3',5'-dichloromethotrexate has been researched along with methotrexate in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (97.37) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fox, BW | 1 |
| Ahlgren, JD; Gullo, JJ; Lokich, JJ; Phillips, JA; Wampler, GL | 1 |
| Fabre, G; Goldman, ID; Seither, R | 1 |
| Eddy, JL; Ihde, DC; Makuch, RW; Matthews, MJ; McIntire, KR; Seeff, LB | 1 |
| Ahlgren, JD; Deeb, Z; Golden, L; Kattah, J; Sisk, R; Smith, JW | 1 |
| Bertino, JR | 1 |
| Doria, MI; DuBrow, RA; Faintuch, J; Levin, B; Riddell, RH; Shepard, KV | 1 |
| Birdsall, B; Cheung, HT; Feeney, J; Hammond, SJ; Roberts, GC; Searle, MS | 1 |
| Birinberg, EM; Gorelik, ESh; Klinov, SV; Kurganov, BI; Sheĭman, BM | 1 |
| Beschorner, J; Cooper, RM; DuBrow, RA; Faintuch, J; Hagle, M; Karl, RC; Levin, B; Shepard, KV; Stablein, D | 1 |
| Donehower, RC; Ettinger, DS; Grochow, LB; Hantel, A; McGuire, WP; Noe, DA; Rowinsky, EK; Vito, BL | 1 |
| Natale, RB; Roberts, JA; Wheeler, RH | 1 |
| Bajorin, D; Heelan, R; Kelsen, D | 1 |
| Beecham, J; Blessing, JA; Homesley, HD; McGehee, R; Roberts, JA | 1 |
| Alonso, MT; Eisenberger, M; Hoth, DF; Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Bertino, JR; Sobrero, AF | 2 |
| Bahendeka, S; Katongole-Mbidde, E; Kyalwazi, SK; Mugerwa, J; Olweny, CL; Otim, D | 1 |
| Ensminger, WD; Keller, JH | 1 |
| Chandler, WF; Doan, KM; Ensminger, WD; Greenberg, HS; Gyves, JW; Kindt, GW; Phillips, TW; Seeger, JF | 1 |
| Donehower, RC; Eddy, JL; Ihde, DC; Myers, CE; Tester, WJ | 1 |
| Friedman, MA | 1 |
| Filov, VA; Kulik, GI | 1 |
| Baker, SR; Natale, RB; Roshon, SG; Wheeler, RH | 1 |
| Morley, GW; Natale, RB; Roberts, JA; Wheeler, RH | 1 |
| Rosowsky, A; Yu, CS | 1 |
| Holland, JF; Kamen, BA; Ohnoshi, T; Ohnuma, T; Scanlon, K; Takahashi, I | 1 |
| Dulmadge, EA; Wilkoff, LJ | 1 |
| Horton, J; Ludlum, DB; Tong, WP; Wisnicki, JL | 1 |
| Fernbach, B; Holland, JF; Ohnuma, T; Takahashi, I | 1 |
| DAVIDSON, JD; OLIVERIO, VT | 2 |
| GOLDIN, A; LYNCH, MR; MEAD, JA; SCHRECKER, AW; VENDITTI, JM | 1 |
| GOLDIN, A; KLINE, I; MEAD, JA; SCHRECKER, AW; VENDITTI, JM | 1 |
| VOGEL, AW | 1 |
| ADAMSON, RH; LOO, TL; MORRIS, HP | 1 |
| GOLDIN, A; HUMPHREYS, SR | 1 |
| BOOTH, BA; SARTORELLI, AC | 1 |
2 review(s) available for 3',5'-dichloromethotrexate and methotrexate
| Article | Year |
|---|---|
Hepatic intraarterial chemotherapy--current status and future prospects--"If you have a short sword, take a step forward".
Topics: Carcinoma, Hepatocellular; Catheterization; Colonic Neoplasms; Doxorubicin; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Methotrexate; Rectal Neoplasms | 1983 |
[Pharmacokinetics of antitumor drugs].
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dichlorodiphenyldichloroethane; Dogs; Doxorubicin; Fluorouracil; Guanazole; Humans; Kinetics; Methotrexate; Mice; Models, Biological; Rats; Thiotepa | 1983 |
2 trial(s) available for 3',5'-dichloromethotrexate and methotrexate
| Article | Year |
|---|---|
Dichloromethotrexate, infusional cisplatin, and infusional 5-fluorouracil for locally advanced or metastatic non-small cell lung cancer. A MAOP study.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Drug Evaluation; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Staging; Remission Induction; Survival Rate | 1991 |
Phase II trial of dichloromethotrexate in epidermoid carcinoma of the esophagus.
Topics: Aged; Carcinoma, Squamous Cell; Clinical Trials as Topic; Drug Evaluation; Esophageal Neoplasms; Hematologic Diseases; Humans; Methotrexate; Middle Aged | 1986 |
34 other study(ies) available for 3',5'-dichloromethotrexate and methotrexate
| Article | Year |
|---|---|
Collateral sensitivity between methylene dimethane sulfonate and halogenated methotrexate derivatives in the Yoshida sarcoma in vivo and in vitro.
Topics: Animals; Cell Survival; Cells, Cultured; Drug Resistance; Mesylates; Methotrexate; Methyl Methanesulfonate; Rats; Sarcoma, Yoshida | 1977 |
Hydroxylation of 4-amino-antifolates by partially purified aldehyde oxidase from rabbit liver.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Aminopterin; Animals; Folic Acid Antagonists; Hydroxylation; Kinetics; Liver; Male; Methotrexate; Polyglutamic Acid; Rabbits; Substrate Specificity | 1986 |
Prognostic factors in patients with hepatocellular carcinoma receiving systemic chemotherapy. Identification of two groups of patients with prospects for prolonged survival.
Topics: Adolescent; Adult; Aged; alpha-Fetoproteins; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Doxorubicin; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Prognosis; Streptozocin; Time Factors | 1985 |
Cochleovestibular toxicity related to dichloromethotrexate.
Topics: Aged; Cochlear Diseases; Hearing Disorders; Humans; Male; Methotrexate; Vestibular Diseases | 1989 |
Pharmacology of dichloromethotrexate.
Topics: Antineoplastic Agents; Humans; Methotrexate | 1989 |
Hepatitis in patients receiving intraarterial chemotherapy for metastatic colorectal carcinoma.
Topics: Bilirubin; Carcinoma; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Hepatitis; Humans; Infusions, Intra-Arterial; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Transaminases | 1987 |
Structural comparisons of complexes of methotrexate analogues with Lactobacillus casei dihydrofolate reductase by two-dimensional 1H NMR at 500 MHz.
Topics: Folic Acid Antagonists; Hydrogen; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase | 1987 |
[Inhibition of muscle glycogen phosphorylase b by 5-methyltetrahydrofolic acid, 3'-chloro- and 3',6'-dichloromethotrexates].
Topics: Adenosine Monophosphate; Animals; Flavin Mononucleotide; In Vitro Techniques; Kinetics; Methotrexate; Muscles; Phosphorylase b; Phosphorylases; Rabbits; Tetrahydrofolates | 1988 |
Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using a subcutaneous implanted pump.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Methotrexate; Middle Aged; Mitomycins; Peptic Ulcer; Prostheses and Implants; Rectal Neoplasms | 1985 |
Clinical and pharmacologic reappraisal of dichloromethotrexate.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Dose-Response Relationship, Drug; Female; Humans; Liver; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Neoplasms | 1988 |
Cisplatin and dichloromethotrexate: a pharmacologically rational combination.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Drug Evaluation; Female; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Methotrexate; Middle Aged; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1987 |
Phase II trial of dichloromethotrexate in patients with advanced squamous cell carcinoma of the cervix: a Gynecologic Oncology Group Study.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Female; Folic Acid Antagonists; Humans; Methotrexate; Uterine Cervical Neoplasms | 1987 |
Dichloromethotrexate--a critical reassessment.
Topics: Animals; Antineoplastic Agents; Drug Evaluation; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Infusions, Intra-Arterial; Kinetics; Methotrexate; Neoplasms; Neoplasms, Experimental | 1985 |
Sequence-dependent synergism between dichloromethotrexate and cisplatin in a human colon carcinoma cell line.
Topics: Cell Line; Cell Survival; Cisplatin; Colonic Neoplasms; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Drug Synergism; Humans; Methotrexate; Time Factors; Tumor Stem Cell Assay | 1985 |
Further experience in treating patients with hepatocellular carcinoma in Uganda.
Topics: Adolescent; Adult; Aged; alpha-Fetoproteins; Azacitidine; Carcinoma, Hepatocellular; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Hepatic Artery; Humans; Injections, Intravenous; Ligation; Liver Neoplasms; Male; Methotrexate; Middle Aged; Pigmentation Disorders; Razoxane; Uganda | 1980 |
Stability of cancer chemotherapeutic agents in a totally implanted drug delivery system.
Topics: Antineoplastic Agents; Cytarabine; Drug Stability; Floxuridine; Infusions, Parenteral; Methotrexate; Vinblastine | 1982 |
New implantable continuous administration and bolus dose intracarotid drug delivery system for the treatment of malignant gliomas.
Topics: Adult; Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Carotid Arteries; Chemotherapy, Cancer, Regional Perfusion; Female; Floxuridine; Glioblastoma; Humans; Macaca mulatta; Male; Methotrexate; Middle Aged | 1982 |
Evaluation of weekly escalating doses of dichloromethotrexate in patients with hepatocellular carcinoma and other solid tumors.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Drug Administration Schedule; Female; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Protein Binding; Serum Albumin | 1982 |
A phase I-II trial of cisplatin and dichloromethotrexate in squamous cell cancer of the head and neck.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local | 1984 |
Combination cisplatin and dichloromethotrexate in patients with advanced or recurrent cervical cancer: a preliminary report.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation, Preclinical; Female; Humans; Infusions, Parenteral; Methotrexate; Middle Aged; Uterine Cervical Neoplasms | 1984 |
Methotrexate analogues. 18. Enhancement of the antitumor effect of methotrexate and 3',5'-dichloromethotrexate by the use of lipid-soluble diesters.
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Esters; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Methods; Methotrexate; Mice; Spectrophotometry, Infrared; Structure-Activity Relationship | 1983 |
Sequence-dependent synergism between dichloromethotrexate and 5-fluorouracil in a human colon carcinoma cell line.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Kinetics; Methotrexate; Time Factors | 1983 |
Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
Topics: Animals; Biological Transport; Cells, Cultured; Drug Interactions; Drug Resistance; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Quinazolines; Tetrahydrofolate Dehydrogenase | 1982 |
Collateral sensitivity to methotrexate and dichloromethotrexate of cultured lymphocytic leukemia L1210 cells resistant to 6-mercaptopurine.
Topics: Animals; Cell Division; Cells, Cultured; Drug Resistance; Leukemia L1210; Mercaptopurine; Methotrexate | 1982 |
A direct analysis of methotrexate, dichloromethotrexate and their 7-hydroxy metabolites in plasma by high pressure liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Metabolic Clearance Rate; Methotrexate; Rabbits | 1980 |
Clinical and laboratory reevalution of dichloromethotrexate.
Topics: Adult; Aged; Antineoplastic Agents; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms | 1980 |
Synthesis of radioactive C136-dichloromethotrexate.
Topics: Folic Acid Antagonists; Humans; Methotrexate | 1961 |
Effect of orally administered 3', 5'-dichloroamethopterin on formate-C14 incorporation in leukemic mice.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Formates; Leukemia, Experimental; Methotrexate; Mice | 1960 |
Influence of the route of administration on the relative effectiveness of 3',5'-dichloroamethopterin and amethopterin against advanced leukemia (L1210) in mice.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Methotrexate; Mice | 1960 |
Tumor and marrow damage occurring from methotrexate, monofluoromethotrexate, difluoromethotrexate, and dichloromethotrexate.
Topics: Animals; Bone Marrow; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Neoplasms, Experimental; Vegetables | 1961 |
Metabolism of C136-dichloromethotrexate by transplantable liver tumors.
Topics: Carcinoma, Hepatocellular; Folic Acid Antagonists; Liver; Liver Neoplasms; Methotrexate | 1962 |
Investigation of tumor variants recovered from mice with systemic leukemia (L1210) after extensive therapy with 3',5'-dichloroamethopterin and 3'-bromo-5'-chloroamethopterin.
Topics: Animals; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Methotrexate; Mice | 1959 |
The physiological disposition of dichloromethotrexate-C136 in animals.
Topics: Folic Acid Antagonists; Methotrexate | 1962 |
Comparative effects of amethopterin and 3',5'-dichloroamethopterin in sensitive and resistant sublines of the Ehrlich carcinoma.
Topics: Animals; Carcinoma; Folic Acid Antagonists; Methotrexate; Neoplasms, Experimental | 1962 |