3,3',4'-trihydroxyflavone has been researched along with 3-hydroxyflavone in 27 studies
| Studies (3,3',4'-trihydroxyflavone) | Trials (3,3',4'-trihydroxyflavone) | Recent Studies (post-2010) (3,3',4'-trihydroxyflavone) | Studies (3-hydroxyflavone) | Trials (3-hydroxyflavone) | Recent Studies (post-2010) (3-hydroxyflavone) |
|---|---|---|---|---|---|
| 39 | 0 | 22 | 3,657 | 84 | 2,242 |
| Protein | Taxonomy | 3,3',4'-trihydroxyflavone (IC50) | 3-hydroxyflavone (IC50) |
|---|---|---|---|
| Pyruvate kinase PKM | Homo sapiens (human) | 1.75 | |
| Cytochrome P450 1B1 | Homo sapiens (human) | 0.09 | |
| Aurora kinase B | Homo sapiens (human) | 4.29 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 18 (66.67) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, X; Hughes, RA; Qin, CX; Williams, SJ; Woodman, OL | 1 |
| Chan, EC; Pannangpetch, P; Woodman, OL | 1 |
| Krishnamachari, V; Levine, LH; Paré, PW; Zhou, C | 1 |
| Callaway, JK; Dusting, GJ; Jarrott, B; Roulston, CL; Woodman, OL | 1 |
| Loft, KJ; Williams, SJ; Woodman, OL; Yap, S | 1 |
| Dusting, GJ; Guo, N; Jiang, F | 1 |
| Malakul, W; Woodman, OL | 1 |
| Dusting, GJ; May, CN; Thomas, CJ; Wang, S; Woodman, OL | 1 |
| Baek, I; Kim, IK; Kim, SH; Seo, M; Song, MJ; Suk, K; Williams, SJ; Woodman, OL | 1 |
| Hart, JL; Leo, CH; Woodman, OL | 2 |
| Crack, PJ; Williams, SJ; Woodman, OL; Yap, S | 1 |
| Connelly, KA; Edgley, AJ; Kelly, DJ; Khong, FL; Krum, H; Qi, W; Woodman, OL; Zhang, Y | 1 |
| Hu, M; Wu, B; Zhang, S | 1 |
| Kim, HY; Kim, IK; Seok, YM; Williams, SJ; Woodman, OL | 1 |
| Jackson, DE; Linden, MD; Mosawy, S; Woodman, OL | 3 |
| Bell, JR; Bogoyevitch, MA; Delbridge, LM; Lim, NR; May, CN; Ng, DC; Silva, LS; Thomas, CJ; Williams, SJ; Woodman, OL; Yap, S; Yeap, YY | 1 |
| Berdeaux, A; Eychenne, N; Long, R; Morin, D; Pons, S; Woodman, OL | 1 |
| Baltaci, AK; Caliskan, M; Demir, EA; Mogulkoc, R; Nurullahoglu Atalik, KE; Oz, M | 1 |
| Kedikaetswe, A; Lim, NR; May, CN; Ng, DC; Thomas, CJ; Woodman, OL; Yeap, YY | 1 |
| Baltaci, AK; Caliskan, M; Menevse, E; Mogulkoc, R | 1 |
| Chan, SMH; Choy, KW; Herbert, TP; Lau, YS; Mustafa, MR; Potocnik, S; Woodman, OL | 1 |
| Chin, KY; Darby, IA; Ng, DCH; Silva, LS; Woodman, OL | 1 |
| Baltaci, AK; Ergene, N; Koc, A; Mogulkoc, R | 1 |
| Chan, EC; Edgley, AJ; Fan Gaskin, JC; Kong, RCK; Peshavariya, HM; Shah, MH | 1 |
27 other study(ies) available for 3,3',4'-trihydroxyflavone and 3-hydroxyflavone
| Article | Year |
|---|---|
Understanding the cardioprotective effects of flavonols: discovery of relaxant flavonols without antioxidant activity.
Topics: Animals; Antioxidants; Aorta, Thoracic; Cardiotonic Agents; Drug Evaluation, Preclinical; Endothelium, Vascular; Flavonols; Free Radical Scavengers; Male; Molecular Structure; Muscle Contraction; Oxidants; Oxidative Stress; Potassium Channels; Potassium Chloride; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Superoxides; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships.
Topics: Animals; Aorta, Thoracic; Apigenin; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Flavonoids; Flavonols; In Vitro Techniques; Luteolin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Quercetin; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2000 |
In vitro flavon-3-ol oxidation mediated by a B ring hydroxylation pattern.
Topics: Chromatography, Liquid; Dimerization; Flavonoids; Flavonols; Hydroxylation; Luteolin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylation; Nitriles; Oxidation-Reduction | 2004 |
Using behaviour to predict stroke severity in conscious rats: post-stroke treatment with 3', 4'-dihydroxyflavonol improves recovery.
Topics: Animals; Behavior, Animal; Brain Mapping; Consciousness; Cytoprotection; Disease Models, Animal; Endothelin-1; Flavonols; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Prognosis; Rats; Rats, Wistar; Reproducibility of Results; Severity of Illness Index; Time Factors | 2008 |
Discovery of water-soluble antioxidant flavonols without vasorelaxant activity.
Topics: Animals; Antioxidants; Aorta, Thoracic; Cardiotonic Agents; Drug Design; Flavonols; Free Radical Scavengers; Phenylephrine; Pyrogallol; Rats; Solubility; Vasodilator Agents | 2008 |
3',4'-Dihydroxyflavonol down-regulates monocyte chemoattractant protein-1 in smooth muscle: role of focal adhesion kinase and PDGF receptor signalling.
Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Cytokines; Down-Regulation; Flavonols; Focal Adhesion Protein-Tyrosine Kinases; Male; Mitogen-Activated Protein Kinase 1; Muscle, Smooth, Vascular; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor | 2009 |
3',4'-Dihydroxyflavonol prevents diabetes-induced endothelial dysfunction in rat aorta.
Topics: Acridines; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Endothelium, Vascular; Flavonols; In Vitro Techniques; Luminescence; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides | 2009 |
3',4'-Dihydroxyflavonol improves post-ischaemic coronary endothelial function following 7days reperfusion in sheep.
Topics: Acetylcholine; Animals; Antioxidants; Endothelium, Vascular; Flavonols; Myocardial Ischemia; Myocardial Reperfusion; Nitroprusside; Phenylephrine; Sheep; Time Factors; Vasodilation | 2009 |
Effects of 3',4'-dihydroxyflavonol on vascular contractions of rat aortic rings.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Biotransformation; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Flavonols; In Vitro Techniques; Male; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin Light Chains; Phenylephrine; Phosphoproteins; Phosphorylation; Potassium Channel Blockers; Potassium Chloride; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Sodium Fluoride; Vasoconstrictor Agents | 2010 |
3',4'-Dihydroxyflavonol restores endothelium-dependent relaxation in small mesenteric artery from rats with type 1 and type 2 diabetes.
Topics: Animals; Antioxidants; Biomimetic Materials; Blood Glucose; Body Weight; Cyclic N-Oxides; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Endothelium, Vascular; Flavonols; Mesenteric Arteries; Metalloporphyrins; Microvessels; Rats; Rats, Sprague-Dawley; Spin Labels; Superoxides; Vasodilation | 2011 |
Synthesis of a hypoxia-targeted conjugate of the cardioprotective agent 3',4'-dihydroxyflavonol and evaluation of its ability to reduce ischaemia/reperfusion injury.
Topics: Animals; Cardiotonic Agents; Chromatography, High Pressure Liquid; Flavonols; Rats; Reperfusion Injury | 2011 |
3',4'-Dihydroxyflavonol reduces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 1; Endothelium, Vascular; Flavonols; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Male; Membrane Glycoproteins; Mesenteric Arteries; Microvessels; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Superoxides; Vasodilation | 2011 |
3',4'-Dihydroxyflavonol antioxidant attenuates diastolic dysfunction and cardiac remodeling in streptozotocin-induced diabetic m(Ren2)27 rats.
Topics: Animals; Antioxidants; Autoradiography; Cardiac Catheterization; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Echocardiography; Flavonols; Homozygote; In Situ Hybridization; Male; NADPH Oxidases; Oxidative Stress; Rats; Rats, Transgenic; Reactive Oxygen Species; Ventricular Dysfunction, Left | 2011 |
Evaluation of 3,3',4'-trihydroxyflavone and 3,6,4'-trihydroxyflavone (4'-O-glucuronidation) as the in vitro functional markers for hepatic UGT1A1.
Topics: Biomarkers; Flavones; Flavonoids; Flavonols; Glucuronides; Glucuronosyltransferase; Humans; Kinetics; Liver; Molecular Structure; Protein Isoforms; Recombinant Proteins | 2011 |
3',4'-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized rat mesenteric artery.
Topics: Animals; Calcium; Cardiovascular Agents; Escin; Flavonols; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Mesenteric Arteries; Permeability; Phenylephrine; Rats; Rats, Sprague-Dawley; Sodium Fluoride; Vasoconstriction | 2012 |
Treatment with quercetin and 3',4'-dihydroxyflavonol inhibits platelet function and reduces thrombus formation in vivo.
Topics: Animals; Antioxidants; Disease Models, Animal; Exocytosis; Female; Flavonols; Male; Mice; Platelet Aggregation; Quercetin; Thrombosis; Time Factors | 2013 |
Inhibition of platelet-mediated arterial thrombosis and platelet granule exocytosis by 3',4'-dihydroxyflavonol and quercetin.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Arteries; Blood Platelets; Cytoplasmic Granules; Exocytosis; Fibrinogen; Flavonols; Humans; Mice; P-Selectin; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Quercetin; Quinacrine; Regional Blood Flow; Thrombosis | 2013 |
Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition.
Topics: Animals; Arsenites; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiotonic Agents; Cell Line; Flavonols; Hydrogen Peroxide; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Myocardial Reperfusion Injury; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Rats; Sheep, Domestic | 2013 |
The cardioprotectant 3',4'-dihydroxyflavonol inhibits opening of the mitochondrial permeability transition pore after myocardial ischemia and reperfusion in rats.
Topics: Animals; Cardiotonic Agents; Flavonols; Malates; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Oxygen Consumption; Pyruvic Acid; Rats, Wistar; Reactive Oxygen Species; Rotenone; Succinic Acid | 2014 |
The flavonols quercetin and 3',4'-dihydroxyflavonol reduce platelet function and delay thrombus formation in a model of type 1 diabetes.
Topics: Animals; Antioxidants; Blood Platelets; Carotid Arteries; Carotid Artery Injuries; Chlorides; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Exocytosis; Ferric Compounds; Flavonols; Laser-Doppler Flowmetry; Mice; Mice, Inbred C57BL; Platelet Activation; Platelet Aggregation; Quercetin; Thrombosis | 2014 |
3',4'-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia.
Topics: Animals; Anti-Anxiety Agents; Antioxidants; Anxiety; Behavior, Animal; Brain Ischemia; Disease Models, Animal; Exploratory Behavior; Flavonols; Injections, Intraperitoneal; Learning Disabilities; Male; Memory; Memory Disorders; Neuroprotective Agents; Pattern Recognition, Physiological; Random Allocation; Rats, Wistar; Reperfusion Injury; Spatial Learning; Time Factors | 2017 |
Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3',4'-dihydroxyflavonol.
Topics: Animals; Cardiotonic Agents; Chromones; Drug Therapy, Combination; Female; Flavonoids; Flavonols; MAP Kinase Signaling System; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Prodrugs; Proto-Oncogene Proteins c-akt; Rats; Sheep; Signal Transduction | 2015 |
The Effect of 3',4'-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion Injury.
Topics: Animals; Brain; Brain Ischemia; Flavonols; Lipid Peroxidation; Male; Rats; Rats, Wistar; Reperfusion Injury; Treatment Outcome | 2016 |
3',4'-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice.
Topics: Animals; Aorta; Apoptosis; Cells, Cultured; Endoplasmic Reticulum Stress; Endothelium, Vascular; Flavonols; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Tunicamycin; Vascular Diseases | 2018 |
Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2.
Topics: Animals; Calcium-Binding Proteins; Cardiotonic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Flavonols; Isolated Heart Preparation; Male; Mitogen-Activated Protein Kinase 9; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley | 2018 |
Effect of 3'-4'-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in rats.
Topics: Animals; Flavonols; Glutathione; Ischemia; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Malondialdehyde; Rats; Rats, Wistar; Reperfusion Injury | 2019 |
Inhibitory Effects of 3',4'-Dihydroxyflavonol in a Mouse Model of Glaucoma Filtration Surgery and TGFβ1-Induced Responses in Human Tenon's Fibroblasts.
Topics: Animals; Collagen; Disease Models, Animal; Fibroblasts; Filtering Surgery; Flavonols; Glaucoma; Humans; Mice; Mice, Inbred C57BL; Mitomycin; Tenon Capsule | 2022 |