3,4-dihydroxyphenylacetic acid has been researched along with tolcapone in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Kaakkola, S; Wurtman, RJ | 1 |
| Brannan, T; Martínez-Tica, J; Yahr, MD | 1 |
| Abe, T; Saheki, M; Takahashi, S; Tohgi, H; Tsukamoto, Y; Yamazaki, K | 1 |
| Da Prada, M; Napolitano, A; Zürcher, G | 1 |
| Männistö, PT; Törnwall, M; Tuomainen, P | 2 |
| Steulet, AF; Stöcklin, K; Waldmeier, P; Wicki, P | 1 |
| Budygin, EA; Gaĭnetdinov, RR; Mannisto, PT; Raevskiĭ, KS | 1 |
| Huotari, M; Laitinen, K; Li, YH; MacDonald, E; Männistö, PT; Wirth, T | 1 |
| Gainetdinov, R; Huotari, M; Männistö, PT | 1 |
| Gerlach, M; Kuhn, W; Lehnfeld, R; Riederer, P; Sontag, KH; Waldmeier, P; Xiao, AY | 1 |
| Forsberg, M; Huotari, M; Kotisaari, S; Laitinen, K; Männistö, PT; Nordberg, HL; Passlin, M; Reenilä, I; Shintani, F; Tanaka, KF; Tuomisto, L | 1 |
| Buhmann, C; Oechsner, M; Strauss, J; Stuerenburg, HJ | 1 |
| Di Monte, DA; Langston, JW; Thiffault, C | 1 |
| Aubin, N; Barneoud, P; Burnier, P; Caille, D; Carter, C; Charieras, T; Curet, O; Gardes, A; George, P; Jegham, S; Le Kim, A; Lolivier, J; Marc, C; Pandini, M; Perron, C; Puech, F; Scatton, B; Sontag, N | 1 |
| Forsberg, MM; Huotari, M; Männistö, PT; Savolainen, J | 1 |
| Bannerman, DM; Harrison, PJ; Laatikainen, LM; Sharp, T; Tunbridge, EM | 1 |
| Harrison, PJ; Laatikainen, LM; Sharp, T; Tunbridge, EM | 1 |
| Aonurm-Helm, A; Kaenmaki, M; Mannisto, PT; Tammimaki, A | 1 |
| Goldstein, DS; Isonaka, R; Jinsmaa, Y; Sharabi, Y | 1 |
| Ito, A; Jamal, M; Kinoshita, H; Miki, T; Ohta, KI; Suzuki, S | 1 |
21 other study(ies) available for 3,4-dihydroxyphenylacetic acid and tolcapone
| Article | Year |
|---|---|
Effects of COMT inhibitors on striatal dopamine metabolism: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Catechols; Chromatography, High Pressure Liquid; Clorgyline; Corpus Striatum; Dialysis; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Nitriles; Nitrophenols; Nomifensine; Rats; Rats, Inbred Strains; Selegiline; Tolcapone | 1992 |
Catechol-O-methyltransferase inhibition increases striatal L-dopa and dopamine: an in vivo study in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Male; Nitrophenols; Rats; Rats, Inbred Strains; Tolcapone | 1992 |
Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Dopamine; Homovanillic Acid; Humans; Levodopa; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 1995 |
Effects of tolcapone, a novel catechol-O-methyltransferase inhibitor, on striatal metabolism of L-dopa and dopamine in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Benzophenones; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Homovanillic Acid; Levodopa; Male; Methylation; Microdialysis; Neostriatum; Nitrophenols; Rats; Tolcapone | 1995 |
Modulation of rat brain endogenous dopamine metabolism by new inhibitors of catechol O-methyltransferase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amidines; Amphetamine; Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dopamine; Homovanillic Acid; Male; Neurons; Nitriles; Nitrophenols; Pimozide; Pyridones; Rats; Rats, Wistar; Tolcapone | 1993 |
Effects of CGP 28014 on the in vivo release and metabolism of dopamine in the rat striatum assessed by brain microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amidines; Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dopamine; Electric Stimulation; Homovanillic Acid; Kinetics; Male; Microdialysis; Nitrophenols; Peritoneum; Pyridones; Rats; Tolcapone | 1993 |
Minor effect of tolcapone, a catechol-O-methyltransferase inhibitor, on extracellular dopamine levels modified by amphetamine or pargyline: a microdialysis study in anaesthetized rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Anesthesia, General; Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Dopamine; Dopamine Agents; Enzyme Inhibitors; Extracellular Space; Homovanillic Acid; Male; Microdialysis; Monoamine Oxidase Inhibitors; Nitrophenols; Pargyline; Rats; Rats, Wistar; Tolcapone | 1996 |
[Effect of subchronic administration of tolcapone on release of striatum dopamine and its metabolites induced by L-DOPA and carbidopa].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dopamine; Dopamine Agents; Drug Synergism; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Nitrophenols; Rats; Rats, Wistar; Tolcapone | 1998 |
No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: a microdialysis study in anaesthetized rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Benzophenones; Brain; Catechol O-Methyltransferase Inhibitors; Catechols; Chloral Hydrate; Dopamine; Enzyme Inhibitors; Extracellular Space; Male; Microdialysis; Nitriles; Nitrophenols; Norepinephrine; Rats; Rats, Wistar; Sympathomimetics; Tolcapone | 1998 |
Microdialysis studies on the action of tolcapone on pharmacologically-elevated extracellular dopamine levels in conscious rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzophenones; Carbidopa; Catechol O-Methyltransferase; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Enzyme Inhibitors; Extracellular Space; Haloperidol; Homovanillic Acid; Levodopa; Male; Microdialysis; Nitrophenols; Piperazines; Rats; Rats, Wistar; Time Factors; Tolcapone; Visual Cortex | 1999 |
The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Hydroxyl Radical; Levodopa; Male; Microdialysis; Nitriles; Nitrophenols; Oxidative Stress; Parkinsonian Disorders; Rats; Rats, Wistar; Tolcapone | 2001 |
Effect of intracerebral 6-nitronoradrenaline, an endogenous catechol-O-methyltransferase (COMT) inhibitor, on striatal dopamine metabolism in anaesthetised rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Binding, Competitive; Carrier Proteins; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; Homovanillic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Monoamine Oxidase; Neostriatum; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitrophenols; Norepinephrine; Piperazines; Rats; Rats, Wistar; Tolcapone | 2001 |
COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Antiparkinson Agents; Benzophenones; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Disease Progression; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 2002 |
Cerebrospinal fluid 3,4-dihydroxyphenylacetic acid level after tolcapone administration as an indicator of nigrostriatal degeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Benzophenones; Biomarkers; Catechol O-Methyltransferase; Corpus Striatum; Disease Models, Animal; Dopamine; Enzyme Activation; Female; Homovanillic Acid; Male; Neurodegenerative Diseases; Nitrophenols; Parkinsonian Disorders; Predictive Value of Tests; Putamen; Saimiri; Substantia Nigra; Tolcapone | 2003 |
SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Interactions; Levodopa; Maze Learning; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Nervous System Diseases; Nitrophenols; Oxazoles; Oxidopamine; Prefrontal Cortex; Quinolines; Rats; Rats, Sprague-Dawley; Serotonin; Stereotyped Behavior; Tolcapone; Tremor; Tyramine | 2004 |
The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Enzyme Inhibitors; Homovanillic Acid; Male; Microdialysis; Nitriles; Nitrophenols; Rats; Rats, Wistar; Solubility; Tolcapone | 2005 |
Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Cognition; Dopamine; Enzyme Inhibitors; Extracellular Space; Female; Hippocampus; Hydroxyindoleacetic Acid; Male; Microdialysis; Nitrophenols; Rats; Reward; Tolcapone | 2012 |
Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Cerebellum; Dopamine; Female; Hippocampus; Male; Nitrophenols; Prefrontal Cortex; Rats; Sex Factors; Tolcapone | 2013 |
Elimination of extracellular dopamine in the medial prefrontal cortex of conscious mice analysed using selective enzyme and uptake inhibitors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Animals; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dopamine; Female; Homovanillic Acid; Male; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Morpholines; Nitrophenols; Pargyline; Prefrontal Cortex; Reboxetine; Synaptosomes; Tolcapone | 2016 |
3,4-Dihydroxyphenylacetaldehyde Is More Efficient than Dopamine in Oligomerizing and Quinonizing
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; alpha-Synuclein; Antioxidants; Cell Line; Copper; Dopamine; Humans; Monoamine Oxidase; Monophenol Monooxygenase; Oligodendroglia; Oxidation-Reduction; Parkinson Disease; Protein Binding; Protein Conformation; Tolcapone | 2020 |
Ethanol concentration induces production of 3,4-dihydroxyphenylacetic acid and homovanillic acid in mouse brain through activation of monoamine oxidase pathway.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aldehyde Dehydrogenase, Mitochondrial; Animals; Brain; Catechol O-Methyltransferase; Clorgyline; Ethanol; Homovanillic Acid; Mice; Monoamine Oxidase; Norepinephrine; Serotonin; Tolcapone | 2022 |