3'-azido-3'-deoxythymidine 5'phosphate and zidovudine triphosphate

3'-azido-3'-deoxythymidine 5'phosphate has been researched along with zidovudine triphosphate in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	19 (67.86)	18.2507
2000's	8 (28.57)	29.6817
2010's	1 (3.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Götte, M; Ly, JK; Marchand, B; Margot, NA; McDermott, M; Miller, MD; Wang, R; White, KL	1
Mellors, JW; Radzio, J; Sheen, CW; Sluis-Cremer, N; Zelina, S	1
Hamzeh, FM; Kornhauser, DM; Kuwahara, SK; Lewis, LD; Lietman, PS; Slusher, JT	1
Britton, S; Eriksson, S; Jacobsson, B; Törnevik, Y	1
Kimura, S; Muramatsu, S; Shimada, K; Takahagi, H; Toyoshima, T	1
Joos, B; Kuster, H; Lüthy, R; Nadai, V; Vogt, M	1
Ashmun, R; Connelly, MC; Fridland, A	1
Carroll, SS; Geib, J; Kuo, LC; Olsen, DB; Shafer, JA; Stahlhut, M	1
Beard, WA; Jaju, M; Wilson, SH	1
Balzarini, J; Eriksson, S; Törnevik, Y; Ullman, B; Wahren, B	1
Darnowski, JW; Goulette, FA	1
Back, D; Barry, M; Beeching, N; Breckenridge, A; Carey, P; Fox, R; Nye, F; Timmins, D; Veal, G; Wild, M	1
Hall, ET; Kuchta, RD; Melançon, P; Yan, JP	1
Crouch, RC; Reardon, JE; St John-Williams, L	1
Bebenek, K; Eckstein, F; Kunkel, TA; Roberts, JD; Thomas, DC	1
Jagannadh, B; Kunwar, AC; Reddy, DV	1
Back, DJ; Barry, MG; Breckenridge, AM; Gibbons, SE; Hoggard, PG; Khoo, SH; Veal, GJ; Wilkins, EG; Williams, O	1
Canard, B; Richardson, CC; Sarfati, SR	1
Bardeguez, AD; Blanchard, S; Flynn, PM; Fridland, A; Jimenez, E; Robbins, B; Rodman, JH; Rodriguez, JF	1
Back, DJ; Barry, MG; Dann, L; Gibbons, SE; Hoggard, PG; Khoo, SH; Lloyd, J; Loveday, C; Wilkins, EG	1
Baker, RC; Brady, MT; Hunkler, JA; McOwen, NM; Nahata, MC; Sobol, BJ; Wintermeyer, SM	1
Andréola, M; Cruchaga, C; Dollé, V; Martínez-Irujo, JJ; Nguyen, CH; Odriozola, L; Pérez-Mediavilla, A; Tarrago-Litvak, L	1
Canard, B; Deval, J; Guerreiro, C; Matamoros, T; Menéndez-Arias, L; Mulard, L	1
Benech, H; Compain, S; Durand-Gasselin, L; Grassi, J	1
Frohn, A; Hartl, MJ; Kretzschmar, B; Nowrouzi, A; Rethwilm, A; Wöhrl, BM	1
Bénech, H; Dehée, A; Dollfus, C; Durand-Gasselin, L; Garbarg-Chenon, A; Grassi, J; Leverger, G; Pruvost, A; Tabone, MD; Vaudre, G	1
Bodem, J; Buchholz, B; Corona, A; Di Santo, R; Jordan, M; Maccioni, E; Schneider, A; Spöring, I; Tramontano, E; Wöhrl, BM	1
Dhawan, RK; Kharbanda, S; Kufe, D; Nakamura, M; Ohno, T	1

Trials

1 trial(s) available for 3'-azido-3'-deoxythymidine 5'phosphate and zidovudine triphosphate

Article	Year
Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers. AIDS (London, England), 1994, Volume: 8, Issue:8 Topics: Acquired Immunodeficiency Syndrome; Adult; Biotransformation; Dideoxynucleotides; HIV Infections; HIV Seronegativity; Humans; Leukocytes, Mononuclear; Middle Aged; Phosphorylation; Reference Values; Thymine Nucleotides; Zidovudine	1994

Other Studies

27 other study(ies) available for 3'-azido-3'-deoxythymidine 5'phosphate and zidovudine triphosphate

Article	Year
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8 Topics: Adenine; Adenosine Triphosphate; Anti-HIV Agents; Base Sequence; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine	2007
Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:1 Topics: Anti-HIV Agents; Drug Resistance, Multiple, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Lamivudine; Models, Molecular; Mutation; Reverse Transcriptase Inhibitors; Thermodynamics; Zidovudine	2008
Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:11 Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dideoxynucleotides; Drug Stability; HIV Infections; Humans; Intracellular Fluid; Leukocytes, Mononuclear; Phosphorylation; Radioimmunoassay; Reproducibility of Results; Sensitivity and Specificity; Thymine Nucleotides; Tritium; Zidovudine	1992
Intracellular metabolism of 3'-azidothymidine in isolated human peripheral blood mononuclear cells. AIDS research and human retroviruses, 1991, Volume: 7, Issue:9 Topics: Adult; Dideoxynucleotides; Female; Half-Life; HIV Infections; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Male; Middle Aged; Phosphorylation; Phytohemagglutinins; Thymine Nucleotides; Zidovudine	1991
A sensitive nonisotopic method for the determination of intracellular azidothymidine 5'-mono-, 5'-di-, and 5'-triphosphate. Analytical biochemistry, 1991, Aug-01, Volume: 196, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Intracellular Fluid; Leukocytes, Mononuclear; Microchemistry; Phosphorylation; Thymine Nucleotides; Zidovudine	1991
A method for the quantification of intracellular zidovudine nucleotides. The Journal of infectious diseases, 1991, Volume: 164, Issue:4 Topics: Alkaline Phosphatase; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Leukocytes, Mononuclear; Phosphorylation; Radioimmunoassay; Thymine Nucleotides; Zidovudine	1991
Relationship of deoxynucleotide changes to inhibition of DNA synthesis induced by the antiretroviral agent 3'-azido-3'-deoxythymidine and release of its monophosphate by human lymphoid cells (CCRF-CEM). Molecular pharmacology, 1990, Volume: 37, Issue:5 Topics: Cell Division; Cell Line; Chromatography, High Pressure Liquid; Deoxyribonucleotides; Dideoxynucleotides; DNA Replication; Flow Cytometry; Kinetics; T-Lymphocytes; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine	1990
Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate. Biochemistry, 1994, Mar-01, Volume: 33, Issue:8 Topics: Antiviral Agents; Base Sequence; Dideoxynucleotides; Diphosphates; DNA Primers; HIV Reverse Transcriptase; HIV-1; Hydrolysis; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Substrate Specificity; Templates, Genetic; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine	1994
Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. The Journal of biological chemistry, 1995, Apr-28, Volume: 270, Issue:17 Topics: Antiviral Agents; Dideoxynucleotides; DNA Primers; HIV Reverse Transcriptase; HIV-1; Kinetics; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides; Zidovudine	1995
Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T-lymph Biochemical pharmacology, 1995, Mar-15, Volume: 49, Issue:6 Topics: Blotting, Northern; Cell Cycle; Cell Division; Cell Line, Transformed; Cell Survival; Dideoxynucleotides; Half-Life; HIV-1; HIV-2; Humans; T-Lymphocytes; Thymine Nucleotides; Virus Replication; Zidovudine	1995
3'-Azido-3'-deoxythymidine cytotoxicity and metabolism in the human colon tumor cell line HCT-8. Biochemical pharmacology, 1994, Nov-01, Volume: 48, Issue:9 Topics: Cell Death; Colonic Neoplasms; Dideoxynucleotides; Humans; Thymidine Kinase; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine	1994
3'-Azido-3'-deoxythymidine potently inhibits protein glycosylation. A novel mechanism for AZT cytotoxicity. The Journal of biological chemistry, 1994, May-20, Volume: 269, Issue:20 Topics: Animals; CHO Cells; Cricetinae; Cytidine Monophosphate N-Acetylneuraminic Acid; Dideoxynucleotides; Glycosylation; Golgi Apparatus; HIV; HIV Infections; Humans; Intracellular Membranes; Kinetics; Membrane Proteins; Nucleoside Diphosphate Sugars; Protein Processing, Post-Translational; Thymine Nucleotides; Uridine Diphosphate Galactose; Uridine Diphosphate N-Acetylglucosamine; Zidovudine	1994
Reduction of 3'-azido-3'-deoxythymidine (AZT) and AZT nucleotides by thiols. Kinetics and product identification. The Journal of biological chemistry, 1994, Jun-10, Volume: 269, Issue:23 Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Dideoxynucleotides; Hydrogen-Ion Concentration; Models, Chemical; Nucleotides; Oxidation-Reduction; Sulfhydryl Compounds; Thymine Nucleotides; Zidovudine	1994
Effects of 3'-azido-3'-deoxythymidine metabolites on simian virus 40 origin-dependent replication and heteroduplex repair in HeLa cell extracts. Molecular pharmacology, 1993, Volume: 43, Issue:1 Topics: Antiviral Agents; Dideoxynucleotides; DNA; DNA Repair; HeLa Cells; Humans; Simian virus 40; Thymine Nucleotides; Virus Replication; Zidovudine	1993
NMR study of dideoxynucleotides with anti-human immunodeficiency virus (HIV) activity. Journal of biochemical and biophysical methods, 1996, Feb-05, Volume: 31, Issue:3-4 Topics: Antiviral Agents; Dideoxynucleotides; HIV; Humans; Inosine Triphosphate; Magnetic Resonance Spectroscopy; Models, Theoretical; Molecular Conformation; Molecular Structure; Thymine Nucleotides; Zidovudine	1996
The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites. AIDS (London, England), 1996, Volume: 10, Issue:12 Topics: Adult; Antiviral Agents; Chromatography, High Pressure Liquid; Dideoxynucleotides; Dose-Response Relationship, Drug; HIV-1; Humans; Male; Phosphorylation; Radioimmunoassay; Thymine Nucleotides; Virus Replication; Zidovudine	1996
Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer. The Journal of biological chemistry, 1998, Jun-05, Volume: 273, Issue:23 Topics: Cross-Linking Reagents; Dideoxynucleotides; DNA Primers; Drug Resistance; Exodeoxyribonucleases; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides; Zidovudine	1998
Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants. The Journal of infectious diseases, 1999, Volume: 180, Issue:6 Topics: Adolescent; Adult; Anti-HIV Agents; Dideoxynucleotides; Female; Fetal Blood; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Phosphorylation; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine	1999
Zidovudine phosphorylation determined sequentially over 12 months in human immunodeficiency virus-infected patients with or without previous exposure to antiretroviral agents. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:3 Topics: Adult; Anti-HIV Agents; Dideoxynucleotides; Female; HIV; HIV Infections; Humans; Longitudinal Studies; Male; Middle Aged; Phosphorylation; Thymine Nucleotides; Zidovudine	2001
Phosphorylated zidovudine concentrations in mononuclear cells in pediatric patients with human immunodeficiency virus infections. Pediatric AIDS and HIV infection, 1997, Volume: 8, Issue:2 Topics: Adolescent; Anti-HIV Agents; Biological Availability; Child; Child, Preschool; Dideoxynucleotides; Dose-Response Relationship, Drug; Female; HIV Infections; Humans; Male; Monocytes; Phosphorylation; Thymine Nucleotides; Treatment Outcome; Zidovudine	1997
Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate. The Journal of biological chemistry, 2003, Oct-24, Volume: 278, Issue:43 Topics: Adenosine Triphosphate; Anti-HIV Agents; Dideoxynucleotides; Diphosphates; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; HIV Reverse Transcriptase; Humans; Mutation, Missense; Nevirapine; Phosphorylation; Protein Subunits; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine	2003
Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues. Journal of molecular biology, 2005, Jun-10, Volume: 349, Issue:3 Topics: Adenosine Triphosphate; Boron Compounds; Dideoxynucleotides; Drug Resistance, Multiple, Viral; HIV-1; Humans; Kinetics; Mutation; Phosphorylation; RNA-Directed DNA Polymerase; Stavudine; Thymidine; Thymine Nucleotides; Time Factors; Zidovudine	2005
Improved method to quantify intracellular zidovudine mono- and triphosphate in peripheral blood mononuclear cells by liquid chromatography-tandem mass spectrometry. Journal of mass spectrometry : JMS, 2007, Volume: 42, Issue:3 Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Leukocytes, Mononuclear; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Thymine Nucleotides; Zidovudine	2007
AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP. Nucleic acids research, 2008, Volume: 36, Issue:3 Topics: Adenosine Triphosphate; Amino Acid Sequence; Dideoxynucleotides; DNA; Drug Resistance, Viral; Escherichia coli; Kinetics; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA; RNA-Directed DNA Polymerase; Sequence Alignment; Spumavirus; Thymine Nucleotides; Zidovudine	2008
High levels of zidovudine (AZT) and its intracellular phosphate metabolites in AZT- and AZT-lamivudine-treated newborns of human immunodeficiency virus-infected mothers. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7 Topics: Anti-HIV Agents; Dideoxynucleotides; Female; Follow-Up Studies; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Leukocytes, Mononuclear; Male; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Thymine Nucleotides; Zidovudine	2008
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors. Nucleic acids research, 2016, Mar-18, Volume: 44, Issue:5 Topics: Amino Acid Sequence; Amino Acid Substitution; Anti-HIV Agents; Cloning, Molecular; Dideoxynucleotides; Drug Resistance, Multiple, Viral; Enzyme Inhibitors; Escherichia coli; Gene Expression; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Recombinant Proteins; Ribonuclease H, Human Immunodeficiency Virus; Thymine Nucleotides; Zidovudine	2016
Effects of granulocyte-macrophage colony-stimulating factor on 3'-azido-3'-deoxythymidine uptake, phosphorylation and nucleotide retention in human U-937 cells. Biochemical pharmacology, 1990, Dec-15, Volume: 40, Issue:12 Topics: Biological Transport; Cell Division; Dideoxynucleotides; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Monocytes; Phosphorylation; Thioinosine; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine	1990