3-4-dehydrobrevicomin has been researched along with 2-(sec-butyl)-4-5-dihydrothiazole* in 3 studies
1 review(s) available for 3-4-dehydrobrevicomin and 2-(sec-butyl)-4-5-dihydrothiazole
| Article | Year |
|---|---|
Electrophysiological and biochemical responses of mouse vomeronasal receptor cells to urine-derived compounds: possible mechanism of action.
Receptor cells of the vomeronasal organ (VNO) are thought to detect pheromone-like molecules important for reproductive physiology. Several compounds derived from male mouse urine have been demonstrated to affect endocrine events in female mice. In the present study, the ability of these compounds to affect VNO activity was tested. In dissociated VNO cells held under voltage clamp conditions, application of dehydro-exo-brevicomin (DHB) evoked an outward current at negative holding potentials and an inward current at positive holding potentials. Under current clamp, DHB reduced action potential firing. Since DHB application caused a decrease in membrane conductance, this compound appeared to act by reducing inward current through closing an ion channel. Biochemical experiments tested the effects of DHB and 2-(sec-butyl)-4,5-dihydrothiazole (SBT) on cAMP levels in the VNO. A mixture of DHB and SBT decreased cAMP levels in VNO sensory tissue and had no effect on VNO non-sensory tissue. The results suggest that pheromones have an inhibitory influence on action potential generation and on cAMP levels in receptor cells of the VNO. Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Electrophysiology; Female; Male; Mice; Neurons; Pheromones; Proteins; Thiazoles; Vomeronasal Organ | 1998 |
2 other study(ies) available for 3-4-dehydrobrevicomin and 2-(sec-butyl)-4-5-dihydrothiazole
| Article | Year |
|---|---|
Positive identification of the puberty-accelerating pheromone of the house mouse: the volatile ligands associating with the major urinary protein.
Five structurally diverse small ligands, all binding to the major urinary protein (MUP) of the male house mouse, show individually puberty-accelerating pheromonal activity in the recipient females. A recombinant MUP (identical structurally to the natural protein) has shown no biological activity. While four of these ligands were previously implicated in oestrus synchronization (Whitten effect), the same chemosignals now appear responsible for both sexual maturation and cycling in adult females. Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Female; Ketones; Ligands; Male; Mice; Mice, Inbred ICR; Molecular Structure; Pheromones; Proteins; Recombinant Fusion Proteins; Sesquiterpenes; Sexual Maturation; Thiazoles | 1999 |
Stereoselectivity in mammalian chemical communication: male mouse pheromones.
Two male mouse pheromones, 3,4-dehydro-exo-brevicomin (DHB) and 2-sec-butyldihydrothiazole (SBT), are chiral molecules which were previously tested in their respective bioassays as racemic mixtures. The focus of this study has been to determine the absolute configuration of their natural forms and its relation to stereospecific biological action. DHB was established as the R,R-enantiomer possessing biological activity. Due to an extremely easy racemization of SBT under very mild conditions, enantioselectivity of its transmission and its action at the receptor site appear to be of secondary importance. Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Estrus; Female; Male; Mice; Mice, Inbred C57BL; Pheromones; Stereoisomerism; Thiazoles | 1995 |