3-(difluoromethyl)-1-(4-methoxyphenyl)-5-(4-(methylsulfinyl)phenyl)pyrazole has been researched along with morphine in 4 studies
| Studies (3-(difluoromethyl)-1-(4-methoxyphenyl)-5-(4-(methylsulfinyl)phenyl)pyrazole) | Trials (3-(difluoromethyl)-1-(4-methoxyphenyl)-5-(4-(methylsulfinyl)phenyl)pyrazole) | Recent Studies (post-2010) (3-(difluoromethyl)-1-(4-methoxyphenyl)-5-(4-(methylsulfinyl)phenyl)pyrazole) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 11 | 0 | 0 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | 3-(difluoromethyl)-1-(4-methoxyphenyl)-5-(4-(methylsulfinyl)phenyl)pyrazole (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujii, T; Goto, T; Motoyama, Y; Ochi, T | 1 |
| Goto, T; Motoyama, Y; Ochi, T | 1 |
| Goto, T; Ochi, T | 1 |
| Mutoh, S; Ochi, T; Ohkubo, Y | 1 |
4 other study(ies) available for 3-(difluoromethyl)-1-(4-methoxyphenyl)-5-(4-(methylsulfinyl)phenyl)pyrazole and morphine
| Article | Year |
|---|---|
The profile of FR140423, a novel anti-inflammatory compound, in yeast-induced rat hyperalgesia.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Dose-Response Relationship, Drug; Hyperalgesia; Indomethacin; Injections, Subcutaneous; Male; Morphine; Naloxone; Narcotic Antagonists; Pyrazoles; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Sulfoxides | 1999 |
The spinal antinociceptive effect of FR140423 is mediated through kyotorphin receptors.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Dipeptides; Endorphins; Enzyme Inhibitors; Guanylate Cyclase; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Methylene Blue; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain Measurement; Pyrazoles; Receptors, Opioid; Spinal Cord; Sulfoxides | 2000 |
The antinociceptive effect of FR140423 in mice: involvement of spinal alpha(2)-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Nociceptors; Pain Measurement; Phentolamine; Prazosin; Propranolol; Pyrazoles; Receptors, Adrenergic, alpha-2; Spinal Cord; Sulfoxides; Yohimbine | 2000 |
Effect of systemic FR140423, a new analgesic compound, in a rat model of postoperative pain: contribution of delta-opioid receptors.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Male; Morphine; Narcotic Antagonists; Pain Threshold; Pain, Postoperative; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Sulfoxides | 2003 |