol; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2017 |
Determination of hydroxytyrosol produced by winemaking yeasts during alcoholic fermentation using a validated UHPLC-HRMS method.
Topics: Chromatography, High Pressure Liquid; Fermentation; Phenylethyl Alcohol; Saccharomyces cerevisiae; Torulaspora; Vitis; Wine | 2018 |
Involvement of bilitranslocase and beta-glucuronidase in the vascular protection by hydroxytyrosol and its glucuronide metabolites in oxidative stress conditions.
Topics: Animals; Antioxidants; Aorta, Thoracic; Biological Transport, Active; Ceruloplasmin; Dietary Supplements; Endothelium, Vascular; Enzyme Inhibitors; Glucaric Acid; Glucuronidase; Glucuronides; In Vitro Techniques; Male; Membrane Transport Modulators; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Phenylmethylsulfonyl Fluoride; Rats, Wistar; tert-Butylhydroperoxide; Vascular Diseases; Vasodilation | 2018 |
Evaluation of phenolic composition and antioxidant activity changes in olive flowers during development using HPLC/DAD and LC-MS/MS.
Topics: Acetates; Antioxidants; Chromatography, High Pressure Liquid; Cyclopentane Monoterpenes; Flavonoids; Flowers; Fruit; Hydroxybenzoates; Iridoids; Lignans; Olea; Phenols; Phenylethyl Alcohol; Plant Leaves; Pyrans; Tandem Mass Spectrometry | 2018 |
Physiological linkage of gender, bioavailable hydroxytyrosol derivatives, and their metabolites with systemic catecholamine metabolism.
Topics: Animals; Catecholamines; Female; Male; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Sex Factors; Tandem Mass Spectrometry | 2017 |
Enzymatic Synthesis of a Novel Neuroprotective Hydroxytyrosyl Glycoside.
Topics: Biocatalysis; Chromatography, Thin Layer; Fungal Proteins; Glycosides; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Olive Oil; Phenols; Phenylethyl Alcohol; Talaromyces; Xylosidases | 2017 |
Alteration in the liver metabolome of rats with metabolic syndrome after treatment with Hydroxytyrosol. A Mass Spectrometry And Nuclear Magnetic Resonance - based metabolomics study.
Topics: Animals; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Metabolic Syndrome; Metabolome; Metabolomics; Phenylethyl Alcohol; Rats; Rats, Wistar | 2018 |
Effect of the composition of extra virgin olive oils on the differentiation and antioxidant capacities of twelve monovarietals.
Topics: Agriculture; Antioxidants; Chile; Food Analysis; Furans; Glucosides; Iridoid Glucosides; Iridoids; Least-Squares Analysis; Lignans; Olive Oil; Phenylethyl Alcohol; Principal Component Analysis; Pyrans | 2018 |
Antioxidant activity of hydroxytyrosyl esters studied in liposome models.
Topics: 2-Naphthylamine; Antioxidants; Esters; Fluoresceins; Laurates; Liposomes; Phenylethyl Alcohol; Phosphatidylcholines; Spectrometry, Fluorescence; Unilamellar Liposomes | 2018 |
Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetic Retinopathy: Relationship with Cardiovascular Biomarkers.
Topics: Animals; Biomarkers; Cardiovascular System; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Humans; Neuroprotective Agents; Olea; Phenylethyl Alcohol; Plant Extracts; Platelet Aggregation; Rats; Rats, Wistar; Retina; Retinal Ganglion Cells | 2018 |
Establishing an Artificial Pathway for Efficient Biosynthesis of Hydroxytyrosol.
Topics: Escherichia coli; Escherichia coli Proteins; Lactococcus lactis; Metabolic Engineering; Phenylethyl Alcohol; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2018 |
Hydroxytyrosol inhibits the inflammatory response of osteoarthritis chondrocytes via SIRT6-mediated autophagy.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Autophagy; Cartilage, Articular; Cell Survival; Chemokine CCL2; Chondrocytes; Gene Expression Regulation; Interleukin-1beta; Interleukin-6; Male; Models, Biological; Osteoarthritis; Phenylethyl Alcohol; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirtuins; Tumor Necrosis Factor-alpha | 2018 |
Simple and efficient sustainable semi-synthesis of oleacein [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate] as potential additive for edible oils.
Topics: Aldehydes; Food Additives; Humans; Iridoid Glucosides; Iridoids; Phenols; Phenylethyl Alcohol; Plant Oils | 2018 |
Fermented Apulian table olives: Effect of selected microbial starters on polyphenols composition, antioxidant activities and bioaccessibility.
Topics: Antioxidants; Biological Availability; Caco-2 Cells; Digestion; Fermentation; Food Microbiology; Glucosides; Humans; Olea; Phenols; Phenylethyl Alcohol; Polyphenols | 2018 |
Inhibition of lysozyme fibrillogenesis by hydroxytyrosol and dopamine: An Atomic Force Microscopy study.
Topics: Amyloid; Dopamine; Humans; Kinetics; Microscopy, Atomic Force; Molecular Structure; Muramidase; Phenylethyl Alcohol | 2018 |
A comprehensive evaluation of tyrosol and hydroxytyrosol derivatives in extra virgin olive oil by microwave-assisted hydrolysis and HPLC-MS/MS.
Topics: Antioxidants; Chromatography, High Pressure Liquid; Food Analysis; Hydrolysis; Limit of Detection; Microwaves; Olive Oil; Phenylethyl Alcohol; Tandem Mass Spectrometry | 2018 |
Protective Effects of Olive Leaf Extract on Acrolein-Exacerbated Myocardial Infarction via an Endoplasmic Reticulum Stress Pathway.
Topics: Acrolein; Animals; Apoptosis; Biological Products; Biomarkers; Cell Line; Cytoprotection; Disease Progression; Endoplasmic Reticulum Stress; Iridoid Glucosides; Iridoids; Isoproterenol; Male; Myocardial Infarction; Myocytes, Cardiac; Particulate Matter; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley | 2018 |
Efficient bioconversion of oleuropein from olive leaf extract to antioxidant hydroxytyrosol by enzymatic hydrolysis and high-temperature degradation.
Topics: Antioxidants; Enzymes; Esters; Hot Temperature; Hydrolysis; Iridoid Glucosides; Iridoids; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves | 2018 |
Oleic Acid and Hydroxytyrosol Inhibit Cholesterol and Fatty Acid Synthesis in C6 Glioma Cells.
Topics: Animals; Anticholesteremic Agents; Cell Line, Tumor; Cholesterol; Fatty Acid Synthases; Glioma; Lipid Metabolism; Oleic Acid; Olive Oil; Phenylethyl Alcohol; Rats | 2017 |
Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Female; Oxidative Stress; Paclitaxel; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Treatment Outcome; Tumor Burden | 2019 |
Protective Effect of Hydroxytyrosol Against Oxidative Stress Mediated by Arsenic-Induced Neurotoxicity in Rats.
Topics: Administration, Oral; Animals; Antioxidants; Arsenites; Blotting, Western; Brain; Caspase 3; Catalase; Cytochromes c; Cytosol; Down-Regulation; Glutathione; Lipid Metabolism; Lipid Peroxidation; Male; Mitochondria; Nerve Tissue Proteins; Oxidative Stress; Phenylethyl Alcohol; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Sodium Compounds; Spectroscopy, Fourier Transform Infrared; Superoxide Dismutase | 2018 |
Improving in vivo conversion of oleuropein into hydroxytyrosol by oral granules containing probiotic Lactobacillus plantarum 299v and an Olea europaea standardized extract.
Topics: Administration, Oral; Animals; Bile; Drug Carriers; Drug Liberation; Feces; Gastric Juice; Iridoid Glucosides; Iridoids; Lactobacillus plantarum; Male; Mice; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Probiotics | 2018 |
Energetic and Structural Properties of Two Phenolic Antioxidants: Tyrosol and Hydroxytyrosol.
Topics: Antioxidants; Calorimetry; Models, Molecular; Phenols; Phenylethyl Alcohol; Quantum Theory; Thermodynamics | 2018 |
Effect of Foods and β-Cyclodextrin on the Bioaccessibility and the Uptake by Caco-2 Cells of Hydroxytyrosol from Either a Pure Standard or Alperujo.
Topics: beta-Cyclodextrins; Biological Availability; Caco-2 Cells; Digestion; Drug Carriers; Drug Delivery Systems; Humans; Intestinal Absorption; Models, Biological; Olea; Phenylethyl Alcohol; Plant Extracts; Waste Products | 2018 |
Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2/HO1 and JAK/STAT signaling pathways.
Topics: Acetylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cytokines; Female; Heme Oxygenase-1; Inflammasomes; Inflammation; Janus Kinases; Lipopolysaccharides; Macrophages, Peritoneal; Membrane Proteins; Mice; Mitogen-Activated Protein Kinases; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Nitrites; Phenylethyl Alcohol; STAT3 Transcription Factor | 2018 |
Hydroxytyrosol nicotinate, a new multifunctional hypolipidemic and hypoglycemic agent.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Inhibitory Concentration 50; Lipids; Male; Mice; Niacin; Oxidative Stress; Phenylethyl Alcohol; Rats | 2018 |
Diet Supplementation with Hydroxytyrosol Ameliorates Brain Pathology and Restores Cognitive Functions in a Mouse Model of Amyloid-β Deposition.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis, Familial; Animals; Antioxidants; Autophagy; Brain; Cognition Disorders; Corneal Dystrophies, Hereditary; Diet; Disease Models, Animal; Glial Fibrillary Acidic Protein; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phenylethyl Alcohol; Presenilin-1; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
Oleuropein and hydroxytyrosol protect rats' pups against bisphenol A induced hypothyroidism.
Topics: Animals; Animals, Suckling; Benzhydryl Compounds; Endocrine Disruptors; Female; Hypothyroidism; Iridoid Glucosides; Iridoids; Lactation; Olea; Phenols; Phenylethyl Alcohol; Plant Leaves; Protective Agents; Rats; Thyroid Hormones | 2018 |
The protective effect of extra-virgin olive oil in the experimental model of multiple sclerosis in the rat.
Topics: Animals; Brain; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Male; Multiple Sclerosis; Oleic Acid; Olive Oil; Phenylethyl Alcohol; Rats; Spinal Cord | 2020 |
Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glucose; Insulin Resistance; Lipid Metabolism; Male; MAP Kinase Signaling System; Mice, Inbred ICR; Non-alcoholic Fatty Liver Disease; Obesity; Panniculitis; Phenylethyl Alcohol | 2018 |
Towards a high yield recovery of polyphenols from olive mill wastewater on activated carbon coated with milk proteins: Experimental design and antioxidant activity.
Topics: Adsorption; Charcoal; Chemical Fractionation; Milk Proteins; Olea; Phenylethyl Alcohol; Polyphenols; Wastewater | 2018 |
Expression of hydroxytyrosol and oleuropein biosynthetic genes are correlated with metabolite accumulation during fruit development in olive, Olea europaea, cv. Koroneiki.
Topics: Fruit; Gene Expression Regulation, Plant; Genes, Plant; Iridoid Glucosides; Iridoids; Olea; Phenylethyl Alcohol | 2018 |
Oleuropein and hydroxytyrosol rich extracts from olive leaves attenuate liver injury and lipid metabolism disturbance in bisphenol A-treated rats.
Topics: Animals; Antioxidants; Benzhydryl Compounds; Humans; Iridoid Glucosides; Iridoids; Lipid Metabolism; Liver Diseases; Male; Olea; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Rats | 2018 |
Selenium and sulphur derivatives of hydroxytyrosol: inhibition of lipid peroxidation in liver microsomes of vitamin E-deficient rats.
Topics: Animals; Disease Models, Animal; Lipid Peroxidation; Microsomes, Liver; Phenylethyl Alcohol; Rats; Selenium; Sulfur; Vitamin E Deficiency | 2019 |
Comparative Analysis of the Effects of Olive Oil Hydroxytyrosol and Its 5-
Topics: Catechols; Chromatography, High Pressure Liquid; Erythrocytes; Glutathione; Hemolysis; Hep G2 Cells; Humans; Mass Spectrometry; Mercuric Chloride; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Protective Agents; Reactive Oxygen Species; Spectrophotometry | 2018 |
3,4-Dihydroxyphenylethanol Assuages Cognitive Impulsivity in Alzheimer's Disease by Attuning HPA-Axis via Differential Crosstalk of α7 nAChR with MicroRNA-124 and HDAC6.
Topics: alpha Karyopherins; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Antioxidants; Corticosterone; Decision Making; Disease Models, Animal; Epigenesis, Genetic; Hippocampus; Histone Deacetylase 6; HSP90 Heat-Shock Proteins; Hypothalamo-Hypophyseal System; Impulsive Behavior; Mice; MicroRNAs; Phenylethyl Alcohol; Pituitary-Adrenal System; Receptors, Glucocorticoid | 2018 |
Inhibitory Activity of Hydroxytyrosol against Streptolysin O-Induced Hemolysis.
Topics: Animals; Anti-Infective Agents; Bacterial Proteins; Blood Cells; Hemolysis; Inhibitory Concentration 50; Olea; Phenylethyl Alcohol; Plant Extracts; Rabbits; Streptolysins | 2018 |
Acrolein-induced atherogenesis by stimulation of hepatic flavin containing monooxygenase 3 and a protection from hydroxytyrosol.
Topics: Acrolein; Animals; Atherosclerosis; ATP Binding Cassette Transporter 1; Biological Transport; Cholesterol; Endothelial Cells; Humans; Inflammation; Lipid Metabolism; Lipoproteins, LDL; Liver; Mice; Oxygenases; Phenylethyl Alcohol; RAW 264.7 Cells; Signal Transduction | 2018 |
Protective effects of hydroxytyrosol against α-synuclein toxicity on PC12 cells and fibril formation.
Topics: alpha-Synuclein; Amyloid; Animals; PC12 Cells; Phenylethyl Alcohol; Rats; Spectrometry, Fluorescence | 2018 |
Olive leaf extract counteracts epithelial to mesenchymal transition process induced by peritoneal dialysis, through the inhibition of TGFβ1 signaling.
Topics: Antigens, Differentiation; Cadherins; Cell Line; Cell Membrane; Epithelial-Mesenchymal Transition; Glucosides; Humans; Iridoid Glucosides; Iridoids; Olea; Peritoneal Dialysis; Phenols; Phenylethyl Alcohol; Plant Extracts; Signal Transduction; Smad Proteins, Receptor-Regulated; Transforming Growth Factor beta1 | 2019 |
The Olive Biophenols Oleuropein and Hydroxytyrosol Selectively Reduce Proliferation, Influence the Cell Cycle, and Induce Apoptosis in Pancreatic Cancer Cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Line, Tumor; Humans; Iridoid Glucosides; Iridoids; Neoplasm Proteins; Olea; Pancreatic Neoplasms; Phenylethyl Alcohol | 2018 |
Effect of edible pectin-fish gelatin films containing the olive antioxidants hydroxytyrosol and 3,4-dihydroxyphenylglycol on beef meat during refrigerated storage.
Topics: Animals; Antioxidants; Cattle; Fishes; Food Packaging; Food Storage; Gelatin; Methoxyhydroxyphenylglycol; Olea; Pectins; Phenylethyl Alcohol; Red Meat; Refrigeration; Thiobarbituric Acid Reactive Substances; Waxes | 2019 |
Effect of natural antioxidants from grape seed and chestnut in combination with hydroxytyrosol, as sodium nitrite substitutes in Cinta Senese dry-fermented sausages.
Topics: Animals; Antioxidants; Bacteria; Consumer Behavior; Fagaceae; Fatty Acids, Volatile; Fermentation; Food Handling; Food Preservation; Food Preservatives; Fruit; Grape Seed Extract; Humans; Lipid Peroxidation; Magnoliopsida; Meat Products; Odorants; Olea; Phenylethyl Alcohol; Plant Extracts; Seeds; Sodium Nitrite; Sus scrofa; Vitis | 2018 |
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives.
Topics: Angiogenesis Inhibitors; Animals; Cattle; Cell Differentiation; Cell Survival; Chick Embryo; Chorioallantoic Membrane; Endothelial Cells; Phenylethyl Alcohol; Structure-Activity Relationship | 2018 |
Fe, Zn and Se Bioavailability in Chicken Meat Emulsions Enriched with Minerals, Hydroxytyrosol and Extra Virgin Olive Oil as Measured by Caco-2 Cell Model.
Topics: Animal Feed; Animals; Biological Availability; Caco-2 Cells; Chickens; Digestion; Food, Fortified; Humans; Intestinal Absorption; Intestinal Mucosa; Iron, Dietary; Minerals; Nutritive Value; Olive Oil; Phenylethyl Alcohol; Poultry Products; Selenium; Zinc | 2018 |
Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells.
Topics: Apoptosis; Cell Line, Tumor; Gene Expression Regulation; Heme Oxygenase-1; Humans; Kelch-Like ECH-Associated Protein 1; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidopamine; Phenylethyl Alcohol; RNA, Messenger; Transcriptional Activation | 2018 |
Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HT.
Topics: Animals; Antioxidants; Diet, High-Fat; Eicosapentaenoic Acid; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phenylethyl Alcohol; Rats | 2018 |
Bioconversion of
Topics: Fermentation; Olea; Olive Oil; Phenylethyl Alcohol | 2018 |
A new multifunctional hydroxytyrosol-clofibrate with hypolipidemic, antioxidant, and hepatoprotective effects.
Topics: Animals; Antioxidants; Body Weight; Clofibrate; Dose-Response Relationship, Drug; Hepatocytes; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Molecular Structure; Organ Size; Phenylethyl Alcohol; Polyethylene Glycols; Structure-Activity Relationship | 2018 |
Structure-antioxidant activity relationship of β-cyclodextrin inclusion complexes with olive tyrosol, hydroxytyrosol and oleuropein: Deep insights from X-ray analysis, DFT calculation and DPPH assay.
Topics: beta-Cyclodextrins; Crystallography, X-Ray; Free Radical Scavengers; Hydrogen Bonding; Iridoid Glucosides; Iridoids; Models, Chemical; Molecular Structure; Phenylethyl Alcohol; Quantum Theory; Structure-Activity Relationship; Thermodynamics | 2018 |
Semisynthesis of ω-Hydroxyalkylcarbonate Derivatives of Hydroxytyrosol as Antitrypanosome Agents.
Topics: Cell Line; Humans; Magnetic Resonance Spectroscopy; Phenylethyl Alcohol; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2018 |
Insecticidal effects of the Olea europaea subsp. laperrinei extracts on the flour Pyralid Ephestia kuehniella.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Hesperidin; Insecticides; Iridoid Glucosides; Iridoids; Larva; Moths; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Quercetin | 2018 |
Preparation and characterization of nanostructured lipid carriers as drug delivery system: Influence of liquid lipid types on loading and cytotoxicity.
Topics: Antioxidants; Cell Survival; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Humans; Lipids; MCF-7 Cells; Nanostructures; Phenylethyl Alcohol; Structure-Activity Relationship | 2018 |
Hypoxia modulates the antioxidant effect of hydroxytyrosol in MCF-7 breast cancer cells.
Topics: Antioxidants; Breast Neoplasms; Cell Line, Tumor; ERRalpha Estrogen-Related Receptor; Humans; Hypoxia; MCF-7 Cells; NF-E2-Related Factor 2; Olive Oil; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenylethyl Alcohol; Reactive Oxygen Species; Receptors, Estrogen; RNA, Messenger; Signal Transduction | 2018 |
Anti-inflammatory effects of olive-derived hydroxytyrosol on lipopolysaccharide-induced inflammation in RAW264.7 cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gene Expression; Inflammation; Inflammation Mediators; Lipopolysaccharides; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Olea; Phenylethyl Alcohol; Plant Extracts; RAW 264.7 Cells | 2018 |
Chemoenzymatic synthesis of hydroxytyrosol monoesters and their suppression effect on nitric oxide production stimulated by lipopolysaccharides.
Topics: Acylation; Animals; Carbon-13 Magnetic Resonance Spectroscopy; Esters; Fungal Proteins; Hydroxylation; Inhibitory Concentration 50; Lipase; Lipopolysaccharides; Mice; Nitric Oxide; Phenylethyl Alcohol; Proton Magnetic Resonance Spectroscopy; RAW 264.7 Cells; Spectrometry, Mass, Electrospray Ionization | 2019 |
Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: involvement of resolvins RvE1/2 and RvD1/2.
Topics: Animals; Diet, High-Fat; Dietary Supplements; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids; Hepatitis; Liver; Male; Mice, Inbred C57BL; NF-kappa B; Phenylethyl Alcohol | 2019 |
Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes.
Topics: Antioxidants; Autophagy; Biocatalysis; Cell Line; Humans; Monocytes; Monophenol Monooxygenase; Olea; Phenylethyl Alcohol; Plant Extracts; Waste Products | 2018 |
Hydroxytyrosol from olive fruits prevents blue-light-induced damage in human keratinocytes and fibroblasts.
Topics: Antioxidants; Cell Line; Cell Survival; Collagen Type I; DNA Damage; Elastin; Fibroblasts; Fruit; Humans; Keratinocytes; Light; Matrix Metalloproteinase 1; Matrix Metalloproteinase 12; Olea; Oxidative Stress; Phenylethyl Alcohol; Proliferating Cell Nuclear Antigen; Radiation-Protective Agents; Reactive Oxygen Species; Skin; Skin Aging; Time Factors | 2019 |
β-Cyclodextrin Does not Alter the Bioaccessibility and the Uptake by Caco-2 Cells of Olive By-Product Phenolic Compounds.
Topics: Antioxidants; beta-Cyclodextrins; Biological Availability; Caco-2 Cells; Caffeic Acids; Coumaric Acids; Glucosides; Humans; Olea; Phenols; Phenylethyl Alcohol; Plant Extracts; Propionates | 2018 |
Lipoprotein Profile in Aged Rats Fed Chia Oil- or Hydroxytyrosol-Enriched Pork in High Cholesterol/High Saturated Fat Diets.
Topics: Adipose Tissue; alpha-Linolenic Acid; Animals; Antioxidants; Cholesterol, Dietary; Diet, High-Fat; Fatty Acids; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Phenylethyl Alcohol; Phospholipids; Plant Oils; Rats, Wistar; Receptors, LDL; Red Meat; Salvia; Seeds; Sterol Regulatory Element Binding Protein 1; Swine; Triglycerides | 2018 |
Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB.
Topics: Adipose Tissue, White; Animals; Antioxidants; Diet, High-Fat; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Phenylethyl Alcohol; PPAR gamma; Sterol Regulatory Element Binding Protein 1; Transcription Factors | 2019 |
Hydroxytyrosol Exerts Anti-Inflammatory and Anti-Oxidant Activities in a Mouse Model of Systemic Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Cytokines; Disease Models, Animal; DNA Damage; Inflammation; Lipopolysaccharides; Mice; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2018 |
Nutraceutical Oils Produced by Olives and
Topics: Carotenoids; Citrus; Dietary Supplements; Flavanones; Food, Fortified; Oils, Volatile; Olea; Phenols; Phenylethyl Alcohol; Plant Oils | 2018 |
Hydroxytyrosol NO regulates oxidative stress and NO production through SIRT1 in diabetic mice and vascular endothelial cells.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Supplements; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phenylethyl Alcohol; Phosphorylation; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirtuin 1; Vasodilator Agents | 2019 |
Identification of hydroxytyrosyl oleate, a derivative of hydroxytyrosol with anti-inflammatory properties, in olive oil by-products.
Topics: Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Dinoprostone; Down-Regulation; Lipopolysaccharides; Macrophages; Magnetic Resonance Spectroscopy; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Oleic Acid; Olive Oil; Phenylethyl Alcohol; RAW 264.7 Cells; Tandem Mass Spectrometry | 2019 |
Effect of different olive oil-derived antioxidants (hydroxytyrosol and 3,4-dihydroxyphenylglycol) on the quality of frozen-thawed ram sperm.
Topics: Acrosome; Animals; Antioxidants; Cryopreservation; Freezing; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Methoxyhydroxyphenylglycol; Olive Oil; Phenylethyl Alcohol; Semen; Semen Analysis; Semen Preservation; Sheep; Sperm Motility | 2019 |
Chromatographic Separation of Phenolic Compounds from Extra Virgin Olive Oil: Development and Validation of a New Method Based on a Biphenyl HPLC Column.
Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Mass Spectrometry; Olive Oil; Phenols; Phenylethyl Alcohol | 2019 |
Strawberry dietary fiber functionalized with phenolic antioxidants from olives. Interactions between polysaccharides and phenolic compounds.
Topics: Antioxidants; Cell Wall; Dietary Fiber; Fragaria; Fruit; Methoxyhydroxyphenylglycol; Olea; Phenols; Phenylethyl Alcohol; Polysaccharides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2019 |
Hydroxytyrosol influences exercise-induced mitochondrial respiratory complex assembly into supercomplexes in rats.
Topics: Animals; Antioxidants; Electron Transport Chain Complex Proteins; Male; Mitochondria; Mitochondrial Proteins; Multiprotein Complexes; Muscle, Skeletal; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Physical Conditioning, Animal; Rats; Rats, Wistar | 2019 |
Effects of olive leaf extract addition on fermentative and oxidative processes of table olives and their nutritional properties.
Topics: Antioxidants; Fermentation; Fermented Foods; Food Microbiology; Food Quality; Glucosides; Lactobacillus plantarum; Nutritive Value; Olea; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Taste | 2019 |
Targeting endothelial-to-mesenchymal transition: the protective role of hydroxytyrosol sulfate metabolite.
Topics: Anti-Inflammatory Agents; Antioxidants; Cells, Cultured; Endothelium; In Vitro Techniques; Inflammation; Mesoderm; Phenylethyl Alcohol; Sulfates | 2020 |
Modulation of LPS-induced nitric oxide production in intestinal cells by hydroxytyrosol and tyrosol metabolites: Insight into the mechanism of action.
Topics: Anti-Inflammatory Agents; Caco-2 Cells; Escherichia coli; Glucuronides; Humans; Lipopolysaccharides; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Olea; Olive Oil; Phenylethyl Alcohol; Signal Transduction; Sulfuric Acid Esters | 2019 |
Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis.
Topics: Biosynthetic Pathways; Directed Molecular Evolution; Escherichia coli; Metabolic Engineering; Mixed Function Oxygenases; Models, Biological; Phenylethyl Alcohol; Substrate Specificity | 2019 |
Antitumor Perspectives of Oleuropein.
Topics: Iridoid Glucosides; Iridoids; Phenylethyl Alcohol | 2019 |
Monitoring of acrylamide and phenolic compounds in table olive after high hydrostatic pressure and cooking treatments.
Topics: Acrylamide; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cooking; Hydrostatic Pressure; Iridoid Glucosides; Iridoids; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Tandem Mass Spectrometry | 2019 |
Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Placental Gene Expression and Fetal Antioxidant Status, DNA-Methylation and Phenotype.
Topics: Animals; Antioxidants; DNA Methylation; Female; Fetal Growth Retardation; Fetus; Gene Expression; Male; Oxidative Stress; Phenotype; Phenylethyl Alcohol; Placenta; Polyphenols; Pregnancy; Swine | 2019 |
In House Validated UHPLC Protocol for the Determination of the Total Hydroxytyrosol and Tyrosol Content in Virgin Olive Oil Fit for the Purpose of the Health Claim Introduced by the EC Regulation 432/2012 for "Olive Oil Polyphenols".
Topics: Chromatography, High Pressure Liquid; Humans; Hydrolysis; Olive Oil; Phenylethyl Alcohol; Polyphenols | 2019 |
Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ
Topics: Acetates; Amyloid beta-Peptides; Biophysical Phenomena; Cell Line, Tumor; Cyclopentane Monoterpenes; Humans; Neuroblastoma; Oxidative Stress; Peptide Fragments; Phenylethyl Alcohol; Pyrans | 2019 |
Protective effect of hydroxytyrosol and rosemary extract in a comparative study of the oxidative stability of Echium oil.
Topics: Antioxidants; Calorimetry, Differential Scanning; Echium; Entropy; Kinetics; Oxidation-Reduction; Phenylethyl Alcohol; Plant Extracts; Plant Oils; Rosmarinus; Temperature | 2019 |
Safety and efficacy of hydroxytyrosol-based formulation on skin inflammation: in vitro evaluation on reconstructed human epidermis model.
Topics: Administration, Topical; Cell Survival; Dermatitis; Drug Compounding; Epidermis; Humans; Lipopolysaccharides; Models, Biological; Phenylethyl Alcohol; Skin Absorption; Skin Cream | 2019 |
Efficient Synthesis of Hydroxytyrosol from l-3,4-Dihydroxyphenylalanine Using Engineered Escherichia coli Whole Cells.
Topics: Escherichia coli; Levodopa; Metabolic Engineering; Phenylethyl Alcohol; Plasmids | 2019 |
Transglycosylation products generated by Talaromyces amestolkiae GH3 β-glucosidases: effect of hydroxytyrosol, vanillin and its glucosides on breast cancer cells.
Topics: Benzaldehydes; Benzyl Alcohols; Breast Neoplasms; Cellulases; Glycosides; Glycosylation; Humans; Hydroquinones; MCF-7 Cells; Phenylethyl Alcohol; Substrate Specificity; Talaromyces | 2019 |
Covalent modification of flaxseed protein isolate by phenolic compounds and the structure and functional properties of the adducts.
Topics: Antioxidants; Coumaric Acids; Flax; Hydrogen-Ion Concentration; Phenols; Phenylethyl Alcohol; Plant Proteins; Polyphenols; Spectroscopy, Fourier Transform Infrared; Surface Properties | 2019 |
(-)-Epigallocatechin-3-gallate and hydroxytyrosol improved antioxidative and anti-inflammatory responses in bovine mammary epithelial cells.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Catechin; Cattle; Cell Line; Epithelial Cells; Phenylethyl Alcohol | 2019 |
The EFSA Health Claim on Olive Oil Polyphenols: Acid Hydrolysis Validation and Total Hydroxytyrosol and Tyrosol Determination in Italian Virgin Olive Oils.
Topics: Formates; Hydrolysis; Italy; Olive Oil; Phenylethyl Alcohol; Polyphenols; Reference Standards; Sulfuric Acids | 2019 |
Chemoenzymatic Synthesis and Radical Scavenging of Sulfated Hydroxytyrosol, Tyrosol, and Acetylated Derivatives.
Topics: Acetylation; Arylsulfotransferase; Bacterial Proteins; Biocatalysis; Chromatography, High Pressure Liquid; Desulfitobacterium; Free Radical Scavengers; Mass Spectrometry; Molecular Structure; Olive Oil; Phenols; Phenylethyl Alcohol; Sulfates | 2019 |
Root verbascoside and oleuropein are potential indicators of drought resistance in olive trees (Olea europaea L.).
Topics: Antioxidants; Apigenin; Droughts; Flavonoids; Glucosides; Iridoid Glucosides; Iridoids; Olea; Phenol; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Plant Roots; Polyphenols; Spectrophotometry, Ultraviolet; Stress, Physiological; Water | 2019 |
Ultrasound-assisted aqueous extraction of total flavonoids and hydroxytyrosol from olive leaves optimized by response surface methodology.
Topics: Antioxidants; Flavonoids; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Sonication; Water | 2019 |
Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats.
Topics: Animals; Aspirin; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Gastric Mucosa; Indomethacin; Male; Olea; Phenylethyl Alcohol; Rats, Sprague-Dawley; Stomach; Stomach Ulcer | 2019 |
Toward a Harmonized and Standardized Protocol for the Determination of Total Hydroxytyrosol and Tyrosol Content in Virgin Olive Oil (VOO). The Pros of a Fit for the Purpose Ultra High Performance Liquid Chromatography (UHPLC) Procedure.
Topics: Chromatography, High Pressure Liquid; Olive Oil; Phenylethyl Alcohol; Proton Magnetic Resonance Spectroscopy; Reference Standards | 2019 |
AKT-GSK3
Topics: Animals; Antioxidants; Apoptosis; Glycogen Synthase Kinase 3 beta; GTP Phosphohydrolases; Mice; Mitochondria; Osteoblasts; Osteoporosis; Oxidative Stress; Phenylethyl Alcohol; Proto-Oncogene Proteins c-akt; Signal Transduction; Transfection | 2019 |
Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Hepatic Fat Accretion and Energy and Fatty Acids Profile of Fetal Tissues.
Topics: Adiposity; Animals; Dietary Supplements; Disease Models, Animal; Energy Metabolism; Fatty Acids; Female; Fetal Growth Retardation; Fetus; Lipid Peroxidation; Liver; Maternal Exposure; Muscle, Skeletal; Phenylethyl Alcohol; Pregnancy; Sus scrofa | 2019 |
Continuous Bioconversion of Oleuropein from Olive Leaf Extract to Produce the Bioactive Product Hydroxytyrosol Using Carrier-Immobilized Enzyme.
Topics: Alginates; Biomass; Bioreactors; Cellulase; Ceramics; Chitosan; Enzymes, Immobilized; Hydrolysis; Iridoid Glucosides; Iridoids; Microscopy, Electron, Scanning; Olea; Phenylethyl Alcohol; Plant Leaves; Substrate Specificity; Thermogravimetry | 2020 |
Hydroxytyrosol prevents dermal papilla cells inflammation under oxidative stress by inducing autophagy.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Cells, Cultured; Hair; Inflammation; Oxidative Stress; Phenylethyl Alcohol; Rats; Skin | 2019 |
Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion of MDA-MB-231 Triple-Negative Breast Cancer Cell via Induction of Autophagy.
Topics: Antineoplastic Agents; Autophagy; Autophagy-Related Proteins; Cell Line, Tumor; Cell Movement; Cell Survival; Gene Expression; Humans; Iridoid Glucosides; Iridoids; Neoplasm Invasiveness; Phenylethyl Alcohol; Triple Negative Breast Neoplasms | 2019 |
Identification and validation of common molecular targets of hydroxytyrosol.
Topics: Computational Biology; Humans; Lipid Metabolism; Liver; MicroRNAs; Phenylethyl Alcohol; Proteins; Proteomics | 2019 |
Identification of putative genes for polyphenol biosynthesis in olive fruits and leaves using full-length transcriptome sequencing.
Topics: Alternative Splicing; Biosynthetic Pathways; Flavonoids; Fruit; Gene Expression Regulation, Plant; Iridoid Glucosides; Iridoids; Olea; Phenylethyl Alcohol; Plant Leaves; Polyphenols; Sequence Analysis, DNA; Transcriptome | 2019 |
Olive-Oil-Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF-κB Pathway.
Topics: Acetates; Catechols; Cell Survival; Cytokines; Dermatitis; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Infant, Newborn; Inflammation Mediators; Keratinocytes; Male; NF-kappa B; Olive Oil; Phenylethyl Alcohol; Polyphenols; Promoter Regions, Genetic; Signal Transduction | 2019 |
Hydroxytyrosol promotes autophagy by regulating SIRT1 against advanced oxidation protein product‑induced NADPH oxidase and inflammatory response.
Topics: Advanced Oxidation Protein Products; Animals; Animals, Newborn; Autophagy; Cells, Cultured; Chondrocytes; Gene Expression Regulation; Inflammation; Interleukin-6; Matrix Metalloproteinase 13; NADPH Oxidases; Oxidation-Reduction; Phenylethyl Alcohol; Rats; Reactive Oxygen Species; RNA Interference; Signal Transduction; Sirtuin 1; Tumor Necrosis Factor-alpha | 2019 |
Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach.
Topics: Animals; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Docosahexaenoic Acids; Drug Synergism; Fatty Liver; Humans; Inflammation; Lipid Metabolism; Liver; Mice; Oxidative Stress; Phenylethyl Alcohol; PPAR alpha | 2019 |
A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol.
Topics: Chemistry Techniques, Synthetic; Humans; Methoxyhydroxyphenylglycol; Molecular Structure; Phenylethyl Alcohol | 2019 |
Effect of oxidative stress and 3-hydroxytyrosol on DNA methylation levels of miR-9 promoters.
Topics: Azacitidine; Cell Line; Demethylation; DNA Methylation; Gene Expression Regulation; Gene Silencing; Humans; Hydrogen Peroxide; MicroRNAs; Oxidative Stress; Phenylethyl Alcohol; Promoter Regions, Genetic; Sirtuin 1 | 2019 |
An hydroxytyrosol enriched extract from olive mill wastewaters exerts antioxidant activity and antimicrobial activity on
Topics: Agrobacterium tumefaciens; Anti-Infective Agents; Antioxidants; Olea; Phenylethyl Alcohol; Phytochemicals; Plant Diseases; Pseudomonas; Wastewater | 2021 |
High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration.
Topics: Adenosine Triphosphate; Animals; Diet, High-Fat; Dietary Supplements; Drug Synergism; Eicosapentaenoic Acid; Energy Metabolism; Fatty Acids, Omega-3; Humans; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Non-alcoholic Fatty Liver Disease; Phenylethyl Alcohol | 2019 |
Protective effects of 3,4-dihydroxyphenylethanol on spinal cord injury-induced oxidative stress and inflammation.
Topics: Animals; Antioxidants; Apoptosis Regulatory Proteins; Cytokines; Inflammation; Lipid Peroxidation; Locomotion; Male; Oxidative Stress; Peroxidase; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord Injuries | 2019 |
Melatonin, protocatechuic acid and hydroxytyrosol effects on vitagenes system against alpha-synuclein toxicity.
Topics: alpha-Synuclein; Animals; Heme Oxygenase (Decyclizing); HSP70 Heat-Shock Proteins; Hydroxybenzoates; Melatonin; Neuroprotective Agents; PC12 Cells; Phenylethyl Alcohol; Rats; Sirtuin 2 | 2019 |
Hydroxytyrosol encapsulated in biocompatible water-in-oil microemulsions: How the structure affects in vitro absorption.
Topics: Antioxidants; Biocompatible Materials; Caco-2 Cells; Cell Survival; Drug Compounding; Dynamic Light Scattering; Electron Spin Resonance Spectroscopy; Emulsions; HT29 Cells; Humans; Intestinal Absorption; Oils; Phenylethyl Alcohol; Water | 2019 |
Hydroxytyrosol inhibits MAO isoforms and prevents neurotoxicity inducible by MPP+ invivo.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Catecholamines; Corpus Striatum; Dopamine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Phenylethyl Alcohol; Protein Isoforms; Rats; Rats, Wistar | 2020 |
Anti-VEGF Signalling Mechanism in HUVECs by Melatonin, Serotonin, Hydroxytyrosol and Other Bioactive Compounds.
Topics: Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Hydroxytryptophol; Indoleacetic Acids; Melatonin; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Phenylethyl Alcohol; Phospholipase C gamma; Proto-Oncogene Proteins c-akt; Serotonin; Signal Transduction; Vascular Endothelial Growth Factor A | 2019 |
Hydroxytyrosol, the Major Phenolic Compound of Olive Oil, as an Acute Therapeutic Strategy after Ischemic Stroke.
Topics: Animal Feed; Animals; Antioxidants; Behavior, Animal; Body Weight; Brain Ischemia; Cognition; Eating; Male; Mice; Mice, Inbred C57BL; Motor Activity; Muscle Strength; Olive Oil; Phenylethyl Alcohol; Random Allocation; Stroke | 2019 |
Hydroxytyrosol Modulates Adipocyte Gene and miRNA Expression Under Inflammatory Condition.
Topics: Adipocytes; Cell Line; DNA; Exosomes; Gene Expression Regulation; Humans; Inflammation; MicroRNAs; Phenylethyl Alcohol; Protein Binding; Reactive Oxygen Species; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2019 |
Overproduction of hydroxytyrosol in Saccharomyces cerevisiae by heterologous overexpression of the Escherichia coli 4-hydroxyphenylacetate 3-monooxygenase.
Topics: Escherichia coli; Mixed Function Oxygenases; Phenylethyl Alcohol; Saccharomyces cerevisiae | 2020 |
Insight into the molecular mechanism underlying the inhibition of α-synuclein aggregation by hydroxytyrosol.
Topics: Acetates; alpha-Synuclein; Antioxidants; Antiparkinson Agents; Cell Line, Tumor; Cell Survival; Cyclopentane Monoterpenes; Humans; Levodopa; Molecular Structure; Parkinson Disease; Phenylethyl Alcohol; Protein Aggregation, Pathological; Protein Binding; Protein Conformation; Proteolysis; Pyrans | 2020 |
Hydroxytyrosol Decreases Phosphatidylserine Exposure and Inhibits Suicidal Death Induced by Lysophosphatidic Acid in Human Erythrocytes.
Topics: Adenosine Triphosphate; Calcium; Cell Size; Eryptosis; Erythrocytes; Glutathione; Humans; Lysophospholipids; Phenylethyl Alcohol; Phosphatidylserines; Reactive Oxygen Species | 2019 |
Therapeutic prospects of hydroxytyrosol on experimentally induced diabetic testicular damage: potential interplay with AMPK expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; AMP-Activated Protein Kinases; Animals; Antioxidants; Diabetes Mellitus, Experimental; Male; Phenylethyl Alcohol; Rats; Rats, Wistar; Testicular Diseases; Testis | 2020 |
Hydroxytyrosol Inhibits LPS-Induced Neuroinflammatory Responses via Suppression of TLR-4-Mediated NF-κB P65 Activation and ERK Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Inflammation; Lipopolysaccharides; Microglia; Phenylethyl Alcohol; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA | 2020 |
Rapid determination of the free and total hydroxytyrosol and tyrosol content in extra virgin olive oil by stable isotope dilution analysis and paper spray tandem mass spectrometry.
Topics: Antioxidants; Hydrolysis; Indicator Dilution Techniques; Olive Oil; Phenylethyl Alcohol; Tandem Mass Spectrometry | 2020 |
Effect of olive-derived antioxidants (3,4-dihydroxyphenylethanol and 3,4 dihydroxyphenylglycol) on sperm motility and fertility in liquid ram sperm stored at 15°C or 5°C.
Topics: Animals; Antioxidants; Female; Fertility; Insemination, Artificial; Male; Methoxyhydroxyphenylglycol; Olea; Phenylethyl Alcohol; Semen; Semen Preservation; Sheep, Domestic; Sperm Motility; Spermatozoa; Temperature | 2020 |
Analysis of chemical composition in Chinese olive leaf tea by UHPLC-DAD-Q-TOF-MS/MS and GC-MS and its lipid-lowering effects on the obese mice induced by high-fat diet.
Topics: Animals; Beverages; Chromatography, Liquid; Diet, High-Fat; Gas Chromatography-Mass Spectrometry; Hyperlipidemias; Iridoid Glucosides; Iridoids; Male; Mice; Mice, Inbred ICR; Obesity; Olea; Phenylethyl Alcohol; Plant Leaves; Tandem Mass Spectrometry | 2020 |
Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats.
Topics: Animals; Dietary Fats; Iridoid Glucosides; Iridoids; Lipid Metabolism; Liver; Liver Diseases; Male; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Rats | 2020 |
Antioxidant properties of two novel lipophilic derivatives of hydroxytyrosol.
Topics: 3,4-Dihydroxyphenylacetic Acid; Antioxidants; Cooking; Hydroquinones; Kinetics; Olive Oil; Phenylethyl Alcohol; Soybean Oil; Structure-Activity Relationship; Temperature | 2020 |
Profile of Chlorophyll Catabolites in Senescent Leaves of
Topics: Aging; Antioxidants; Araceae; Chlorophyll; Chromatography, High Pressure Liquid; Esters; Oxidation-Reduction; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Spectrometry, Mass, Electrospray Ionization | 2020 |
Characterization of the microbial community composition in Italian Cinta Senese sausages dry-fermented with natural extracts as alternatives to sodium nitrite.
Topics: Fermentation; Fermented Foods; Grape Seed Extract; Italy; Meat Products; Microbiota; Phenylethyl Alcohol; Sodium Nitrite | 2020 |
Maternal Supplementation of Inositols, Fucoxanthin, and Hydroxytyrosol in Pregnant Murine Models of Hypertension.
Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Hypertension; Inositol; Mice; Mice, Knockout; Phenylethyl Alcohol; Pregnancy; Random Allocation; Xanthophylls | 2020 |
Oleic acid and hydroxytyrosol present in olive oil promote ROS and inflammatory response in normal cultures of murine dermal fibroblasts through the NF-κB and NRF2 pathways.
Topics: Animals; Cells, Cultured; Fibroblasts; Gene Expression Regulation; Inflammation; Male; Mice; NF-E2-Related Factor 2; NF-kappa B; Oleic Acid; Olive Oil; Phenylethyl Alcohol; Reactive Oxygen Species | 2020 |
Developing a highly efficient hydroxytyrosol whole-cell catalyst by de-bottlenecking rate-limiting steps.
Topics: Bacterial Proteins; Biosensing Techniques; Biosynthetic Pathways; Corynebacterium glutamicum; Directed Molecular Evolution; Escherichia coli; Escherichia coli Proteins; Feasibility Studies; Free Radical Scavengers; Metabolic Engineering; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Mutation; Phenylethyl Alcohol; Transcription Factors; Tyrosine; Tyrosine 3-Monooxygenase; Vanillic Acid | 2020 |
Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in
Topics: Acetates; alpha-Synuclein; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Cyclopentane Monoterpenes; Disease Models, Animal; Dopaminergic Neurons; Parkinson Disease; Phenylethyl Alcohol; Polyphenols; Pyrans; Treatment Outcome | 2020 |
Synergistic Neuroprotective Effect of Endogenously-Produced Hydroxytyrosol and Synaptic Vesicle Proteins on Pheochromocytoma Cell Line Against Salsolinol.
Topics: Adrenal Gland Neoplasms; Animals; Catalase; Cytosol; Dopamine; Drug Synergism; Flavonoids; Glutathione Peroxidase; Hydrogen Peroxide; Isoquinolines; Malondialdehyde; Metabolome; Neuroprotective Agents; PC12 Cells; Phenylethyl Alcohol; Pheochromocytoma; Rats; Superoxide Dismutase; Synaptic Vesicles; Transcription, Genetic | 2020 |
A coupled enzymatic reaction of tyrosinase and glucose dehydrogenase for the production of hydroxytyrosol.
Topics: Bacillus megaterium; Biocatalysis; Bioreactors; Enzymes, Immobilized; Escherichia coli; Glucose 1-Dehydrogenase; Monophenol Monooxygenase; NAD; Oxidation-Reduction; Phenylethyl Alcohol; Silanes | 2020 |
Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion via Induction of Autophagy in ER-Positive Breast Cancer Cell Lines (MCF7 and T47D).
Topics: Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Iridoid Glucosides; MCF-7 Cells; Phenylethyl Alcohol | 2021 |
Crosstalk between hydroxytyrosol, a major olive oil phenol, and HIF-1 in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Olive Oil; Phenol; Phenylethyl Alcohol; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Biomechanical properties enhancement of gamma radiation-sterilized cortical bone using antioxidants.
Topics: Animals; Antioxidants; Biomechanical Phenomena; Bone Transplantation; Cattle; Femur; Gamma Rays; Hardness; Phenylethyl Alcohol; Radiation-Protective Agents; Sterilization; Stress, Mechanical; Thioctic Acid | 2020 |
3-Hydroxytyrosol Promotes Angiogenesis In Vitro by Stimulating Endothelial Cell Migration.
Topics: Cell Movement; Cell Survival; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Matrix Metalloproteinase 2; Neovascularization, Physiologic; Phenylethyl Alcohol; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-akt; rho-Associated Kinases; Signal Transduction; src-Family Kinases; Vascular Endothelial Growth Factor Receptor-1; Wound Healing | 2020 |
Beer Phenolic Composition of Simple Phenols, Prenylated Flavonoids and Alkylresorcinols.
Topics: Beer; Fermentation; Flavanones; Flavonoids; Phenols; Phenylethyl Alcohol; Prenylation; Propiophenones; Xanthones | 2020 |
3,4-Dihydroxyphenethyl nitrate with nitric oxide releasing, antioxidant, hypoglycemic and hypolipidemic effects.
Topics: Administration, Oral; Animals; Antioxidants; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Hypolipidemic Agents; Mice; Molecular Structure; Nitrates; Nitric Oxide; Phenylethyl Alcohol; Streptozocin | 2020 |
Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats.
Topics: Animals; Antioxidants; Down-Regulation; Glucose; Glucose Transporter Type 4; Male; Muscle, Skeletal; Phenylethyl Alcohol; Phosphorylation; Physical Conditioning, Animal; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Rats; Rats, Wistar | 2021 |
Inhibition of human islet amyloid polypeptide aggregation and cellular toxicity by oleuropein and derivatives from olive oil.
Topics: Acetates; Cell Survival; Cyclopentane Monoterpenes; Diabetes Mellitus, Type 2; Diet, Mediterranean; Fluorescence; Humans; Inhibitory Concentration 50; Iridoid Glucosides; Iridoids; Islet Amyloid Polypeptide; Islets of Langerhans; Microscopy, Atomic Force; Olive Oil; Phenylethyl Alcohol; Phospholipids; Pyrans; Structure-Activity Relationship | 2020 |
Hydroxytyrosol suppresses LPS-induced intrahepatic inflammatory responses via inhibition of ERK signaling pathway activation in acute liver injury.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Inflammation; Lipopolysaccharides; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Phenylethyl Alcohol; RAW 264.7 Cells | 2020 |
Engineering
Topics: Escherichia coli; Metabolic Engineering; Phenylethyl Alcohol; Tyrosine | 2020 |
Targeted Lipidomics Profiling Reveals the Generation of Hydroxytyrosol-Fatty Acids in Hydroxytyrosol-Fortified Oily Matrices: New Analytical Methodology and Cytotoxicity Evaluation.
Topics: Cell Survival; Chromatography, High Pressure Liquid; Fatty Acids; Food, Fortified; Humans; Lipidomics; Phenylethyl Alcohol; Plant Oils; Tandem Mass Spectrometry | 2020 |
Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration.
Topics: Animals; Diet, High-Fat; Docosahexaenoic Acids; Humans; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Phenylethyl Alcohol; Random Allocation | 2020 |
Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin.
Topics: Amyloid; Amyloidogenic Proteins; Amyloidosis; Antioxidants; Cell Line, Tumor; Humans; Insulin; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Polyphenols; Protein Aggregation, Pathological | 2020 |
Use of olive (Olea europaea L.) leaves as beer ingredient, and their influence on beer chemical composition and antioxidant activity.
Topics: Antioxidants; Beer; Female; Food Handling; Humans; Humulus; Iridoid Glucosides; Iridoids; Male; Olea; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Polyphenols; Taste | 2020 |
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers.
Topics: Angiogenesis Inhibitors; Animals; Aorta; Apoptosis; Endothelial Cells; Ethers; Olive Oil; Phenols; Phenylethyl Alcohol | 2020 |
Protective effects of olive oil phenolics oleuropein and hydroxytyrosol against hydrogen peroxide-induced DNA damage in human peripheral lymphocytes.
Topics: Antioxidants; DNA Damage; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Hydrogen Peroxide; Iridoid Glucosides; Iridoids; Lymphocytes; Olive Oil; Phenylethyl Alcohol | 2021 |
Efficacy and safety of oral administration of a product based on hydroxytyrosol as preventive therapy for recurrent vulvo-vaginal candidosis: a prospective observational pilot study.
Topics: Administration, Oral; Adult; Antifungal Agents; Candidiasis, Vulvovaginal; Copper; Drug Combinations; Female; Humans; Middle Aged; Phenylethyl Alcohol; Pilot Projects; Plant Extracts; Prospective Studies; Quality of Life; Reinfection; Sexual Behavior; Time Factors; Treatment Outcome | 2020 |
The decrease in the health benefits of extra virgin olive oil during storage is conditioned by the initial phenolic profile.
Topics: Antioxidants; Area Under Curve; Chromatography, High Pressure Liquid; Food Storage; Iridoids; Olive Oil; Phenols; Phenylethyl Alcohol; ROC Curve; Tandem Mass Spectrometry; Time Factors | 2021 |
Oxidative polymerization of hydroxytyrosol catalyzed by laccase, tyrosinase or horseradish peroxidase: influencing factors and molecular simulations.
Topics: Catalysis; Horseradish Peroxidase; Laccase; Molecular Docking Simulation; Monophenol Monooxygenase; Oxidative Stress; Phenylethyl Alcohol; Polymerization | 2021 |
Hydroxytyrosol enhances cisplatin-induced ototoxicity: Possible relation to the alteration in the activity of JNK and AIF pathways.
Topics: Animals; Animals, Newborn; Anti-Infective Agents; Antineoplastic Agents; Apoptosis Inducing Factor; Cells, Cultured; Cisplatin; Dose-Response Relationship, Drug; Hair Cells, Auditory; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Ototoxicity; Phenylethyl Alcohol | 2020 |
Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia.
Topics: Adult; Case-Control Studies; Dermis; Extracellular Matrix; Female; Fibroblasts; Fibromyalgia; Humans; Inflammation; Middle Aged; Oxidation-Reduction; Phenylethyl Alcohol; Plant Oils; Proteome; Treatment Outcome | 2020 |
Hydroxytyrosol ameliorates oxidative challenge and inflammatory response associated with lipopolysaccharide-mediated sepsis in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; C-Reactive Protein; Catalase; Cytokines; Glutathione; Leukocyte Count; Lipopolysaccharides; Male; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenylethyl Alcohol; Sepsis; Spleen; Superoxide Dismutase | 2021 |
Quercetin and hydroxytyrosol as modulators of hepatic steatosis: A NAFLD-on-a-chip study.
Topics: Hep G2 Cells; Humans; Lab-On-A-Chip Devices; Liver; Models, Biological; Non-alcoholic Fatty Liver Disease; Phenylethyl Alcohol; Quercetin | 2021 |
A Quantitative Phytochemical Comparison of Olive Leaf Extracts on the Australian Market.
Topics: Antioxidants; Iridoid Glucosides; Iridoids; Olea; Phenylethyl Alcohol; Phytochemicals; Plant Extracts; Plant Leaves; Plants, Medicinal; Polyphenols | 2020 |
Oxidative polymerization process of hydroxytyrosol catalysed by polyphenol oxidases or peroxidase: Characterization, kinetics and thermodynamics.
Topics: Calorimetry; Catalysis; Catechol Oxidase; Horseradish Peroxidase; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kinetics; Laccase; Oxidation-Reduction; Phenylethyl Alcohol; Polymerization; Spectroscopy, Fourier Transform Infrared; Thermodynamics | 2021 |
Protective effect of olive oil polyphenol phase II sulfate conjugates on erythrocyte oxidative-induced hemolysis.
Topics: Amidines; Antioxidants; Erythrocytes; Hemolysis; Humans; Olive Oil; Oxidation-Reduction; Oxidative Stress; Phenylethyl Alcohol; Polyphenols; Protective Agents; Sulfates | 2020 |
Protective Effects of Eicosapentaenoic Acid Plus Hydroxytyrosol Supplementation Against White Adipose Tissue Abnormalities in Mice Fed a High-Fat Diet.
Topics: Adipose Tissue, White; Animals; Diet, High-Fat; Eicosapentaenoic Acid; Gene Expression Regulation; Male; Mice; Obesity; Phenylethyl Alcohol | 2020 |
Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Mitochondria; Phenylethyl Alcohol | 2022 |
The metabolic dysfunction of white adipose tissue induced in mice by a high-fat diet is abrogated by co-administration of docosahexaenoic acid and hydroxytyrosol.
Topics: Adipokines; Adipose Tissue, White; Animals; Diet, High-Fat; Dietary Supplements; Docosahexaenoic Acids; Glucose; Humans; Lipogenesis; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Obesity; Phenylethyl Alcohol; PPAR gamma; Sterol Regulatory Element Binding Protein 1 | 2020 |
Olive oil varieties and ripening stages containing the antioxidants hydroxytyrosol and derivatives in compliance with EFSA health claim.
Topics: Antioxidants; Food Safety; Insurance Benefits; Olive Oil; Phenylethyl Alcohol | 2021 |
Potential Beneficial Effects of Extra Virgin Olive Oils Characterized by High Content in Minor Polar Compounds in Nephropathic Patients: A Pilot Study.
Topics: Aged; Chromatography, High Pressure Liquid; Diet, Mediterranean; Female; Humans; Male; Middle Aged; Olive Oil; Phenols; Phenylethyl Alcohol; Renal Insufficiency, Chronic | 2020 |
Target and Suspect HRMS Metabolomics for the Determination of Functional Ingredients in 13 Varieties of Olive Leaves and Drupes from Greece.
Topics: Chromatography, High Pressure Liquid; Geography; Greece; Hot Temperature; Iridoid Glucosides; Iridoids; Limit of Detection; Metabolomics; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Reproducibility of Results; Seasons; Seeds; Tandem Mass Spectrometry; Time Factors | 2020 |
The Hydroxytyrosol Induces the Death for Apoptosis of Human Melanoma Cells.
Topics: Antioxidants; Apoptosis; Cell Movement; Cell Proliferation; Humans; Melanoma; Phenylethyl Alcohol; Reactive Oxygen Species; Tumor Cells, Cultured | 2020 |
Synthesis and antioxidant activity of conjugates of hydroxytyrosol and coumarin.
Topics: Antioxidants; Apoptosis; Benzothiazoles; Biphenyl Compounds; Cell Line; Cell Survival; Coumarins; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Molecular Structure; Phenylethyl Alcohol; Picrates; Reactive Oxygen Species; Structure-Activity Relationship; Sulfonic Acids | 2020 |
Pilot study for the evaluation of safety profile of a potential inhibitor of SARS-CoV-2 endocytosis.
Topics: Adult; Aged; Aged, 80 and over; alpha-Cyclodextrins; Antiviral Agents; Betacoronavirus; Caco-2 Cells; Cell Culture Techniques; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Endocytosis; Female; Humans; Male; Middle Aged; Oral Sprays; Pandemics; Phenylethyl Alcohol; Pilot Projects; Pneumonia, Viral; SARS-CoV-2; Young Adult | 2020 |
A pilot study on the preventative potential of alpha-cyclodextrin and hydroxytyrosol against SARS-CoV-2 transmission.
Topics: Adult; alpha-Cyclodextrins; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cyprus; Endocytosis; Female; Humans; Male; Middle Aged; Oral Sprays; Pandemics; Phenylethyl Alcohol; Pilot Projects; Pneumonia, Viral; SARS-CoV-2; Viral Load | 2020 |
A new family of hydroxytyrosol phenolipids for the antioxidant protection of liposomal systems.
Topics: Antioxidants; Hydrophobic and Hydrophilic Interactions; Liposomes; Oxidation-Reduction; Phenylethyl Alcohol | 2021 |
Antioxidant and Biological Activities of Hydroxytyrosol and Homovanillic Alcohol Obtained from Olive Mill Wastewaters of Extra-Virgin Olive Oil Production.
Topics: Animals; Antioxidants; Cell Line; Cell Proliferation; Homovanillic Acid; Humans; Olea; Olive Oil; Phenylethyl Alcohol; Plant Extracts; Rats; Reactive Oxygen Species; Waste Products; Wastewater | 2020 |
Strawberry Puree Functionalized with Natural Hydroxytyrosol: Effects on Vitamin C and Antioxidant Activity.
Topics: Antioxidants; Ascorbic Acid; Biological Products; Chromatography, High Pressure Liquid; Drug Stability; Fragaria; Molecular Structure; Oxidation-Reduction; Phenylethyl Alcohol; Solutions; Temperature | 2020 |
Hydroxytyrosol inhibits apoptosis in ischemia/reperfusion-induced acute kidney injury via activating Sonic Hedgehog signaling pathway.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Survival; Cells, Cultured; Disease Models, Animal; Hedgehog Proteins; Humans; Male; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2020 |
Investigation of the Anti-Cancer Effects of Free and PLGA-PAA Encapsulated Hydroxytyrosol on the MCF-7 Breast Cancer Cell Line.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Female; Humans; MCF-7 Cells; Nanoparticles; Phenylethyl Alcohol | 2022 |
The Impact of Olive Oil Compounds on the Metabolic Reprogramming of Cutaneous Melanoma Cell Models.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Cellular Reprogramming Techniques; Humans; MAP Kinase Signaling System; Melanoma; Neoplasm Proteins; Olive Oil; Phenylethyl Alcohol; Skin Neoplasms | 2021 |
Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA-PAA nano-encapsulation on PANC-1 pancreatic cancer cell line.
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Curcumin; Humans; Nanoparticles; Pancreatic Neoplasms; Phenylethyl Alcohol | 2021 |
The SARS-CoV-2-Inactivating Activity of Hydroxytyrosol-Rich Aqueous Olive Pulp Extract (HIDROX
Topics: Administration, Topical; Animals; Antiviral Agents; Carbohydrates; Chlorocebus aethiops; Coronavirus Nucleocapsid Proteins; Genome, Viral; Glycosylation; Microbial Sensitivity Tests; Olea; Phenylethyl Alcohol; Phosphoproteins; Plant Extracts; SARS-CoV-2; Skin Cream; Spike Glycoprotein, Coronavirus; Vero Cells; Virus Inactivation | 2021 |
Usefulness of Extra Virgin Olive Oil Minor Polar Compounds in the Management of Chronic Kidney Disease Patients.
Topics: Aged; Aged, 80 and over; Albuminuria; Aldehydes; Antioxidants; Azotemia; Biomarkers; Body Composition; C-Reactive Protein; Cyclopentane Monoterpenes; Diet, Mediterranean; Female; Glomerular Filtration Rate; Humans; Inflammation; Male; Middle Aged; Olive Oil; Oxidative Stress; Phenols; Phenylethyl Alcohol; Polyphenols; Renal Insufficiency, Chronic; Surveys and Questionnaires; Uric Acid | 2021 |
3-Hydroxytyrosol regulates biofilm growth in Cunninghamella elegans.
Topics: Biofilms; Cunninghamella; Phenylethyl Alcohol | 2021 |
Gender differences in the antioxidant response of oral administration of hydroxytyrosol and oleuropein against N-ethyl-N-nitrosourea (ENU)-induced glioma.
Topics: Administration, Oral; Animals; Antioxidants; Ethylnitrosourea; Glioma; Iridoid Glucosides; Phenylethyl Alcohol; Rats; Sex Characteristics | 2021 |
Keratinocytes Migration Promotion, Proliferation Induction, and Free Radical Injury Prevention by 3-Hydroxytirosol.
Topics: Antioxidants; Cell Movement; Cell Proliferation; Cells, Cultured; Epidermis; Free Radical Scavengers; Free Radicals; Humans; Hydrogen Peroxide; Keratinocytes; Oxidants; Phenylethyl Alcohol; Signal Transduction; Wound Healing | 2021 |
A Comparison of the Anti-Cancer Effects of Free and PLGA-PAA Encapsulated Hydroxytyrosol on the HT-29 Colorectal Cancer Cell Line.
Topics: Acrylic Resins; Antineoplastic Agents; Capsules; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Nanoparticles; Phenylethyl Alcohol; Polyesters; Polyglycolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured | 2022 |
Hydroxytyrosol as anti-parkinsonian molecule: Assessment using in-silico and MPTP-induced Parkinson's disease model.
Topics: Animals; Antiparkinson Agents; Blood Platelets; Computer Simulation; Dopamine; Dopaminergic Neurons; Humans; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Dynamics Simulation; Monoamine Oxidase; MPTP Poisoning; Neostriatum; Olive Oil; Parkinson Disease, Secondary; Phenylethyl Alcohol; Substantia Nigra | 2021 |
Nano-encapsulation of hydroxytyrosol into formulated nanogels improves therapeutic effects against hepatic steatosis: An in vitro study.
Topics: Humans; Nanogels; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phenylethyl Alcohol | 2021 |
Hydroxytyrosol alleviates oxidative stress and neuroinflammation and enhances hippocampal neurotrophic signaling to improve stress-induced depressive behaviors in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cytokines; Depression; Disease Models, Animal; Hindlimb Suspension; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Phenylethyl Alcohol; Signal Transduction; Stress, Psychological; Swimming | 2021 |
The Potential of Virgin Olive Oil from cv. Chondrolia Chalkidikis and Chalkidiki (Greece) to Bear Health Claims according to the European Legislation.
Topics: alpha-Tocopherol; Chromatography, High Pressure Liquid; Colorimetry; Europe; Fatty Acids; Food Analysis; Greece; Nutrition Policy; Olea; Oleic Acid; Olive Oil; Phenol; Phenylethyl Alcohol; Spectrophotometry, Ultraviolet; Temperature; Tocopherols; Vitamin E | 2021 |
Association of antioxidant monophenolic compounds with β-cyclodextrin-functionalized cellulose and starch substrates.
Topics: Acrolein; Antioxidants; Benzaldehydes; beta-Cyclodextrins; Butanes; Carboxylic Acids; Cellulose; Cross-Linking Reagents; Cymenes; Drug Liberation; Kinetics; Phenols; Phenylethyl Alcohol; Starch | 2021 |
Olive polyphenols attenuate TNF-α-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.
Topics: 3T3 Cells; Animals; Culture Media, Conditioned; Interleukin-6; Iridoid Glucosides; Macrophage Colony-Stimulating Factor; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Olea; Oncogene Protein v-akt; Phenylethyl Alcohol; Polyphenols; Rotenone; Signal Transduction; Tumor Necrosis Factor-alpha | 2021 |
Determination of hydroxytyrosol and tyrosol in human urine after intake of extra virgin olive oil produced with an ultrasounds-based technology.
Topics: Adult; Aged; Antioxidants; Female; Humans; Male; Middle Aged; Olive Oil; Phenylethyl Alcohol; Plant Oils; Technology; Young Adult | 2021 |
Hydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Line; Chemokines; Cisplatin; Humans; Kidney; Male; MARVEL Domain-Containing Proteins; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; Phenylethyl Alcohol | 2021 |
Structural Features and Toxicity of α-Synuclein Oligomers Grown in the Presence of DOPAC.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Synuclein; Amyloid; Cell Proliferation; Dopamine; Dopaminergic Neurons; Humans; Oxidative Stress; Parkinson Disease; Phenylethyl Alcohol; Protein Aggregation, Pathological; Protein Multimerization | 2021 |
EVOO Polyphenols Relieve Synergistically Autophagy Dysregulation in a Cellular Model of Alzheimer's Disease.
Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Autophagy; Cell Line; Cyclopentane Monoterpenes; Diet, Mediterranean; Humans; Mitochondria; Models, Neurological; Nerve Degeneration; Neurons; Olive Oil; Peptide Fragments; Phenylethyl Alcohol; Polyphenols; Proteasome Endopeptidase Complex; Pyrans; Reactive Oxygen Species; Ubiquitin | 2021 |
One-Step Extraction of Olive Phenols from Aqueous Solution Using β-Cyclodextrin in the Solid State, a Simple Eco-Friendly Method Providing Photochemical Stability to the Extracts.
Topics: Antioxidants; beta-Cyclodextrins; Dietary Supplements; Olea; Olive Oil; Phenylethyl Alcohol; Plant Extracts; Wastewater | 2021 |
Hydroxytyrosol alleviate intestinal inflammation, oxidative stress and apoptosis resulted in ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Inflammation; Male; Olea; Oxidative Stress; Phenylethyl Alcohol; Plant Extracts; Rats | 2021 |
De novo biosynthesis of tyrosol acetate and hydroxytyrosol acetate from glucose in engineered Escherichia coli.
Topics: Acetates; Escherichia coli; Glucose; Humans; Olive Oil; Phenylethyl Alcohol | 2021 |
Hydroxytyrosol prevents periodontitis-induced bone loss by regulating mitochondrial function and mitogen-activated protein kinase signaling of bone cells.
Topics: Animals; Cell Differentiation; MAP Kinase Signaling System; Mice; Mitochondria; Mitogen-Activated Protein Kinases; Osteoblasts; Osteoclasts; Periodontitis; Phenylethyl Alcohol; Signal Transduction | 2021 |
Olive Pomace Phenolic Compounds Stability and Safety Evaluation: From Raw Material to Future Ophthalmic Applications.
Topics: Aldehydes; Cell Line; Chromatography, High Pressure Liquid; Comet Assay; Cornea; Drug Evaluation, Preclinical; Drug Stability; Humans; Olea; Ophthalmic Solutions; Phenols; Phenylethyl Alcohol; Plant Extracts; Tandem Mass Spectrometry | 2021 |
Production of hydroxytyrosol rich extract from Olea europaea leaf with enhanced biological activity using immobilized enzyme reactors.
Topics: Antioxidants; Enzymes, Immobilized; Iridoids; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves | 2022 |
Metabolic engineering of Saccharomyces cerevisiae for hydroxytyrosol overproduction directly from glucose.
Topics: Culture Media; Escherichia coli; Fermentation; Glucose; Metabolic Engineering; Phenylethyl Alcohol; Saccharomyces cerevisiae | 2022 |
Hydroxytyrosol effectively improves the quality of pig sperm at 17 °C.
Topics: Animals; Female; Insemination, Artificial; Male; Phenylethyl Alcohol; Pregnancy; Semen Preservation; Sperm Motility; Spermatozoa; Swine | 2022 |
Dietary polyphenol oleuropein and its metabolite hydroxytyrosol are moderate skin permeable elastase and collagenase inhibitors with synergistic cellular antioxidant effects in human skin fibroblasts.
Topics: Antioxidants; Fibroblasts; Humans; Hydrogen Peroxide; Iridoid Glucosides; Iridoids; Matrix Metalloproteinase Inhibitors; Pancreatic Elastase; Phenylethyl Alcohol; Polyphenols; Reactive Oxygen Species | 2022 |
Oleil Hydroxytyrosol (HTOL) Exerts Anti-Myeloma Activity by Antagonizing Key Survival Pathways in Malignant Plasma Cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Multiple Myeloma; Phenylethyl Alcohol; Plasma Cells; Signal Transduction | 2021 |
Immunomodulatory and antioxidant effects of hydroxytyrosol in cyclophosphamide-induced immunosuppressed broilers.
Topics: Animals; Antioxidants; Chickens; Cyclophosphamide; Male; Phenylethyl Alcohol | 2022 |
Inhibition of the pesticide rotenone-induced Ca
Topics: Calcium; Cell Survival; Oxidative Stress; Pesticides; Phenylethyl Alcohol; Rotenone | 2021 |
Nutrigenomic Effect of Hydroxytyrosol in Vascular Endothelial Cells: A Transcriptomic Profile Analysis.
Topics: Down-Regulation; Gene Expression Profiling; Gene Ontology; Human Umbilical Vein Endothelial Cells; Humans; NF-kappa B; Nutrigenomics; Phenylethyl Alcohol; Reproducibility of Results; Signal Transduction; Unfolded Protein Response; Up-Regulation | 2021 |
Development of Analytical Strategies for the Determination of Olive Fruit Bioactive Compounds Using UPLC-HRMS and HPLC-DAD. Chemical Characterization of
Topics: Aldehydes; Chromatography, High Pressure Liquid; Fruit; Glucosides; Greece; Iridoids; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Phytochemicals; Tandem Mass Spectrometry; Tocopherols | 2021 |
Improvement of quality of life by intake of hydroxytyrosol in patients with lymphedema and association of lymphedema genes with obesity.
Topics: Adult; Antioxidants; Body Mass Index; Cohort Studies; Computational Biology; Female; Genetic Testing; Humans; Lymphedema; Male; Middle Aged; Obesity; Olive Oil; Phenylethyl Alcohol; Quality of Life; Surveys and Questionnaires | 2021 |
Effect of a dietary supplement on the reduction of lymphedema-progression in mouse tail-cut model.
Topics: Animals; Citrus; Dietary Supplements; Disease Models, Animal; Disease Progression; Lymphedema; Mice; Olea; Oryza; Phenylethyl Alcohol; Plant Extracts; Tail; Treatment Outcome; Vitamin A; Wound Healing | 2021 |
Proposal of a food supplement for the management of post-COVID syndrome.
Topics: Acetylcarnitine; Adult; Aged; COVID-19; Dietary Supplements; Fatigue; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Phenylethyl Alcohol; Pilot Projects; Post-Acute COVID-19 Syndrome; SARS-CoV-2; Self Report; Surveys and Questionnaires; Vitamins | 2021 |
Prevention of the proliferation of oral pathogens due to prolonged mask use based on α-cyclodextrin and hydroxytyrosol mouthwash.
Topics: alpha-Cyclodextrins; Candida albicans; Halitosis; Humans; Masks; Mouth Mucosa; Mouthwashes; Neisseria; Phenylethyl Alcohol; Staphylococcus aureus; Time Factors | 2021 |
In vitro and clinical studies on the efficacy of α-cyclodextrin and hydroxytyrosol against SARS-CoV-2 infection.
Topics: Administration, Intranasal; Adult; Aged; alpha-Cyclodextrins; Animals; Anti-Infective Agents; Cell Line; Chlorocebus aethiops; COVID-19; Female; Gene Expression; Health Personnel; Humans; Male; Middle Aged; Phenylethyl Alcohol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; SARS-CoV-2; Virus Internalization; Young Adult | 2021 |
Scoping review on the role and interactions of hydroxytyrosol and alpha-cyclodextrin in lipid-raft-mediated endocytosis of SARS-CoV-2 and bioinformatic molecular docking studies.
Topics: alpha-Cyclodextrins; Angiotensin-Converting Enzyme 2; Binding Sites; Computational Biology; COVID-19; Humans; Membrane Microdomains; Molecular Docking Simulation; Phenylethyl Alcohol; Protein Binding; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Virus Internalization | 2021 |
Isotopic labelling-based analysis elucidates biosynthesis pathways in Saccharomyces cerevisiae for Melatonin, Serotonin and Hydroxytyrosol formation.
Topics: Fermentation; Fermented Beverages; Melatonin; Phenylethyl Alcohol; Saccharomyces cerevisiae; Serotonin | 2022 |
Conjugated Metabolites of Hydroxytyrosol and Tyrosol Contribute to the Maintenance of Nitric Oxide Balance in Human Aortic Endothelial Cells at Physiologically Relevant Concentrations.
Topics: Antioxidants; Aorta; Endothelial Cells; Humans; Molecular Structure; Nitric Oxide; Phenylethyl Alcohol | 2021 |
Synthesis of Tyrosol and Hydroxytyrosol Glycofuranosides and Their Biochemical and Biological Activities in Cell-Free and Cellular Assays.
Topics: Cell-Free System; Free Radical Scavengers; Hep G2 Cells; Humans; Phenylethyl Alcohol | 2021 |
Nanoencapsulation of hydroxytyrosol in chitosan crosslinked with sodium bisulfate tandem ultrasonication: Techno-characterization, release and antiproliferative properties.
Topics: Antioxidants; Chitosan; Nanocapsules; Particle Size; Phenylethyl Alcohol; Sulfates; Ultrasonics | 2022 |
Niosomal formulation of hydroxytyrosol, a polyphenolic antioxidant, for enhancing transdermal delivery across human cadaver skin.
Topics: Administration, Cutaneous; Antioxidants; Cadaver; Humans; Lecithins; Liposomes; Phenylethyl Alcohol; Skin; Surface-Active Agents | 2022 |
[Metabolic engineering of Escherichia coli for production of hydroxytyrosol].
Topics: Escherichia coli; Fermentation; Glucose; Metabolic Engineering; Phenylethyl Alcohol | 2021 |
Synergistic Effect of Squalene and Hydroxytyrosol on Highly Invasive MDA-MB-231 Breast Cancer Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Diet, Mediterranean; DNA Damage; Drug Synergism; Female; Humans; Olive Oil; Phenylethyl Alcohol; Reactive Oxygen Species; Squalene | 2022 |
Soybean oil organogelled emulsions as oral delivery systems of hydroxytyrosol and hydroxytyrosol alkyl esters.
Topics: Emulsions; Esters; Phenylethyl Alcohol; Soybean Oil | 2022 |
Hydroxytyrosol Alleviates Dextran Sulfate Sodium-Induced Colitis by Modulating Inflammatory Responses, Intestinal Barrier, and Microbiome.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Phenylethyl Alcohol | 2022 |
Metabolomic and Transcriptional Profiling of Oleuropein Bioconversion into Hydroxytyrosol during Table Olive Fermentation by
Topics: Fermentation; Iridoid Glucosides; Olea; Phenylethyl Alcohol | 2022 |
Development and physicochemical characterization of nanoliposomes with incorporated oleocanthal, oleacein, oleuropein and hydroxytyrosol.
Topics: Aldehydes; Cyclopentane Monoterpenes; Humans; Iridoid Glucosides; Olea; Phenols; Phenylethyl Alcohol | 2022 |
Hydroxytyrosol alleviates dextran sodium sulfate-induced colitis by inhibiting NLRP3 inflammasome activation and modulating gut microbiota in vivo.
Topics: Animals; Antioxidants; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Inflammasomes; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Phenylethyl Alcohol; Sulfates | 2022 |
Neuroprotective Effect of 3',4'-Dihydroxyphenylglycol in Type-1-like Diabetic Rats-Influence of the Hydroxytyrosol/3',4'-dihydroxyphenylglycol Ratio.
Topics: Animals; Diabetes Mellitus, Experimental; Neuroprotective Agents; Phenylethyl Alcohol; Rats; Rats, Wistar | 2022 |
Host-guest inclusion complexes of hydroxytyrosol with cyclodextrins: Development of a potential functional ingredient for food application.
Topics: Antioxidants; Calorimetry, Differential Scanning; Cyclodextrins; Phenylethyl Alcohol; Powders; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2022 |
Recovery of Hydroxytyrosol from Olive Mill Wastewater Using the Promiscuous Hydrolase/Acyltransferase PestE.
Topics: Acetates; Acyltransferases; Antioxidants; Hydrolases; Olea; Olive Oil; Phenylethyl Alcohol; Wastewater | 2022 |
The combination of HT-ac and HBET improves the cognitive and learning abilities of heat-stressed mice by maintaining mitochondrial function through the PKA-CREB-BDNF pathway.
Topics: Acetates; Animals; Brain-Derived Neurotrophic Factor; Cognition; Hot Temperature; Mice; Mitochondria; Phenylethyl Alcohol | 2022 |
Optimizing the Extraction Conditions of Hydroxytyrosol from Olive Leaves Using a Modified Spherical Activated Carbon: A New Experimental Design.
Topics: Charcoal; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Research Design | 2022 |
Positive postprandial glycaemic and appetite-related effects of wheat breads enriched with either α-cyclodextrin or hydroxytyrosol/α-cyclodextrin inclusion complex.
Topics: Adult; alpha-Cyclodextrins; Appetite; Blood Glucose; Bread; Cross-Over Studies; Glucose; Humans; Insulin; Phenylethyl Alcohol; Postprandial Period; Triticum | 2022 |
A Bi-enzymatic Immobilized Nanobiocatalyst for the Biotransformation of Oleuropein to Hydroxytyrosol.
Topics: Biotransformation; Candida; Enzymes, Immobilized; Iridoid Glucosides; Phenylethyl Alcohol | 2022 |
Hydroxytyrosol Alleviated Hypoxia-Mediated PC12 Cell Damage through Activating PI3K/AKT/mTOR-HIF-1
Topics: Animals; Cell Hypoxia; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; PC12 Cells; Phenylethyl Alcohol; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2022 |
3,4-Dihydroxyphenylethanol and 3,4-dihydroxyphenylacetic acid affect the aggregation process of E46K variant of α-synuclein at different extent: Insights into the interplay between protein dynamics and catechol effect.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Synuclein; Catechols; Dopamine; Humans; Parkinson Disease; Phenylethyl Alcohol | 2022 |
Incorporation of hydroxytyrosol alkyl esters of different chain length as antioxidant strategy in walnut oil spray-dried microparticles with a sodium alginate outer layer.
Topics: Alginates; Antioxidants; Esters; Juglans; Phenylethyl Alcohol | 2022 |
Hydroxytyrosol improves strenuous exercise-associated cardiac pathological changes
Topics: Animals; Cardiomegaly; Homeostasis; Male; Mitochondria; Mitochondrial Proteins; Myocytes, Cardiac; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley | 2022 |
Sensitive Detection of Hydroxytyrosol in Extra Virgin Olive Oils with a Novel Biosensor Based on Single-Walled Carbon Nanotubes and Tyrosinase.
Topics: Biosensing Techniques; Electrochemical Techniques; Electrodes; Monophenol Monooxygenase; Nanotubes, Carbon; Olive Oil; Phenylethyl Alcohol | 2022 |
Hydroxytyrosol and resveratrol improves kinetic and flow cytometric parameters of cryopreserved bull semen with low cryotolerance.
Topics: Animals; Antioxidants; Buffaloes; Cattle; Cryopreservation; Cryoprotective Agents; Male; Phenylethyl Alcohol; Resveratrol; Semen; Semen Analysis; Semen Preservation; Sperm Motility; Spermatozoa | 2022 |
Combination Treatment with Hydroxytyrosol and Vitamin E Improves NAFLD-Related Fibrosis.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Liver; Liver Cirrhosis; Mice; Non-alcoholic Fatty Liver Disease; Phenylethyl Alcohol; Reactive Oxygen Species; Transcription Factors; Transforming Growth Factor beta; Vitamin E | 2022 |
Effect of olive polyphenols on lipid oxidation of high-fat beef during digestion.
Topics: Animals; Antioxidants; Cattle; Digestion; Malondialdehyde; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils; Polyphenols; Pyrans | 2022 |
Evolution of Hydroxytyrosol, Hydroxytyrosol 4-β-d-Glucoside, 3,4-Dihydroxyphenylglycol and Tyrosol in Olive Oil Solid Waste or "Alperujo".
Topics: Glucosides; Olea; Olive Oil; Phenols; Phenylethyl Alcohol; Solid Waste | 2022 |
Approaches in Hydroxytyrosol Supplementation on Epithelial-Mesenchymal Transition in TGFβ1-Induced Human Respiratory Epithelial Cells.
Topics: Alveolar Epithelial Cells; Cadherins; Dietary Supplements; Epithelial-Mesenchymal Transition; Humans; Molecular Docking Simulation; Phenylethyl Alcohol; Proto-Oncogene Proteins c-akt; Transforming Growth Factor beta1; Vimentin | 2023 |
Efficient production of hydroxytyrosol by directed evolution of HpaB in Escherichia coli.
Topics: Antioxidants; Escherichia coli; Mixed Function Oxygenases; Phenylethyl Alcohol | 2023 |
Unveiling How Hydroxytyrosol Destabilizes α-Syn Oligomers Using Molecular Simulations.
Topics: alpha-Synuclein; Humans; Neurodegenerative Diseases; Parkinson Disease; Phenylethyl Alcohol | 2023 |
Production of hydroxytyrosol through whole-cell bioconversion from L-DOPA using engineered Escherichia coli.
Topics: Escherichia coli; Hydrogen Peroxide; Levodopa; Phenylethyl Alcohol | 2023 |
Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis.
Topics: Adolescent; Adult; Aged; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Middle Aged; Phenylethyl Alcohol; Polyphenols; Young Adult | 2023 |
Modeling the antimicrobial effects of olive mill waste extract, rich in hydroxytyrosol, on the growth of lactic acid bacteria using response surface methodology.
Topics: Anti-Infective Agents; Antioxidants; Lactobacillales; Olea; Olive Oil; Phenylethyl Alcohol | 2023 |
Enhancing physical and chemical stability of hygroscopic hydroxytyrosol by cocrystal formation.
Topics: Antioxidants; Niacinamide; Phenylethyl Alcohol; Wettability | 2023 |