3-4-di-o-caffeoylquinic-acid and caffeic-acid

The synthesis, cytotoxicity, anti-leishmanial and anti-trypanosomal activities of twelve triclosan-caffeic acid hybrids are described herein. The structure of the synthesized products was elucidated by a combination of spectrometric analyses. The synthesized compounds were evaluated against amastigotes forms of L. (V) panamensis, which is the most prevalent Leishmania species in Colombia, and against Trypanosoma cruzi, which is the pathogenic species to humans. Cytotoxicity was evaluated against human U-937 macrophages. Eight compounds were active against L. (V) panamensis (18-23, 26 and 30) and eight of them against T. cruzi (19-22, 24 and 28-30) with EC

Topics: Antiprotozoal Agents; Caffeic Acids; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Leishmania; Macrophages; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Triclosan; Trypanosoma cruzi

To investigate the chemical constituents of Ipomoea batatas.. Silica gel column chromatography and Sephadex LH-20 were used to separate and purify the compounds from the EtOAc and n-BuOH soluble fraction of ethanol extracts. The chemical structures were elucidated on the basis of physic-chemical properties and spectral data.. Four compounds were isolated and identify as citrusin C (1), caffeicacid (2), 3,4-di-O-caffeoylquinic acid (3), 1,2,3,4-tetrahydro-beta-carboline-3-carboylic acid (4).. Compounds 1-4 are isolated for the first time from I. batatas.

Topics: Alkaloids; Caffeic Acids; Carbolines; Chlorogenic Acid; Ipomoea batatas; Plant Leaves; Plants, Medicinal; Spectrophotometry, Ultraviolet

The methanol extract from Dipsacus asper Wall (Dipsacaceae) was found to show antioxidant activity against free radical and Cu(2+)-mediated LDL oxidation. In further study, to identify active constituents from the plant, six caffeoyl quinic acid derivatives: 3,4-di-O-caffeoylquinic acid (1), methyl 3,4-di-O-caffeoyl quinate (2), 3,5-di-O-caffeoylquinic acid (3), methyl 3,5-di-O-caffeoyl quinate (4), 4,5-di-O-caffeoylquinic acid (5) and methyl 4,5-di-O-caffeoyl quinate (6) were isolated. Their structures were identified by spectroscopic methods including 2D-NMR. The isolated compounds, 1-6, were found to be potent scavengers of the free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), and are more potent than butylated hydroxyl toluene (BHT) used as a positive control. The compounds 1-6 also inhibited Cu(2+)-mediated low-density lipoprotein (LDL) oxidation. They increased the lag time of conjugated dienes formation and inhibited the generation of thiobarbituric acid reactive substances (TBARS) in a dose-dependent manner. These results suggested that Dipsacus asper due to its antioxidant constituents, 1-6, may have a role to play in preventing the development and progression of atherosclerotic disease.

Topics: alpha-Tocopherol; Antioxidants; Biphenyl Compounds; Butylated Hydroxytoluene; Caffeic Acids; Chlorogenic Acid; Copper; Dipsacaceae; Dose-Response Relationship, Drug; Free Radical Scavengers; Gallic Acid; Humans; Hydrazines; Lipid Peroxidation; Lipoproteins, LDL; Malondialdehyde; Methanol; Molecular Structure; Monosaccharides; Picrates; Plant Extracts; Plant Roots; Plants, Medicinal; Quinic Acid; Thiobarbituric Acid Reactive Substances