Compounds > 3',4'-dihydroxyflavone
Page last updated: 2024-09-04

3',4'-dihydroxyflavone and kaempferol

3',4'-dihydroxyflavone has been researched along with kaempferol in 8 studies

Compound Research Comparison

Studies
(3',4'-dihydroxyflavone)		Trials
(3',4'-dihydroxyflavone)		Recent Studies (post-2010)
(3',4'-dihydroxyflavone)		Studies
(kaempferol)		Trials
(kaempferol)		Recent Studies (post-2010) (kaempferol)
310141,5776900

Protein Interaction Comparison

ProteinTaxonomy3',4'-dihydroxyflavone (IC50)kaempferol (IC50)
rac GTPase-activating protein 1 isoform aHomo sapiens (human)44.49
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1Homo sapiens (human)9.933
Interstitial collagenaseHomo sapiens (human)2.635
Cytochrome P450 1A1Homo sapiens (human)0.632
MyeloperoxidaseHomo sapiens (human)2.24
Cytochrome P450 1A2Homo sapiens (human)0.716
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.33
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)2.7
Androgen receptorHomo sapiens (human)9.7
SialidaseClostridium perfringens8
Solute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)4
Serine/threonine-protein kinase pim-1Homo sapiens (human)1.3
Steroid hormone receptor ERR1Homo sapiens (human)9.64
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)2.2
17-beta-hydroxysteroid dehydrogenase type 1Homo sapiens (human)1.05
TyrosinaseHomo sapiens (human)1
Aldo-keto reductase family 1 member B1Homo sapiens (human)10
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)3.5
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)3.5
Casein kinase II subunit alpha'Homo sapiens (human)0.7
Dipeptidyl peptidase 4Homo sapiens (human)0.49
Aryl hydrocarbon receptorHomo sapiens (human)0.028
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)2.32
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)0.36
Xanthine dehydrogenase/oxidaseHomo sapiens (human)1.06
Glycogen synthase kinase-3 alphaHomo sapiens (human)3.5
Glycogen synthase kinase-3 betaHomo sapiens (human)3.5
Death-associated protein kinase 1Homo sapiens (human)10
Casein kinase II subunit betaHomo sapiens (human)0.7
Casein kinase II subunit alphaHomo sapiens (human)0.7
Cyclin-dependent kinase 6Homo sapiens (human)3.5
Cyclin-dependent-like kinase 5 Homo sapiens (human)3.5
Cyclin homologHerpesvirus saimiri (strain 11)3.5
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)3.5
Cytochrome P450 1B1Homo sapiens (human)0.047
Casein kinase II subunit alpha 3Homo sapiens (human)0.4
Inositol polyphosphate multikinaseHomo sapiens (human)4.4
3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)4
Aurora kinase BHomo sapiens (human)4.03
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)3.5
NADPH oxidase 4Homo sapiens (human)1.2
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)3.1
Inositol hexakisphosphate kinase 2Homo sapiens (human)2.5
Short transient receptor potential channel 5Homo sapiens (human)3.9
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)5.45

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's2 (25.00)29.6817
2010's3 (37.50)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Guinea, M; Parellada, J1
Debyser, Z; Glisic, S; Mouscadet, JF; Veljkovic, N; Veljkovic, V1
Gavande, N; Hanrahan, JR; Hibbs, DE; Kim, MS; Matin, A; Roubin, RH; Salam, NK; Yang, NX1
Kogami, Y; Matsuda, H; Nakamura, S; Sugiyama, T; Ueno, T; Yoshikawa, M1
Doddareddy, MR; Gavande, N; Groundwater, PW; Hibbs, DE; Matin, A; Nammi, S; Roubin, RH1
Chakraborty, A; Chakraborty, M; Frye, SV; Gu, C; Pearce, KH; Puhl-Rubio, AC; Shears, SB; Stashko, MA; Wang, H; Wang, X1
Fernandes, E; Fernandes, PA; Freitas, M; Oliveira, A; Proença, C; Ramos, MJ; Ribeiro, D; Silva, AMS; Sousa, JLC1
Albiñana, CB; Brynda, J; Fanfrlík, J; Flieger, M; Hodek, J; Karlukova, E; Konvalinka, J; Kožíšek, M; Machara, A; Majer, P; Radilová, K; Weber, J; Zima, V1

Other Studies

8 other study(ies) available for 3',4'-dihydroxyflavone and kaempferol

ArticleYear
Flavonoid inhibitors of trypsin and leucine aminopeptidase: a proposed mathematical model for IC50 estimation.
    Journal of natural products, 1995, Volume: 58, Issue:6

    Topics: Flavonoids; Kinetics; Leucyl Aminopeptidase; Models, Biological; Regression Analysis; Structure-Activity Relationship; Trypsin Inhibitors

1995
Simple criterion for selection of flavonoid compounds with anti-HIV activity.
    Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5

    Topics: Anti-HIV Agents; Computational Biology; Flavonoids; Humans; Models, Molecular; Quantitative Structure-Activity Relationship

2007
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.
    Journal of medicinal chemistry, 2009, Nov-12, Volume: 52, Issue:21

    Topics: Benzopyrans; Cell Line; Humans; PPAR alpha; PPAR gamma; Structure-Activity Relationship

2009
Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
    Bioorganic & medicinal chemistry, 2011, May-01, Volume: 19, Issue:9

    Topics: 3T3-L1 Cells; Adipogenesis; Animals; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; Deoxyglucose; Fatty Acid-Binding Proteins; Flavonoids; Glucose Transporter Type 4; Mice; PPAR gamma; Structure-Activity Relationship

2011
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.
    Bioorganic & medicinal chemistry, 2013, Feb-01, Volume: 21, Issue:3

    Topics: Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Isoflavones; Models, Molecular; Molecular Structure; Peroxisome Proliferator-Activated Receptors; Structure-Activity Relationship

2013
Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.
    Journal of medicinal chemistry, 2019, 02-14, Volume: 62, Issue:3

    Topics: Binding Sites; Crystallography, X-Ray; HCT116 Cells; Humans; Inositol Phosphates; Molecular Structure; Phosphotransferases (Alcohol Group Acceptor); Phosphotransferases (Phosphate Group Acceptor); Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quercetin; Structure-Activity Relationship

2019
Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase.
    Journal of natural products, 2020, 05-22, Volume: 83, Issue:5

    Topics: Drug Design; Enzyme Inhibitors; Flavonoids; Fructose; Fructose-Bisphosphatase; Humans; Hypoglycemic Agents; Liver; Molecular Structure

2020
Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
    European journal of medicinal chemistry, 2020, Dec-15, Volume: 208

    Topics: Antiviral Agents; Crystallography, X-Ray; Drug Evaluation, Preclinical; Endonucleases; Enzyme Assays; Enzyme Inhibitors; Flavonoids; Influenza A virus; Microbial Sensitivity Tests; Molecular Structure; Protein Binding; Protein Domains; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Viral Proteins

2020