3,4-dihydroxyphenylacetic acid has been researched along with levodopa in 340 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 83 (24.41) | 18.7374 |
| 1990's | 137 (40.29) | 18.2507 |
| 2000's | 79 (23.24) | 29.6817 |
| 2010's | 38 (11.18) | 24.3611 |
| 2020's | 3 (0.88) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| de Vries, JA; Fremouw-Ottevangers, DC; Muskiet, FA; van der Meulen, J; Wolthers, BG | 1 |
| Dabagov, NS; Skoldinov, AP; Uspenskiĭ, AE | 1 |
| Maître, L; Waldmeier, PC | 2 |
| Green, JP; Mizoguchi, H; Orlowski, M; Wilk, S | 1 |
| Davis, JM; Helgeson, E; Narasimhachari, N; Prakash, U | 1 |
| Ekel, TM; Hearing, VJ | 1 |
| Adams, RN; Delcore, R; Plotsky, PM; Strope, E; Wightman, RM | 1 |
| Delini-Stula, A; Maître, L; Waldmeier, PC | 1 |
| Alm, P; Petterson, GB | 1 |
| Crowley, TJ; Hoehn, MM; Rutledge, CO | 1 |
| Argiolas, A; Di Chiara, G; Gessa, GL; Porceddu, ML; Vargiu, L | 1 |
| Dolphin, A; Jenner, P; Marsden, CD | 1 |
| Knopp, W; Messiha, FS | 1 |
| Bronaugh, RL; Hoehn, MM; MacMurtry, RJ; Rutledge, CO | 1 |
| Eplov, L; Nielsen, M; Scheel-Krüger, J | 1 |
| Krane, RJ; Murdock, MI; Olsson, CA; Sax, DS | 1 |
| Watson, E; Wilk, S | 1 |
| Cheng, LK; Fung, HL | 1 |
| Rinne, UK; Siirtola, T; Sonninen, V | 1 |
| Fernandes, MH; Soares-da-Silva, P | 4 |
| Fernandes, MH; Pestana, M; Soares-da-Silva, P | 4 |
| Melamed, E | 2 |
| De Klippel, N; Deleu, D; Devrieze, A; Ebinger, G; Herregodts, P; Michotte, Y; Sarre, S | 1 |
| Borisenko, SA; Männistö, PT; Törnwall, M; Tuomainen, P; Tuominen, RK | 1 |
| Soares-da-Silva, P | 1 |
| Bjurling, P; Gillberg, PG; Långström, B; Miwa, S; Odano, I; Watanabe, Y; Yumoto, N | 1 |
| Brannan, T; Martínez-Tica, J; Yahr, MD | 4 |
| Kaakkola, S; Männistö, PT; Tuomainen, P; Wurtman, RJ | 1 |
| De Klippel, N; Deleu, D; Ebinger, G; Herregodts, P; Michotte, Y; Sarre, S | 1 |
| Jenner, P; Marsden, CD; Rose, S | 3 |
| Castro, R; Rodriguez, M | 1 |
| Krause, JE; Sivam, SP | 1 |
| Cano, J; Machado, A; Venero, JL | 2 |
| Dluzen, D; McDermott, J | 1 |
| Carey, RJ | 1 |
| Wikberg, T | 1 |
| Barbato, GF; Kruzelock, RP | 1 |
| Abbate, GM; Nieduzak, TR; Schmidt, CJ; Taylor, VL | 1 |
| Karg, E; Rorsman, H; Rosengren, E | 1 |
| Dluzen, DE; McDermott, JL | 1 |
| Goshima, Y; Misu, Y; Nakamura, S | 1 |
| Cummings, J; Matheson, LM; Maurice, L; Smyth, JF | 1 |
| Darchen, F; Henry, JP; Horellou, P; Mallet, J; Marlier, L; Privat, A; Scherman, D | 1 |
| Engel, JA; Hulthe, P; Johannessen, K; Pettersson, G | 1 |
| Snyder, GL; Zigmond, MJ | 1 |
| Cedarbaum, JM; Clark, M; Harts, A; Kutt, H; Silvestri, M | 1 |
| Buu, NT; Lussier, C | 1 |
| Bhardwaj, A; Brannan, T; Martinez-Tica, J; Weinberger, J; Yahr, M | 1 |
| Cummings, J; Matheson, LM; Smyth, JF | 1 |
| Bondarenko, NA; Kudrin, VS; Miroshnichenko, II; Rayevsky, KS | 1 |
| Bordet, S; Commissiong, JW; Karoum, F; Zhang, C | 1 |
| Brannan, T; Kaufmann, H; Knott, P; Yahr, M | 1 |
| Di Paolo, T; Harnois, C | 1 |
| Bédard, PJ; Di Paolo, T; Rouillard, C | 1 |
| Buu, NT; Debinski, W | 1 |
| Bonnet, JJ; Costentin, J; Vaugeois, JM | 1 |
| Carlsson, A; Eriksson, T; Wiesel, K | 1 |
| Flauto, C; Groppetti, A; Parati, E; Parenti, M; Vescovi, A | 1 |
| Bédard, P; Boucher, R; Daigle, M; Di Paolo, T | 1 |
| Gross, J; Horvath, G; Lun, A; Nagy, I; Szuecz, L | 1 |
| Buu, NT | 1 |
| Imazu, Y; Kobayashi, K; Shohmori, T | 1 |
| Akiyama, A; Nakazato, T | 3 |
| Robertson, GS; Robertson, HA | 1 |
| Aperia, A; Bertorello, A | 1 |
| Commissiong, JW | 2 |
| Cassel, G; Persson, SA; Sellström, A | 1 |
| Cohen, Y; el Gemayel, G; Jacquot, C; Prioux-Guyonneau, M; Trouvin, JH | 2 |
| Ehrenström, F; Johansson, P | 1 |
| Cooper, DR; Jenner, P; Marrel, C; Marsden, CD; Testa, B; van de Waterbeemd, H | 1 |
| Brannan, T; Kaufmann, H; Knott, P; Leung, L; Yahr, M | 1 |
| Kuhr, WG; May, LJ; Wightman, RM | 1 |
| Bretton, C; Hof, P; Ofori, S; Schorderet, M | 1 |
| Cannon-Spoor, E; Chuang, LW; Costa, E; Freed, WJ; Karoum, F; Wyatt, RJ | 1 |
| Cohen, G; Spina, MB | 1 |
| Fukuda, H; Fukuyama, H; Hara, K; Kameyama, M; Nakamura, S | 1 |
| Domino, EF; Greenberg, HS; Hood, TW | 1 |
| Ehrenström, F | 1 |
| Bondarenko, NA; Kudrin, VS; Miroshnichenko, II | 1 |
| Bourke, CA | 1 |
| Buu, NT; Duhaime, J; Kuchel, O; Racz, K; Schlager, G | 1 |
| Aoki, S; Inukai, K; Kobayashi, M; Koshikawa, N; Sakurai, M | 1 |
| Algeri, S; Olgiati, VR; Stramentinoli, G | 1 |
| Hara, K; Iijima, S; Kameyama, M; Nakamura, S | 1 |
| Bradbrook, ID; Gillies, HC; Morrison, PJ; Rogers, HJ | 1 |
| Buu, NT; Duhaime, J; Kuchel, O | 1 |
| Bennett, BA; Freed, CR | 1 |
| Adachi, K; Ando, K; Kumazawa, T | 1 |
| Globus, M; Melamed, E; Rosenthal, J; Uzzan, A | 1 |
| Bailey, BA; Boulton, AA; Durden, DA; Yu, PH | 1 |
| Concas, A; Porceddu, ML | 1 |
| Beitz, DC; Christian, LL; Draper, DD; Erlander, MG; Murrin, LC; Parliman, JA; Pfeiffer, RF | 1 |
| Rorie, DK; Tyce, GM | 1 |
| Kaakkola, S; Männistö, PT; Mäntylä, R; Nissinen, E; Vuorela, A | 1 |
| Hefti, F; Liebman, J; Melamed, E; Schlosberg, AJ; Wurtman, RJ | 1 |
| Jackson, DM; Miller, LP; Walters, JR | 1 |
| Baker, H; Joh, TH; Kawano, T; Margolis, FL | 1 |
| Kikuchi, T; Watanabe, H; Watanabe, K | 1 |
| Saeed Dar, M; Wooles, WR | 1 |
| Brown, JW; Kramarcy, NR; Thurmond, JB | 1 |
| Johnston, CA; Negro-Vilar, A; Spinedi, E | 1 |
| Globus, M; Melamed, E | 1 |
| Baraczka, K; Fekete, MI; Kanyicska, B | 1 |
| Deupree, JD; Murrin, LC; Pfeiffer, RF; Schneider, MB | 1 |
| Jenner, P; Kelly, E; Kilpatrick, G; Lees, A; Marsden, CD; Rose, S; Rupniak, NM | 1 |
| Lobo, RA; Shoupe, D | 1 |
| Watanabe, H | 1 |
| Cooper, DR; Fleminger, S; Hall, MD; Jenner, P; Marsden, CD; Rupniak, NM | 1 |
| Achilli, G; Algeri, S; Perego, C; Ponzio, F; Rinaldi, G | 1 |
| Ricaurte, GA; Schuster, CR; Seiden, LS | 1 |
| Cooper, DR; Jenner, P; Marrel, C; Marsden, CD; Quinn, N; Testa, B; van de Waterbeemd, H | 1 |
| Calne, DB; Chuang, LW; Eisler, T; Karoum, F; Klein, DF; Liebowitz, MR; Quitkin, FM; Wyatt, RJ | 1 |
| Bird, ED; Langlais, PJ; McEntee, WJ | 1 |
| Nissinen, E; Taskinen, J | 1 |
| Fahn, S; Reches, A | 1 |
| Bierer, DW; Quebbemann, AJ | 1 |
| Deleu, D; Ebinger, G; Michotte, Y; Sarre, S; Van Belle, K | 1 |
| Christensen, NJ; Eldrup, E; Jacobsen, J; Mogensen, P; Pakkenberg, H | 1 |
| Lee, T; Teo, WL; Wong, PT | 1 |
| Cano, J; de la Roza, C; Machado, A; Venero, JL | 1 |
| Kaakkola, S; Kask, A; Männistö, PT; Törnwall, M; Tuomainen, P | 1 |
| Lima, L; Urbina, M | 1 |
| Abe, T; Saheki, M; Takahashi, S; Tohgi, H; Tsukamoto, Y; Yamazaki, K | 1 |
| DeMaggio, AJ; Juneau, PL; LeWitt, PA; Loeffler, DA; Matson, WR; Milbury, PE | 1 |
| Bankiewicz, KS; Finberg, JP; Goldstein, DS; Kopin, IJ; Wang, J | 1 |
| Alexiuk, NA; Green-Johnson, J; Ryan, E; Vriend, J | 1 |
| Block, F; Clement, HW; Grote, C; Sontag, KH; Wesemann, W | 1 |
| Hashiguti, H; Ikeda, T; Maruyama, W; Nakahara, D; Naoi, M | 1 |
| Hosokawa, S; Matsuo, M; Murakami, M; Nakamura, J; Okuno, Y; Yamada, H; Yamada, T | 1 |
| Koitabashi, T; Koshiro, A; Sato, S | 1 |
| Da Prada, M; Napolitano, A; Zürcher, G | 1 |
| Farris, DB; Graham, DG; Montine, TJ | 1 |
| Demaggio, AJ; Havaich, M; Juneau, PL; Lewitt, PA; Loeffler, DA | 1 |
| Dluzen, DE; Liu, B | 1 |
| Pestana, M; Soares-da-Silva, P | 2 |
| Brannan, T; Prikhojan, A; Yahr, MD | 3 |
| Hashiguti, H; Kaneda, N; Nagatsu, T; Nakahara, D; Sasaoka, T | 1 |
| Ikawa, K; Kaneno, S; Toru, M; Watanabe, A | 1 |
| Gayrard, V; Malpaux, B; Thiéry, JC; Tillet, Y | 1 |
| Fernandes, MH; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| De Klippel, N; Ebinger, G; Herregodts, P; Michotte, Y; Sarre, S | 1 |
| Bennett, JP; Parker, WD; Smith, TS | 1 |
| Asanuma, M; Kawada, Y; Kondo, Y; Mori, A; Ogawa, N; Yamamoto, M | 1 |
| Dluzen, DE; Guan, X | 1 |
| Deleu, D; Ebinger, G; Michotte, Y; Sarre, S | 2 |
| Abercrombie, ED; Wachtel, SR | 1 |
| Abercrombie, ED; Jackson, D; Zigmond, MJ | 1 |
| Hossain, MA; Weiner, N | 1 |
| Kuchel, OG; Shigetomi, S | 1 |
| Messenger, NJ; Rowe, SJ; Warner, AE | 1 |
| LeWitt, PA | 1 |
| Baraldo, M; Benetello, P; Furlanut, M; Hassan, E; Zara, G | 1 |
| Copeland, LG; Dutton, J; Playfer, JR; Roberts, NB | 1 |
| Gordin, A; Harjola, VP; Karlsson, M; Keränen, T; Korpela, K; Pentikäinen, PJ; Rita, H; Seppälä, L; Wikberg, T | 1 |
| Folio, CJ; Goldstein, DS; Grossman, E; Keiser, HR; Kopin, IJ; Wolfovitz, E | 1 |
| O'Connell, MT; Patsalos, PN; Quinn, NP; Wenning, GK | 1 |
| Fernandes, MH; Pestana, M; Pinto-do-O, PC; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Berlin, I; Launay, JM; Olivares, R; Puech, AJ; Said, S; Spreux-Varoquaux, O | 1 |
| Chang, WY; Webster, RA | 1 |
| Dluzen, DE; Liu, B; McDermott, JL | 1 |
| Ahlskog, JE; Low, PA; Nickander, KK; O'Brien, JF; Tyce, GM; Uitti, RJ | 1 |
| Dethy, S; Goldman, S; Hildebrand, J; Laute, MA; Naini, AB; Przedborski, S; Raftopoulos, C | 1 |
| Freestone, S; Johnston, NR; Lee, MR; Li Kam Wa, TC; Samson, RR | 1 |
| Frain, O; Guibert, B; Leviel, V; Olivier, V; Pasqualini, C | 1 |
| Bringmann, G; Clement, HW; Feineis, D; Grote, C; Riederer, P; Sontag, KH; Wesemann, W | 1 |
| Maruyama, W; Naoi, M; Narabayashi, H | 1 |
| Ichikawa, M; Matsuyama, K; Nakashima, M; Nakashima, MN; Sakurai, M; Sasaki, H; Zhao, MF | 1 |
| Atlas, D; Djaldetti, R; Melamed, E | 1 |
| Andre, MH; Bruguerolle, B; Grignon, S | 1 |
| Achilli, G; Banting, A; Banting, S; Le Bars, D; Weil-Fugazza, J | 1 |
| Dluzen, DE; Xu, K | 2 |
| Obata, T; Yamanaka, Y | 1 |
| Crevoisier, C; Dingemanse, J; Kleinbloesem, CH; Wood, ND; Zürcher, G | 1 |
| DeMaggio, AJ; Havaich, MK; Juneau, PL; LeWitt, PA; Loeffler, DA | 1 |
| Bunzow, JR; Chester, JA; Dziewczapolski, G; Falzone, TL; Fang, Y; Gershanik, O; Grandy, DK; Larson, JL; Low, MJ; McDougall, JA; Phillips, TJ; Pugsley, TA; Rubinstein, M; Saez, C; Zhang, G | 1 |
| Bencsics, C; Kang, UJ; Wachtel, SR | 1 |
| Baldaia, J; Faria, MS; Guerra, LE; Oliveira, JG; Pestana, M; Santos, A; Soares-da-Silva, P | 1 |
| Budygin, EA; Gaĭnetdinov, RR; Mannisto, PT; Raevskiĭ, KS | 1 |
| Bankiewicz, K; Finberg, JP; Goldstein, DS; Harvey-White, J; Kopin, IJ; Wang, J | 1 |
| Myers, CS; Wagner, GC; Witten, M; Yu, YL | 1 |
| Hashitani, T; Kumazaki, M; Mizukawa, K; Nishino, H | 1 |
| Brannan, T; Martínez-Tica, J; Prikhojan, A; Yahr, MD | 1 |
| Bergquist, J; Silberring, J | 1 |
| Guerra, L; Jardim, H; Pestana, M; Serrão, P; Soares-da-Silva, P | 1 |
| Kashihara, K; Marui, K; Sakai, K; Shohmori, T | 1 |
| Ebinger, G; Izurieta-Sánchez, P; Michotte, Y; Sarre, S | 1 |
| Biggs, CS; Fisher, A; Starr, MS | 1 |
| Afonso, C; Guerra, L; Jardim, H; Pestana, M; Santos, N; Serrão, P; Soares-da-Silva, P | 1 |
| Chen, CF; Chueh, FS; Chueh, FY; Hsieh, MT; Lin, MT; Lin, SM | 1 |
| Calas, A; Delhaye-Bouchaud, N; Gainetdinov, R; Melnikova, V; Nicolaidis, S; Orosco, M; Rayevsky, K; Sapronova, A; Ugrumov, M | 1 |
| Arnold, LA; Camp, DM; Hyland, K; Juneau, PL; LeWitt, PA; Loeffler, DA | 1 |
| Hayashi, H; Ishii, S; Kagamiyama, H; Okamoto, A | 1 |
| Kannari, K; Maeda, T; Matsunaga, M; Suda, T; Tanaka, H; Tomiyama, M | 2 |
| Damhaut, P; Dethy, S; Goldman, S; Laute, MA | 1 |
| Halladay, AK; Myers, CS; Wagner, GC; Widmer, DA | 1 |
| Biggs, CS; Starr, MS | 1 |
| Guimaraes, JT; Hussain, T; Kansra, V; Lokhandwala, MF; Pestana, M; Serrao, MP; Soares-Da-Silva, P; Vieira-Coelho, MA | 1 |
| Gainetdinov, R; Huotari, M; Männistö, PT | 1 |
| Biggs, CS; Eradiri, O; Fisher, A; Starr, MS | 1 |
| Jackson, M; Jenner, P; Treseder, SA | 1 |
| Alessandrì, MG; Bassi, L; Corsini, GU; Ferrucci, M; Fornai, F; Giorgi, FS | 1 |
| Doroshenko, EM; Etingof, RN; Lavrikova, EV; Pozdeyev, NV | 1 |
| Cerqueira-Gomes, M; Damasceno, A; Ferreira, A; Pestana, M; Polónia, J; Soares-da-Silva, P | 1 |
| Peng, Y; Shui, H; Tsai, Y; Wu, R | 1 |
| Fitzgerald, RS; Shirahata, M; Wang, HY | 1 |
| Delogu, MR; Desole, MS; Enrico, P; Esposito, G; Grella, G; Miele, E; Miele, M; Migheli, R; Mura, MA; Serra, PA | 1 |
| Armando, I; Barontini, M; Carranza, A; Nowicki, S | 1 |
| Abeling, NG; Barth, PG; Bräutigam, C; Fiumara, A; Hoffmann, GF; Jaeken, J; Knust, A; van Gennip, AH; Wevers, RA | 1 |
| Asanuma, M; Ogawa, N; Tanaka, K | 1 |
| Marburger, A; Morgenstern, R; Reum, T; Sohr, R | 1 |
| DeJesus, OT; Stein, TD | 1 |
| Guimarães, JT; Pestana, M; Serrão, P; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Jenner, P; Rose, S; Treseder, SA | 1 |
| Beauregard, M; Chapados, C; Gélinas, S; Gosselin, I; Martinoli, MG | 1 |
| Hadjiconstantinou, M; Neff, NH; Wemlinger, TA | 1 |
| Chang, CK; Cheng, JT; Chi, TC; Lee, JJ; Liu, IM; Yu, HJ | 1 |
| Gerlach, M; Kuhn, W; Lehnfeld, R; Riederer, P; Sontag, KH; Waldmeier, P; Xiao, AY | 1 |
| Hainzl, D; Loureiro, AI; Parada, A; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Bettencourt, P; Cerqueira-Gomes, M; Correia, F; Ferreira, A; Martins, L; Pestana, M; Serrão, P; Soares-Da-Silva, P | 1 |
| Ferger, B; Schmidt, N; Schulz, JB; Teismann, P; Xia, XG | 1 |
| Abe, K; Miyatake, T; Ren, J; Sano, T; Shinohara, T; Taguchi, K; Utsunomiya, I; Wasai, T | 1 |
| Buhmann, C; Oechsner, M; Strauss, J; Stuerenburg, HJ | 1 |
| Armando, I; Barontini, M; Carranza, A; Karabatas, L | 1 |
| Chen, JF; Cuellar, B; Fredduzzi, S; Impagnatiello, F; Monopoli, A; Moratalla, R; Ongini, E; Schwarzschild, MA; Xu, K | 1 |
| Forsberg, M; Gogos, JA; Huotari, M; Hyttinen, J; Karayiorgou, M; Koponen, O; Männistö, PT; Raasmaja, A | 1 |
| Bettencourt, P; Cerqueira-Gomes, M; Ferreira, A; Friões, F; Pestana, M; Pimenta, J; Soares-da-Silva, P | 1 |
| Conti, G; Fornai, F; Gesi, M; Ruffoli, R; Santinami, A | 1 |
| Halliwell, B; Jenner, P; Spencer, JP; Whiteman, M | 1 |
| Clement, HW; Grote, C; Heiser, P; Wesemann, W | 1 |
| Caudle, WM; Miller, GW; Reverón, ME; Tillerson, JL | 1 |
| Archer, T; Fredriksson, A | 1 |
| Gu, SD; Sun, XF; Wang, W; Zhao, DZ | 1 |
| Bergquist, F; Niazi Shahabi, H; Nissbrandt, H | 1 |
| Antkiewicz-Michaluk, L; Herman, ZS; Obuchowicz, E; Romańska, I | 1 |
| Bonnet, JJ; Costentin, J; Dourmap, N; Janin, F; Legros, H | 2 |
| Dziubina, A; Gołembiowska, K | 4 |
| Bergquist, J; Markides, KE; Sjöberg, PJ; Törnkvist, A | 1 |
| Schmidt, WJ; Srinivasan, J | 1 |
| Ben Shachar, D; Stephenson, G; Youdim, MB | 1 |
| Gluck, MR; Granson, H; Santana, LA; Yahr, MD | 1 |
| Aubin, N; Barneoud, P; Burnier, P; Caille, D; Carter, C; Charieras, T; Curet, O; Gardes, A; George, P; Jegham, S; Le Kim, A; Lolivier, J; Marc, C; Pandini, M; Perron, C; Puech, F; Scatton, B; Sontag, N | 1 |
| Itakura, T; Kakishita, K; Nakao, N; Shintani-Mizushima, A | 1 |
| Cooper, T; Hashim, A; Lajtha, A; Lonow, R; Rossi, S; Sershen, H; Singer, S; Verzosa, S | 1 |
| Harsing, LG; Juranyi, Z; Levay, G; Marko, B; Sziray, N | 1 |
| Ogawa, N; Tanaka, K | 1 |
| Bergquist, J; Dibó, G; Rajda, C; Vécsei, L | 1 |
| Asanuma, M; Diaz-Corrales, FJ; Miyazaki, I; Ogawa, N; Shimizu, M; Tanaka, K | 1 |
| Johirul, M; Kim, RE; Shiddiky, A; Shim, YB | 1 |
| Casarejos, MJ; Correa, C; García de Yébenes, J; Mena, MA; Menéndez, J; Rodríguez-Navarro, JA; Solano, RM | 1 |
| Bishop, C; Taylor, JL; Walker, PD | 1 |
| Kadota, S; Li, X; Matsumoto, K; Murakami, Y; Tezuka, Y; Wu, Y | 1 |
| Bezard, E; Bioulac, B; Boraud, T; Gross, CE; Harnack, D; Klitgaard, H; Kupsch, A; Meissner, W; Morgenstern, R; Ravenscroft, P; Reese, R | 1 |
| Carl, JL; Karimi, M; Loftin, S; Perlmutter, JS | 1 |
| Arai, A; Baba, M; Kannari, K; Shen, H; Tomiyama, M | 1 |
| Liu, GP; Ma, Q; Shi, N | 1 |
| Adachi, K; Kondo, T; Kusumoto, H; Miwa, H; Shimazu, S | 1 |
| Giasson, BI; Ischiropoulos, H; Lynch, DR; Mazzulli, JR; Mishizen, AJ; Nagatsu, T; Nakashima, A; Ota, A; Thomas, SA | 1 |
| Cooper, JD; Davies, MI; Heppert, KE; Lunte, SM | 1 |
| Dopico, JG; Gómez, I; González-Mora, JL; Morales, I; Obeso, JA; Rodríguez, M; Rodríguez-Oroz, MC; Sabaté, M | 1 |
| Gacsalyi, I; Harsing, LG; Juranyi, Z; Levay, G; Marko, B; Megyeri, K; Sziray, N | 1 |
| Arrúe, A; Grandoso, L; Hernández, RM; Linazasoro, G; Manuel, I; Orive, G; Pedraz, JL; Ponce, S; Rodríguez, A; Rodríguez-Puertas, R; Ruiz-Ortega, JA; Ugedo, L; Ulibarri, I; Zumárraga, M | 1 |
| Barbanoj, M; Kulisevsky, J; Pérez, V; Rodríguez-Alvarez, J; Rubio, A; Sosti, V | 1 |
| Buck, K; Ferger, B | 1 |
| Artusi, R; Caselli, G; Lanza, M; Makovec, F; Michotte, Y; Sarre, S | 1 |
| Bishop, C; Dupre, KB; Eskow, KL; Klioueva, A; Lormand, L; Negron, GE; Park, JY; Steiniger, A | 1 |
| Malmlöf, T; Schilström, B; Svensson, TH | 1 |
| Barnum, CJ; Bishop, C; Dickinson, SO; Dupre, KB; Eskow, KL; Park, JY | 1 |
| Dziubina, A; Gołembiowska, K; Kamińska, K; Kowalska, M | 1 |
| Furuse, M; Hamasu, K; Kabuki, Y; Shigemi, K | 1 |
| Bertoldi, M; Voltattorni, CB | 1 |
| Kostrzewa, RA; Kostrzewa, RM; Nowak, P; Skaba, D | 1 |
| Chung, CY; Hallett, PJ; Isacson, O; Koprich, JB | 1 |
| Darvas, M; Palmiter, RD | 1 |
| Mertens, B; Michotte, Y; Sarre, S; Vanderheyden, P | 1 |
| Fukumura, T; Hosoi, R; Inoue, O; Nakao, R; Okada, M; Suzuki, K; Zhang, MR | 1 |
| Andersen, ML; Barnabé, GF; Dombrowski, PA; Lima, MM; Reksidler, AB; Tufik, S; Vital, MA | 1 |
| Borah, A; Mohanakumar, KP | 1 |
| García-Horsman, JA; Käenmäki, M; Kambur, O; Karvonen, E; Keisala, T; Kulesskaya, N; Männistö, PT; Rauvala, H; Tammimäki, A | 1 |
| Allen, E; Carlson, KM; Cavanaugh, JE; Zigmond, MJ | 1 |
| Christensen, BM; Erickson, SM; Han, Q; Harich, K; Huang, Y; Li, J; Vavricka, C | 1 |
| Barbosa, DJ; Branco, PS; Capela, JP; Carvalho, F; de Lourdes Bastos, M; Duarte, JA; Fernandes, E; Ferreira, LM; Oliveira, JM; Silva, R; Siopa, F | 1 |
| Doorn, JA; Florang, VR; Mexas, LM | 1 |
| Birbeck, JA; Bosse, KE; Colombo, ML; France, MM; Maina, FK; Mathews, TA; Roberts, JJ | 1 |
| Ansorge, MS; Esposito, E; Gingrich, JA; Gray, N; Moore, H; Morelli, E; Rebello, TJ; Steele, K | 1 |
| Amalric, M; Blobaum, AL; Bode, J; Bridges, TM; Bubser, M; Conn, PJ; Daniels, JS; Dickerson, JW; Engers, DW; Hopkins, CR; Italiano, K; Jadhav, S; Jones, CK; Lindsley, CW; Morrison, RD; Niswender, CM; Thompson, AD; Turle-Lorenzo, N | 1 |
| Chao, OY; Huston, JP; Mattern, C; Nikolaus, S; Pum, ME; Ruocco, LA; Silva, AM; Wessler, J | 1 |
| Baker, H; Morgan, LD; Patel, BA; Yeoman, MS | 1 |
| Goldstein, DS; Holmes, C; Sharabi, Y | 1 |
| Kulkarni, N; Ledeen, RW; Lu, ZH; Wu, G | 1 |
| Ballaz, S; Fuentes, A; Morales, I; Obeso, JA; Rodriguez, M | 1 |
| Czarnecka, A; Kamińska, K; Konieczny, J; Lenda, T; Lorenc-Koci, E | 1 |
| Agostino, PV; Bussi, IL; Golombek, DA; Levín, G | 1 |
| Li, B; Li, Y; Sun, Y; Wu, Y; Yang, J; Yu, J | 1 |
| Deng, M; Fang, Y; Huang, L; Li, L; Zhang, S | 1 |
| Di Paolo, T; Grégoire, L; Morin, N; Morissette, M | 1 |
| Stansley, BJ; Yamamoto, BK | 1 |
| Bergeron, Y; Bermejo, MK; Caron, MG; Cyr, M; Gainetdinov, RR; Hossain, MM; Kile, B; Masoud, ST; Miller, GW; Nguyen, LT; Ramsey, AJ; Richardson, JR; Salahpour, A; Siesser, WB; Sotnikova, TD; Vecchio, LM; Wightman, RM | 1 |
| Cooney, A; Goldstein, DS; Jinsmaa, Y; Sharabi, Y; Sullivan, P | 1 |
| Felger, JC; Hernandez, CR; Miller, AH | 1 |
| Aguirre, N; Barros-Miñones, L; Beitia, G; Goñi-Allo, B; Puerta, E; Suquia, V | 1 |
| Asahina, M; Higuchi, Y; Hirano, S; Kuwabara, S; Uchiyama, T; Yamamoto, T; Yamanaka, Y | 1 |
| Kim, AR; Ugryumov, MV | 1 |
| Chen, G; He, Y; Liu, S; Liu, Z; Wei, N; You, J; Zhao, XE; Zheng, L; Zhu, S | 1 |
| Andersen, AD; Binzer, M; Blaabjerg, M; Gramsbergen, JBP; Kamal, A; Kjaer, TW; Stenager, E; Thagesen, H | 1 |
| Doyle, KM; Kelly, JP; Moreira da Silva Santos, A | 1 |
| Han, Q; Li, J; Liang, J; Liao, C; Upadhyay, A | 1 |
| Hoon, M; Petzer, A; Petzer, JP; Viljoen, F | 1 |
| Khan, SS; Mirza, T; Naeem, S; Najam, R; Sikandar, B | 1 |
| Chahine, LM; Coffey, CS; Czech, C; Dukart, J; Dziadek, S; Foroud, T; Galasko, D; Gerken, T; Hutten, SJ; Kremer, T; Marek, K; Mollenhauer, B; Pagano, G; Poston, KL; Seibyl, J; Siebourg-Polster, J; Simuni, T; Staempfli, A; Tanner, CM; Taylor, KI; Toga, AW; Trenkwalder, C; Weintraub, D | 1 |
| Allen, RA; Bales, KL; Chesler, KC; Motz, CT; Pardue, MT; Vo, HK | 1 |
| Chakraborty, R; Hattar, S; Iuvone, PM; Landis, EG; Mazade, R; Pardue, MT; Stone, RA; Strickland, R; Yang, V | 1 |
3 review(s) available for 3,4-dihydroxyphenylacetic acid and levodopa
| Article | Year |
|---|---|
Renal dopaminergic mechanisms in renal parenchymal diseases, hypertension, and heart failure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Heart Failure; Hemodynamics; Humans; Hypertension, Renal; Kidney Diseases; Kidney Transplantation; Levodopa; Nephrons; Receptors, Dopamine D1; Sodium | 2000 |
Novel aspects of dopamine oxidative metabolism (confounding outcomes take place of certainties).
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Isoenzymes; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Species Specificity; Substantia Nigra | 2001 |
3,4-Dihydroxyphenylacetaldehyde synthase and cuticle formation in insects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Humans; Insect Proteins; Insecta; Levodopa | 2018 |
8 trial(s) available for 3,4-dihydroxyphenylacetic acid and levodopa
| Article | Year |
|---|---|
Conjugation of L-DOPA and its metabolites after oral and intravenous administration to Parkinsonian patients.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Aged; Clinical Trials as Topic; Dopamine; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Humans; Infusions, Parenteral; Levodopa; Male; Middle Aged; Parkinson Disease; Parkinson Disease, Postencephalitic; Tritium | 1975 |
The effect of an increased ratio of carbidopa to levodopa on the pharmacokinetics of levodopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Carbidopa; Dopamine; Drug Interactions; Female; Humans; Kinetics; Levodopa; Male; Random Allocation | 1985 |
Derivation of urinary dopamine from plasma dihydroxyphenylalanine in humans.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Dihydroxyphenylalanine; Dopamine; Female; Humans; Kidney; Levodopa; Male; Middle Aged; Sodium, Dietary | 1993 |
Monoamine oxidase A and B activities in heavy smokers.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Blood Platelets; Blood Pressure; Cotinine; Depression; Female; Glycine; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase; Norepinephrine; Resorcinols; Smoking | 1995 |
Renal metabolism and effects of the glutamyl derivatives of L-dopa and 5-hydroxytryptophan in man.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Adult; Cross-Over Studies; Dihydroxyphenylalanine; Dipeptides; Dopamine; Humans; Hydroxyindoleacetic Acid; Kidney; Levodopa; Male; Serotonin; Single-Blind Method; Sodium | 1996 |
The metabolism of L-DOPA and L-threo-3,4-dihydroxyphenylserine and their effects on monoamines in the human brain: analysis of the intraventricular fluid from parkinsonian patients.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Antiparkinson Agents; Biogenic Monoamines; Cerebral Ventricles; Combined Modality Therapy; Dopamine; Droxidopa; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Middle Aged; Norepinephrine; Parkinson Disease; Reference Values; Stereotaxic Techniques; Thalamus | 1996 |
Pharmacodynamics of benserazide assessed by its effects on endogenous and exogenous levodopa pharmacokinetics.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Antiparkinson Agents; Benserazide; Carboxy-Lyases; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Levodopa; Male; Middle Aged; Tyrosine | 1997 |
The ability of grafted human sympathetic neurons to synthesize and store dopamine: a potential mechanism for the clinical effect of sympathetic neuron autografts in patients with Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Brain Tissue Transplantation; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine; Female; Ganglia, Sympathetic; Graft Survival; Humans; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neurons; Neuropeptides; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reserpine; Transplantation, Heterologous; Tyrosine 3-Monooxygenase; Up-Regulation; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2004 |
329 other study(ies) available for 3,4-dihydroxyphenylacetic acid and levodopa
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Determination of some L-3,4-dihydroxyphenylalanine and dopamine metabolites in urine by means of mass fragmentography.
Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; Adult; Aging; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Flavoring Agents; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Humans; Infant; Infant, Newborn; Lactates; Levodopa; Middle Aged; Neuroblastoma; Phenylethyl Alcohol | 1978 |
[Pharmacology of several aromatic amino acid decarboxylase inhibitors].
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Drug Interactions; Indoles; Kidney; Lactates; Levodopa; Methyldopa; Phenylacetates; Rabbits | 1978 |
Neurochemical investigations of the interaction of N,N-dimethyltryptamine with dopaminergic system in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Brain; Corpus Striatum; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Female; Homovanillic Acid; Levodopa; Monoamine Oxidase; N,N-Dimethyltryptamine; Norepinephrine; Normetanephrine; Rats; Time Factors; Tryptamines; Tyramine | 1977 |
gamma-Glutamyl DOPA and gamma-glutamyl dopamine: effect on plasma glucose levels.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Glucose; Dihydroxyphenylalanine; Dopamine; Female; Homovanillic Acid; Levodopa; Pancreas; Rats; Time Factors | 1979 |
Simultaneous determination by GC-MS-SIM of o-, m-, p-hydroxyphenylacetic acid, 3:4-dihydroxyphenylacetic acid and homovanillic acid in biological samples using a common selected ion.
Topics: 3,4-Dihydroxyphenylacetic Acid; Carbidopa; Chromatography, Gas; Homovanillic Acid; Humans; Levodopa; Mass Spectrometry; Methods; Phenylacetates | 1978 |
Mammalian tyrosinase. A comparison of tyrosine hydroxylation and melanin formation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Binding Sites; Catechol Oxidase; Dihydroxyphenylalanine; Dopamine; Kinetics; Levodopa; Melanins; Melanocytes; Mice; Monophenol Monooxygenase; Time Factors; Tyrosine | 1976 |
Liquid chromatographic monitoring of CSF metabolites.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Rabbits; Rats; Serotonin | 1977 |
Preferential deamination of dopamine by an A type monoamine oxidase in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Clorgyline; Corpus Striatum; Deamination; Dihydroxyphenylalanine; Dopamine; Female; Homovanillic Acid; Levodopa; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Motor Activity; Normetanephrine; Phenethylamines; Rats; Reserpine; Serotonin; Tyramine | 1976 |
L-DOPA metabolism in the rat exocrine pancreas - a biochemical study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopa Decarboxylase; Dopamine; Female; Levodopa; Male; Microsomes; Monoamine Oxidase; Pancreas; Pancreatic Juice; Rats | 1976 |
Dopamine correlates of neurological and psychological status in untreated Parkinsonism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Affect; Aged; Dopamine; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; MMPI; Parkinson Disease; Psychopathology | 1976 |
Evidence for dopamine receptors mediating sedation in the mouse brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Brain; Dose-Response Relationship, Drug; Levodopa; Mice; Motor Activity; Pimozide; Receptors, Dopamine; Tranquilizing Agents | 1976 |
Noradrenaline synthesis from L-DOPA in rodents and its relationship to motor activity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain Chemistry; Catecholamines; Homovanillic Acid; Levodopa; Male; Methoxyhydroxyphenylglycol; Methyltyrosines; Mice; Motor Activity; Norepinephrine; Rats; Reserpine; Time Factors | 1976 |
Comparison of short and long-lasting effects of pargyline on cerebral dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cisterna Magna; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Injections; Injections, Intravenous; Levodopa; Methyldopa; Monoamine Oxidase; Pargyline; Rats; Time Factors; Tyrosine | 1976 |
A study of endogenous dopamine metabolism in Gilles de la Tourette's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Dopamine; Epinephrine; Haloperidol; Homovanillic Acid; Humans; Imipramine; Levodopa; Male; Tourette Syndrome | 1976 |
The effect of amitriptyline, desipramine and imipramine on the vivo brain synthesis of 3H-noradrenaline from 3H-L-dopa in the rat.
Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Benserazide; Brain; Chromatography, Thin Layer; Desipramine; Dopamine; Imipramine; Levodopa; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Normetanephrine; Rats; Tryptamines | 1975 |
Effects of levodopa on the bladder outlet.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Dopamine; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Ureter; Urinary Bladder; Urinary Bladder Neck Obstruction; Urination | 1975 |
Assessment of cerebrospinal fluid levels of dopamine metabolites by gas chromatography.
Topics: 3,4-Dihydroxyphenylacetic Acid; Chromatography, Gas; Dopamine; Homovanillic Acid; Levodopa; Parkinson Disease; Phenylacetates; Propionates | 1975 |
Effects of chronic oral administration on the disposition of laevodopa and its major metabolites in the plasma of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Catecholamines; Homovanillic Acid; Levodopa; Male; Methyldopa; Rats; Time Factors; Vanilmandelic Acid | 1975 |
Urinary excretion of monoamines and their metabolites in patients with Parkinson's disease. Response to long-term treatment with levodopa alone or in combination with a dopa decarboxylase inhibitor and clinical correlations.
Topics: 3,4-Dihydroxyphenylacetic Acid; Benserazide; Biogenic Amines; Dopamine; Female; Homovanillic Acid; Humans; Hydrazines; Hydroxyindoleacetic Acid; Levodopa; Male; Metanephrine; Middle Aged; Normetanephrine; Parkinson Disease; Tyramine; Vanilmandelic Acid | 1975 |
Effect of alpha-human atrial natriuretic peptide on the synthesis of dopamine in the rat kidney.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3',5'-Cyclic-GMP Phosphodiesterases; Aging; Animals; Atrial Natriuretic Factor; Dopamine; In Vitro Techniques; Kidney; Levodopa; Male; Purinones; Rats; Rats, Inbred Strains; Sodium, Dietary | 1992 |
Deamination of newly-formed dopamine in rat renal tissues.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Deamination; Dopamine; In Vitro Techniques; Kidney; Levodopa; Male; Pargyline; Picolinic Acids; Rats; Rats, Wistar; Thiazoles | 1991 |
Biochemical and functional differences between dopamine formed from endogenous tyrosine and exogenous L-dopa in nigrostriatal dopaminergic neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Levodopa; Male; Neurons; Rats; Reserpine; Substantia Nigra; Tyrosine | 1992 |
Biotransformation of L-dopa in striatum and substantia nigra of rats with a unilateral, nigrostriatal lesion: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthetics; Animals; Biotransformation; Corpus Striatum; Dialysis; Dopamine; Extracellular Space; Homovanillic Acid; Levodopa; Male; Oxidopamine; Rats; Rats, Wistar; Substantia Nigra | 1992 |
Effect of nitecapone and clorgyline, given intracerebro-ventricularly on L-dopa metabolism in the rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Carbidopa; Catechols; Cerebral Ventricles; Clorgyline; Corpus Striatum; Dopamine; Homovanillic Acid; Hypothalamus; Injections, Intraventricular; Levodopa; Male; Pentanones; Prolactin; Rats; Rats, Wistar; Thyrotropin | 1992 |
Actin cytoskeleton, tubular sodium and the renal synthesis of dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Actins; Animals; Biological Transport; Colchicine; Cytochalasin B; Cytoskeleton; Dopamine; Kidney; Kidney Cortex; Kidney Tubules; Levodopa; Male; Ouabain; Rats; Rats, Wistar; Sodium | 1992 |
Sodium-dependence and ouabain-sensitivity of the synthesis of dopamine in renal tissues of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biological Transport, Active; Dopamine; Drug Resistance; In Vitro Techniques; Kidney; Levodopa; Male; Ouabain; Rats; Rats, Inbred Strains; Sodium | 1992 |
Assessment of dopamine and its metabolites in the intracellular and extracellular compartments of the rat striatum after peripheral administration of L-[11C]dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Extracellular Space; Homovanillic Acid; Injections, Intravenous; Intracellular Fluid; Kinetics; Levodopa; Male; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
Catechol-O-methyltransferase inhibition increases striatal L-dopa and dopamine: an in vivo study in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Male; Nitrophenols; Rats; Rats, Inbred Strains; Tolcapone | 1992 |
Effects of systemic carbidopa on dopamine synthesis in rat hypothalamus and striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Corpus Striatum; Depression, Chemical; Dialysis; Dopamine; Homovanillic Acid; Hypothalamus; Injections, Intraperitoneal; Levodopa; Male; Perfusion; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
High-performance liquid chromatography with electrochemical detection for the determination of levodopa, catecholamines and their metabolites in rat brain dialysates.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Caudate Nucleus; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Epinephrine; Homovanillic Acid; Injections, Intraperitoneal; Levodopa; Male; Methyldopa; Norepinephrine; Rats; Rats, Inbred Strains; Substantia Nigra | 1992 |
Peripheral pharmacokinetic handling and metabolism of L-dopa in the rat: the effect of route of administration and carbidopa pretreatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Aorta, Thoracic; Carbidopa; Chromatography, High Pressure Liquid; Homovanillic Acid; Injections, Intravenous; Levodopa; Male; Rats; Rats, Inbred Strains; Tyrosine | 1991 |
Apomorphine lowers dopamine synthesis for up to 48 h: implications for drug sensitization.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Apomorphine; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Administration Schedule; Levodopa; Motor Activity; Rats; Rats, Inbred Strains; Reference Values; Time Factors; Tyrosine 3-Monooxygenase | 1991 |
Compensatory activation of substance P biosynthesis by L-dihydroxyphenylalanine in striatonigral neurons of neonatal dopaminergic denervated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Blotting, Northern; Brain; Dopamine; Female; Injections, Intraperitoneal; Levodopa; Male; Phenylacetates; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA, Messenger; Substance P; Tachykinins | 1990 |
Age effects on monoamine turnover of the rat substantia nigra.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Aging; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Biogenic Monoamines; Dopamine; Homovanillic Acid; Hydrazines; In Vitro Techniques; Levodopa; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Pargyline; Rats; Rats, Inbred Strains; Serotonin; Substantia Nigra | 1991 |
Effect of dietary protein on striatal dopamine formation following L-dopa administration: an in vivo study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dialysis; Dietary Proteins; Dopamine; Extracellular Space; Homovanillic Acid; In Vitro Techniques; Levodopa; Male; Rats; Rats, Inbred Strains | 1991 |
Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Corpus Striatum; Dopamine; Levodopa; Male; Pulsatile Flow; Rats; Rats, Inbred Strains | 1991 |
A study on the renal synthesis of dopamine in aged rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Chromatography, High Pressure Liquid; Dopamine; Kidney; Levodopa; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1991 |
Chronic L-dopa treatment in the unilateral 6-OHDA rat: evidence for behavioral sensitization and biochemical tolerance.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Carbidopa; Corpus Striatum; Denervation; Drug Tolerance; Functional Laterality; Homovanillic Acid; Levodopa; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1991 |
Simultaneous determination of levodopa, its main metabolites and carbidopa in plasma by liquid chromatography.
Topics: 3,4-Dihydroxyphenylacetic Acid; Carbidopa; Chromatography, High Pressure Liquid; Chromatography, Liquid; Freeze Drying; Homovanillic Acid; Humans; Hydrogen-Ion Concentration; Levodopa; Solutions; Tyrosine | 1991 |
Genotype differences in catecholamine concentrations in hypothalamus, intramedial hyperstriatum ventrale, and optic tectum of newly hatched chicks.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Catecholamines; Chickens; Corpus Striatum; Dopamine; Epinephrine; Functional Laterality; Genotype; Hypothalamus; Levodopa; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Species Specificity; Superior Colliculi | 1991 |
5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Anti-Arrhythmia Agents; Brain; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Homovanillic Acid; Levodopa; Male; Nomifensine; Piperidines; Rats; Rats, Inbred Strains; Ritanserin; Serotonin Antagonists; Stereoisomerism; Time Factors | 1991 |
Hydrogen peroxide as a mediator of dopac-induced effects on melanoma cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Catalase; Cell Line; Humans; Hydrogen Peroxide; Levodopa; Melanins; Melanoma; Monophenol Monooxygenase; Phenylacetates | 1991 |
The effect of long-term treatment with deprenyl on basal and L-dopa evoked dopamine release in vitro from the corpus striatum of aged rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Amphetamine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Levodopa; Male; Rats; Selegiline | 1991 |
L-dopa facilitates the release of endogenous norepinephrine and dopamine via presynaptic beta 1- and beta 2-adrenoceptors under essentially complete inhibition of L-aromatic amino acid decarboxylase in rat hypothalamic slices.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic beta-Antagonists; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Dopamine; Electric Stimulation; Hydrazines; Hypothalamus; In Vitro Techniques; Kinetics; Levodopa; Male; Norepinephrine; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1990 |
Pharmacokinetics, bioavailability, metabolism, tissue distribution and urinary excretion of gamma-L-glutamyl-L-dopa in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biological Availability; Dihydroxyphenylalanine; Dopamine; Female; Humans; Kidney; Levodopa; Liver; Middle Aged; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Exogeneous expression of L-dopa and dopamine in various cell lines following transfer of rat and human tyrosine hydroxylase cDNA: grafting in an animal model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Disease Models, Animal; DNA; Dopamine; Enzyme Induction; Graft Survival; Levodopa; Male; Neuroblastoma; Parkinson Disease; Rats; Rats, Inbred Strains; Recombinant Fusion Proteins; Transplantation, Heterotopic; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1990 |
Effect of long-term L-dopa administration on striatal extracellular dopamine release.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Extracellular Space; Homovanillic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Role of monoamine oxidase A and B in the deamination of newly-formed dopamine in the rat kidney.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Deamination; Dopamine; In Vitro Techniques; Kidney; Levodopa; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Picolinic Acids; Rats; Rats, Inbred Strains; Thiazoles | 1990 |
Effect of amperozide on the synthesis and turnover of monoamines in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; alpha-Methyltyrosine; Animals; Biogenic Monoamines; Brain Chemistry; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Levodopa; Male; Methyltyrosines; Norepinephrine; Piperazines; Psychotropic Drugs; Rats; Rats, Inbred Strains; Serotonin | 1990 |
The effects of L-dopa on in vitro dopamine release from striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Calcium; Corpus Striatum; Dopamine; Hydroxydopamines; In Vitro Techniques; Levodopa; Male; Oxidopamine; Rats; Rats, Inbred Strains | 1990 |
L-deprenyl, levodopa pharmacokinetics, and response fluctuations in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Humans; Levodopa; Middle Aged; Parkinson Disease; Phenethylamines; Psychomotor Performance; Selegiline | 1990 |
Origin of dopamine in the rat adrenal cortex.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Cortex; Animals; Dopamine; Epinephrine; Hydroxydopamines; Levodopa; Male; Monoamine Oxidase; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains | 1990 |
Striatal L-dopa metabolism studied in vivo in rats with nigrostriatal lesions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxydopamines; Levodopa; Male; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1990 |
Method for the determination of gamma-L-glutamyl-L-dihydroxyphenylalanine and its major metabolites L-dihydroxyphenylalanine, dopamine and 3,4-dihydroxyphenylacetic acid by high-performance liquid chromatography with electrochemical detection.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Humans; Kidney; Levodopa; Liver; Phenylacetates; Rats | 1990 |
Cognitive deficiency induced by the acute stress in rats: a possible role of brain catecholaminergic systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain Chemistry; Cognition Disorders; Dihydroxyphenylalanine; Escape Reaction; Exploratory Behavior; Levodopa; Male; Norepinephrine; Rats; Stress, Physiological | 1990 |
Effect of precursors on the synthesis of catecholamines and on neurotransmission in the superior cervical ganglion of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Action Potentials; Animals; Aspartame; Catecholamines; Dipeptides; Dopamine; Electric Stimulation; Ganglia, Sympathetic; Levodopa; Male; Nialamide; Norepinephrine; Rats; Rats, Inbred Strains; Synaptic Transmission; Tyrosine | 1990 |
In vivo studies of striatal dopamine release and metabolism following administration of L-dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxydopamines; Levodopa; Male; Neural Pathways; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Synaptic Transmission | 1990 |
Decreased dopamine in the retinas of patients with Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Dopamine; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Retina | 1990 |
Effects of chronic treatment of MPTP monkeys with bromocriptine alone or in combination with SKF 38393.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Brain; Brain Chemistry; Bromocriptine; Dopamine; Female; Homovanillic Acid; Kinetics; Levodopa; Macaca fascicularis; Motor Activity; MPTP Poisoning; Parkinson Disease, Secondary; Receptors, Dopamine; Spiperone | 1990 |
Vesicular and ganglionic norepinephrine in the rat: progressive increase with age.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain; Catecholamines; Chromatography, High Pressure Liquid; Cytoplasm; Dopamine; Ganglia, Sympathetic; Levodopa; Male; Norepinephrine; Osmolar Concentration; Rats; Rats, Inbred Strains; Synaptic Vesicles | 1990 |
Relationship between the effects of dexamphetamine on locomotion and on striatal [3H]GBR 12783 binding in vivo.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine Antagonists; Homovanillic Acid; Levodopa; Male; Mice; Motor Activity; Piperazines; Reserpine | 1990 |
Rat brain concentration of administered amino acids: dependence on time of day for administration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Animals; Brain Chemistry; Dihydroxyphenylalanine; Drug Administration Schedule; Hydroxyindoleacetic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Serotonin; Time Factors; Tryptophan | 1986 |
Manganese neurotoxicity: effects of L-DOPA and pargyline treatments.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Basal Ganglia Diseases; Corpus Striatum; Dopamine; Drug Synergism; Hydroxyindoleacetic Acid; Levodopa; Male; Manganese Poisoning; Pargyline; Parkinson Disease; Rats; Serotonin | 1986 |
Long-term effects of MPTP on central and peripheral catecholamine and indoleamine concentrations in monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Brain; Bromocriptine; Catecholamines; Chromatography, High Pressure Liquid; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Macaca fascicularis; Parkinson Disease, Secondary; Prolactin; Pyridines | 1986 |
Effect of mild postnatal hypoxia and L-dopa administration on dopamine concentration in striata of the newborn rat and long term sequelae on dopamine turnover.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Hypoxia, Brain; Levodopa; Rats; Rats, Inbred Strains; Reference Values | 1989 |
Modification of vesicular dopamine and norepinephrine by monoamine oxidase inhibitors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Cytoplasm; Dopamine; Levodopa; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Reserpine; Synaptic Vesicles | 1989 |
Comparative study of sulpiride and haloperidol on dopamine turnover in the rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Brain; Dopamine; Haloperidol; Levodopa; Male; Rats; Rats, Inbred Strains; Sulpiride | 1989 |
Effect of exogenous L-dopa on behavior in the rat: an in vivo voltammetric study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Electrochemistry; Injections, Intraperitoneal; Injections, Intraventricular; Levodopa; Male; Rats; Rats, Inbred Strains | 1989 |
Evidence that L-dopa-induced rotational behavior is dependent on both striatal and nigral mechanisms.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Biomechanical Phenomena; Corpus Striatum; Dopamine; Levodopa; Male; Rats; Rats, Inbred Strains; Rotation; Stereotyped Behavior; Substantia Nigra | 1989 |
Effect of L-DOPA, dopamine, dihydroxyphenyl acetic acid and homovanillic acid on Na,K-ATPase activity in rat proximal tubule segments.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Homovanillic Acid; Kidney Tubules, Proximal; Levodopa; Male; Phenylacetates; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase | 1987 |
The synthesis and metabolism of catecholamines in the spinal cord of the rat after acute and chronic transections.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catecholamines; Cordotomy; Dopamine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homovanillic Acid; Levodopa; Norepinephrine; Rats; Rats, Inbred Strains; Spinal Cord | 1985 |
Acute cyanide intoxication and central transmitter systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Animals; Apomorphine; Brain; Cyanides; Cyclic GMP; Dopamine; gamma-Aminobutyric Acid; Homovanillic Acid; Levodopa; Male; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Spiperone | 1985 |
Re-evaluation of the L-dopa loading effect on dopamine metabolism in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Therapy, Combination; Homovanillic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Tyrosine | 1986 |
Dopaminergic metabolism in various rat brain areas after L-dopa loading.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Methoxytryptamine; Animals; Brain Chemistry; Corpus Striatum; Dopamine; Hippocampus; Homovanillic Acid; Levodopa; Male; Rats; Rats, Inbred Strains | 1986 |
Circadian rhythms and contents of catechols in different brain structures, peripheral organs and plasma of the Atlantic cod, Gadus morhua.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Catecholamines; Circadian Rhythm; Dopamine; Epinephrine; Fishes; Levodopa; Myocardium; Norepinephrine; Spleen; Tissue Distribution | 1987 |
L-dopa esters as potential prodrugs: effect on brain concentration of dopamine metabolites in reserpinized mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Male; Mice; Olfactory Bulb; Pharmaceutical Preparations; Prodrugs; Reserpine | 1987 |
Intracerebral dialysis monitoring of striatal dopamine release and metabolism in response to L-dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Corpus Striatum; Dialysis; Dopamine; Homovanillic Acid; Levodopa; Male; Rats; Rats, Inbred Strains | 1989 |
Differentiation of dopamine overflow and uptake processes in the extracellular fluid of the rat caudate nucleus with fast-scan in vivo voltammetry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Benztropine; Bupropion; Caudate Nucleus; Dopamine; Electric Stimulation; Electrochemistry; Extracellular Space; Kinetics; Levodopa; Male; Microelectrodes; Neurotransmitter Uptake Inhibitors; Nomifensine; Piperazines; Propiophenones; Rats; Rats, Inbred Strains | 1988 |
Investigation of dopamine content, synthesis, and release in the rabbit retina in vitro: I. Effects of dopamine precursors, reserpine, amphetamine, and L-DOPA decarboxylase and monoamine oxidase inhibitors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Dopamine; Female; Levodopa; Male; Monoamine Oxidase Inhibitors; Pargyline; Rabbits; Reserpine; Retina; Selegiline; Tyrosine | 1986 |
D-dopa and L-dopa similarly elevate brain dopamine and produce turning behavior in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Carbidopa; Cerebral Ventricles; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Stereotyped Behavior; Structure-Activity Relationship | 1988 |
Exposure of striatal [corrected] synaptosomes to L-dopa increases levels of oxidized glutathione.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brocresine; Carbidopa; Catalase; Chromatography, High Pressure Liquid; Glutathione; Glutathione Disulfide; Hydrogen Peroxide; Levodopa; Male; Peroxides; Rats; Rats, Inbred Strains; Reserpine; Synaptosomes; tert-Butylhydroperoxide | 1988 |
The effect of carbidopa on plasma and muscle levels of L-dopa, dopamine, and their metabolites following L-dopa administration to rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Drug Synergism; Homovanillic Acid; Levodopa; Muscles; Rats; Tyrosine | 1988 |
Biochemical aspects of Parkinson-dementia complex.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dementia; Female; Humans; Levodopa; Male; Mice; Middle Aged; Oxygen; Parkinson Disease; Pyridines; Serotonin; Tryptophan Hydroxylase | 1988 |
Possible treatment of Parkinson's disease with intrathecal medication in the MPTP model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Homovanillic Acid; Infusion Pumps; Injections, Spinal; Levodopa; Parkinson Disease, Secondary; Pyridines; Time Factors | 1988 |
Determinations of catechols in small volumes of plasma using ion-pair reversed phase liquid chromatography/electrochemistry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catecholamines; Chromatography, High Pressure Liquid; Dopamine; Epinephrine; Fishes; Levodopa; Male; Microchemistry; Norepinephrine; Physical Exertion; Rats; Rats, Inbred Strains; Stress, Physiological | 1988 |
[Effect of L-dihydroxyphenylalanine on rat behavior and on catecholamine metabolism of the brain in rats with different degrees of emotional-behavioral reactivity].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Benserazide; Brain; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Drug Combinations; Drug Interactions; Emotions; Levodopa; Male; Rats | 1988 |
A novel nigrostriatal dopaminergic disorder in sheep affected by Tribulus terrestris staggers.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Efferent Pathways; Female; Levodopa; Movement Disorders; Phenylacetates; Plant Poisoning; Sheep; Sheep Diseases; Substantia Nigra | 1987 |
L-dopa metabolism in genetically hypertensive mice: effect of pargyline.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Weight; Brain; Dopamine; Dopamine beta-Hydroxylase; Drug Interactions; Hypertension; Levodopa; Mice; Norepinephrine; Normetanephrine; Pargyline | 1987 |
Monitoring of dopamine metabolism by in vivo voltammetry and high performance liquid chromatography in L-dopa-treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catechols; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Norepinephrine; Oxidation-Reduction; Proteins; Rats | 1987 |
Biochemical and behavioural indices of striatal dopaminergic activity after 6-methyltetrahydropterin.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Catalepsy; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Levodopa; Male; Neurons; Pterins; Rats; Rats, Inbred Strains; Reserpine | 1987 |
[Psychiatric symptoms and plasma levodopa dynamics in Parkinson's disease].
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Dopamine; Female; Hallucinations; Humans; Levodopa; Male; Middle Aged; Parkinson Disease | 1987 |
The effects of domperidone on the absorption of levodopa in normal subjects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Domperidone; Female; Half-Life; Humans; Intestinal Absorption; Kinetics; Levodopa | 1986 |
Handling of dopamine and dopamine sulfate by isolated perfused rat kidney.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Denervation; Dopamine; In Vitro Techniques; Kidney; Levodopa; Male; Norepinephrine; Pargyline; Perfusion; Rats; Rats, Inbred Strains | 1986 |
Mobilization of storage pool dopamine and late ipsilateral augmentation of striatal dopamine synthesis in the trained circling rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Kinetics; Levodopa; Male; Motor Activity; Rats; Rats, Inbred Strains; Tyrosine | 1986 |
Simultaneous determination of catechols in thalamic slices with liquid chromatography/electrochemistry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catecholamines; Chromatography, Liquid; Dopamine; Electrochemistry; Epinephrine; Levodopa; Male; Methoxyhydroxyphenylglycol; Mice; Norepinephrine; Thalamus | 1987 |
Biochemical effects of chronic L-dopa treatment in rats: implications for emergence of tolerance phenomena in patients with Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Brain; Dopamine; Drug Administration Schedule; Drug Tolerance; Homovanillic Acid; Humans; Levodopa; Male; Parkinson Disease; Rats | 1987 |
Stereospecific deuterium substitution at the alpha-carbon position of dopamine and its effect on oxidative deamination catalyzed by MAO-A and MAO-B from different tissues.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aldehydes; Animals; Blood Platelets; Chromatography, High Pressure Liquid; Deamination; Decarboxylation; Deuterium; Dopamine; Female; Humans; Kinetics; Levodopa; Liver; Male; Monoamine Oxidase; Oxidation-Reduction; Parkinson Disease; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Stereoisomerism | 1986 |
Metabolism of catecholamines in the developing spinal cord of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Fetus; Homovanillic Acid; Levodopa; Norepinephrine; Rats; Spinal Cord; Tissue Distribution | 1985 |
Partial protection by CDP-choline against kainic acid-induced lesion in the rat caudate nucleus.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Choline; Cytidine Diphosphate Choline; Dopamine; Kainic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Time Factors | 1985 |
Effects of L-dopa supplementation on concentrations of brain catechols, dopamine receptor binding and the incidence of pale, soft and exudative meat in stress-susceptible pigs.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Brain Mapping; Catecholamines; Dopamine; Epinephrine; Levodopa; Meat; Norepinephrine; Receptors, Dopamine; Species Specificity; Stress, Physiological; Swine; Swine Diseases | 1985 |
Effects of L-dopa and L-tyrosine on release of free and conjugated dopamine, homovanillic acid and dihydroxyphenylacetic acid from slices of rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Calcium; Corpus Striatum; Dopamine; Homovanillic Acid; In Vitro Techniques; Levodopa; Male; Phenethylamines; Phenylacetates; Potassium; Rats; Tyrosine | 1985 |
Serotonergic neurones are not involved in action of L-dopa in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Stem; Disease Models, Animal; Dopa Decarboxylase; Dopamine; Homovanillic Acid; Levodopa; Parkinson Disease; Raphe Nuclei; Rats; Serotonin; Tyrosine 3-Monooxygenase | 1980 |
Chronic L-DOPA-pretreatment of rats: an electrophysiological and biochemical study in the basal ganglia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Basal Ganglia; Benserazide; Corpus Striatum; Dextroamphetamine; Dopamine; Evoked Potentials; Homovanillic Acid; Levodopa; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Synaptic Transmission; Tyrosine 3-Monooxygenase | 1982 |
Transneuronal regulation of tyrosine hydroxylase expression in olfactory bulb of mouse and rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Afferent Pathways; Animals; Benserazide; Dihydroxyphenylalanine; Dopamine; Female; Levodopa; Mice; Mice, Inbred Strains; Neurons; Norepinephrine; Olfactory Bulb; Rats; Rats, Inbred Strains; Reserpine; Species Specificity; Tyrosine 3-Monooxygenase | 1983 |
Effects of d-coclaurine and d-reticuline, benzyltetrahydroisoquinoline alkaloids, on levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid in the mouse striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; 4-Butyrolactone; Alkaloids; Animals; Antipsychotic Agents; Benzylisoquinolines; Corpus Striatum; Homovanillic Acid; Injections, Intraventricular; Isoquinolines; Levodopa; Male; Mice; Phenylacetates | 1983 |
The effect of acute ethanol on dopamine metabolism and other neurotransmitters in the hypothalamus and the corpus striatum of mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Ethanol; gamma-Aminobutyric Acid; Homovanillic Acid; Hypothalamus; Levodopa; Male; Mice; Mice, Inbred ICR; Neurotransmitter Agents; Norepinephrine | 1984 |
Effects of drug-induced changes in brain monoamines on aggression and motor behavior in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Aggression; Amphetamine; Animals; Biogenic Amines; Brain Chemistry; Diet; Dose-Response Relationship, Drug; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Mice; Motor Activity; Tyrosine | 1984 |
Aromatic L-amino acid decarboxylase activity in the rat median eminence, neurointermediate lobe and anterior lobe of the pituitary. Physiological and pharmacological implications for pituitary regulation.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Aromatic-L-Amino-Acid Decarboxylases; Brain; Dopamine; Hydroxyindoleacetic Acid; In Vitro Techniques; Levodopa; Male; Median Eminence; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Rats; Serotonin | 1984 |
Combined administration of direct dopamine receptor agonists and L-dopa does not interfere with utilization of exogenous L-dopa in rat corpus striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Bromocriptine; Corpus Striatum; Dopamine; Levodopa; Male; Muridae; Receptors, Dopamine; Synaptic Transmission | 1983 |
Changes in dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in human cerebrospinal fluid after L-dopa and deprenyl administration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Benserazide; Dopamine; Humans; Levodopa; Monoamine Oxidase; Phenethylamines; Phenylacetates; Selegiline | 1983 |
Dopamine receptors: effects of chronic L-dopa and bromocriptine treatment in an animal model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Bromocriptine; Corpus Striatum; Disease Models, Animal; Dopamine; Humans; Hydroxydopamines; Kinetics; Levodopa; Male; Membranes; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1984 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the common marmoset.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Callitrichinae; Caudate Nucleus; Dopamine; Female; Homovanillic Acid; Levodopa; Parkinson Disease, Secondary; Putamen; Pyridines | 1984 |
Evidence for altered catecholamine metabolism in polycystic ovary syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Adult; Carbidopa; Catecholamines; Drug Therapy, Combination; Female; Follicle Stimulating Hormone; Homovanillic Acid; Humans; Levodopa; Luteinizing Hormone; Methoxyhydroxyphenylglycol; Pituitary Hormone-Releasing Hormones; Polycystic Ovary Syndrome | 1984 |
Activation of dopamine synthesis in mesolimbic dopamine neurons by immobilization stress in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Haloperidol; Humans; Levodopa; Limbic System; Male; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Psychological | 1984 |
Behavioural and biochemical alterations in the function of dopamine receptors following repeated administration of L-DOPA to rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Animals; Apomorphine; Behavior, Animal; Body Weight; Brain Chemistry; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Humans; Levodopa; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior | 1984 |
Does acute L-DOPA increase active release of dopamine from dopaminergic neurons?
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Male; Nerve Endings; Rats; Rats, Inbred Strains | 1983 |
Increased dopamine metabolism in the rat neostriatum after toxic doses of d-methylamphetamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Dopamine; Hydrazines; Kinetics; Levodopa; Male; Methamphetamine; Putamen; Rats; Rats, Inbred Strains | 1983 |
L-Dopa methyl ester--a candidate for chronic systemic delivery of L-Dopa in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Levodopa; Limbic System; Male; Mice; Parkinson Disease; Reserpine | 1984 |
Metabolism of (-) deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: a biochemical assessment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Amphetamines; Biogenic Amines; Carbidopa; Depression; Drug Combinations; Female; Humans; Levodopa; Male; Methamphetamine; Middle Aged; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Selegiline; Tyramine | 1982 |
Rapid liquid-chromatographic measurement of 3-methoxy-4-hydroxyphenylglycol and other monoamine metabolites in human cerebrospinal fluid.
Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; Aged; Carbidopa; Chromatography, High Pressure Liquid; Glycols; Homovanillic Acid; Humans; Levodopa; Male; Methoxyhydroxyphenylglycol; Vanilmandelic Acid | 1980 |
Simultaneous determination of carbidopa, levodopa and 3,4-dihydroxyphenyl-acetic acid using high-performance liquid chromatography with electrochemical detection.
Topics: 3,4-Dihydroxyphenylacetic Acid; Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Humans; Levodopa; Phenylacetates | 1982 |
3-O-methyldopa blocks dopa metabolism in rat corpus striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Levodopa; Male; Methyltyrosines; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1982 |
Interference of levodopa and its metabolites with colorimetry of uric acid.
Topics: 3,4-Dihydroxyphenylacetic Acid; Colorimetry; Dopamine; Homovanillic Acid; Humans; Levodopa; Parkinson Disease; Uric Acid | 1981 |
Quantitative microdialysis for studying the in vivo L-DOPA kinetics in blood and skeletal muscle of the dog.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Proteins; Calibration; Dialysis; Dogs; Dopamine; Injections, Intramuscular; Injections, Intravenous; Levodopa; Male; Methyldopa; Microchemistry; Muscle, Skeletal; Protein Binding; Reference Standards; Reproducibility of Results; Tyrosine | 1995 |
CSF and plasma concentrations of free norepinephrine, dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), 3,4-dihydroxyphenylalanine (DOPA), and epinephrine in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Humans; Levodopa; Lumbosacral Region; Male; Middle Aged; Norepinephrine; Parkinson Disease; Severity of Illness Index | 1995 |
A microdialysis study on striatal dopamine, 5-HT and metabolites in conscious rats after various treatments: evidence for extravesicular release of dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxydopamines; Hydroxyindoleacetic Acid; Kainic Acid; Levodopa; Male; Microdialysis; Neurons; Putamen; Rats; Rats, Sprague-Dawley; Reserpine; Serotonin; Tyramine | 1993 |
Age-related changes on monoamine turnover in hippocampus of rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Dopamine; Hippocampus; Hydroxyindoleacetic Acid; Immunohistochemistry; Levodopa; Male; Monoamine Oxidase; Norepinephrine; Rats; Rats, Wistar; Serotonin | 1993 |
Effect of ageing on monoamine turnover in the prefrontal cortex of rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Biogenic Monoamines; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Pargyline; Prefrontal Cortex; Probenecid; Rats; Rats, Wistar; Serotonin; Tyrosine 3-Monooxygenase | 1993 |
Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amidines; Animals; Biogenic Monoamines; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Neostriatum; Nitriles; Pyridones; Rats; Rats, Wistar; Stereotaxic Techniques; Tryptophan; Tyrosine | 1994 |
Dopamine and serotonin turnover rate in the retina of rabbit, rat, goldfish, and Eugerres plumieri: light effects in goldfish and rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; alpha-Methyltyrosine; Animals; Carbidopa; Dopamine; Fenclonine; Goldfish; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Light; Male; Methyltyrosines; Pargyline; Perciformes; Rabbits; Rats; Rats, Sprague-Dawley; Retina; Serotonin; Species Specificity | 1994 |
Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Dopamine; Homovanillic Acid; Humans; Levodopa; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 1995 |
Markers of dopamine depletion and compensatory response in striatum and cerebrospinal fluid.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Male; Parkinson Disease; Rabbits; Reserpine | 1995 |
Influence of selective inhibition of monoamine oxidase A or B on striatal metabolism of L-DOPA in hemiparkinsonian rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dialysis; Dopamine; Homovanillic Acid; Indans; Levodopa; Male; Monoamine Oxidase Inhibitors; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline; Substantia Nigra | 1995 |
Determination of amino acids and monoamine neurotransmitters in caudate nucleus of seizure-resistant and seizure-prone BALB/c mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Animals; Biogenic Monoamines; Caudate Nucleus; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Homovanillic Acid; Hydrazines; Hydroxyindoleacetic Acid; Levodopa; Mice; Mice, Inbred BALB C; Seizures; Serotonin; Tyrosine 3-Monooxygenase | 1993 |
Functional studies on monoaminergic transmitter release in parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Apomorphine; Biogenic Monoamines; Dopamine; Dopamine Agents; Dopamine Antagonists; Hydroxyindoleacetic Acid; Levodopa; Male; Monoamine Oxidase Inhibitors; Parkinson Disease, Secondary; Rats; Rats, Wistar; Stereotyped Behavior; Tryptophan | 1993 |
Effect of repeated electroconvulsive shock on striatal L-dopa and dopamine metabolism: an in vivo study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Corpus Striatum; Dopamine; Electroshock; Extracellular Space; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Oxidopamine; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1993 |
Simultaneous determination of in vivo hydroxylation of tyrosine and tryptophan in rat striatum by microdialysis-HPLC: relationship between dopamine and serotonin biosynthesis.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Homovanillic Acid; Hydrazines; Hydroxyindoleacetic Acid; Hydroxylation; Kinetics; Levodopa; Male; Microdialysis; Rats; Rats, Wistar; Serotonin; Tryptophan; Tryptophan Hydroxylase; Tyrosine; Tyrosine 3-Monooxygenase | 1993 |
Effect of chronic L-dopa administration on serum luteinizing hormone levels in male rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Weight; Hypothalamus; Levodopa; Luteinizing Hormone; Male; Organ Size; Prolactin; Rats; Rats, Wistar | 1995 |
Pharmacokinetic and pharmacodynamic studies of L-dopa in rats. II. Effect of L-dopa on dopamine and dopamine metabolite concentration in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Homovanillic Acid; Levodopa; Male; Models, Biological; Neostriatum; Rats; Rats, Wistar | 1994 |
Effects of tolcapone, a novel catechol-O-methyltransferase inhibitor, on striatal metabolism of L-dopa and dopamine in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Benzophenones; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Homovanillic Acid; Levodopa; Male; Methylation; Microdialysis; Neostriatum; Nitrophenols; Rats; Tolcapone | 1995 |
Covalent crosslinking of neurofilament proteins by oxidized catechols as a potential mechanism of Lewy body formation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Stem; Catechols; Cross-Linking Reagents; Dopamine; Levodopa; Lewy Bodies; Lysine; Neurofilament Proteins; Oxidation-Reduction; Swine | 1995 |
Levodopa administration to normal rats: influence on striatal oxidized glutathione concentration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Carbidopa; Corpus Striatum; Dose-Response Relationship, Drug; Glutathione; Glutathione Disulfide; Kinetics; Levodopa; Male; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Cell Compartmentation; Corpus Striatum; Dopamine; Drug Interactions; Levodopa; Male; Rats; Rats, Sprague-Dawley; Research Design; Reserpine; Secretory Rate | 1994 |
Effect of type A and B monoamine oxidase selective inhibition by Ro 41-1049 and Ro 19-6327 on dopamine outflow in rat kidney slices.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Dopamine; In Vitro Techniques; Isoenzymes; Kidney Cortex; Levodopa; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Picolinic Acids; Rats; Rats, Wistar; Thiazoles | 1994 |
Effect of a selective MAO-A inhibitor (Ro 41-1049) on striatal L-dopa and dopamine metabolism: an in vivo study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catechols; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Thiazoles | 1994 |
Normalization of tyrosine hydroxylase activity in vivo in the striatum of transgenic mice carrying human tyrosine hydroxylase gene: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Chromatography, High Pressure Liquid; Corpus Striatum; Humans; Hydrazines; Levodopa; Mice; Mice, Transgenic; Microdialysis; RNA Probes; Tyrosine 3-Monooxygenase | 1993 |
Modulation of [3H]mazindol binding sites in rat striatum by dopaminergic agents.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Binding Sites; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Male; Mazindol; Methyltyrosines; Neostriatum; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Wistar; Receptors, Presynaptic; Tyrosine 3-Monooxygenase | 1993 |
Estradiol increases tyrosine hydroxylase activity of the A15 nucleus dopaminergic neurons during long days in the ewe.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Dialysis; Dopamine; Estradiol; Female; Homovanillic Acid; Hypothalamus; Levodopa; Luteinizing Hormone; Neurons; Nomifensine; Norepinephrine; Ovariectomy; Oxidopamine; Photoperiod; Sheep; Tyrosine 3-Monooxygenase | 1994 |
In vivo effects of the monoamine oxidase inhibitors Ro 41-1049 and Ro 19-6327 on the production and fate of renal dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Kidney; Levodopa; Male; Monoamine Oxidase Inhibitors; Picolinic Acids; Rats; Rats, Wistar; Thiazoles; Tissue Distribution | 1994 |
Biotransformation of locally applied L-dopa in the corpus striatum of the hemi-parkinsonian rat studied with microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Biotransformation; Corpus Striatum; Denervation; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Homovanillic Acid; Levodopa; Male; Microdialysis; Nomifensine; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Tetrodotoxin | 1994 |
L-dopa increases nigral production of hydroxyl radicals in vivo: potential L-dopa toxicity?
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Dopamine; Homovanillic Acid; Hydroxyl Radical; Levodopa; Microdialysis; Mitochondria; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Selegiline; Stereotaxic Techniques; Substantia Nigra | 1994 |
The renal handling of dopamine originating from L-dopa and gamma-glutamyl-L-dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Electrochemistry; In Vitro Techniques; Kidney; Levodopa; Male; Rats; Rats, Wistar | 1994 |
Differential effects of chronic L-dopa treatment on lipid peroxidation in the mouse brain with or without pretreatment with 6-hydroxydopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Homovanillic Acid; Levodopa; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Nerve Tissue Proteins; Neurons; Oxidopamine; Thiobarbituric Acid Reactive Substances | 1994 |
L-dopa reverses castration-induced disruption of dishabituation responses to female chemical cues in male rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Cues; Discrimination, Psychological; Female; Habituation, Psychophysiologic; Levodopa; Male; Olfactory Bulb; Orchiectomy; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Urine | 1994 |
The effect of carbidopa on the pharmacokinetics and metabolism of intravenously administered levodopa in blood plasma and skeletal muscle.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Dogs; Dopamine; Extracellular Space; Half-Life; Injections, Intravenous; Levodopa; Male; Microdialysis; Muscles; Tyrosine | 1993 |
Chronic administration does not alter the accumulation of L-dopa into muscle.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Carbidopa; Dopamine; Drug Therapy, Combination; Homovanillic Acid; Levodopa; Long-Term Care; Male; Metabolic Clearance Rate; Muscles; Rats; Rats, Wistar | 1994 |
L-3,4-dihydroxyphenylalanine-induced dopamine release in the striatum of intact and 6-hydroxydopamine-treated rats: differential effects of monoamine oxidase A and B inhibitors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dopamine; Levodopa; Male; Monoamine Oxidase Inhibitors; Nerve Endings; Oxidopamine; Picolinic Acids; Rats; Rats, Sprague-Dawley; Selegiline | 1994 |
A comparative study on the synthesis of dopamine in the human, dog and rat kidney.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Decarboxylation; Dogs; Dopamine; Humans; In Vitro Techniques; Kidney; Kidney Cortex; Kinetics; Levodopa; Male; Middle Aged; Rats; Rats, Wistar | 1993 |
Impact of L-dopa on striatal acetylcholine release: effects of 6-hydroxydopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Animals; Corpus Striatum; Dopamine; Extracellular Space; Levodopa; Male; Neurons; Nomifensine; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 1993 |
Dopaminergic functional supersensitivity: effects of chronic L-dopa and carbidopa treatment in an animal model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biopterins; Brain Diseases; Carbidopa; Corpus Striatum; Cyclic AMP; Disease Models, Animal; Dopamine; Dopamine D2 Receptor Antagonists; Homovanillic Acid; Levodopa; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred F344; Receptors, Dopamine D1; Receptors, Dopamine D2; Sensitivity and Specificity; Substantia Nigra; Time Factors | 1993 |
Dopaminergic abnormalities in hypertension associated with moderate renal insufficiency.
Topics: 3,4-Dihydroxyphenylacetic Acid; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Diastole; Dihydroxyphenylalanine; Dopamine; Female; Homovanillic Acid; Humans; Hypertension; Kidney Failure, Chronic; Levodopa; Male; Middle Aged; Reference Values; Sodium | 1994 |
The role of noradrenaline in the differentiation of amphibian embryonic neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphibians; Animals; Blastocyst; Chromatography, High Pressure Liquid; Cleavage Stage, Ovum; Dopamine; Embryo, Nonmammalian; Embryonic Induction; Gastrula; Immunohistochemistry; Levodopa; Nervous System; Neurons; Norepinephrine; Xenopus laevis | 1993 |
Studies on the role of sodium on the synthesis of dopamine in the rat kidney.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amiloride; Amphotericin B; Animals; Biological Transport; Carrier Proteins; Dopamine; Extracellular Space; Kidney; Kidney Tubules; Kinetics; Levodopa; Male; Monoamine Oxidase Inhibitors; Ouabain; Rats; Rats, Wistar; Sodium; Sodium-Hydrogen Exchangers | 1993 |
Simultaneous monitoring of levodopa, dopamine and their metabolites in skeletal muscle and subcutaneous tissue in different pharmacological conditions using microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Chromatography, High Pressure Liquid; Dialysis; Dogs; Dopamine; Electrochemistry; Extracellular Space; Injections, Intravenous; Levodopa; Male; Methyldopa; Muscles; Skin | 1993 |
Assessment of the dopaminergic lesion in Parkinson's disease by CSF markers.
Topics: 3,4-Dihydroxyphenylacetic Acid; Brain; Dopamine; Homovanillic Acid; Humans; Levodopa; Neurons; Parkinson Disease | 1993 |
Plasma levels of levodopa and its main metabolites in parkinsonian patients after conventional and controlled-release levodopa-carbidopa associations.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Blood-Brain Barrier; Carbidopa; Delayed-Action Preparations; Dopamine; Dose-Response Relationship, Drug; Drug Combinations; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Tyrosine | 1993 |
Measuring L-dopa in plasma and urine to monitor therapy of elderly patients with Parkinson disease treated with L-dopa and a dopa decarboxylase inhibitor.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Aromatic Amino Acid Decarboxylase Inhibitors; Chromatography, High Pressure Liquid; Dopamine; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease | 1993 |
The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Electrocardiography; Half-Life; Homovanillic Acid; Humans; Levodopa; Male; Nitriles; Reference Values; Tyrosine | 1993 |
Involvement of tubular sodium in the formation of dopamine in the human renal cortex.
Topics: 3,4-Dihydroxyphenylacetic Acid; Biological Transport; Decarboxylation; Dopamine; Extracellular Space; Humans; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Levodopa; Male; Middle Aged; Osmolar Concentration; Sodium | 1993 |
A clinical and pharmacokinetic case study of an interaction of levodopa and antituberculous therapy in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Antitubercular Agents; Dopa Decarboxylase; Homovanillic Acid; Humans; Isoniazid; Levodopa; Male; Middle Aged; Parkinson Disease; Rifampin; Tuberculosis, Pulmonary | 1995 |
Assessment of renal dopaminergic system activity during cyclosporine A administration in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Blood Pressure; Catechol O-Methyltransferase; Creatinine; Cyclosporine; Dopamine; Homovanillic Acid; In Vitro Techniques; Injections, Subcutaneous; Kidney Cortex; Kidney Tubules; Levodopa; Male; Monoamine Oxidase; Potassium; Rats; Rats, Wistar; Sodium; Urea | 1995 |
Effects of 3-O-methyl on L-dopa-facilitated synthesis and efflux of dopamine from rat striatal slices.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Cerebrospinal Fluid; Corpus Striatum; Dopamine; Drug Interactions; Levodopa; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Tyrosine | 1995 |
Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Estradiol; Female; Levodopa; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; MPTP Poisoning; Osmolar Concentration; Ovariectomy | 1996 |
Levodopa and deprenyl treatment effects on peripheral indices of oxidant stress in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Aged, 80 and over; Cysteinyldopa; Humans; Levodopa; Malondialdehyde; Methoxyhydroxyphenylglycol; Middle Aged; Oxidative Stress; Parkinson Disease; Selegiline | 1996 |
Does treatment with dopamine agonists affect utilization of exogenous levodopa in the parkinsonian striatum?
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Corpus Striatum; Dopamine Agonists; Drug Therapy, Combination; Levodopa; Male; Parkinson Disease; Rats | 1995 |
Slow increase of homovanillic acid in cerebrospinal fluid after levodopa administration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Carbidopa; Drug Administration Schedule; Drug Combinations; Female; Homovanillic Acid; Humans; Hydrocephalus; Levodopa; Male; Middle Aged | 1996 |
Rapid stimulation of striatal dopamine synthesis by estradiol.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Corpus Striatum; Dopamine; Enzyme Inhibitors; Estradiol; Female; Hydrazines; Levodopa; Ovariectomy; Rats | 1996 |
Biochemical lesions of the nigrostriatal system by TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline) and derivatives.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbolines; Corpus Striatum; Dopamine; Electrochemistry; Levodopa; Male; Neurotoxins; Rats; Rats, Wistar; Sensitivity and Specificity; Substantia Nigra | 1995 |
In vivo microdialysis to determine the relative pharmacokinetics of drugs.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Benserazide; Brain Chemistry; Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Drug Interactions; Electrochemistry; Homovanillic Acid; Levodopa; Male; Methoxyhydroxyphenylglycol; Microdialysis; Neostriatum; Rats; Rats, Wistar | 1996 |
Effect of subcutaneous administration of levodopa ethyl ester, a soluble prodrug of levodopa, on dopamine metabolism in rodent striatum: implication for treatment of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Behavior, Animal; Dopamine; Injections, Subcutaneous; Levodopa; Male; Mice; Mice, Inbred C57BL; Neostriatum; Oxidopamine; Prodrugs; Rats; Stereotyped Behavior; Sympatholytics | 1996 |
Circadian phase dependent pharmacokinetics of L-dopa, its main metabolites (3-OMD, HVA, DOPAC) and carbidopa in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Area Under Curve; Carbidopa; Circadian Rhythm; Half-Life; Homovanillic Acid; Levodopa; Male; Methyldopa; Rats; Rats, Wistar | 1996 |
Tyrosine and tryptophan derivatives in pig lumbar cerebrospinal fluid. Effects of subchronic administration of dopa associated with benserazide.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Benserazide; Drug Interactions; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Kynurenine; Levodopa; Male; Methoxyhydroxyphenylglycol; Normetanephrine; Swine; Tryptamines; Tryptophan; Tyrosine | 1996 |
An in vivo comparison of the capacity of striatal versus extrastriatal brain regions to form dopamine from exogenously administered L-dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biotransformation; Brain Chemistry; Cerebellum; Dopamine; Dopamine Agents; Extracellular Space; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Neostriatum; Occipital Lobe; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Corpus Striatum; Dopamine; Levodopa; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sympathectomy, Chemical | 1996 |
Protective effect of carbidopa on hydroxyl radical generation in the rat striatum by dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dopamine; Dopamine Agents; Free Radicals; Hydroxides; Levodopa; Male; Microdialysis; Neostriatum; Neuroprotective Agents; Rats; Rats, Wistar; Sodium Salicylate | 1996 |
Peripheral and central inhibitors of catechol-O-methyl transferase: effects on liver and brain COMT activity and L-DOPA metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine; Homovanillic Acid; Levodopa; Liver; Male; Nitriles; Rats; Rats, Sprague-Dawley | 1997 |
Effects of enhanced striatal dopamine turnover in vivo on glutathione oxidation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Dopamine; Glutathione; Glutathione Disulfide; Levodopa; Male; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1994 |
Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Sequence; Animals; Antipsychotic Agents; Behavior, Animal; Central Nervous System Depressants; Clozapine; Cocaine; Corpus Striatum; Dopamine; Dopamine Agents; Ethanol; Genotype; Humans; Levodopa; Locomotion; Maternal Behavior; Methamphetamine; Mice; Mice, Knockout; Molecular Sequence Data; Motor Activity; Mutagenesis, Site-Directed; Narcotics; Nucleus Accumbens; Receptors, Dopamine D2; Receptors, Dopamine D4; Sensitivity and Specificity; Substantia Nigra; Transcription, Genetic | 1997 |
Role of aromatic L-amino acid decarboxylase for dopamine replacement by genetically modified fibroblasts in a rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Catecholamines; Cell Transplantation; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine; Female; Fibroblasts; Genetic Therapy; GTP Cyclohydrolase; Homovanillic Acid; Levodopa; Microdialysis; Parkinson Disease; Rats; Rats, Inbred F344; Recombinant Proteins; Transfection; Tyrosine 3-Monooxygenase | 1997 |
Assessment of renal dopaminergic system activity during the recovery of renal function in human kidney transplant recipients.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kidney; Kidney Transplantation; Levodopa; Male; Middle Aged; Postoperative Period | 1997 |
[Effect of subchronic administration of tolcapone on release of striatum dopamine and its metabolites induced by L-DOPA and carbidopa].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dopamine; Dopamine Agents; Drug Synergism; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Nitrophenols; Rats; Rats, Wistar; Tolcapone | 1998 |
Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine oxidase B by R(+)-N-propargyl-1-aminoindan (rasagiline) in the monkey.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Corpus Striatum; Dopamine; Homovanillic Acid; Indans; Isoenzymes; Levodopa; Macaca mulatta; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors | 1998 |
L-DOPA exacerbates amphetamine-induced dopamine depletion.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Chromatography, High Pressure Liquid; Corpus Striatum; Dextroamphetamine; Dopamine; Drug Synergism; Frontal Lobe; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Mice; Organ Specificity; Serotonin | 1998 |
Dopamine metabolism in the striatum of hemiparkinsonian model rats with dopaminergic grafts.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Brain Tissue Transplantation; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Fetal Tissue Transplantation; Functional Laterality; Haloperidol; Homovanillic Acid; Kinetics; Levodopa; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Methamphetamine; Microdialysis; Motor Activity; Nerve Tissue Proteins; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Rotation; Tritium; Tyrosine 3-Monooxygenase | 1998 |
In vivo comparison of the effects of inhibition of MAO-A versus MAO-B on striatal L-DOPA and dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline | 1995 |
Identification of catecholamines in the immune system by electrospray ionization mass spectrometry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Catecholamines; Dopamine; Electrophoresis, Capillary; Humans; Immune System; Levodopa; Mass Spectrometry; Neutrophils; Norepinephrine | 1998 |
Reduced urinary excretion of dopamine and metabolites in chronic renal parenchymal disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Biopsy; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Chronic Disease; Creatinine; Dopamine; Female; Follow-Up Studies; Glomerulonephritis; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kidney Tubules; Levodopa; Male; Middle Aged; Monoamine Oxidase; Phosphates; Potassium; Sodium | 1998 |
L-DOPA does not facilitate nitric oxide production in the rat striatum and substantia nigra: in vivo microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Extracellular Space; Levodopa; Male; Microdialysis; Nitric Oxide; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1998 |
Effect of trihexyphenidyl, a non-selective antimuscarinic drug, on decarboxylation of L-dopa in hemi-Parkinson rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Biotransformation; Corpus Striatum; Decarboxylation; Dopamine; Drug Interactions; Homovanillic Acid; Levodopa; Male; Microdialysis; Muscarinic Antagonists; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Substantia Nigra; Trihexyphenidyl | 1998 |
The antiparkinsonian drug budipine stimulates the activity of aromatic L-amino acid decarboxylase and enhances L-DOPA-induced dopamine release in rat substantia nigra.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Antiparkinson Agents; Aromatic-L-Amino-Acid Decarboxylases; Corpus Striatum; Dopamine; Drug Synergism; Kinetics; Levodopa; Male; Microdialysis; Piperidines; Rats; Rats, Wistar; Reserpine; Substantia Nigra; Time Factors | 1998 |
Renal dopaminergic system in nephrotic syndrome and after remission.
Topics: 3,4-Dihydroxyphenylacetic Acid; Child; Dopamine; Drug Therapy, Combination; Edema; Female; Follow-Up Studies; Glucocorticoids; Homovanillic Acid; Humans; Immunosuppressive Agents; Levodopa; Male; Nephrosis, Lipoid; Norepinephrine; Proteinuria; Remission Induction; Sodium | 1998 |
Catecholaminergic mechanisms-mediated hypothermia induced by magnolol in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Biphenyl Compounds; Body Temperature; Catecholamines; Colon; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Homovanillic Acid; Hypothalamus; Hypothermia, Induced; Injections, Intraperitoneal; Injections, Intraventricular; Levodopa; Lignans; Male; Norepinephrine; Oxidopamine; Rats; Rats, Sprague-Dawley | 1998 |
Alteration in L-DOPA evoked dopamine and DOPAC output under conditions of impaired vesicular dopamine storage.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Dopamine Agents; Levodopa; Male; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Reserpine; Synaptic Vesicles; Tetrabenazine | 1998 |
Dopamine turnover in the mediobasal hypothalamus in rat fetuses.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cells, Cultured; Dopamine; Female; Fetus; Hypothalamus, Middle; Levodopa; Male; Neurons; Norepinephrine; Pregnancy; Rats; Rats, Wistar; Sex Characteristics | 1999 |
Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cerebellum; Corpus Striatum; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Lipid Peroxidation; Male; Mesencephalon; Oxidative Stress; Parkinson Disease, Secondary; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Aromatic L-amino acid decarboxylase: conformational change in the flexible region around Arg334 is required during the transaldimination process.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alanine Racemase; Amino Acids; Aminoethylphosphonic Acid; Arginine; Aromatic-L-Amino-Acid Decarboxylases; Benzenesulfonates; Chromatography, High Pressure Liquid; Chymotrypsin; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Kinetics; Levodopa; Plasmids; Protein Binding; Protein Conformation; Spectrophotometry; Time Factors; Trypsin | 1998 |
Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5,7-Dihydroxytryptamine; Animals; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Levodopa; Male; Microdialysis; Neurons; Oxidopamine; Rats; Rats, Wistar; Rotation; Serotonin; Serotonin Agents; Stereotyped Behavior | 1999 |
Pergolide potentiates L-DOPA-induced dopamine release in rat striatum after lesioning with 6-hydroxydopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Disease Models, Animal; Dopamine; Dopamine Agonists; Drug Synergism; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Motor Activity; Neostriatum; Neurons; Oxidopamine; Parkinson Disease, Secondary; Pergolide; Rats; Rats, Wistar | 1999 |
Neurotoxic effects of amphetamine plus L-DOPA.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Brain; Corpus Striatum; Dextroamphetamine; Dopamine; Drug Interactions; Frontal Lobe; Homovanillic Acid; Hypothalamus; Levodopa; Male; Mice; Neurons; Neurotoxins; Organ Specificity; Serotonin; Time Factors | 1999 |
Microdialysis study of the effects of the antiparkinsonian drug budipine on L-DOPA-induced release of dopamine and 5-hydroxytryptamine by rat substantia nigra and corpus striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Levodopa; Male; Microdialysis; Piperidines; Rats; Rats, Wistar; Reserpine; Serotonin; Substantia Nigra; Tyrosine 3-Monooxygenase | 1999 |
High-speed voltammetry: dual measurement of dopamine and serotonin.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Dopamine; Dopamine Agents; Electrochemistry; Hydroxyindoleacetic Acid; Ion-Selective Electrodes; Levodopa; Male; Potentiometry; Rats; Rats, Wistar; Serotonin; Uric Acid | 1999 |
Aging, high salt intake, and renal dopaminergic activity in Fischer 344 rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Analysis of Variance; Animals; Aromatic-L-Amino-Acid Decarboxylases; Catecholamines; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Kidney; Levodopa; Male; Monoamine Oxidase; Rats; Rats, Inbred F344; Sodium Chloride, Dietary; Sodium-Potassium-Exchanging ATPase | 1999 |
Microdialysis studies on the action of tolcapone on pharmacologically-elevated extracellular dopamine levels in conscious rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzophenones; Carbidopa; Catechol O-Methyltransferase; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Enzyme Inhibitors; Extracellular Space; Haloperidol; Homovanillic Acid; Levodopa; Male; Microdialysis; Nitrophenols; Piperazines; Rats; Rats, Wistar; Time Factors; Tolcapone; Visual Cortex | 1999 |
Reserpine pretreatment prevents increases in extracellular striatal dopamine following L-DOPA administration in rats with nigrostriatal denervation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Denervation; Dopamine; Extracellular Space; Homovanillic Acid; Levodopa; Male; Oxidopamine; Rats; Rats, Wistar; Reserpine; Substantia Nigra | 2000 |
Dual effects of L-3,4-dihydroxyphenylalanine on aromatic L-amino acid decarboxylase, dopamine release and motor stimulation in the reserpine-treated rat: evidence that behaviour is dopamine independent.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Dopamine Agents; Levodopa; Male; Motor Activity; Rats; Rats, Wistar; Reserpine | 2000 |
The effects of central aromatic amino acid DOPA decarboxylase inhibition on the motor actions of L-DOPA and dopamine agonists in MPTP-treated primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Callithrix; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hydrazines; Levodopa; Male; Motor Activity; Quinolones; Quinpirole; Thiophenes; Tyrosine | 2000 |
Modulation of dihydroxyphenylacetaldehyde extracellular levels in vivo in the rat striatum after different kinds of pharmacological treatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Uptake Inhibitors; Homovanillic Acid; Levodopa; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley | 2000 |
The effects of melatonin and L-DOPA on the diurnal rhythms of free amino acids content in the rat retina.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Animals; Chromatography, High Pressure Liquid; Circadian Rhythm; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Lighting; Male; Melatonin; Rats; Rats, Wistar; Retina | 2000 |
Evaluation of L-DOPA biotransformation during repeated L-DOPA infusion into the striatum in freely-moving young and old rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Locomotion; Male; Microdialysis; Rats; Rats, Wistar | 2000 |
L-DOPA and high oxygen influence release of catecholamines from the cat carotid body.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carotid Body; Catecholamines; Cats; Chemoreceptor Cells; Dopamine; Female; Homovanillic Acid; In Vitro Techniques; Levodopa; Male; Norepinephrine; Oxygen | 2000 |
Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: potential implications to L-DOPA long-term therapy of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Ascorbic Acid; Chlorides; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis Solutions; Dopamine; Homovanillic Acid; Infusion Pumps; Levodopa; Male; Manganese; Manganese Compounds; Microdialysis; Movement; Oxidation-Reduction; Parkinson Disease; Rats; Rats, Wistar; Time Factors; Uric Acid | 2000 |
L-Dopa uptake and dopamine production in proximal tubular cells are regulated by beta(2)-adrenergic receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Binding Sites; Biological Transport; Bucladesine; Cells, Cultured; Dopamine; Epinephrine; Isoproterenol; Kidney Tubules, Proximal; Kinetics; Levodopa; Male; Norepinephrine; Propanolamines; Protein Binding; Rats; Rats, Wistar; Receptors, Adrenergic, beta-2; Terbutaline | 2000 |
Pathobiochemical implications of hyperdopaminuria in patients with aromatic L-amino acid decarboxylase deficiency.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Homovanillic Acid; Humans; Levodopa | 2000 |
Bromocriptine markedly suppresses levodopa-induced abnormal increase of dopamine turnover in the parkinsonian striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Bromocriptine; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Male; Parkinson Disease; Rats; Rats, Sprague-Dawley | 2000 |
Comparison by microdialysis of striatal L-DOPA after its systemic administration in rats with probes implanted acutely or through a guide cannula.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catheterization; Corpus Striatum; Dopamine; Extracellular Space; Levodopa; Male; Microdialysis; Prostheses and Implants; Rats; Rats, Wistar | 2000 |
Effect of 6-fluoro-m-tyrosine on dopamine release and metabolism in rat striatum using in vivo microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Fluorine Radioisotopes; Homovanillic Acid; Levodopa; Male; Microdialysis; Neostriatum; Neurons; Rats; Rats, Sprague-Dawley; Tyrosine | 2000 |
Concerted action of dopamine on renal and intestinal Na(+)-K(+)-ATPase in the rat remnant kidney.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alkaline Phosphatase; Animals; Aromatic-L-Amino-Acid Decarboxylases; Catechol O-Methyltransferase; Dopamine; Electrolytes; gamma-Glutamyltransferase; Homovanillic Acid; Intestines; Jejunum; Kidney; Levodopa; Male; Monoamine Oxidase; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Sodium, Dietary; Water-Electrolyte Imbalance | 2000 |
The central aromatic amino acid DOPA decarboxylase inhibitor, NSD-1015, does not inhibit L-DOPA-induced circling in unilateral 6-OHDA-lesioned-rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Biogenic Monoamines; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Dopamine Antagonists; Drug Combinations; Enzyme Inhibitors; Haloperidol; Homovanillic Acid; Hydrazines; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Rats; Rats, Wistar; Stereotyped Behavior; Tyrosine | 2001 |
Effect of oxidative stress on stability and structure of neurofilament proteins.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Ascorbic Acid; Chlorides; Circular Dichroism; Dopamine; Electrophoresis, Polyacrylamide Gel; Ferric Compounds; Free Radicals; Levodopa; Molecular Weight; Neurofilament Proteins; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Swine | 2000 |
SCH 23390 enhances exogenous L-DOPA decarboxylation in nigrostriatal neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Benzazepines; Corpus Striatum; Decarboxylation; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Dopamine Antagonists; Levodopa; Male; Mice; Substantia Nigra | 2000 |
Changes in endogenous monoamines in aged rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Biogenic Monoamines; Catechol O-Methyltransferase; Cerebral Cortex; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Monoamine Oxidase; Norepinephrine; Rats; Rats, Wistar; Serotonin | 2001 |
The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Hydroxyl Radical; Levodopa; Male; Microdialysis; Nitriles; Nitrophenols; Oxidative Stress; Parkinsonian Disorders; Rats; Rats, Wistar; Tolcapone | 2001 |
BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetophenones; Animals; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Methylation; Rats; Rats, Wistar; Time Factors; Tyrosine | 2001 |
Heart failure, aging, and renal synthesis of dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Age Factors; Aged; Aging; Aldosterone; Cardiac Output, Low; Case-Control Studies; Creatinine; Diet, Sodium-Restricted; Dopamine; Echocardiography; Female; Homovanillic Acid; Humans; Kidney; Levodopa; Male; Middle Aged; Norepinephrine; Statistics as Topic; Urine | 2001 |
Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Benzazepines; Brain Diseases; Carbidopa; Carrier Proteins; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine D2 Receptor Antagonists; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Malonates; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuropeptides; Oxidopamine; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Reserpine; Succinate Dehydrogenase; Sulpiride; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2001 |
Stereoselective effect of (R)- and (S)-1-methyl-1,2,3,4-tetrahydroisoquinolines on a mouse model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Cell Count; Disease Models, Animal; Dopamine; Dopamine Antagonists; Drug Interactions; Homovanillic Acid; Hydroxyindoleacetic Acid; Hypokinesia; Immunohistochemistry; Isoquinolines; Levodopa; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Neurotoxins; Parkinsonian Disorders; Serotonin; Stereoisomerism; Substantia Nigra; Tetrahydroisoquinolines; Tyrosine 3-Monooxygenase | 2001 |
COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Antiparkinson Agents; Benzophenones; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Disease Progression; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 2002 |
Decreased tubular uptake of L-3,4-dihydroxyphenylalanine in streptozotocin-induced diabetic rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biological Transport; Diabetes Mellitus, Experimental; Dopamine; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Kidney; Kidney Tubules, Proximal; Levodopa; Male; Osmolar Concentration; Rats; Rats, Wistar | 2001 |
Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adaptation, Physiological; Animals; Autoradiography; Behavior, Animal; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Dynorphins; Female; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Motor Activity; Nerve Tissue Proteins; Oxidopamine; Parkinson Disease, Secondary; Receptor, Adenosine A2A; Receptors, Purinergic P1; RNA, Messenger; Substantia Nigra | 2002 |
Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthesia; Animals; Carbidopa; Catechol O-Methyltransferase; Corpus Striatum; Dopamine; Dopamine Agents; Female; Homovanillic Acid; Levodopa; Male; Methoxyhydroxyphenylglycol; Methyldopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Norepinephrine | 2002 |
The renal dopaminergic system, neurohumoral activation, and sodium handling in heart failure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aldosterone; Atrial Natriuretic Factor; Case-Control Studies; Catecholamines; Creatinine; Dopamine; Female; Glomerular Filtration Rate; Heart Failure; Humans; Kidney; Levodopa; Male; Natriuretic Peptide, Brain; Sodium | 2002 |
Behavioral activity and stereotypy in rats induced by L-DOPA metabolites: a possible role in the adverse effects of chronic L-DOPA treatment of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Behavior, Animal; Benzazepines; Dopamine; Injections, Intraventricular; Kinetics; Levodopa; Male; Parkinson Disease; Rats; Rats, Wistar; Stereotyped Behavior | 2002 |
5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caspase 3; Caspases; Catecholamines; Cell Survival; Cells, Cultured; Cysteine; Cysteinyldopa; DNA; Dopamine; Dose-Response Relationship, Drug; Enzyme Activation; Intracellular Fluid; Levodopa; Methamphetamine; Neurons; Purines; Pyrimidines; Rats; Reactive Oxygen Species | 2002 |
Effect of lazaroid pretreatment on dopamine-induced impairment of the rat nigrostriatal system.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carotid Arteries; Constriction; Corpus Striatum; Dopamine; Dopamine Agents; Electrochemistry; Free Radical Scavengers; Hypovolemia; Hypoxia, Brain; Injections; Levodopa; Male; Neuroprotective Agents; Pregnatrienes; Rats; Rats, Wistar; Reference Values; Substantia Nigra | 2002 |
Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Antiparkinson Agents; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Forelimb; Homovanillic Acid; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Tissue Proteins; Neuropeptides; Parkinsonian Disorders; Postural Balance; Recovery of Function; Tyrosine 3-Monooxygenase; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins; Walking | 2002 |
An antihypokinesic action of alpha2-adrenoceptors upon MPTP-induced behaviour deficits in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Clonidine; Dopamine; Dopamine Agonists; Drug Interactions; Drug Therapy, Combination; Guanfacine; Homovanillic Acid; Levodopa; Male; Mice; Mice, Inbred C57BL; Neostriatum; Neurons; Parkinsonian Disorders; Prazosin; Receptors, Adrenergic, alpha-2; Synaptic Transmission; Yohimbine | 2003 |
[The effect of shourong compound formula on levels of dopamine and its metabolites in brain of Parkinson's disease mice induced by reserpine].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Brain; Dopamine; Drug Combinations; Drug Synergism; Drugs, Chinese Herbal; Homovanillic Acid; Levodopa; Male; Mice; Parkinson Disease, Secondary; Plant Extracts; Plants, Medicinal; Reserpine | 2002 |
An investigation of dopaminergic metabolites in the striatum and in the substantia nigra in vivo utilising radiolabelled L-DOPA and high performance liquid chromatography: a new approach in the search for transmitter metabolites.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Agents; Enzyme Inhibitors; Homovanillic Acid; Isothiocyanates; Levodopa; Male; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Tritium | 2003 |
Increased striatal neuropeptide Y immunoreactivity and its modulation by deprenyl, clonidine and L-dopa in MPTP-treated mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Chromatography, High Pressure Liquid; Clonidine; Corpus Striatum; Dopamine; Homovanillic Acid; Immunohistochemistry; Levodopa; Male; Mice; MPTP Poisoning; Neuropeptide Y; Neuroprotective Agents; Selegiline; Serotonin | 2003 |
Semi-chronic increase in striatal level of 3,4-dihydroxyphenylacetaldehyde does not result in alteration of nigrostriatal dopaminergic neurones.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aldehyde Dehydrogenase; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Disulfiram; Dopamine; Dopamine Agents; Enzyme Inhibitors; Levodopa; Male; Neurons; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Effect of the adenosine A2A receptor antagonist 8-(3-chlorostyryl)caffeine on L-DOPA biotransformation in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Benserazide; Brain Chemistry; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Male; Microdialysis; Rats; Rats, Wistar; Reserpine | 2004 |
Analysis of catecholamines and related substances using porous graphitic carbon as separation media in liquid chromatography-tandem mass spectrometry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Chromatography, Liquid; Dopamine; Epinephrine; Graphite; Hydrogen-Ion Concentration; Levodopa; Norepinephrine; Spectrometry, Mass, Electrospray Ionization; Substantia Nigra; Swine; Tyrosine; Vanilmandelic Acid | 2004 |
Behavioral and neurochemical effects of noradrenergic depletions with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in 6-hydroxydopamine-induced rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Basal Ganglia; Behavior, Animal; Benzylamines; Brain Chemistry; Catalepsy; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Locus Coeruleus; Male; Motor Activity; Norepinephrine; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Serotonin; Statistics, Nonparametric; Tyrosine | 2004 |
Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Brain; Brocresine; Chromatography, High Pressure Liquid; Deferoxamine; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Exploratory Behavior; Functional Laterality; Homovanillic Acid; Iron; Iron Chelating Agents; Levodopa; Male; Motor Activity; Neurodegenerative Diseases; Neurotransmitter Agents; Oxidopamine; Parkinson Disease; Piperazines; Quinolines; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Carbidopa; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Isoxazoles; Levodopa; Microdialysis; Oxidopamine; Parkinson Disease; Rats; Zonisamide | 2004 |
SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Interactions; Levodopa; Maze Learning; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Nervous System Diseases; Nitrophenols; Oxazoles; Oxidopamine; Prefrontal Cortex; Quinolines; Rats; Rats, Sprague-Dawley; Serotonin; Stereotyped Behavior; Tolcapone; Tremor; Tyramine | 2004 |
Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Area Under Curve; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Denervation; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Malonates; Methyltyrosines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reserpine; Serotonin; Substantia Nigra; Time Factors; Triazines; Triazoles; Xanthines | 2004 |
[Assessment of the in vitro and in vivo toxicity of 3,4-dihydroxyphenylacetaldehyde (DOPAL)].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Levodopa; Male; Neostriatum; Rats; Rats, Sprague-Dawley | 2004 |
Nicotine-induced changes in neurotransmitter levels in brain areas associated with cognitive function.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cognition; Dopamine; Hydroxyindoleacetic Acid; Levodopa; Male; Neurotransmitter Agents; Nicotine; Norepinephrine; Organ Specificity; Rats; Rats, Sprague-Dawley; Serotonin | 2004 |
AMPA receptor blockade potentiates the stimulatory effect of L-DOPA on dopamine release in dopamine-deficient corticostriatal slice preparation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzodiazepines; Cerebral Cortex; Dopamine; Dopamine Agents; Electric Stimulation; Homovanillic Acid; In Vitro Techniques; Levodopa; Neostriatum; Oxidopamine; Rats; Receptors, AMPA; Sympatholytics | 2004 |
Dopamine agonist cabergoline inhibits levodopa-induced caspase activation in 6-OHDA-lesioned mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Cabergoline; Carbidopa; Caspases; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Agonists; Drug Combinations; Drug Interactions; Enzyme Activation; Ergolines; Glutathione; Homovanillic Acid; Levodopa; Male; Mice; Mice, Inbred ICR; Neurotoxicity Syndromes; Oxidopamine; Thiobarbituric Acid Reactive Substances | 2005 |
Increased dopamine content in lymphocytes from high-dose L-Dopa-treated Parkinson's disease patients.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Antiparkinson Agents; Dopamine; Dose-Response Relationship, Drug; Electrophoresis, Capillary; Female; Humans; Levodopa; Lymphocytes; Male; Middle Aged; Neuroimmunomodulation; Parkinson Disease; Up-Regulation | 2005 |
Pramipexole has ameliorating effects on levodopa-induced abnormal dopamine turnover in parkinsonian striatum and quenching effects on dopamine-semiquinone generated in vitro.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antiparkinson Agents; Benzoquinones; Benzothiazoles; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electron Spin Resonance Spectroscopy; Functional Laterality; Homovanillic Acid; Levodopa; Male; Mice; Mice, Inbred ICR; Oxidopamine; Parkinson Disease; Pramipexole; Thiazoles; Time Factors | 2005 |
Microchip capillary electrophoresis with a cellulose-DNA-modified screen-printed electrode for the analysis of neurotransmitters.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Ascorbic Acid; Buffers; Cattle; Cellulose; DNA, Single-Stranded; Dopamine; Electrophoresis, Microchip; Levodopa; Microelectrodes; Neurotransmitter Agents; Norepinephrine | 2005 |
Differential effects of l-DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal-enriched cultures from parkin knockout and wild-type mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antimetabolites; Antiparkinson Agents; Apoptosis; Biogenic Monoamines; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Dopamine; Embryo, Mammalian; Glutathione; Levodopa; MAP Kinase Signaling System; Mesencephalon; Mice; Mice, Knockout; Neurons; Phosphatidylinositol 3-Kinases; Signal Transduction; Ubiquitin-Protein Ligases | 2005 |
Dopamine D1 and D2 receptor contributions to L-DOPA-induced dyskinesia in the dopamine-depleted rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Dyskinesia, Drug-Induced; Hydroxyindoleacetic Acid; Levodopa; Male; Norepinephrine; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Serotonin | 2005 |
Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Dopamine; Fungicides, Industrial; Herbicides; Immunohistochemistry; Levodopa; Male; Maneb; Mice; Mice, Inbred C57BL; Motor Activity; Neostriatum; Nerve Degeneration; Neuroprotective Agents; Paraquat; Parkinson Disease, Secondary; Phytotherapy; Plant Roots; Polygonum; Substantia Nigra; Tyrosine 3-Monooxygenase | 2005 |
Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Agents; Dyskinesias; Extracellular Fluid; Homovanillic Acid; Levodopa; Male; Membrane Potentials; Microdialysis; Neurons; Oxidopamine; Rats; Rats, Wistar; Substantia Nigra | 2006 |
Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of levodopa, 3-O-methyldopa, dopamine, carbidopa and 3,4-dihydroxyphenyl acetic acid.
Topics: 3,4-Dihydroxyphenylacetic Acid; Calibration; Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Levodopa; Tyrosine | 2006 |
Reuptake of L-DOPA-derived extracellular dopamine in the striatum with dopaminergic denervation via serotonin transporters.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Fluid; Fluoxetine; Homovanillic Acid; Levodopa; Male; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins | 2006 |
Tyrosine hydroxylase as a target for deltamethrin in the nigrostriatal dopaminergic pathway.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Gene Expression Regulation, Enzymologic; Hominidae; Insecticides; Levodopa; Male; Nitriles; Pyrethrins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase | 2006 |
Effects of subchronic treatment with selegiline on L-DOPA-induced increase in extracellular dopamine level in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Space; Homovanillic Acid; Injections, Intraperitoneal; Levodopa; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Selegiline; Time Factors | 2006 |
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Synuclein; Amino Acid Substitution; Animals; Catechols; Cell Differentiation; Cell Line, Tumor; Cerebral Cortex; Corpus Striatum; Cytosol; Dopamine; Humans; Levodopa; Mice; Mice, Transgenic; Mutation, Missense; Nerve Degeneration; Neuroblastoma; Oxidation-Reduction; Parkinson Disease; Parkinsonian Disorders; Protein Conformation; Recombinant Fusion Proteins; Solubility; Transfection; Tretinoin; Tyrosine 3-Monooxygenase | 2006 |
Evaluation of an osmotic pump for microdialysis sampling in an awake and untethered rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Brain Chemistry; Dopamine; Extracellular Fluid; Homovanillic Acid; Hydroxyindoleacetic Acid; Infusion Pumps; Levodopa; Male; Microdialysis; Neurochemistry; Neurotransmitter Agents; Osmotic Pressure; Rats; Rats, Sprague-Dawley; Serotonin; Up-Regulation; Wakefulness | 2007 |
Different levodopa actions on the extracellular dopamine pools in the rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Electrochemistry; Extracellular Fluid; Levodopa; Male; Medial Forebrain Bundle; Microdialysis; Rats; Rats, Sprague-Dawley; Reaction Time; Substantia Nigra | 2007 |
Effects of 2,3-benzodiazepine AMPA receptor antagonists on dopamine turnover in the striatum of rats with experimental parkinsonism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Benzodiazepines; Corpus Striatum; Dopamine; Dopamine Agents; Drug Interactions; Functional Laterality; Homovanillic Acid; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 2007 |
Long-term survival of encapsulated GDNF secreting cells implanted within the striatum of parkinsonized rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Cell Line; Cell Survival; Corpus Striatum; Dopamine; Drug Compounding; Drug Delivery Systems; Fibroblasts; Glial Cell Line-Derived Neurotrophic Factor; Homovanillic Acid; Levodopa; Male; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley | 2007 |
Modulation of the motor response to dopaminergic drugs in a parkinsonian model of combined dopaminergic and noradrenergic degeneration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Benzylamines; Brain; Caffeine; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Male; Motor Activity; Neurotoxins; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley | 2007 |
Intrastriatal inhibition of aromatic amino acid decarboxylase prevents l-DOPA-induced dyskinesia: a bilateral reverse in vivo microdialysis study in 6-hydroxydopamine lesioned rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Behavior, Animal; Benserazide; Brain Injuries; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Drug Interactions; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Microdialysis; Oxidopamine; Rats; Rats, Wistar | 2008 |
In vivo neurochemical effects of the NR2B selective NMDA receptor antagonist CR 3394 in 6-hydroxydopamine lesioned rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adamantane; Amidines; Animals; Antiparkinson Agents; Basal Ganglia; Denervation; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Levodopa; Male; Medial Forebrain Bundle; Microdialysis; Oxidopamine; Parkinsonian Disorders; Perfusion; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2008 |
Effects of coincident 5-HT1A receptor stimulation and NMDA receptor antagonism on L-DOPA-induced dyskinesia and rotational behaviors in the hemi-parkinsonian rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Levodopa; Male; Medial Forebrain Bundle; Motor Activity; Motor Skills; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Receptor Agonists; Stereotyped Behavior | 2008 |
Altered behavioural and neurochemical profile of L-DOPA following deuterium substitutions in the molecule.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain Chemistry; Carbidopa; Deuterium; Dopamine; Dopamine Agents; Levodopa; Male; Microdialysis; Motor Activity; Rats; Rats, Wistar; Time Factors | 2008 |
The role of the dorsal raphe nucleus in the development, expression, and treatment of L-dopa-induced dyskinesia in hemiparkinsonian rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Hydroxyindoleacetic Acid; Levodopa; Male; Medial Forebrain Bundle; Motor Activity; Neurons; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Agents | 2009 |
Effect of adenosine A(2A) receptor antagonists on L-DOPA-induced hydroxyl radical formation in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Area Under Curve; Benserazide; Catalepsy; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Rats; Rats, Wistar; Time Factors; Triazines; Triazoles; Xanthines | 2009 |
L-DOPA attenuates hyperactivity of Roborovskii hamsters.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain; Cricetinae; Dopamine; Dopamine Agents; Hyperkinesis; Levodopa; Male; Motor Activity; Neurotransmitter Agents; Norepinephrine; Serotonin | 2009 |
Multiple roles of the active site lysine of Dopa decarboxylase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alanine; Amino Acid Substitution; Ammonia; Animals; Binding Sites; Catalysis; Deamination; Decarboxylation; Dopa Decarboxylase; Dopamine; Hydrogen Bonding; Hydrolysis; Kidney; Kinetics; Levodopa; Lysine; Models, Chemical; Molecular Structure; Oxidation-Reduction; Protein Binding; Protein Conformation; Pyridoxal Phosphate; Structure-Activity Relationship; Swine | 2009 |
Acute L: -DOPA effect on hydroxyl radical- and DOPAC-levels in striatal microdialysates of parkinsonian rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Female; Hydroxyindoleacetic Acid; Hydroxyl Radical; Injections, Intraventricular; Levodopa; Male; Microdialysis; Oxidopamine; Parkinsonian Disorders; Pregnancy; Rats; Sympatholytics; Time Factors | 2010 |
Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cell Line; Corpus Striatum; Dopamine; Female; Gene Expression; Gene Expression Profiling; Humans; In Vitro Techniques; Leupeptins; Levodopa; Models, Neurological; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Presynaptic Terminals; rab3 GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Synaptic Vesicles; Ventral Tegmental Area | 2009 |
Restricting dopaminergic signaling to either dorsolateral or medial striatum facilitates cognition.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Body Weight; Cognition; Conditioning, Operant; Corpus Striatum; Discrimination Learning; Dopamine; Dopamine Agents; Exploratory Behavior; Feeding Behavior; Female; Gene Expression Regulation; Gene Transfer Techniques; Homovanillic Acid; Levodopa; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neuropsychological Tests; Recognition, Psychology; Signal Transduction; Tyrosine 3-Monooxygenase | 2010 |
Direct angiotensin II type 2 receptor stimulation decreases dopamine synthesis in the rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benzimidazoles; Biphenyl Compounds; Catheterization; Central Nervous System Agents; Corpus Striatum; Dopa Decarboxylase; Dopamine; Extracellular Space; Hydrazines; Imidazoles; Levodopa; Male; Microdialysis; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles; Tyrosine 3-Monooxygenase | 2010 |
Microdialysis with radiometric monitoring of L-[β-11C]DOPA to assess dopaminergic metabolism: effect of inhibitors of L-amino acid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase on rat striatal dialysate.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Biotransformation; Catechol O-Methyltransferase Inhibitors; Catechols; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Enzyme Inhibitors; Extracellular Fluid; Homovanillic Acid; Levodopa; Male; Microdialysis; Monoamine Oxidase Inhibitors; Neostriatum; Pargyline; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet | 2011 |
Distinct effects of intranigral L-DOPA infusion in the MPTP rat model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antiparkinson Agents; Cell Count; Disease Models, Animal; Dopamine; Drug Interactions; Gene Expression Regulation; Homovanillic Acid; Levodopa; Male; Movement; Neurons; Neurotoxins; Parkinsonian Disorders; Rats; Rats, Wistar; Reaction Time; Substantia Nigra; Tyrosine 3-Monooxygenase | 2009 |
Salicylic acid protects against chronic L-DOPA-induced 6-OHDA generation in experimental model of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Male; Medial Forebrain Bundle; Mice; Mice, Inbred BALB C; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Salicylates | 2010 |
Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain; Carbidopa; Catechol O-Methyltransferase; Dopamine; Drug Combinations; Extracellular Space; Female; Levodopa; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Mutation; Phenotype; Sensory Gating; Sex Factors; Social Dominance | 2010 |
L-DOPA reverses motor deficits associated with normal aging in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain; Brain Chemistry; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Male; Mice; Mice, Inbred C57BL; Psychomotor Performance | 2011 |
From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Dopa Decarboxylase; Drosophila melanogaster; Insect Proteins; Insecta; Levodopa | 2011 |
Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Antioxidants; Brain; Deoxyepinephrine; Dopamine; Glutathione; Hallucinogens; Hydrogen Peroxide; Levodopa; Male; Membrane Potential, Mitochondrial; Mice; Oxidative Stress; Protein Carbonylation; Serotonin; Synaptosomes | 2012 |
Inhibition and covalent modification of tyrosine hydroxylase by 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Glands; Animals; Blotting, Western; Cell Line, Tumor; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetics; Levodopa; Protein Processing, Post-Translational; Rats; Time Factors; Tyrosine 3-Monooxygenase | 2011 |
Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Benserazide; Caffeine; Dopamine; Glutamic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles | 2012 |
Aberrant striatal dopamine transmitter dynamics in brain-derived neurotrophic factor-deficient mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain-Derived Neurotrophic Factor; Chromatography, Liquid; Corpus Striatum; Dopamine; Electric Stimulation; Electrochemical Techniques; Extracellular Fluid; Homeostasis; Homovanillic Acid; Levodopa; Linear Models; Mice; Mice, Knockout; Microdialysis; Motor Activity; Potassium Chloride; Time Factors | 2012 |
Chronic 5-HT transporter blockade reduces DA signaling to elicit basal ganglia dysfunction.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Animals, Newborn; Basal Ganglia; Cell Count; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Exploratory Behavior; Fluoxetine; Homovanillic Acid; Levodopa; Male; Mice; Mice, Transgenic; Movement Disorders; Psychomotor Performance; Random Allocation; Rotarod Performance Test; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Substantia Nigra; Ventral Tegmental Area | 2011 |
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Brain; Calcium Signaling; Catalepsy; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Glutamic Acid; Haloperidol; HEK293 Cells; Humans; Levodopa; Male; Monoamine Oxidase; Motor Neuron Disease; Oxidopamine; Parkinson Disease; Picolinic Acids; Protein Binding; Psychomotor Performance; Pyrimidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reaction Time; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate; Substantia Nigra; Thallium; Transfection; Triazoles; Tyrosine 3-Monooxygenase | 2012 |
Intranasally applied L-DOPA alleviates parkinsonian symptoms in rats with unilateral nigro-striatal 6-OHDA lesions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Intranasal; Amphetamine; Analysis of Variance; Animals; Antiparkinson Agents; Benserazide; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Electrochemistry; Exploratory Behavior; Forelimb; Functional Laterality; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Motor Activity; Motor Skills; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Substantia Nigra; Sympatholytics | 2012 |
Chromatographic assay to study the activity of multiple enzymes involved in the synthesis and metabolism of dopamine and serotonin.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Biological Assay; Central Nervous System; Chromatography; Dopamine; Dopamine Agents; Hydroxyindoleacetic Acid; Levodopa; Lymnaea; Models, Biological; Molecular Structure; Serotonin; Tryptophan; Tyrosine | 2012 |
The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Oxidative Stress; Rats; Rats, Wistar; Reserpine; Triazines; Triazoles; Vesicular Monoamine Transport Proteins | 2012 |
Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson's disease and other synucleinopathies.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Biomarkers; Catecholamines; Dopamine Agents; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Levodopa; Male; Methoxyhydroxyphenylglycol; Middle Aged; Multiple System Atrophy; Parkinsonian Disorders; Positron-Emission Tomography; Pure Autonomic Failure; ROC Curve | 2012 |
Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Aging; Animals; Antiparkinson Agents; Blotting, Western; Cell Count; Dopamine; Dopaminergic Neurons; Female; G(M1) Ganglioside; Gangliosides; Humans; Immunohistochemistry; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Acetylgalactosaminyltransferases; Parkinson Disease; Polypeptide N-acetylgalactosaminyltransferase; Synucleins; Tyrosine 3-Monooxygenase | 2012 |
Striatal interaction among dopamine, glutamate and ascorbate.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antioxidants; Ascorbic Acid; Basal Ganglia Diseases; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Dopamine Antagonists; Electrochemistry; Fluorometry; Glutamic Acid; Haloperidol; Levodopa; Male; Microdialysis; Neostriatum; Rats; Rats, Sprague-Dawley | 2012 |
Chronic L-DOPA treatment attenuates behavioral and biochemical deficits induced by unilateral lactacystin administration into the rat substantia nigra.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Catalepsy; Cysteine Proteinase Inhibitors; Dopamine Agonists; Dose-Response Relationship, Drug; Functional Laterality; Levodopa; Male; Oxidopamine; Rats; Rats, Wistar; Reaction Time; Serotonin; Substantia Nigra | 2014 |
Involvement of dopamine signaling in the circadian modulation of interval timing.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Circadian Rhythm; Corpus Striatum; Discrimination, Psychological; Dopamine; Dopamine Agents; Levodopa; Male; Mice, Inbred C57BL; Motor Activity; Period Circadian Proteins; Photic Stimulation; Random Allocation; RNA, Messenger; Signal Transduction; Substantia Nigra; Time Perception; Tyrosine 3-Monooxygenase | 2014 |
Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Atrazine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Fetus; Herbicides; Homovanillic Acid; Levodopa; Maternal-Fetal Exchange; Nuclear Receptor Subfamily 4, Group A, Member 2; Pregnancy; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2014 |
Coadministration of β-asarone and levodopa increases dopamine in rat brain by accelerating transformation of levodopa: a different mechanism from Madopar.
Topics: 3,4-Dihydroxyphenylacetic Acid; Allylbenzene Derivatives; Animals; Anisoles; Benserazide; Catechol O-Methyltransferase; Corpus Striatum; Dopamine; Dopamine Agents; Drug Combinations; Drug Interactions; Homovanillic Acid; Levodopa; Male; Monoamine Oxidase; Rats; Serotonin; Tyrosine 3-Monooxygenase | 2014 |
Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Brain; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Combinations; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Female; Homovanillic Acid; Levodopa; Macaca fascicularis; Ovariectomy; Parkinsonian Disorders; Protein Binding; Pyridines; Serotonin | 2015 |
Chronic L-dopa decreases serotonin neurons in a subregion of the dorsal raphe nucleus.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Levodopa; Male; Neurons; Oxidative Stress; Prefrontal Cortex; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin | 2014 |
Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Dyskinesia Agents; Cell Death; Cytosol; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Levodopa; Mesencephalon; Mice, Inbred C57BL; Mice, Transgenic; Motor Skills; Movement Disorders; Oxidative Stress; Parkinsonian Disorders; Vesicular Monoamine Transport Proteins | 2015 |
The serotonin aldehyde, 5-HIAL, oligomerizes alpha-synuclein.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; alpha-Synuclein; Animals; Dopamine; Hydroxyindoleacetic Acid; Isoenzymes; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; PC12 Cells; Polymerization; Rats; Serotonin | 2015 |
Levodopa reverses cytokine-induced reductions in striatal dopamine release.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dopamine Agents; Female; Interferon-alpha; Levodopa; Macaca mulatta; Male; Microdialysis | 2015 |
Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aconitate Hydratase; alpha-Methyltyrosine; Animals; Body Temperature; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Electron Transport Complex I; Gene Expression Regulation; Hallucinogens; Homovanillic Acid; Levodopa; Male; Mice; Mice, Inbred C57BL; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Tyrosine 3-Monooxygenase | 2015 |
Subthalamic Nucleus Deep Brain Stimulation Modulate Catecholamine Levels with Significant Relations to Clinical Outcome after Surgery in Patients with Parkinson's Disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Area Under Curve; Catecholamines; Deep Brain Stimulation; Female; Homovanillic Acid; Humans; Levodopa; Linear Models; Male; Middle Aged; Parkinson Disease; Postoperative Period; Quality of Life; ROC Curve; Severity of Illness Index; Subthalamic Nucleus; Treatment Outcome | 2015 |
Changes in plasma catecholamines levels as preclinical biomarkers in experimental models of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Disease Progression; Dopamine; Epinephrine; Levodopa; Male; Mice, Inbred C57BL; MPTP Poisoning; Norepinephrine; Prodromal Symptoms; Severity of Illness Index | 2015 |
Determination of dopamine, serotonin, biosynthesis precursors and metabolites in rat brain microdialysates by ultrasonic-assisted in situ derivatization-dispersive liquid-liquid microextraction coupled with UHPLC-MS/MS.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Dyskinesias; Epinephrine; Hydroxyindoleacetic Acid; Levodopa; Liquid Phase Microextraction; Male; Norepinephrine; Rats, Sprague-Dawley; Rhodamines; Serotonin; Tandem Mass Spectrometry; Tryptophan; Ultrasonics | 2016 |
Cerebrospinal fluid levels of catecholamines and its metabolites in Parkinson's disease: effect of l-DOPA treatment and changes in levodopa-induced dyskinesia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Aging; Antiparkinson Agents; Catecholamines; Dopamine; Dyskinesia, Drug-Induced; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Norepinephrine; Parkinson Disease | 2017 |
Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and Neurotrophin Levels in Rat Brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Central Nervous System Stimulants; Dopamine; Dose-Response Relationship, Drug; Gene Expression Regulation; Homovanillic Acid; Levodopa; Locomotion; Male; Methamphetamine; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; Time Factors | 2017 |
The Design and Evaluation of an l-Dopa-Lazabemide Prodrug for the Treatment of Parkinson's Disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biological Availability; Carbidopa; Corpus Striatum; Dopamine; Drug Combinations; HeLa Cells; Humans; Levodopa; Male; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Permeability; Picolinic Acids; Prodrugs; Solubility; Structure-Activity Relationship | 2017 |
Neuroprotective effect of diclofenac on chlorpromazine induced catalepsy in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Catalepsy; Chlorpromazine; Corpus Striatum; Diclofenac; Dopamine; Female; Levodopa; Male; Motor Activity; Neuroprotective Agents; Rats; Rats, Wistar | 2019 |
Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Homovanillic Acid; Humans; Levodopa; Neurotransmitter Agents; Parkinson Disease | 2021 |
Voluntary oral dosing for precise experimental compound delivery in adult rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Levodopa; Male; Rats; Rats, Long-Evans | 2022 |
Melanopsin modulates refractive development and myopia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Axial Length, Eye; Cornea; Disease Models, Animal; Dopamine; Dopamine Agents; Female; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myopia; Refraction, Ocular; Retina; Retinal Ganglion Cells; Rod Opsins; Visual Pathways | 2022 |