Compounds > 3,4-dihydro-5-methyl-1(2h)-isoquinolinone
Page last updated: 2024-09-04

3,4-dihydro-5-methyl-1(2h)-isoquinolinone and 4-amino-1,8-naphthalimide

3,4-dihydro-5-methyl-1(2h)-isoquinolinone has been researched along with 4-amino-1,8-naphthalimide in 2 studies

Compound Research Comparison

Studies
(3,4-dihydro-5-methyl-1(2h)-isoquinolinone)		Trials
(3,4-dihydro-5-methyl-1(2h)-isoquinolinone)		Recent Studies (post-2010)
(3,4-dihydro-5-methyl-1(2h)-isoquinolinone)		Studies
(4-amino-1,8-naphthalimide)		Trials
(4-amino-1,8-naphthalimide)		Recent Studies (post-2010) (4-amino-1,8-naphthalimide)
160288043

Protein Interaction Comparison

ProteinTaxonomy3,4-dihydro-5-methyl-1(2h)-isoquinolinone (IC50)4-amino-1,8-naphthalimide (IC50)
Chain A, Poly(adp-ribose) PolymeraseGallus gallus (chicken)0.18
Chain A, Poly(adp-ribose) PolymeraseGallus gallus (chicken)0.18
Chain A, Poly(adp-ribose) PolymeraseGallus gallus (chicken)0.18
Poly [ADP-ribose] polymerase 2Mus musculus (house mouse)0.027
Poly [ADP-ribose] polymerase 1Homo sapiens (human)0.065

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Camaioni, E; Costantino, G; Macchiarulo, A; Pellicciari, R1
Almassy, RJ; Boritzki, TJ; Calabrese, CR; Calvert, AH; Curtin, NJ; Ekkers, A; Golding, BT; Griffin, RJ; Hostomsky, Z; Kumpf, RA; Kyle, S; Li, J; Maegley, KA; Newell, DR; Thomas, HD; Tikhe, JG; Wang, LZ; Webber, SE; Yu, XH; Zhang, C1

Other Studies

2 other study(ies) available for 3,4-dihydro-5-methyl-1(2h)-isoquinolinone and 4-amino-1,8-naphthalimide

ArticleYear
Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis.
    Journal of medicinal chemistry, 2001, Nov-08, Volume: 44, Issue:23

    Topics: Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Ligands; Models, Molecular; Naphthalenes; Phenanthridines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Binding; Quantitative Structure-Activity Relationship; Quinazolines

2001
Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.
    Journal of medicinal chemistry, 2004, Oct-21, Volume: 47, Issue:22

    Topics: Antineoplastic Agents; Azepines; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Design; Drug Resistance, Neoplasm; Drug Synergism; Humans; Indoles; Models, Molecular; Poly(ADP-ribose) Polymerase Inhibitors; Structure-Activity Relationship; Topoisomerase I Inhibitors

2004