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3',5'-dimethylacetaminophen and acetaminophen

3',5'-dimethylacetaminophen has been researched along with acetaminophen in 9 studies

*Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. [MeSH]

*Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. [MeSH]

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19906 (66.67)18.7374
1990's3 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Calder, IC; Fernando, CR; Ham, KN1
Bruno, MK; Cohen, SD; Khairallah, EA2
Fischer, V; Mason, RP2
Harvison, PJ; Moldéus, P; Nelson, SD; Porubek, DJ; Rundgren, M1
de Vries, J; Debets, AJ; van de Straat, R; Vermeulen, NP1
Kao, KJ; Pizzo, SV; Rauckman, EJ; Rosen, GM; Shorr, RI1
Moldéus, P; Nelson, S; Rundgren, M; Weis, M1

Reviews

1 review(s) available for 3',5'-dimethylacetaminophen and acetaminophen

ArticleYear
Free radicals of acetaminophen: their subsequent reactions and toxicological significance.
    Federation proceedings, 1986, Volume: 45, Issue:10

    Topics: Acetaminophen; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Electron Spin Resonance Spectroscopy; Free Radicals; Horseradish Peroxidase; Hydrogen Peroxide; Imines; Lactoperoxidase; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Peroxidases; Superoxides

1986

Other Studies

8 other study(ies) available for 3',5'-dimethylacetaminophen and acetaminophen

ArticleYear
Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:11

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Female; Kidney Diseases; Mice; Quinones; Rats

1980
Selective alterations in the patterns of newly synthesized proteins by acetaminophen and its dimethylated analogues in primary cultures of mouse hepatocytes.
    Toxicology and applied pharmacology, 1992, Volume: 112, Issue:2

    Topics: Acetaminophen; Animals; Cells, Cultured; Dactinomycin; Electrophoresis; Enzyme Induction; Heme Oxygenase (Decyclizing); Liver; Male; Mice; Mice, Inbred C57BL; Protein Biosynthesis; Tumor Suppressor Protein p53

1992
Selective alterations in the profiles of newly synthesized proteins by acetaminophen (APAP) and its dimethylated analogues: relationship to oxidative stress.
    Advances in experimental medicine and biology, 1991, Volume: 283

    Topics: Acetaminophen; Animals; Biotransformation; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Protein Biosynthesis; Proteins

1991
Investigation of mechanisms of acetaminophen toxicity in isolated rat hepatocytes with the acetaminophen analogues 3,5-dimethylacetaminophen and 2,6-dimethylacetaminophen.
    Molecular pharmacology, 1987, Volume: 31, Issue:6

    Topics: Acetaminophen; Animals; Carmustine; Dithiothreitol; Glutathione; Glutathione Reductase; In Vitro Techniques; Kinetics; Lipid Peroxides; Liver; Male; Maleates; Rats; Rats, Inbred Strains

1987
The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.
    Biochemical pharmacology, 1987, Jul-01, Volume: 36, Issue:13

    Topics: Acetaminophen; Animals; Benzoquinones; Carmustine; Chemical and Drug Induced Liver Injury; Glutathione; Imines; Lipid Peroxides; Liver; Liver Diseases; Male; Maleates; Oxidation-Reduction; Quinones; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1987
In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis.
    Thrombosis research, 1985, Apr-01, Volume: 38, Issue:1

    Topics: Acetaminophen; Arachidonic Acid; Arachidonic Acids; Humans; Platelet Aggregation; Serotonin; Thromboxane B2; Thromboxanes

1985
Stable free radical and benzoquinone imine metabolites of an acetaminophen analogue.
    The Journal of biological chemistry, 1984, Aug-25, Volume: 259, Issue:16

    Topics: Acetaminophen; Benzoquinones; Electron Spin Resonance Spectroscopy; Free Radicals; Horseradish Peroxidase; Hydrogen Peroxide; Imines; Indicators and Reagents; Kinetics; Oxidation-Reduction; Peroxidases

1984
Peroxidase-catalyzed oxidation of 3,5-dimethyl acetaminophen causes cell death by selective protein thiol modification in isolated rat hepatocytes.
    Chemico-biological interactions, 1996, May-06, Volume: 100, Issue:3

    Topics: Acetaminophen; Animals; Cell Death; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Glutathione; Liver; Male; Peroxidase; Rats; Rats, Wistar; Sodium Dodecyl Sulfate; Sulfhydryl Compounds; Time Factors

1996