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3'-azido-3'-deoxy-5'-o-beta-glucopyranuronosylthymidine and zidovudine

3'-azido-3'-deoxy-5'-o-beta-glucopyranuronosylthymidine has been researched along with zidovudine in 50 studies

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19903 (6.00)18.7374
1990's42 (84.00)18.2507
2000's3 (6.00)29.6817
2010's1 (2.00)24.3611
2020's1 (2.00)2.80

Authors

AuthorsStudies
Gallo, JM; Mehta, M; Qian, MX; Swagler, AR; Vishwanathan, CT1
Borvák, J; Kasanická, J; Mayer, V1
Bonnez, W; Marder, V; Morse, GD; Olson, J; Plank, C; Portmore, AC; Reichman, RC; Taylor, C1
Biollaz, J; Chatton, JY; Chave, JP; Glauser, MP; Munafo, A; Roch-Ramel, F; Steinhäuslin, F1
Bennett, WM; Gilbert, DN; Kohlhepp, SJ; Kremer, D; Munar, MY; Stinnett, EA; Swan, SK; Young, EW1
Back, DJ; Colbert, J; Howe, JL1
Gallo, JM; Qian, MX; Swagler, AR1
Finco, TS; Gallo, JM; Qian, MX1
Back, DJ; Breckenridge, AM; Sim, SM1
Ahmed, AE; Douidar, SM; Loh, JP; Nokta, M; Pollard, RB1
Cretton, EM; Sommadossi, JP1
Bevan, RJ; Cretton, EM; Goudgaon, NM; Schinazi, RF; Sommadossi, JP; Xie, MY1
Stretcher, BN1
Kamali, F; Rawlins, MD1
Chaput, JC; Colin, JN; Delfraissy, JF; Naveau, S; Singlas, E; Taburet, AM; Zorza, G1
Blum, MR; Broder, S; de Miranda, P; Good, SS; Myers, CE; Thomas, RV; Yarchoan, R1
Colaneri, S; Fillastre, JP; Pioger, JC; Singlas, E; Taburet, AM1
Balfour, HH; Chinnock, BJ; de Miranda, P; Fletcher, CV; Henry, K; Quinn, RP1
Asgari, M; Back, DJ1
Cameron, W; Gallicano, K; Garber, G; Pakuts, A; Sahai, J1
Agrawal, KC; Akula, S; George, WJ; Greenspan, DL; Hyslop, NE; Lertora, JJ; Rege, AB1
Plasse, JC; Schrive, I1
Bezek, S; Bohov, P; Kukan, M1
Beijnen, JH; Burger, DM; Koks, CH; Meenhorst, PL; Underberg, WJ; van der Heijde, JF1
Back, DJ; Barry, M; Beeching, N; Bergin, C; Breckenridge, AM; Howe, JL; Mulcahy, F; Nye, F; Ormesher, S1
Domin, BA; Mahony, WB; Zimmerman, TP1
Back, DJ; Barry, M; Beeching, N; Breckenridge, AM; Howe, JL; Nye, F; Swart, AM; Weller, IV1
Czochralska, B; Kawczyński, W; Shugar, D1
Beijnen, JH; Burger, DM; Koks, CH; Meenhorst, PL1
Boucher, FD; Crain, MJ; Elkins, MM; McKinney, R; Mirochnick, M; Modlin, JF; Pelton, S; Ruff, A; Weller, S; Wilfert, C1
Gallo, JM; Mehta, M; Qian, M; Swagler, AR1
Daniel, SS; Garland, M; Myers, MM; Stark, RI; Szeto, HH; Tropper, PJ2
Brouwer, KL; Cheeseman, SH; Eyster, E; Lemon, SM; Moore, KH; Opheim, K; Raasch, RH; van der Horst, CM1
Cameron, DW; Gallicano, K; Pakuts, A; Sahai, J; Seguin, I; Swick, L1
Nadal, T; Ortuño, J; Pascual, JA1
Bacracheva, N; Kamali, F1
Back, D; Bland, M; Fleming, SC; Griffin, GE; Kapembwa, MS; Orr, M; Wells, C1
Fried, K; Wainer, IW1
Akula, SK; Dejace, PM; Dreisbach, AW; Lertora, JJ; Rege, AB1
Binienda, ZK; Gillam, MP; Lipe, GW; Patterson, TA; Sandberg, JA; Slikker, W1
Barthel, B; Brockmeyer, NH; Goos, M; Mertins, L; Tillmann, I1
Pei, JC; Pike, IM; Van Harken, DR; Wagner, J1
Fayz, S; Inaba, T1
Motohashi, M; Nakagawa, Y; Okuda, T1
Collier, AC; Keelan, JA; Mitchell, MD; Paxton, JW; Tingle, MD; Van Zijl, PE1
Bauman, JN; Court, MH; Goosen, TC; Hurst, SI; Menning, LC; Milad, M; Peterkin, V; Tugnait, M; Williams, JA1
Chan, C; Flexner, C; Lee, LS; Lietman, PS; Parsons, TL; Wise, SD1
Hanioka, N; Ikushiro, S; Nagaoka, K; Narimatsu, S; Yamano, S1
Ambati, J; Ambati, K; Ambati, M; Ambati, VL; Apicella, I; Baker, KL; Gelfand, BD; Marion, KM; Narendran, S; Pereira, F; Sadda, SR; Varshney, A; Wang, SB; Yerramothu, P1

Reviews

2 review(s) available for 3'-azido-3'-deoxy-5'-o-beta-glucopyranuronosylthymidine and zidovudine

ArticleYear
State-of-the-art of zidovudine monitoring.
    Journal of clinical laboratory analysis, 1991, Volume: 5, Issue:1

    Topics: Adult; Chromatography, High Pressure Liquid; Fluorescence Polarization Immunoassay; HIV Infections; Humans; Infant; Radioimmunoassay; Zidovudine

1991
Column-switching techniques in the biomedical analysis of stereoisomeric drugs: why, how and when.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Feb-07, Volume: 689, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Humans; Leucovorin; Stereoisomerism; Tamoxifen; Verapamil; Zidovudine

1997

Trials

9 trial(s) available for 3'-azido-3'-deoxy-5'-o-beta-glucopyranuronosylthymidine and zidovudine

ArticleYear
Trimethoprim, alone or in combination with sulphamethoxazole, decreases the renal excretion of zidovudine and its glucuronide.
    British journal of clinical pharmacology, 1992, Volume: 34, Issue:6

    Topics: Adult; Drug Interactions; Female; HIV Infections; Humans; Infusions, Intravenous; Male; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Zidovudine

1992
Pharmacokinetics of simultaneously administered zidovudine and didanosine in HIV-seropositive male patients.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1995, Sep-01, Volume: 10, Issue:1

    Topics: Adult; Cross-Over Studies; Didanosine; Drug Interactions; Drug Therapy, Combination; HIV Seropositivity; Humans; Male; Metabolic Clearance Rate; Zidovudine

1995
Pharmacokinetic interaction between zidovudine and valproic acid in patients infected with human immunodeficiency virus.
    Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:3

    Topics: Adult; Biological Availability; Drug Synergism; Half-Life; HIV Infections; Humans; Linear Models; Male; Middle Aged; Valproic Acid; Zidovudine

1994
Pharmacokinetics of zidovudine and dideoxyinosine alone and in combination in patients with the acquired immunodeficiency syndrome.
    British journal of clinical pharmacology, 1994, Volume: 37, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Chromatography, High Pressure Liquid; Didanosine; Drug Interactions; Drug Therapy, Combination; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Zidovudine

1994
Phase I evaluation of zidovudine administered to infants exposed at birth to the human immunodeficiency virus.
    The Journal of pediatrics, 1993, Volume: 122, Issue:1

    Topics: Administration, Oral; Anemia; Drug Administration Schedule; Drug Tolerance; Female; HIV Infections; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Male; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications, Infectious; Zidovudine

1993
Pharmacokinetics and bioavailability of zidovudine and its glucuronidated metabolite in patients with human immunodeficiency virus infection and hepatic disease (AIDS Clinical Trials Group protocol 062).
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:12

    Topics: Administration, Oral; Adult; Antiviral Agents; Biological Availability; Female; HIV Infections; Humans; Injections, Intravenous; Liver Diseases; Male; Middle Aged; Zidovudine

1995
Effect of rifabutin on the pharmacokinetics of zidovudine in patients infected with human immunodeficiency virus.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21, Issue:4

    Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Reverse Transcriptase Inhibitors; Rifabutin; Zidovudine

1995
Pharmacokinetic interaction of megestrol acetate with zidovudine in human immunodeficiency virus-infected patients.
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:11

    Topics: Administration, Oral; Adult; Anti-HIV Agents; Appetite Stimulants; Area Under Curve; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Half-Life; HIV Infections; Humans; Male; Megestrol Acetate; Middle Aged; Radioimmunoassay; Zidovudine

1997
Possible differential induction of phase 2 enzyme and antioxidant pathways by american ginseng, Panax quinquefolius.
    Journal of clinical pharmacology, 2008, Volume: 48, Issue:5

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Anti-HIV Agents; Antioxidants; Area Under Curve; Biomarkers, Pharmacological; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyguanosine; Dose-Response Relationship, Drug; Drug Interactions; F2-Isoprostanes; Female; Ginsenosides; HIV Infections; HIV Protease Inhibitors; Humans; Male; Metabolic Clearance Rate; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Panax; Phytotherapy; Plant Extracts; Zidovudine

2008

Other Studies

39 other study(ies) available for 3'-azido-3'-deoxy-5'-o-beta-glucopyranuronosylthymidine and zidovudine

ArticleYear
Pharmacokinetic evaluation of drug interactions with anti-human immunotrophic virus (HIV) Drugs. III. 2',3'-Dideoxycytidine (ddC) and zidovudine in monkeys.
    Pharmaceutical research, 1992, Volume: 9, Issue:2

    Topics: Animals; Antiviral Agents; Drug Interactions; HIV; Macaca fascicularis; Male; Zalcitabine; Zidovudine

1992
HPLC-monitoring of AZT in HIV-infected patient's plasma: a critical study.
    Acta virologica, 1992, Volume: 36, Issue:5

    Topics: Calibration; Chromatography, High Pressure Liquid; HIV Infections; Humans; Reference Standards; Reproducibility of Results; Zidovudine

1992
Intravenous and oral zidovudine pharmacokinetics and coagulation effects in asymptomatic human immunodeficiency virus-infected hemophilia patients.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:10

    Topics: Administration, Oral; Adult; Blood Coagulation; Chromatography, High Pressure Liquid; Half-Life; Hemophilia A; HIV Infections; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Zidovudine

1992
Zidovudine pharmacokinetics in five HIV seronegative patients undergoing continuous ambulatory peritoneal dialysis.
    Pharmacotherapy, 1992, Volume: 12, Issue:1

    Topics: Administration, Oral; Adult; Dialysis Solutions; HIV Seropositivity; Humans; Kidney Diseases; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Reproducibility of Results; Zidovudine

1992
Extrahepatic metabolism of zidovudine.
    British journal of clinical pharmacology, 1992, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Duodenum; Humans; In Vitro Techniques; Kidney; Male; Microsomes; Microsomes, Liver; Middle Aged; Zidovudine

1992
Pharmacokinetics of anti-HIV nucleosides in microswine.
    The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:12

    Topics: Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Didanosine; Half-Life; HIV; Male; Nucleosides; Swine; Swine, Miniature; Zalcitabine; Zidovudine

1991
Rapid and simultaneous determination of zidovudine and its glucuronide metabolite in plasma and urine. Application to the pharmacokinetic interaction of zidovudine and probenecid in the monkey.
    Journal of pharmaceutical and biomedical analysis, 1991, Volume: 9, Issue:3

    Topics: Animals; Chromatography, Liquid; Drug Interactions; Half-Life; Haplorhini; Probenecid; Zidovudine

1991
The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes.
    British journal of clinical pharmacology, 1991, Volume: 32, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Chromatography, High Pressure Liquid; Didanosine; Drug Interactions; Female; Glucuronosyltransferase; Humans; Male; Microsomes, Liver; Middle Aged; Salicylates; Sulfanilamide; Sulfanilamides; Zidovudine

1991
Metabolic interaction of recombinant interferon-beta and zidovudine in AIDS patients.
    Journal of interferon research, 1991, Volume: 11, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Biological Availability; Chromatography, High Pressure Liquid; Demography; Drug Therapy, Combination; Half-Life; Humans; Injections, Subcutaneous; Interferon Type I; Kidney Function Tests; Kinetics; Liver Function Tests; Male; Recombinant Proteins; Zidovudine

1991
Modulation of 3'-azido-3'-deoxythymidine catabolism by probenecid and acetaminophen in freshly isolated rat hepatocytes.
    Biochemical pharmacology, 1991, Sep-12, Volume: 42, Issue:7

    Topics: Acetaminophen; Animals; Body Fluid Compartments; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleosides; Drug Interactions; Humans; Liver; Probenecid; Rats; Rats, Inbred Strains; Zidovudine

1991
Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells.
    Molecular pharmacology, 1991, Volume: 39, Issue:2

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Dideoxynucleosides; Extracellular Space; Gas Chromatography-Mass Spectrometry; Hematopoietic Stem Cells; Humans; Intracellular Fluid; Liver; Microsomes, Liver; Rats; Rats, Inbred Strains; Time Factors; Tritium; Zidovudine

1991
Simple and rapid assay for zidovudine and zidovudine glucuronide in plasma using high-performance liquid chromatography.
    Journal of chromatography, 1990, Sep-14, Volume: 530, Issue:2

    Topics: Chromatography, High Pressure Liquid; Hot Temperature; Humans; Trichloroacetic Acid; Zidovudine

1990
Pharmacokinetics of zidovudine in patients with liver cirrhosis.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:6

    Topics: Adult; Humans; Liver Cirrhosis; Middle Aged; Zidovudine

1990
Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex.
    Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Drug Interactions; Drug Therapy, Combination; Half-Life; Humans; Male; Middle Aged; Probenecid; Regression Analysis; Zidovudine

1989
Comparative pharmacokinetics of zidovudine (AZT) and its metabolite (G.AZT) in healthy subjects and HIV seropositive patients.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:6

    Topics: Adult; HIV Seropositivity; Humans; Male; Middle Aged; Zidovudine

1989
Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex.
    JAMA, 1988, May-27, Volume: 259, Issue:20

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Chromatography, High Pressure Liquid; Humans; Male; Radioimmunoassay; Semen; Thymidine; Zidovudine

1988
Effect of azoles on the glucuronidation of zidovudine by human liver UDP-glucuronosyltransferase.
    The Journal of infectious diseases, 1995, Volume: 172, Issue:6

    Topics: Antifungal Agents; Antiviral Agents; Drug Interactions; Fluconazole; Glucuronosyltransferase; Humans; Itraconazole; Ketoconazole; Liver; Zidovudine

1995
Quantification of zidovudine and one of its metabolites in plasma and urine by solid-phase extraction and high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical applications, 1994, Jul-01, Volume: 657, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Molecular Structure; Sensitivity and Specificity; Zidovudine

1994
Hepatobiliary disposition of 3'-azido-3'-deoxythymidine (AZT) in the rat: effect of phenobarbitone induction.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:7

    Topics: Animals; Bile; Bone Marrow; Cattle; Cell Survival; Cells, Cultured; Chromatography, Thin Layer; Dinitrophenols; Dose-Response Relationship, Drug; Drug Interactions; Duodenum; Glucuronosyltransferase; Humans; Liver; Male; Phenobarbital; Potassium Cyanide; Rats; Rats, Wistar; Temperature; Zidovudine

1994
Short-term, combined use of paracetamol and zidovudine does not alter the pharmacokinetics of either drug.
    The Netherlands journal of medicine, 1994, Volume: 44, Issue:5

    Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Drug Interactions; Drug Therapy, Combination; Humans; Male; Zidovudine

1994
Inhibition of thymidine transport by 3'-azido-3'-deoxythymidine and its metabolites.
    Oncology research, 1993, Volume: 5, Issue:12

    Topics: Biological Transport; Dideoxynucleosides; Erythrocytes; Humans; Thymidine; Zidovudine

1993
Zidovudine pharmacokinetics in zidovudine-induced bone marrow toxicity.
    British journal of clinical pharmacology, 1994, Volume: 37, Issue:1

    Topics: Administration, Oral; Adult; Animals; Bone Marrow Diseases; Chromatography, High Pressure Liquid; HIV Infections; Humans; Male; Middle Aged; Zidovudine

1994
Electrochemical reduction products of azido nucleosides, including zidovudine (AZT): mechanisms and relevance to their intracellular metabolism.
    Acta biochimica Polonica, 1993, Volume: 40, Issue:2

    Topics: Antiviral Agents; Dideoxynucleotides; Electrochemistry; Electrolysis; Intracellular Fluid; Nucleosides; Oxidation-Reduction; Polarography; Thymine Nucleotides; Zidovudine

1993
Pharmacokinetic interaction between rifampin and zidovudine.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:7

    Topics: Adult; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Middle Aged; Rifampin; Tuberculosis; Zidovudine

1993
Pharmacokinetic evaluation of drug interactions with anti-human immunodeficiency virus drugs. VI. Effect of the calcium channel blocker nimodipine on zidovudine kinetics in monkeys.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:1

    Topics: Animals; Calcium Channel Blockers; Drug Interactions; Injections, Intravenous; Macaca fascicularis; Male; Models, Biological; Nimodipine; Random Allocation; Zidovudine

1993
Zidovudine kinetics in the pregnant baboon.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, Feb-01, Volume: 11, Issue:2

    Topics: Absorption; Administration, Oral; Animals; Animals, Newborn; Antiviral Agents; Biological Availability; Female; Fetal Blood; Gestational Age; Half-Life; Infusions, Intravenous; Maternal-Fetal Exchange; Papio; Pregnancy; Pregnancy, Animal; Tissue Distribution; Zidovudine

1996
Rapid and sensitive determination of zidovudine and zidovudine glucuronide in human plasma by ion-pair high-performance liquid chromatography.
    Journal of chromatography. A, 1996, Jan-15, Volume: 721, Issue:1

    Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Quality Control; Reproducibility of Results; Sensitivity and Specificity; Zidovudine

1996
Lack of interaction between zidovudine and 4-methyl-amino-antipyrine, the active metabolite of metamizole, in human liver in vitro.
    Methods and findings in experimental and clinical pharmacology, 1995, Volume: 17, Issue:5

    Topics: Antiviral Agents; Dipyrone; Drug Interactions; Glucuronates; Humans; In Vitro Techniques; Male; Microsomes, Liver; Pyrazolones; White People; Zidovudine

1995
Impaired absorption of zidovudine in patients with AIDS-related small intestinal disease.
    AIDS (London, England), 1996, Volume: 10, Issue:13

    Topics: Acquired Immunodeficiency Syndrome; Adult; Chronic Disease; Diarrhea; Humans; Intestine, Small; Male; Middle Aged; Triolein; Zidovudine

1996
Valproic acid increases cerebrospinal fluid zidovudine levels in a patient with AIDS.
    The American journal of the medical sciences, 1997, Volume: 313, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Anticonvulsants; Drug Interactions; Humans; Kinetics; Male; Valproic Acid; Zidovudine

1997
Transplacental pharmacokinetics and fetal distribution of azidothymidine, its glucuronide, and phosphorylated metabolites in late-term rhesus macaques after maternal infusion.
    Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:4

    Topics: Animals; Anti-HIV Agents; Female; Fetus; Macaca mulatta; Maternal-Fetal Exchange; Pregnancy; Pregnancy, Animal; Tissue Distribution; Zidovudine

1997
Pharmacokinetic interaction of fluconazole and zidovudine in HIV-positive patients.
    European journal of medical research, 1997, Sep-29, Volume: 2, Issue:9

    Topics: 17-Hydroxycorticosteroids; Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antifungal Agents; Antipyrine; Candidiasis, Oral; Drug Interactions; Drug Therapy, Combination; Fluconazole; Half-Life; Humans; Hydrocortisone; Male; Zidovudine

1997
Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:7

    Topics: Chromatography, Thin Layer; Dipyridamole; Enzyme Activation; Enzyme Inhibitors; Enzyme Repression; Ethacrynic Acid; Humans; Indomethacin; Microsomes, Liver; Oxidoreductases; Zidovudine

1998
Placental transfer and fetal metabolism of zidovudine in the baboon.
    Pediatric research, 1998, Volume: 44, Issue:1

    Topics: Amniotic Fluid; Analysis of Variance; Animals; Female; Fetal Blood; Fetus; Half-Life; Maternal-Fetal Exchange; Metabolic Clearance Rate; Papio; Placenta; Pregnancy; Zidovudine

1998
Complete two-dimensional separation for analysis of acidic compounds in plasma using column-switching reversed-phase liquid chromatography.
    Journal of chromatography. B, Biomedical sciences and applications, 1999, Apr-16, Volume: 726, Issue:1-2

    Topics: Acids; Animals; Calibration; Chromatography, Liquid; Probenecid; Rats; Reproducibility of Results; Zidovudine

1999
Human placental glucuronidation and transport of 3'azido-3'-deoxythymidine and uridine diphosphate glucuronic acid.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:8

    Topics: Biological Transport; Dose-Response Relationship, Drug; Female; Humans; Placenta; Uridine Diphosphate Glucuronic Acid; Zidovudine

2004
Udp-glucuronosyltransferase 2b7 is the major enzyme responsible for gemcabene glucuronidation in human liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:9

    Topics: Caproates; Cells, Cultured; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Microsomes, Liver; Minor Histocompatibility Antigens; Phenotype; Recombinant Proteins; Zidovudine

2005
The effects of N-glycosylation on the glucuronidation of zidovudine and morphine by UGT2B7 expressed in HEK293 cells.
    Drug metabolism and pharmacokinetics, 2012, Volume: 27, Issue:4

    Topics: Biotransformation; Blotting, Western; Genotype; Glucuronosyltransferase; Glycosylation; HEK293 Cells; Humans; Kinetics; Morphine Derivatives; Mutagenesis, Site-Directed; Mutation; Phenotype; Protein Processing, Post-Translational; Substrate Specificity; Transfection; Zidovudine

2012
A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration.
    Investigative ophthalmology & visual science, 2020, 08-03, Volume: 61, Issue:10

    Topics: Animals; Blotting, Western; Caspase 1; Choroidal Neovascularization; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Geographic Atrophy; Interleukin-1beta; Intravitreal Injections; Macrophages; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Retinal Pigment Epithelium; Reverse Transcriptase Inhibitors; Zidovudine; Zonula Occludens-1 Protein

2020