3'-azido-3'-deoxythymidine 5'phosphate and zidovudine

3'-azido-3'-deoxythymidine 5'phosphate has been researched along with zidovudine in 91 studies

Research

Studies (91)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.10)	18.7374
1990's	50 (54.95)	18.2507
2000's	35 (38.46)	29.6817
2010's	5 (5.49)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fillion, G; Fillion, MP; Gouyette, C; Huynh-Dinh, T; Namane, A	1
Aubertin, AM; Girardet, JL; Gosselin, G; Imbach, JL; Kirn, A; Lefebvre, I; Périgaud, C; Pompon, A	1
Busson, R; De Keukeleire, D; Dugué, L; Froeyen, M; Herdewijn, P; Heyerick, A; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Vanheusden, V	1
Herdewijn, P; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Van Rompaey, P; Vanheusden, V	1
Baba, M; Cheng, YC; Dutschman, GE; Hsu, CH; Hu, R; Krishnan, P; Tanaka, H; Yang, G	1
Boryski, J; Dąbrowska, A; Figlerowicz, M; Guranowski, A; Kołodziej, K; Kraszewski, A; Lipniacki, A; Piasek, A; Pietrusiewicz, ZM; Romanowska, J; Sobkowski, M; Stawiński, J; Szymańska-Michalak, A	1
Froeyen, M; Helynck, O; Munier-Lehmann, H; Van Calenbergh, S; Van Poecke, S	1
Hamzeh, FM; Kornhauser, DM; Kuwahara, SK; Lewis, LD; Lietman, PS; Slusher, JT	1
Achiwa, K; Ikeda, K; Nagao, Y	1
Civil, R; Downey, KM; Mian, AM; So, AG; Tan, CK	1
Britton, S; Eriksson, S; Jacobsson, B; Törnevik, Y	1
Kimura, S; Muramatsu, S; Shimada, K; Takahagi, H; Toyoshima, T	1
Agarwal, RP; Mian, AM	1
Joos, B; Kuster, H; Lüthy, R; Nadai, V; Vogt, M	1
de Clercq, E; Jansen, RW; Meijer, DK; Molema, G; Pauwels, R	1
Herdewijn, P; Jansen, RW; Meijer, DK; Molema, G; Moolenaar, F; Visser, J	1
Chu, CK; Colby, CB; Schinazi, RF; Sommadossi, JP; Williams, GJ; Zhu, Z	1
Dhawan, RK; Kharbanda, S; Kufe, D; Nakamura, M; Ohno, T	1
Hurtubise, PE; Pesce, AJ; Stretcher, BN; Wermeling, JR	1
Brown, PR; Jang, NI; Macbride, D; Pivarnik, PE; Sehgal, RK; Shirali, SS; Singh, HK; Turcotte, JG	1
Ashmun, R; Connelly, MC; Fridland, A	1
Bretner, M; Ciesla, J; Ciesla, JM; Dzik, JM; Kulikowski, T; Rode, W; Shugar, D	1
Downey, KM; Mian, AM; Scott, WA; So, AG; Tan, CK; Zhan, X	1
Carroll, SS; Geib, J; Kuo, LC; Olsen, DB; Shafer, JA; Stahlhut, M	1
Beard, WA; Jaju, M; Wilson, SH	1
Hendriks, MM; Kuipers, ME; Meijer, DK; Swart, PJ	1
Balzarini, J; Eriksson, S; Törnevik, Y; Ullman, B; Wahren, B	1
Darnowski, JW; Goulette, FA	1
Back, D; Barry, M; Beeching, N; Breckenridge, A; Carey, P; Fox, R; Nye, F; Timmins, D; Veal, G; Wild, M	1
Agbaria, R; Cooney, D; Gupta, M; Mazumder, A; Pommier, Y	1
Hall, ET; Kuchta, RD; Melançon, P; Yan, JP	1
Crouch, RC; Reardon, JE; St John-Williams, L	1
Czochralska, B; Kawczyński, W; Shugar, D	1
Aubertin, AM; Gosselin, G; Imbach, JL; Kirn, A; Lefebvre, I; Périgaud, C; Pompon, A; Stawinski, J; Szabo, T	1
Aubertin, AM; Gosselin, G; Imbach, JL; Kirn, A; Lefebvre, I; Pompon, A; Puech, F	1
Bebenek, K; Eckstein, F; Kunkel, TA; Roberts, JD; Thomas, DC	1
Bridges, EG; Faraj, A; Sommadossi, JP	1
Harrington, JA; Reardon, JE; Spector, T	1
Copeland, WC; Lam, NK; Wang, TS	1
Jagannadh, B; Kunwar, AC; Reddy, DV	1
Bushman, FD; Farnet, CM; Lipford, JR; Wang, B	1
Back, DJ; Barry, MG; Breckenridge, AM; Gibbons, SE; Hoggard, PG; Khoo, SH; Veal, GJ; Wilkins, EG; Williams, O	1
Kenyon, GL	1
Goody, RS; Konrad, M; Lavie, A; Reinstein, J; Schlichting, I; Vetter, IR	1
Anderson, KS; Kerr, SG	1
Drake, RR; Hong, H; Hume, SD; Milne, GW; Neamati, N; Pilon, AA; Pommier, Y; Sunthankar, P	1
Canard, B; Richardson, CC; Sarfati, SR	1
Brossette, T; Clayette, P; Creminon, C; Dereudre-Bosquet, N; Dormont, D; Goujon, L; Grassi, J; Lebeau, L; Mioskowski, C	1
De Clercq, E; Esté, JA; Kuipers, ME; Meijer, DK; Reymen, D; Swart, PJ; Witvrouw, M	1
Matsuura, SE; Meyer, PR; Mian, AM; Scott, WA; So, AG	1
Bârzu, O; Carniel, E; Chenal-Francisque, V; Christova, P; Gilles, AM; Li de la Sierra, I; Tourneux, L	1
Balzarini, J; Cahard, D; De Clercq, E; McGuigan, C; Naesens, L; Pathirana, R; Saboulard, D; Salgado, A; Velazquez, S	1
Bardeguez, AD; Blanchard, S; Flynn, PM; Fridland, A; Jimenez, E; Robbins, B; Rodman, JH; Rodriguez, JF	1
Aquaro, S; Balzarini, J; De Clercq, E; Knispel, T; Meier, C; Naesens, L; Perno, C	1
Brundiers, R; Goody, RS; Konrad, M; Lavie, A; Ostermann, N; Reinstein, J; Schlichting, I; Veit, T	1
Back, DJ; Gibbons, SE; Hoggard, PG; Karbwang, J; Khoo, SH; Na Bangchang, K; Phiboonbhanakit, D; Wattanagoon, Y	1
Aquaro, S; Balzarini, J; Bianchi, V; De Clercq, E; Knispel, T; Meier, C; Perno, CF; Rampazzo, C	1
Brundiers, R; Goody, RS; Konrad, M; Lavie, A; Ostermann, N; Padiyar, S; Reinstein, J; Schlichting, I; Veit, T	1
Matsuura, SE; Meyer, PR; Schinazi, RF; Scott, WA; So, AG	1
Back, DJ; Barry, MG; Dann, L; Gibbons, SE; Hoggard, PG; Khoo, SH; Lloyd, J; Loveday, C; Wilkins, EG	1
Arnold, E; Boyer, PL; Hughes, SH; Sarafianos, SG	3
Johnson, S	1
Baker, RC; Brady, MT; Hunkler, JA; McOwen, NM; Nahata, MC; Sobol, BJ; Wintermeyer, SM	1
Barber, GN; Boise, LH; Cabral, L; Deyev, VV; Feuer, G; Ghosh, SK; Harrington, WJ; Mian, AM; Shank, NC; Toomey, NL; Wood, C	1
Arnold, E; Birktoft, JJ; Boyer, PL; Clark, AD; Das, K; Hughes, SH; Ilankumaran, P; Jerina, DM; Ramesha, AR; Sarafianos, SG; Sayer, JM; Tuske, S	1
Bazmi, HZ; Chopra, RR; Matsuura, SE; Mellors, JW; Meyer, PR; Pendarvis, E; Scott, WA; Zonarich, D	1
Alvarez, K; Boretto, J; Canard, B; Deval, J; Guerreiro, C; Sarfati, S; Selmi, B	1
Andréola, M; Cruchaga, C; Dollé, V; Martínez-Irujo, JJ; Nguyen, CH; Odriozola, L; Pérez-Mediavilla, A; Tarrago-Litvak, L	1
Konrad, M; Lavie, A	1
Einarsson, R; Eriksson, S; Grassi, J; Lindh, M; Ohrvik, A	1
Andronova, V; Galegov, G; Karpenko, I; Kukhanova, M; Popov, K; Shirokova, E; Skoblov, Y	1
Mak, IT; Nedelec, LF; Weglicki, WB	1
Bentley, AT; Gingerich, J; Hatch, M; McKee, EE; Susan-Resiga, D	1
Alnouti, Y; Bartlett, MG; White, CA	1
Adam, V; Bourgeois, D; Fioravanti, E; Munier-Lehmann, H	1
Canard, B; Deval, J; Guerreiro, C; Matamoros, T; Menéndez-Arias, L; Mulard, L	1
Ludek, OR; Meier, C	1
Aubertin, AM; Boggetto, N; Condom, R; Di Giorgio, A; Liotard, JF; Mehiri, M; Patino, N; Reboud-Ravaux, M	1
Mellors, JW; Parikh, UM; Sheen, CW; Sluis-Cremer, N; Torres, PS; Zelina, S	1
Arnold, E; Dharmasena, S; Parniak, MA; Pongracz, Z; Sarafianos, SG	1
Benech, H; Compain, S; Durand-Gasselin, L; Grassi, J	1
Lefebvre, I; Périgaud, C; Perrin, C; Puy, JY	1
Frohn, A; Hartl, MJ; Kretzschmar, B; Nowrouzi, A; Rethwilm, A; Wöhrl, BM	1
Bénech, H; Dehée, A; Dollfus, C; Durand-Gasselin, L; Garbarg-Chenon, A; Grassi, J; Leverger, G; Pruvost, A; Tabone, MD; Vaudre, G	1
Bergan, K; Chan, JM; Krysiak, K; Nagy, E; Oldfield, E; Parniak, MA; Secrest, A; Song, Y; Tovian, Z	1
Beltran, T; Lefebvre, I; Périgaud, C; Peyrottes, S	1
Brannigan, JA; Carrero-Lerida, J; Fogg, MJ; Gilbert, IH; González-Pacanowska, D; Ruiz-Perez, LM; Silva, AP; Whittingham, JL; Wilkinson, AJ; Wilson, KS	1
Acosta-Hoyos, AJ; Matsuura, SE; Meyer, PR; Scott, WA	1
Bodem, J; Buchholz, B; Corona, A; Di Santo, R; Jordan, M; Maccioni, E; Schneider, A; Spöring, I; Tramontano, E; Wöhrl, BM	1

Reviews

1 review(s) available for 3'-azido-3'-deoxythymidine 5'phosphate and zidovudine

Article	Year
Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase. Mini reviews in medicinal chemistry, 2004, Volume: 4, Issue:4 Topics: Anti-HIV Agents; Dideoxynucleotides; Humans; Nucleoside-Phosphate Kinase; Nucleotides; Phosphorylation; Prodrugs; Protein Conformation; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymine Nucleotides; Zidovudine	2004

Article

Year

Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase.

Mini reviews in medicinal chemistry, 2004, Volume: 4, Issue:4

Topics: Anti-HIV Agents; Dideoxynucleotides; Humans; Nucleoside-Phosphate Kinase; Nucleotides; Phosphorylation; Prodrugs; Protein Conformation; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymine Nucleotides; Zidovudine

2004

Trials

2 trial(s) available for 3'-azido-3'-deoxythymidine 5'phosphate and zidovudine

Article	Year
Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers. AIDS (London, England), 1994, Volume: 8, Issue:8 Topics: Acquired Immunodeficiency Syndrome; Adult; Biotransformation; Dideoxynucleotides; HIV Infections; HIV Seronegativity; Humans; Leukocytes, Mononuclear; Middle Aged; Phosphorylation; Reference Values; Thymine Nucleotides; Zidovudine	1994
Pharmacokinetics of zidovudine phosphorylation in human immunodeficiency virus-positive thai patients and healthy volunteers. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:7 Topics: Adult; Anti-HIV Agents; Dideoxynucleotides; Female; HIV Infections; Humans; Male; Phosphorylation; Reverse Transcriptase Inhibitors; Thailand; Thymine Nucleotides; Zidovudine	2000

Other Studies

88 other study(ies) available for 3'-azido-3'-deoxythymidine 5'phosphate and zidovudine

Article	Year
Improved brain delivery of AZT using a glycosyl phosphotriester prodrug. Journal of medicinal chemistry, 1992, Aug-07, Volume: 35, Issue:16 Topics: Animals; Brain; Chromatography, High Pressure Liquid; Esters; Half-Life; Male; Mice; Prodrugs; Synaptosomes; Zidovudine	1992
Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: intracellular delivery of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate. Journal of medicinal chemistry, 1995, Sep-29, Volume: 38, Issue:20 Topics: Antiviral Agents; Biological Transport; Cell Line; Dideoxynucleotides; Drug Stability; HIV-1; Thymine Nucleotides; Zidovudine	1995
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. Journal of medicinal chemistry, 2003, Aug-28, Volume: 46, Issue:18 Topics: Antitubercular Agents; Azides; Enzyme Inhibitors; Humans; Kinetics; Models, Molecular; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Nucleosides; Nucleotides; Structure-Activity Relationship; Thymidine Monophosphate	2003
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Bioorganic & medicinal chemistry letters, 2003, Sep-15, Volume: 13, Issue:18 Topics: Antitubercular Agents; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Structure-Activity Relationship; Thymidine; Thymine Nucleotides	2003
Comparison of the phosphorylation of 4'-ethynyl 2',3'-dihydro-3'-deoxythymidine with that of other anti-human immunodeficiency virus thymidine analogs. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:5 Topics: Anti-HIV Agents; Humans; Nucleoside-Phosphate Kinase; Phosphorylation; Stavudine; Structure-Activity Relationship; Zidovudine	2007
Aryl H-phosphonates 17: (N-aryl)phosphoramidates of pyrimidine nucleoside analogues and their synthesis, selected properties, and anti-HIV activity. Journal of medicinal chemistry, 2011, Oct-13, Volume: 54, Issue:19 Topics: Anti-HIV Agents; Cells, Cultured; HIV Reverse Transcriptase; HIV-1; Humans; Hydrophobic and Hydrophilic Interactions; Organophosphonates; Pyrimidine Nucleosides; Reverse Transcriptase Inhibitors; Structure-Activity Relationship	2011
Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase. Bioorganic & medicinal chemistry, 2011, Dec-15, Volume: 19, Issue:24 Topics: Humans; Models, Molecular; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Protein Kinase Inhibitors; Thymidine; Thymidine Monophosphate; Tuberculosis	2011
Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:11 Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dideoxynucleotides; Drug Stability; HIV Infections; Humans; Intracellular Fluid; Leukocytes, Mononuclear; Phosphorylation; Radioimmunoassay; Reproducibility of Results; Sensitivity and Specificity; Thymine Nucleotides; Tritium; Zidovudine	1992
Synthesis of sialic acid-containing nucleotide sugars: CMP-sialic acid analogs. Carbohydrate research, 1992, Feb-07, Volume: 224 Topics: Antiviral Agents; Cytidine Monophosphate; Dideoxynucleotides; N-Acetylneuraminic Acid; N-Acylneuraminate Cytidylyltransferase; Sialic Acids; Sialyltransferases; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine	1992
Inhibition of the RNase H activity of HIV reverse transcriptase by azidothymidylate. Biochemistry, 1991, May-21, Volume: 30, Issue:20 Topics: Antiviral Agents; Cloning, Molecular; Deoxyribonucleotides; Dideoxynucleotides; Endoribonucleases; Escherichia coli; HIV; Kinetics; Nucleic Acid Synthesis Inhibitors; Recombinant Proteins; Reverse Transcriptase Inhibitors; Ribonuclease H; Ribonucleotides; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine	1991
Intracellular metabolism of 3'-azidothymidine in isolated human peripheral blood mononuclear cells. AIDS research and human retroviruses, 1991, Volume: 7, Issue:9 Topics: Adult; Dideoxynucleotides; Female; Half-Life; HIV Infections; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Male; Middle Aged; Phosphorylation; Phytohemagglutinins; Thymine Nucleotides; Zidovudine	1991
A sensitive nonisotopic method for the determination of intracellular azidothymidine 5'-mono-, 5'-di-, and 5'-triphosphate. Analytical biochemistry, 1991, Aug-01, Volume: 196, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Intracellular Fluid; Leukocytes, Mononuclear; Microchemistry; Phosphorylation; Thymine Nucleotides; Zidovudine	1991
Thymidine and zidovudine metabolism in chronically zidovudine-exposed cells in vitro. Biochemical pharmacology, 1991, Jul-25, Volume: 42, Issue:4 Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Phosphorylation; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides; Time Factors; Zidovudine	1991
A method for the quantification of intracellular zidovudine nucleotides. The Journal of infectious diseases, 1991, Volume: 164, Issue:4 Topics: Alkaline Phosphatase; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Leukocytes, Mononuclear; Phosphorylation; Radioimmunoassay; Thymine Nucleotides; Zidovudine	1991
Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro. Biochemical pharmacology, 1990, Dec-15, Volume: 40, Issue:12 Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; Dideoxynucleotides; Drug Carriers; Glycoproteins; HIV Infections; Humans; In Vitro Techniques; Lysine; Serum Albumin; Thymine Nucleotides; Zidovudine	1990
Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates. Journal of medicinal chemistry, 1991, Volume: 34, Issue:3 Topics: Antiviral Agents; Dideoxynucleotides; Drug Carriers; Drug Stability; Glycoproteins; HIV-1; Hydrolysis; Mannose; Proteins; Serum Albumin; Thymine Nucleotides; Zidovudine	1991
Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs. Molecular pharmacology, 1990, Volume: 38, Issue:6 Topics: Antiviral Agents; Bone Marrow; Chromatography, High Pressure Liquid; Dideoxynucleotides; HIV; Humans; Leukocytes, Mononuclear; Thymine Nucleotides; Zidovudine	1990
Effects of granulocyte-macrophage colony-stimulating factor on 3'-azido-3'-deoxythymidine uptake, phosphorylation and nucleotide retention in human U-937 cells. Biochemical pharmacology, 1990, Dec-15, Volume: 40, Issue:12 Topics: Biological Transport; Cell Division; Dideoxynucleotides; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Monocytes; Phosphorylation; Thioinosine; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine	1990
In vitro measurement of phosphorylated zidovudine in peripheral blood leucocytes. Therapeutic drug monitoring, 1990, Volume: 12, Issue:5 Topics: Alkaline Phosphatase; Chromatography, High Pressure Liquid; Dideoxynucleotides; Dose-Response Relationship, Drug; Humans; Leukocytes; Phosphorylation; Radioimmunoassay; Thymine Nucleotides; Time Factors; Zidovudine	1990
Preparative-scale high-performance liquid chromatographic separation and purification of 3'-azido-3'-deoxythymidine-5'-phosphate. Journal of chromatography, 1990, Jan-19, Volume: 499 Topics: Chromatography, High Pressure Liquid; Dideoxynucleotides; Thymine Nucleotides; Zidovudine	1990
Relationship of deoxynucleotide changes to inhibition of DNA synthesis induced by the antiretroviral agent 3'-azido-3'-deoxythymidine and release of its monophosphate by human lymphoid cells (CCRF-CEM). Molecular pharmacology, 1990, Volume: 37, Issue:5 Topics: Cell Division; Cell Line; Chromatography, High Pressure Liquid; Deoxyribonucleotides; Dideoxynucleotides; DNA Replication; Flow Cytometry; Kinetics; T-Lymphocytes; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine	1990
Interaction of the 5'-phosphates of the anti-HIV agents, 3'-azido-3'-deoxythymidine and 3'-azido-2',3'-dideoxyuridine, with thymidylate synthase. Biochemical and biophysical research communications, 1988, Sep-30, Volume: 155, Issue:3 Topics: Animals; Antiviral Agents; Dideoxynucleotides; Hymenolepis; Leukemia L1210; Thymidylate Synthase; Thymine Nucleotides; Zidovudine	1988
Catalytically distinct conformations of the ribonuclease H of HIV-1 reverse transcriptase by substrate cleavage patterns and inhibition by azidothymidylate and N-ethylmaleimide. Biochemistry, 1994, Feb-15, Volume: 33, Issue:6 Topics: Catalysis; Cations, Divalent; Dideoxynucleotides; Ethylmaleimide; HIV Reverse Transcriptase; HIV-1; Kinetics; Magnesium; Manganese; Poly A; Poly C; Poly G; Poly T; Protein Conformation; Ribonuclease H; RNA-Directed DNA Polymerase; Substrate Specificity; Thymine Nucleotides; Zidovudine	1994
Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate. Biochemistry, 1994, Mar-01, Volume: 33, Issue:8 Topics: Antiviral Agents; Base Sequence; Dideoxynucleotides; Diphosphates; DNA Primers; HIV Reverse Transcriptase; HIV-1; Hydrolysis; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Substrate Specificity; Templates, Genetic; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine	1994
Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. The Journal of biological chemistry, 1995, Apr-28, Volume: 270, Issue:17 Topics: Antiviral Agents; Dideoxynucleotides; DNA Primers; HIV Reverse Transcriptase; HIV-1; Kinetics; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides; Zidovudine	1995
Optimization of the reaction conditions for the synthesis of neoglycoprotein-AZT-monophosphate conjugates. Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6 Topics: Antiviral Agents; Dideoxynucleotides; Drug Carriers; Glycoproteins; Humans; Lactose; Phosphorylation; Prodrugs; Serum Albumin; Thymine Nucleotides; Zidovudine	1995
Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T-lymph Biochemical pharmacology, 1995, Mar-15, Volume: 49, Issue:6 Topics: Blotting, Northern; Cell Cycle; Cell Division; Cell Line, Transformed; Cell Survival; Dideoxynucleotides; Half-Life; HIV-1; HIV-2; Humans; T-Lymphocytes; Thymine Nucleotides; Virus Replication; Zidovudine	1995
3'-Azido-3'-deoxythymidine cytotoxicity and metabolism in the human colon tumor cell line HCT-8. Biochemical pharmacology, 1994, Nov-01, Volume: 48, Issue:9 Topics: Cell Death; Colonic Neoplasms; Dideoxynucleotides; Humans; Thymidine Kinase; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine	1994
Inhibition of human immunodeficiency virus type 1 integrase by 3'-azido-3'-deoxythymidylate. Proceedings of the National Academy of Sciences of the United States of America, 1994, Jun-21, Volume: 91, Issue:13 Topics: Base Sequence; Dideoxynucleotides; DNA; DNA Nucleotidyltransferases; HIV-1; Integrases; Kinetics; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Recombinant Proteins; Sequence Deletion; Substrate Specificity; Thymine Nucleotides; Virus Integration; Zidovudine	1994
3'-Azido-3'-deoxythymidine potently inhibits protein glycosylation. A novel mechanism for AZT cytotoxicity. The Journal of biological chemistry, 1994, May-20, Volume: 269, Issue:20 Topics: Animals; CHO Cells; Cricetinae; Cytidine Monophosphate N-Acetylneuraminic Acid; Dideoxynucleotides; Glycosylation; Golgi Apparatus; HIV; HIV Infections; Humans; Intracellular Membranes; Kinetics; Membrane Proteins; Nucleoside Diphosphate Sugars; Protein Processing, Post-Translational; Thymine Nucleotides; Uridine Diphosphate Galactose; Uridine Diphosphate N-Acetylglucosamine; Zidovudine	1994
Reduction of 3'-azido-3'-deoxythymidine (AZT) and AZT nucleotides by thiols. Kinetics and product identification. The Journal of biological chemistry, 1994, Jun-10, Volume: 269, Issue:23 Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Dideoxynucleotides; Hydrogen-Ion Concentration; Models, Chemical; Nucleotides; Oxidation-Reduction; Sulfhydryl Compounds; Thymine Nucleotides; Zidovudine	1994
Electrochemical reduction products of azido nucleosides, including zidovudine (AZT): mechanisms and relevance to their intracellular metabolism. Acta biochimica Polonica, 1993, Volume: 40, Issue:2 Topics: Antiviral Agents; Dideoxynucleotides; Electrochemistry; Electrolysis; Intracellular Fluid; Nucleosides; Oxidation-Reduction; Polarography; Thymine Nucleotides; Zidovudine	1993
5'-Hydrogenphosphonates of anti-HIV nucleoside analogues revisited: controversial mode of action. Antiviral research, 1993, Volume: 22, Issue:2-3 Topics: Cell Line; Dideoxynucleotides; Drug Stability; HIV-1; Humans; Prodrugs; T-Lymphocytes; Thymine Nucleotides; Virus Replication; Zidovudine	1993
Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process. Antiviral research, 1993, Volume: 22, Issue:2-3 Topics: Adenine; Antiviral Agents; B-Lymphocytes; Cell Line; Dideoxynucleosides; Dideoxynucleotides; Esters; HIV-1; Humans; Organophosphonates; Oxidoreductases; Prodrugs; T-Lymphocytes; Thymine Nucleotides; Uridine Monophosphate; Zidovudine	1993
Effects of 3'-azido-3'-deoxythymidine metabolites on simian virus 40 origin-dependent replication and heteroduplex repair in HeLa cell extracts. Molecular pharmacology, 1993, Volume: 43, Issue:1 Topics: Antiviral Agents; Dideoxynucleotides; DNA; DNA Repair; HeLa Cells; Humans; Simian virus 40; Thymine Nucleotides; Virus Replication; Zidovudine	1993
Inhibition of mammalian DNA polymerase-associated 3' to 5' exonuclease activity by 5'-monophosphates of 3'-azido-3'-deoxythymidine and 3'-amino-3'-deoxythymidine. Biochemical pharmacology, 1993, Apr-22, Volume: 45, Issue:8 Topics: Animals; Cattle; Dideoxynucleotides; DNA Replication; Exonucleases; Nucleic Acid Synthesis Inhibitors; Thymidine Monophosphate; Thymine Nucleotides; Thymus Gland; Zidovudine	1993
3'-azido-3'-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:4 Topics: Cell Line; Dideoxynucleotides; DNA Repair; DNA, Single-Stranded; Exonucleases; Humans; Hydrolysis; Thymine Nucleotides; Zidovudine	1993
Fidelity studies of the human DNA polymerase alpha. The most conserved region among alpha-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis. The Journal of biological chemistry, 1993, May-25, Volume: 268, Issue:15 Topics: Base Sequence; Dideoxynucleotides; DNA; DNA Polymerase II; DNA Replication; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Recombinant Proteins; Substrate Specificity; Templates, Genetic; Thymine Nucleotides; Zidovudine	1993
NMR study of dideoxynucleotides with anti-human immunodeficiency virus (HIV) activity. Journal of biochemical and biophysical methods, 1996, Feb-05, Volume: 31, Issue:3-4 Topics: Antiviral Agents; Dideoxynucleotides; HIV; Humans; Inosine Triphosphate; Magnetic Resonance Spectroscopy; Models, Theoretical; Molecular Conformation; Molecular Structure; Thymine Nucleotides; Zidovudine	1996
Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules. Proceedings of the National Academy of Sciences of the United States of America, 1996, Sep-03, Volume: 93, Issue:18 Topics: Anthraquinones; Antiviral Agents; Base Sequence; Dideoxynucleotides; DNA; DNA Nucleotidyltransferases; DNA, Complementary; Escherichia coli; HIV-1; Integrases; Molecular Sequence Data; RNA, Viral; Thymine Nucleotides; Topoisomerase I Inhibitors; Virus Integration; Virus Replication; Zidovudine	1996
The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites. AIDS (London, England), 1996, Volume: 10, Issue:12 Topics: Adult; Antiviral Agents; Chromatography, High Pressure Liquid; Dideoxynucleotides; Dose-Response Relationship, Drug; HIV-1; Humans; Male; Phosphorylation; Radioimmunoassay; Thymine Nucleotides; Virus Replication; Zidovudine	1996
AZT monophosphate knocks thymidylate kinase for a loop. Nature structural biology, 1997, Volume: 4, Issue:8 Topics: Dideoxynucleotides; Drug Design; Models, Molecular; Nucleoside-Phosphate Kinase; Prodrugs; Protein Conformation; Thymidine Monophosphate; Thymine Nucleotides; Transcription, Genetic; Zidovudine	1997
Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation. Nature structural biology, 1997, Volume: 4, Issue:8 Topics: Computer Simulation; Crystallography; Dideoxynucleotides; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Motion; Nucleoside-Phosphate Kinase; Phosphorylation; Prodrugs; Saccharomyces cerevisiae; Substrate Specificity; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine	1997
Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance. Biochemistry, 1997, Nov-18, Volume: 36, Issue:46 Topics: Anti-HIV Agents; Dideoxynucleotides; Drug Resistance; HIV Reverse Transcriptase; HIV-1; Kinetics; Mutation; Reverse Transcriptase Inhibitors; Ribonuclease H; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine	1997
Identification of a nucleotide binding site in HIV-1 integrase. Proceedings of the National Academy of Sciences of the United States of America, 1998, Apr-14, Volume: 95, Issue:8 Topics: Affinity Labels; Amino Acid Sequence; Base Sequence; Binding Sites; Computer Simulation; Conserved Sequence; Dideoxynucleotides; DNA Primers; HIV Integrase; HIV-1; Hydrogen Bonding; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Peptide Fragments; Protein Structure, Secondary; Recombinant Proteins; Thymine Nucleotides; Virus Replication; Zidovudine	1998
Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer. The Journal of biological chemistry, 1998, Jun-05, Volume: 273, Issue:23 Topics: Cross-Linking Reagents; Dideoxynucleotides; DNA Primers; Drug Resistance; Exodeoxyribonucleases; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides; Zidovudine	1998
Monitoring of intracellular levels of 5'-monophosphate-AZT using an enzyme immunoassay. Journal of immunological methods, 1998, Sep-01, Volume: 218, Issue:1-2 Topics: Dideoxynucleotides; Haptens; HIV Seronegativity; Humans; Immunoenzyme Techniques; Leukocytes, Mononuclear; Sensitivity and Specificity; Thymine Nucleotides; Zidovudine	1998
Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged human serum albumins (NCAs) and AZT. Journal of drug targeting, 1999, Volume: 6, Issue:5 Topics: Aconitic Acid; Anti-HIV Agents; Anticoagulants; Cell Culture Techniques; Dideoxynucleotides; Drug Combinations; Drug Stability; Drug Synergism; Giant Cells; Humans; Serum Albumin; Serum Albumin, Human; Static Electricity; T-Lymphocytes; Thymine Nucleotides; Time Factors; Zidovudine	1999
A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase. Molecular cell, 1999, Volume: 4, Issue:1 Topics: Adenosine Triphosphate; Deoxyadenine Nucleotides; Dideoxynucleotides; Dinucleoside Phosphates; DNA Primers; Drug Resistance; HIV Reverse Transcriptase; Kinetics; Mutation; Nucleotides; Templates, Genetic; Thymine Nucleotides; Zidovudine	1999
The highly similar TMP kinases of Yersinia pestis and Escherichia coli differ markedly in their AZTMP phosphorylating activity. European journal of biochemistry, 1999, Oct-01, Volume: 265, Issue:1 Topics: Amino Acid Sequence; Cloning, Molecular; Dideoxynucleotides; Enzyme Stability; Escherichia coli; Molecular Sequence Data; Nucleoside-Phosphate Kinase; Phosphorylation; Polymerase Chain Reaction; Recombinant Proteins; Sequence Homology, Amino Acid; Species Specificity; Substrate Specificity; Thymine Nucleotides; Yersinia; Yersinia pestis; Zidovudine	1999
Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine. Molecular pharmacology, 1999, Volume: 56, Issue:4 Topics: Amino Acids; Animals; Anti-HIV Agents; Biotransformation; Dideoxynucleotides; Drug Design; Esterases; Esters; HIV; Humans; Liver; Male; Mice; Nucleosides; Prodrugs; Rats; Rats, Wistar; Reverse Transcriptase Inhibitors; Stavudine; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine	1999
Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants. The Journal of infectious diseases, 1999, Volume: 180, Issue:6 Topics: Adolescent; Adult; Anti-HIV Agents; Dideoxynucleotides; Female; Fetal Blood; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Phosphorylation; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine	1999
Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine). Molecular pharmacology, 1999, Volume: 56, Issue:6 Topics: Anti-HIV Agents; Cell Line; Culture Media; Dideoxynucleotides; Drug Stability; Humans; Hydrogen-Ion Concentration; Organophosphates; Prodrugs; Stavudine; Thymidine Kinase; Thymine Nucleotides; Tritium; Tumor Cells, Cultured; Zidovudine	1999
Modifying human thymidylate kinase to potentiate azidothymidine activation. The Journal of biological chemistry, 1999, Dec-10, Volume: 274, Issue:50 Topics: Amino Acid Sequence; Amino Acid Substitution; Cloning, Molecular; Dideoxynucleotides; Escherichia coli; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleoside-Phosphate Kinase; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Thymine Nucleotides; Zidovudine	1999
Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP. Molecular pharmacology, 2000, Volume: 58, Issue:5 Topics: 5'-Nucleotidase; Anti-HIV Agents; Culture Media; Dideoxynucleotides; Half-Life; Humans; Hydrogen-Ion Concentration; Leukocytes, Mononuclear; Macrophages; Monocytes; Stavudine; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides; Time Factors; Tritium; Tumor Cells, Cultured; Zidovudine	2000
Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. Journal of molecular biology, 2000, Nov-17, Volume: 304, Issue:1 Topics: Anti-HIV Agents; Binding Sites; Catalysis; Crystallography, X-Ray; Dideoxynucleotides; Enzyme Stability; Escherichia coli; Humans; Kinetics; Models, Molecular; Mutation; Nucleoside-Phosphate Kinase; Nucleotides; Phosphorylation; Prodrugs; Protein Binding; Protein Conformation; Recombinant Fusion Proteins; Thymine Nucleotides; Zidovudine	2000
Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:12 Topics: Adenosine Triphosphate; Dideoxynucleotides; DNA Primers; HIV Reverse Transcriptase; Reverse Transcriptase Inhibitors; Stavudine; Templates, Genetic; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine	2000
Zidovudine phosphorylation determined sequentially over 12 months in human immunodeficiency virus-infected patients with or without previous exposure to antiretroviral agents. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:3 Topics: Adult; Anti-HIV Agents; Dideoxynucleotides; Female; HIV; HIV Infections; Humans; Longitudinal Studies; Male; Middle Aged; Phosphorylation; Thymine Nucleotides; Zidovudine	2001
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase. Journal of virology, 2001, Volume: 75, Issue:10 Topics: Adenosine Triphosphate; Anti-HIV Agents; Dideoxynucleotides; Drug Resistance; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Mutagenesis; Protein Conformation; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine	2001
Low-dose, sublingual AZT-monophosphate therapy for HIV+ patients? Medical hypotheses, 2001, Volume: 56, Issue:3 Topics: Administration, Sublingual; Anti-HIV Agents; Dideoxynucleotides; HIV; HIV Infections; HIV Seropositivity; Humans; Models, Biological; Thymidine Kinase; Thymine Nucleotides; Virus Replication; Zidovudine	2001
Phosphorylated zidovudine concentrations in mononuclear cells in pediatric patients with human immunodeficiency virus infections. Pediatric AIDS and HIV infection, 1997, Volume: 8, Issue:2 Topics: Adolescent; Anti-HIV Agents; Biological Availability; Child; Child, Preschool; Dideoxynucleotides; Dose-Response Relationship, Drug; Female; HIV Infections; Humans; Male; Monocytes; Phosphorylation; Thymine Nucleotides; Treatment Outcome; Zidovudine	1997
The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1. Journal of virology, 2002, Volume: 76, Issue:7 Topics: Adenosine Triphosphate; Dideoxynucleotides; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Mutation; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine	2002
Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision. Journal of virology, 2002, Volume: 76, Issue:18 Topics: Adenosine Triphosphate; Anti-HIV Agents; Dideoxynucleotides; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine	2002
Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-kappa B. Blood, 2003, Mar-15, Volume: 101, Issue:6 Topics: Adult; Apoptosis; Apoptosis Regulatory Proteins; Dideoxynucleotides; Gene Expression; Herpesvirus 8, Human; Humans; I-kappa B Kinase; I-kappa B Proteins; Interferon-alpha; Lymphoma, AIDS-Related; Male; Membrane Glycoproteins; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Serine-Threonine Kinases; Remission Induction; RNA, Messenger; Thymine Nucleotides; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Zidovudine	2003
Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA. The EMBO journal, 2002, Dec-02, Volume: 21, Issue:23 Topics: Dideoxynucleotides; DNA; Drug Resistance, Viral; HIV-1; Humans; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine	2002
Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase. Journal of virology, 2003, Volume: 77, Issue:11 Topics: Antiviral Agents; Binding Sites; Cell Line; Deoxyadenine Nucleotides; Dideoxynucleotides; Diphosphates; DNA Primers; Drug Resistance, Viral; Foscarnet; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Templates, Genetic; Thymine Nucleotides; Zidovudine	2003
The Y181C substitution in 3'-azido-3'-deoxythymidine-resistant human immunodeficiency virus, type 1, reverse transcriptase suppresses the ATP-mediated repair of the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer. The Journal of biological chemistry, 2003, Oct-17, Volume: 278, Issue:42 Topics: Adenosine Triphosphate; Anti-HIV Agents; Bacteriophages; Dideoxynucleotides; DNA; DNA Primers; DNA Repair; Drug Resistance, Viral; HIV Reverse Transcriptase; Kinetics; Thymine Nucleotides; Time Factors; Zidovudine	2003
Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate. The Journal of biological chemistry, 2003, Oct-24, Volume: 278, Issue:43 Topics: Adenosine Triphosphate; Anti-HIV Agents; Dideoxynucleotides; Diphosphates; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; HIV Reverse Transcriptase; Humans; Mutation, Missense; Nevirapine; Phosphorylation; Protein Subunits; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine	2003
Sensitive nonradiometric method for determining thymidine kinase 1 activity. Clinical chemistry, 2004, Volume: 50, Issue:9 Topics: Biomarkers, Tumor; Breast Neoplasms; Dideoxynucleotides; Female; HeLa Cells; Hematologic Neoplasms; Humans; Immunoenzyme Techniques; Prohibitins; Regression Analysis; Reproducibility of Results; Thymidine Kinase; Thymine Nucleotides; Zidovudine	2004
Intracellular metabolism and pharmacokinetics of 5'-hydrogenphosphonate of 3'-azido-2',3'-dideoxythymidine, a prodrug of 3'-azido-2',3'-dideoxythymidine. Antiviral research, 2004, Volume: 63, Issue:2 Topics: Administration, Oral; Animals; Anti-HIV Agents; Brain; Dideoxynucleotides; Dihydropyridines; Gastric Mucosa; HL-60 Cells; Humans; Injections, Intravenous; Intestinal Mucosa; Liver; Mice; Muscles; Prodrugs; Spleen; Thymine Nucleotides; Tissue Distribution; Zidovudine	2004
Pro-oxidant properties and cytotoxicity of AZT-monophosphate and AZT. Cardiovascular toxicology, 2004, Volume: 4, Issue:2 Topics: Animals; Aorta; Cattle; Cell Survival; Cells, Cultured; Dideoxynucleotides; Endothelial Cells; Endothelium, Vascular; Free Radicals; Glutathione; In Vitro Techniques; Intracellular Membranes; Lipid Peroxidation; Magnesium; Microsomes, Liver; Molsidomine; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thymidine; Thymine Nucleotides; Zidovudine	2004
Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity. Cardiovascular toxicology, 2004, Volume: 4, Issue:2 Topics: Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biological Transport; Chromatography, High Pressure Liquid; Dideoxynucleotides; DNA, Mitochondrial; In Vitro Techniques; Mitochondria, Heart; Phosphorylation; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Thymidine; Thymine Nucleotides; Time Factors; Zidovudine	2004
Simultaneous quantitation of zidovudine and zidovudine monophosphate from plasma, amniotic fluid and tissues by micellar capillary electrophoresis. Biomedical chromatography : BMC, 2004, Volume: 18, Issue:8 Topics: Amniotic Fluid; Animals; Dideoxynucleotides; Electrophoresis, Capillary; Female; Fetus; Micelles; Placenta; Pregnancy; Protein Denaturation; Rats; Sensitivity and Specificity; Solvents; Thymine Nucleotides; Zidovudine	2004
The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition. Biochemistry, 2005, Jan-11, Volume: 44, Issue:1 Topics: Binding Sites; Binding, Competitive; Dideoxynucleotides; DNA Replication; Kinetics; Models, Molecular; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Protein Conformation; Thymine Nucleotides; Zidovudine	2005
Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues. Journal of molecular biology, 2005, Jun-10, Volume: 349, Issue:3 Topics: Adenosine Triphosphate; Boron Compounds; Dideoxynucleotides; Drug Resistance, Multiple, Viral; HIV-1; Humans; Kinetics; Mutation; Phosphorylation; RNA-Directed DNA Polymerase; Stavudine; Thymidine; Thymine Nucleotides; Time Factors; Zidovudine	2005
Synthesis of carbocyclic nucleotides as potential substrates for thymidylate kinase. Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:5-7 Topics: Antineoplastic Agents; Antiviral Agents; Carbon; Catalysis; Chemistry, Pharmaceutical; Dideoxynucleotides; Drug Design; Hydrolysis; Models, Chemical; Nucleoside-Phosphate Kinase; Nucleotides; Substrate Specificity; Thymine Nucleotides; Zidovudine	2005
AZT and AZT-monophosphate prodrugs incorporating HIV-protease substrate fragment: synthesis and evaluation as specific drug delivery systems. Antiviral chemistry & chemotherapy, 2006, Volume: 17, Issue:4 Topics: Amides; Anti-HIV Agents; Cells, Cultured; Dideoxynucleotides; Drug Delivery Systems; Drug Evaluation; Drug Stability; Esters; HIV Infections; HIV Protease; HIV-1; Humans; Inhibitory Concentration 50; Models, Biological; Phosphoric Acids; Prodrugs; Protease Inhibitors; Thymidine Kinase; Thymine Nucleotides; Zidovudine	2006
Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1 Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Cytidine Triphosphate; Dideoxynucleosides; Dideoxynucleotides; Drug Resistance, Multiple, Viral; Genotype; Glutamic Acid; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Lysine; Mutagenesis, Site-Directed; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; Tenofovir; Thymine Nucleotides; Zidovudine	2007
3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase. Biochemistry, 2007, Jan-23, Volume: 46, Issue:3 Topics: Adenosine Triphosphate; Dideoxynucleotides; HIV Reverse Transcriptase; Kinetics; Thymine Nucleotides; Zidovudine	2007
Improved method to quantify intracellular zidovudine mono- and triphosphate in peripheral blood mononuclear cells by liquid chromatography-tandem mass spectrometry. Journal of mass spectrometry : JMS, 2007, Volume: 42, Issue:3 Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Leukocytes, Mononuclear; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Thymine Nucleotides; Zidovudine	2007
Quantification of zidovudine and its monophosphate in cell extracts by on-line solid-phase extraction coupled to liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Oct-15, Volume: 858, Issue:1-2 Topics: Chromatography, High Pressure Liquid; Dideoxynucleotides; Molecular Structure; Reproducibility of Results; Solid Phase Extraction; Thymine Nucleotides; Zidovudine	2007
AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP. Nucleic acids research, 2008, Volume: 36, Issue:3 Topics: Adenosine Triphosphate; Amino Acid Sequence; Dideoxynucleotides; DNA; Drug Resistance, Viral; Escherichia coli; Kinetics; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA; RNA-Directed DNA Polymerase; Sequence Alignment; Spumavirus; Thymine Nucleotides; Zidovudine	2008
High levels of zidovudine (AZT) and its intracellular phosphate metabolites in AZT- and AZT-lamivudine-treated newborns of human immunodeficiency virus-infected mothers. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7 Topics: Anti-HIV Agents; Dideoxynucleotides; Female; Follow-Up Studies; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Leukocytes, Mononuclear; Male; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Thymine Nucleotides; Zidovudine	2008
Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation. Bioorganic & medicinal chemistry, 2008, Oct-01, Volume: 16, Issue:19 Topics: Adenosine Triphosphate; Anti-HIV Agents; Catalysis; Cell Line, Tumor; Dideoxynucleotides; Diphosphonates; DNA Primers; Enzyme Inhibitors; Halogens; HIV Reverse Transcriptase; Humans; Inhibitory Concentration 50; Phosphoric Acids; Quantitative Structure-Activity Relationship; Regression Analysis; Thymine Nucleotides; Zidovudine	2008
Decomposition of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate (AZTMP) prodrugs in biological media studied by on-line solid-phase extraction coupled to liquid chromatography mass spectrometry. Biomedical chromatography : BMC, 2009, Volume: 23, Issue:11 Topics: Biological Products; Chromatography, Liquid; Dideoxynucleotides; Drug Stability; Mass Spectrometry; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Solubility; Thymine Nucleotides; Zidovudine	2009
Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase. The Biochemical journal, 2010, May-27, Volume: 428, Issue:3 Topics: Deoxyguanine Nucleotides; Dideoxynucleotides; Kinetics; Nucleoside-Phosphate Kinase; Phosphorylation; Plasmodium falciparum; Substrate Specificity; Thymine Nucleotides; Zidovudine	2010
A role of template cleavage in reduced excision of chain-terminating nucleotides by human immunodeficiency virus type 1 reverse transcriptase containing the M184V mutation. Journal of virology, 2012, Volume: 86, Issue:9 Topics: Adenosine Triphosphate; Dideoxynucleotides; DNA Primers; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Nucleotides; Ribonuclease H; RNA, Viral; Thymine Nucleotides; Zidovudine	2012
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors. Nucleic acids research, 2016, Mar-18, Volume: 44, Issue:5 Topics: Amino Acid Sequence; Amino Acid Substitution; Anti-HIV Agents; Cloning, Molecular; Dideoxynucleotides; Drug Resistance, Multiple, Viral; Enzyme Inhibitors; Escherichia coli; Gene Expression; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Recombinant Proteins; Ribonuclease H, Human Immunodeficiency Virus; Thymine Nucleotides; Zidovudine	2016