Compounds > 3-3--dihydroxyisorenieratene

3-3--dihydroxyisorenieratene and zinquin

3-3--dihydroxyisorenieratene has been researched along with zinquin* in 1 studies

Other Studies

1 other study(ies) available for 3-3--dihydroxyisorenieratene and zinquin

Article	Year
3,3'-Dihydroxyisorenieratene prevents UV-induced formation of reactive oxygen species and the release of protein-bound zinc ions in human skin fibroblasts. Molecular nutrition & food research, 2010, Volume: 54, Issue:2 3,3'-Dihydroxyisorenieratene (DHIR) is a structurally unusual carotenoid exhibiting bifunctional antioxidant properties. It is synthesized by Brevibacterium linens, used in dairy industry for the production of red smear cheeses. The compound protects cellular structures against photo-oxidative damage and inhibits the UV-dependent formation of thymidine dimers. Here we show that DHIR prevents a UV-induced intracellular release of zinc ions from proteins in human dermal fibroblasts. The effect is correlated with a decreased formation of intracellular reactive oxygen species. In contrast, zinc release from cellular proteins induced by hyperthermia is not affected by pretreatment of cells with the antioxidant DHIR. It is suggested that the intracellular zinc release upon UV irradiation is due to oxidative modifications of the zinc ligands in proteins (e.g. cysteine) and that protection by DHIR is due to intracellular scavenging of reactive oxygen species generated in photo-oxidation. Topics: Carotenoids; Cell Line; Cell Survival; Chelating Agents; Dose-Response Relationship, Radiation; Fibroblasts; Fluorescent Dyes; Free Radical Scavengers; Hot Temperature; Humans; Lutein; Quinolones; Reactive Oxygen Species; Skin; Stress, Physiological; Tosyl Compounds; Ultraviolet Rays; Zinc	2010

Article

Year

3,3'-Dihydroxyisorenieratene prevents UV-induced formation of reactive oxygen species and the release of protein-bound zinc ions in human skin fibroblasts.

Molecular nutrition & food research, 2010, Volume: 54, Issue:2

3,3'-Dihydroxyisorenieratene (DHIR) is a structurally unusual carotenoid exhibiting bifunctional antioxidant properties. It is synthesized by Brevibacterium linens, used in dairy industry for the production of red smear cheeses. The compound protects cellular structures against photo-oxidative damage and inhibits the UV-dependent formation of thymidine dimers. Here we show that DHIR prevents a UV-induced intracellular release of zinc ions from proteins in human dermal fibroblasts. The effect is correlated with a decreased formation of intracellular reactive oxygen species. In contrast, zinc release from cellular proteins induced by hyperthermia is not affected by pretreatment of cells with the antioxidant DHIR. It is suggested that the intracellular zinc release upon UV irradiation is due to oxidative modifications of the zinc ligands in proteins (e.g. cysteine) and that protection by DHIR is due to intracellular scavenging of reactive oxygen species generated in photo-oxidation.

Topics: Carotenoids; Cell Line; Cell Survival; Chelating Agents; Dose-Response Relationship, Radiation; Fibroblasts; Fluorescent Dyes; Free Radical Scavengers; Hot Temperature; Humans; Lutein; Quinolones; Reactive Oxygen Species; Skin; Stress, Physiological; Tosyl Compounds; Ultraviolet Rays; Zinc

2010