3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and cyclic gmp

3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with cyclic gmp in 90 studies

Research

Studies (90)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	15 (16.67)	18.2507
2000's	65 (72.22)	29.6817
2010's	10 (11.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ko, FN; Kuo, SC; Lee, FY; Teng, CM; Wu, CC	2
Cheng, ZJ; Guh, JH; Kuo, SC; Lee, FY; Yu, SM	1
Bauersachs, J; Busse, R; Kast, R; Mülsch, A; Schäfer, A; Stasch, JP	1
Ko, FN; Teng, CM; Wu, CC	1
Förstermann, U; Gath, I; Nawrath, H; Wegener, JW	1
La, M; Schmidt, HH; Weeger, M; Zabel, U	1
Friebe, A; Koesling, D; Müllershausen, F; Schultz, G; Smolenski, A; Walter, U	1
Corbalán, R; Felipo, V; Miñana, MD; Montoliu, C; Teng, CM	1
Galle, J; Hatzelmann, A; Hübner, U; Schmidt, HH; Wagner, B; Wanner, C; Zabel, U	1
Hwang, TL; Teng, CM; Wu, CC	1
Kuo, SC; Lee, FY; Teng, CM; Wu, CC	1
Hobbs, AJ; Hussain, MB; MacAllister, RJ	1
Friebe, A; Koesling, D; Mergia, E; Russwurm, M	1
Linz, W; Malinski, T; Ruetten, H; Schindler, U; Schoenafinger, K; Strobel, H; Wiemer, G; Wohlfart, P	1
Mullan, M; Paris, D; Town, T	1
Chapman, GB; Durante, W; Evans, AJ; Peyton, KJ; Schafer, AI; Tulis, DA	1
Koesling, D; Mayer, B; Schmidt, K; Schrammel, A	1
Brien, JF; Marks, GS; McLaughlin, BE; Nakatsu, K; O'Reilly, DA	1
Chiang, HT; Li, HF; Wu, SN	1
Bae, JM; Choi, E; Chun, YS; Kim, MS; Park, JW; Teng, CM; Yeo, EJ	1
Bruckdorfer, KR; Friebe, A; Koesling, D; Naseem, KM; Sabetkar, M; Tullett, JM	1
Corbalán, R; Córdoba, J; Felipo, V; López-Talavera, J; Martinez, L; Monfort, P	1
Becker, C; Bergemann, C; Fischer, Y; Graf, B; Hamidizadeh, M; Löken, C	1
Chang, LC; Huang, LJ; Kuo, SC; Wang, JP	1
Ferrero, R; Torres, M	1
Garthwaite, G; Garthwaite, J; Goodwin, DA; Neale, S; Riddall, D	1
Alajuuma, P; Kotikoski, H; Laippala, P; Moilanen, E; Oksala, O; Salmenperä, P; Vapaatalo, H	1
Bohl Masters, KS; Durante, W; Evans, AJ; Lipke, EA; Peyton, KJ; Schafer, AI; Schiesser, RL; Tulis, DA; West, JL	1
Allen, JC; Kahn, AM; Zhang, S	1
Brioni, JD; Chang, R; Hsieh, G; Kolasa, T; Miller, LN; Moreland, RB; Nakane, M; Terranova, MA	1
Chang, LC; Hsu, MF; Huang, LJ; Kuo, SC; Raung, SL; Wang, JP	1
Ndisang, JF; Wang, R; Zhao, W	1
Homer, KL; Wanstall, JC	1
Brioni, JD; Chang, R; Hsieh, GC; Kolasa, T; Miller, LN; Moreland, RB; Nakane, M	1
Brioni, JD; Hsieh, GC; Moreland, RB; O'Neill, AB; Sullivan, JP	1
Che, Y; Li, CG; Rand, MJ	1
Bredt, DS	1
Guh, JH; Hwang, TL; Teng, CM; Wu, CC	1
Ho, PY; Hsu, HK; Juan, SH; Lee, WS; Liang, YC; Lin, CH; Teng, CM	1
Schmidt, P; Schramm, M; Schröder, H; Stasch, JP	1
Cheng, SJ; Hung, HW; Hwang, TL; Kao, SH; Teng, CM; Wu, CC	1
Chan, JY; Chan, SH; Chang, AY	1
Adragna, NC; Di Fulvio, M; Lauf, PK	1
Gao, H; Kaminski, A; Morgan, NG	1
Balashova, N; Beuve, A; Chang, FJ; Lamothe, M; Shirokov, R	1
Friebe, A; Koesling, D; Mullershausen, F; Russwurm, M	1
Chun, YS; Park, JW; Yeo, EJ	1
Baughman, VL; Gavrilyuk, V; Pelligrino, DA; Wolde, HM; Xu, HL	1
Imai, A; Komine, N; Nashida, T; Shimomura, H; Shimooka, S; Tanaka, S	1
Tulis, DA	1
Chang, MS; Chen, BC; Lee, WS; Lin, CH; Sheu, JR	1
Delago, A; Elphick, MR; Ott, SR	1
Cogolludo, A; Gonzalez-Luis, G; Lodi, F; Lopez-Farre, A; Moreno, L; Perez-Vizcaino, F; Tamargo, J; Villamor, E	1
Chen, JY; Lapolt, PS; Stewart, RL; Tafoya, MA	1
Chang, YL; Chen, HL; Guh, JH; Huang, DM; Kuo, SC; Lee, FY; Pan, SL; Teng, CM; Wang, SW	1
Cole, KR; Lanning, KM; Linder, AE; McCluskey, LP; Webb, RC	1
Chang, JH; Chang, YL; Cheng, FC; Guh, JH; Kuo, SC; Lee, FY; Pan, SL; Peng, CY; Teng, CM	1
Elsner, N; Ganter, GK; Günther, C; Heinrich, R; Kunst, M; Lakes-Harlan, R; Wenzel, B	1
Chen, YM; Chiang, WC; Hsieh, BS; Lin, SL; Teng, CM; Tsai, TJ	1
Bagcivan, I; Cetin, A; Cetin, M; Demirkoprulu, N; Karadas, B; Kaya, T; Soydan, AS	1
Cheng, JT; Liao, CH; Teng, CM	1
Chang, YL; Guh, JH; Huang, DM; Kuo, SC; Lee, FY; Lin, CH; Liu, YN; Pai, HC; Pan, SL; Peng, CY; Teng, CM	1
Bagcivan, I; Duman, M; Karadas, B; Kaya, T; Sarac, B; Turan, M	1
Abdallah, Y; Euler, G; Piper, HM; Schlüter, KD; Tastan, H	1
Blevins, DE; Drummond, JT; Lutz, MC; Nickels, TJ; Reed, GW; Wilson, DF	1
Fu, WM; Jeng, KC; Kuo, SC; Lee, FY; Liou, HC; Lu, DY; Tang, CH; Teng, CM	1
Fu, WM; Lin, CJ; Liou, HC; Lu, DY; Yeh, WL	1
Bilodeau, ML; Hamm, HE	1
Brouckaert, P; Buys, E; Nimmegeers, S; Sips, P; Van de Voorde, J	1
Bagcivan, I; Berkan, O; Doğan, K; Kaya, T; Yildirim, K; Yildirim, S	1
Huang, CT; Liao, CH; Lin, CY; Lin, YC; Tsai, IF; Yang, CM	1
Green, AK; Squires, PE; Stratton, RC	1
Garthwaite, J; Halvey, EJ; Roy, B	1
Brouckaert, P; Buys, E; De Backer, O; Elinck, E; Lefebvre, RA; Sips, P	1
Chien, WL; Fu, WM; Liang, KC	1
Dismuke, WM; Ellis, DZ; Sharif, NA	1
Aydin, C; Bagcivan, I; Koyuncu, A; Ozer, H; Soylu, S; Topcu, O; Yildirim, S	1
Durante, W; Keswani, AN; Peyton, KJ; Schafer, AI; Tulis, DA	1
Kohr, MJ; Traynham, CJ; Wang, H; Ziolo, MT	1
Choi, I; Jeong, M; Kang, YH; Kim, MJ; Kim, MS; Kim, TD; Lee, SH; Myung, PK; Piao, ZH; Suh, HW; Yoon, SR; Yun, S	1
Bicker, G; Böger, N; Eickhoff, R; Holstein, GR; Kerssen, U; Lorbeer, C; Martinelli, GP; Stern, M; Ziegler, M	1
Hung, CC; Liou, HH	1
Liu, S; Luo, J; Wang, Y; Yang, X; Yang, Z	1
Altun, A; Bagcivan, I; Durmus, N; Gursoy, S; Ozdemir, E	1
Buck, J; Hess, KC; Levin, LR; Ramos-Espiritu, LS	1
Gajdus, M; Glaza, I; Gurtowska, N; Rzepka, A; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R	1
Bagcivan, I; Karadas, B; Parlak, M; Temiz, TK; Turgut, B; Turgut, NH	1
Chang, SF; Fong, TH; Huang, HP; Tsui, L; Wang, IJ	1
Blood, AB; Liu, T; Longo, LD; Power, GG; Schroeder, HJ; Terry, MH; Wilson, SM; Zhang, M	1

Reviews

3 review(s) available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and cyclic gmp

Article	Year
Nitric oxide signaling in brain: potentiating the gain with YC-1. Molecular pharmacology, 2003, Volume: 63, Issue:6 Topics: Animals; Brain; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; Indazoles; Nitric Oxide; Signal Transduction	2003
Versatile pharmacological actions of YC-1: anti-platelet to anticancer. Cancer letters, 2004, Apr-15, Volume: 207, Issue:1 Topics: Animals; Antineoplastic Agents; Cyclic GMP; Guanylate Cyclase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Neoplasms; Platelet Aggregation Inhibitors; Transcription Factors	2004
Salutary properties of YC-1 in the cardiovascular and hematological systems. Current medicinal chemistry. Cardiovascular and hematological agents, 2004, Volume: 2, Issue:4 Topics: Animals; Blood; Cardiovascular System; Cyclic GMP; Enzyme Activators; Humans; Indazoles; Nitric Oxide; Platelet Aggregation Inhibitors	2004

Other Studies

87 other study(ies) available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and cyclic gmp

Article	Year
YC-1, a novel activator of platelet guanylate cyclase. Blood, 1994, Dec-15, Volume: 84, Issue:12 Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alprostadil; Animals; Bleeding Time; Blood Platelets; Calcium; Colforsin; Collagen; Cyclic AMP; Cyclic GMP; Drug Interactions; Enzyme Activation; Guanylate Cyclase; Imidazoles; Indazoles; Indomethacin; Methemoglobin; Mice; Molecular Structure; Nitroprusside; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Prostaglandin D2; Rabbits; Superoxide Dismutase; Thromboxane A2	1994
Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells. The Biochemical journal, 1995, Mar-15, Volume: 306 ( Pt 3) Topics: Animals; Cell Cycle; Cell Division; Cells, Cultured; Cyclic GMP; Flow Cytometry; Indazoles; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Rats	1995
YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. British journal of pharmacology, 1995, Volume: 116, Issue:3 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Blood Platelets; Collagen; Cyclic AMP; Cyclic GMP; Dideoxyadenosine; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Guanylate Cyclase; Hemoglobins; Humans; Indazoles; Nitric Oxide; Phosphodiesterase Inhibitors; Phthalazines; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Solubility; Thrombin; Thromboxane A2; Vasoconstrictor Agents	1995
Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. British journal of pharmacology, 1997, Volume: 120, Issue:4 Topics: Animals; Cells, Cultured; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Rabbits; Rats; Rats, Inbred WKY; Superoxides; Vasodilator Agents	1997
Inhibition of platelet adhesion to collagen by cGMP-elevating agents. Biochemical and biophysical research communications, 1997, Feb-13, Volume: 231, Issue:2 Topics: Actins; Adult; Blood Platelets; Calcium; Collagen; Cyclic GMP; Humans; Indazoles; Nitroprusside; Platelet Aggregation; Platelet Aggregation Inhibitors	1997
Activation of soluble guanylyl cyclase by YC-1 in aortic smooth muscle but not in ventricular myocardium from rat. British journal of pharmacology, 1997, Volume: 122, Issue:7 Topics: Adrenergic beta-Agonists; Animals; Calcium; Cyclic AMP; Cyclic GMP; Enzyme Activation; Female; Guanylate Cyclase; Indazoles; Isoproterenol; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Vasoconstriction	1997
Human soluble guanylate cyclase: functional expression and revised isoenzyme family. The Biochemical journal, 1998, Oct-01, Volume: 335 ( Pt 1) Topics: Amino Acid Sequence; Animals; Cattle; Cyclic GMP; Guanosine Triphosphate; Guanylate Cyclase; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Nitroprusside; Platelet Aggregation Inhibitors; Protein Conformation; Rats; Recombinant Proteins; Solubility; Spodoptera; Vasodilator Agents	1998
YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets. Molecular pharmacology, 1998, Volume: 54, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Carbon Monoxide; Cyclic AMP; Cyclic GMP; Drug Synergism; Humans; Indazoles; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphorylation; Platelet Aggregation Inhibitors; Vasodilator Agents	1998
Chronic hyperammonemia in rats impairs activation of soluble guanylate cyclase in neurons and in lymphocytes: a putative peripheral marker for neurological alterations. Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2 Topics: Ammonia; Animals; Biomarkers; Cells, Cultured; Chronic Disease; Cyclic GMP; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanylate Cyclase; Hepatic Encephalopathy; Indazoles; Lymphocytes; Neurons; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Time Factors	1999
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity. British journal of pharmacology, 1999, Volume: 127, Issue:1 Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Vasodilator Agents	1999
YC-1 potentiates nitric oxide-induced relaxation in guinea-pig trachea. British journal of pharmacology, 1999, Volume: 128, Issue:3 Topics: Animals; Cyclic AMP; Cyclic GMP; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Nitric Oxide; Superoxides; Trachea	1999
YC-1 potentiates the antiplatelet effect of hydrogen peroxide via sensitization of soluble guanylate cyclase. European journal of pharmacology, 1999, Sep-24, Volume: 381, Issue:2-3 Topics: Antioxidants; Blood Platelets; Catalase; Cyclic GMP; Glucose Oxidase; Glutathione Peroxidase; Guanylate Cyclase; Hemostatics; Humans; Hydrogen Peroxide; In Vitro Techniques; Indazoles; Mannitol; Platelet Aggregation Inhibitors; Superoxide Dismutase; Thrombin	1999
Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta. British journal of pharmacology, 1999, Volume: 128, Issue:5 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta, Thoracic; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanylate Cyclase; Homeostasis; Indazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrogen Oxides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Purinones; Spermine	1999
A point-mutated guanylyl cyclase with features of the YC-1-stimulated enzyme: implications for the YC-1 binding site? Biochemistry, 1999, Nov-16, Volume: 38, Issue:46 Topics: Animals; Binding Sites; Catalytic Domain; Cattle; Conserved Sequence; Cyclic GMP; Dimerization; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Indazoles; Magnesium; Manganese; Mutagenesis, Site-Directed; Nitric Oxide; Point Mutation; Solubility	1999
Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase. British journal of pharmacology, 1999, Volume: 128, Issue:6 Topics: Animals; Aorta, Thoracic; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Ionophores; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Rats; Rats, Wistar; Solubility; Time Factors	1999
Novel strategies for opposing murine microglial activation. Neuroscience letters, 2000, Jan-07, Volume: 278, Issue:1-2 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Cells, Cultured; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dipyridamole; Enzyme Inhibitors; Flavonoids; Guanylate Cyclase; Imidazoles; Indazoles; Isoenzymes; Lipopolysaccharides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Microglia; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylcholine; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha	2000
YC-1, a benzyl indazole derivative, stimulates vascular cGMP and inhibits neointima formation. Biochemical and biophysical research communications, 2000, Dec-20, Volume: 279, Issue:2 Topics: Angioplasty, Balloon; Animals; Carotid Arteries; Carotid Artery Injuries; Carotid Stenosis; Cyclic GMP; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Indazoles; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Recurrence; RNA, Messenger; Transcription, Genetic; Tunica Intima	2000
Molecular mechanisms involved in the synergistic activation of soluble guanylyl cyclase by YC-1 and nitric oxide in endothelial cells. Molecular pharmacology, 2001, Volume: 59, Issue:2 Topics: Animals; Cells, Cultured; Cyclic GMP; Drug Synergism; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Swine	2001
YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate. Canadian journal of physiology and pharmacology, 2001, Volume: 79, Issue:1 Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Enzyme Activators; In Vitro Techniques; Indazoles; Isometric Contraction; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Rabbits; Vasodilator Agents	2001
Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH3 cells. Biochemical pharmacology, 2001, Apr-01, Volume: 61, Issue:7 Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cyclic GMP; Drug Interactions; Electrophysiology; Enzyme Activators; Indazoles; Kinetics; Large-Conductance Calcium-Activated Potassium Channels; Membrane Potentials; PC12 Cells; Pheochromocytoma; Pituitary Gland; Potassium Channels; Potassium Channels, Calcium-Activated; Rats; Tumor Cells, Cultured; Vinca Alkaloids	2001
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells. Biochemical pharmacology, 2001, Apr-15, Volume: 61, Issue:8 Topics: Cell Hypoxia; Cyclic GMP; DNA-Binding Proteins; Drug Interactions; Endothelial Growth Factors; Enzyme Activators; Erythropoietin; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lymphokines; Nuclear Proteins; Oxygen; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
Synergism between nitric oxide and hydrogen peroxide in the inhibition of platelet function: the roles of soluble guanylyl cyclase and vasodilator-stimulated phosphoprotein. Nitric oxide : biology and chemistry, 2001, Volume: 5, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Blood Platelets; Blood Proteins; Carbazoles; Cell Adhesion Molecules; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; Humans; Hydrazines; Hydrogen Peroxide; In Vitro Techniques; Indazoles; Indoles; Kinetics; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Phosphoproteins; Phosphoserine; Platelet Aggregation; Platelet Aggregation Inhibitors; Subcellular Fractions; Thrombin	2001
Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis. Neuroscience, 2001, Volume: 104, Issue:4 Topics: Animals; Cerebellum; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Excitatory Amino Acid Agonists; Glutamic Acid; Guanylate Cyclase; Hepatic Encephalopathy; Hyperammonemia; Immunoblotting; Indazoles; Lymphocytes; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Synaptic Transmission	2001
Inhibition of glucose transport by cyclic GMP in cardiomyocytes. Life sciences, 2001, Aug-10, Volume: 69, Issue:12 Topics: Animals; Biological Transport; Cell Hypoxia; Cell Membrane Permeability; Cells, Cultured; Cyclic GMP; Deoxyglucose; Drug Combinations; Female; Glucose Transporter Type 4; Glycolysis; Hydrogen Peroxide; Indazoles; Insulin; Microscopy, Confocal; Monosaccharide Transport Proteins; Muscle Proteins; Myocardium; Oligomycins; Oxadiazoles; Rats; Rats, Sprague-Dawley; Rotenone	2001
Inhibition of extracellular Ca(2+) entry by YC-1, an activator of soluble guanylyl cyclase, through a cyclic GMP-independent pathway in rat neutrophils. Biochemical pharmacology, 2001, Sep-15, Volume: 62, Issue:6 Topics: Animals; Calcium; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Indazoles; Ion Transport; Manganese; Neutrophils; Phosphorylation; Platelet Aggregation Inhibitors; Rats; Solubility; Tyrosine	2001
Prolonged exposure to YC-1 induces apoptosis in adrenomedullary endothelial and chromaffin cells through a cGMP-independent mechanism. Neuropharmacology, 2001, Volume: 41, Issue:7 Topics: Adrenal Medulla; Animals; Apoptosis; Cattle; Cell Adhesion; Cell Size; Cells, Cultured; Chromaffin Cells; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium; Enzyme Activators; Indazoles; Intracellular Fluid; Time Factors	2001
Soluble guanylyl cyclase activator YC-1 protects white matter axons from nitric oxide toxicity and metabolic stress, probably through Na(+) channel inhibition. Molecular pharmacology, 2002, Volume: 61, Issue:1 Topics: Animals; Axons; Cyclic GMP; Drug Interactions; Enzyme Activators; Glucose; Guanylate Cyclase; Indazoles; Male; Nitric Oxide; Oxygen; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels	2002
Comparison of nitric oxide donors in lowering intraocular pressure in rabbits: role of cyclic GMP. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2002, Volume: 18, Issue:1 Topics: Animals; Arginine; Cyclic GMP; Female; Indazoles; Intraocular Pressure; Male; Nitric Oxide Donors; Nitric Oxide Synthase; Purinones; Rabbits	2002
YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function. Biochemical and biophysical research communications, 2002, Mar-08, Volume: 291, Issue:4 Topics: Angioplasty, Balloon; Animals; Arterial Occlusive Diseases; Blood Platelets; Carotid Stenosis; Cell Adhesion; Cell Division; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Hydrogels; Indazoles; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Polyethylene Glycols; Rats; Rats, Sprague-Dawley	2002
Insulin increases NADH/NAD+ redox state, which stimulates guanylate cyclase in vascular smooth muscle. American journal of hypertension, 2002, Volume: 15, Issue:3 Topics: Animals; Cells, Cultured; Cyclic GMP; Dogs; Guanylate Cyclase; Indazoles; Insulin; Isocitrates; Lactic Acid; Muscle, Smooth, Vascular; NAD; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxaloacetic Acid; Oxidation-Reduction; Pyruvic Acid; Stimulation, Chemical	2002
Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1. International journal of impotence research, 2002, Volume: 14, Issue:2 Topics: Animals; Cell Line; Cloning, Molecular; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Isoenzymes; Male; Muscle, Smooth; Nitric Oxide; Penis; Rabbits; Rats; Recombinant Proteins	2002
Inhibition of superoxide anion generation by YC-1 in rat neutrophils through cyclic GMP-dependent and -independent mechanisms. Biochemical pharmacology, 2002, Feb-15, Volume: 63, Issue:4 Topics: Animals; Calcium; Cell-Free System; Cyclic GMP; Enzyme Activators; In Vitro Techniques; Indazoles; Mitogen-Activated Protein Kinases; Neutrophils; Phosphatidylinositol 3-Kinases; Phospholipase D; Phosphorylation; Protein Kinase C; Rats; Respiratory Burst; Superoxides	2002
Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:3 Topics: Animals; Blood Pressure; Culture Techniques; Cyclic GMP; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hypertension; Indazoles; Male; Mesenteric Arteries; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents	2002
Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate. British journal of pharmacology, 2002, Volume: 137, Issue:7 Topics: Adenosine Diphosphate; Animals; Catalase; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Indazoles; Male; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thapsigargin; Thionucleotides; Vasoconstriction	2002
A-350619: a novel activator of soluble guanylyl cyclase. Life sciences, 2003, Jan-17, Volume: 72, Issue:9 Topics: Acrylamides; Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Penile Erection; Rabbits; Rats; Rats, Wistar; Spodoptera	2003
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats. European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2 Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroprusside; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Quinoxalines; Rabbits; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents; Vasodilator Agents	2003
Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle. European journal of pharmacology, 2003, Feb-21, Volume: 462, Issue:1-3 Topics: Animals; Aorta; Azoles; Copper; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Enzyme Activators; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Indazoles; Isoindoles; Male; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Organoselenium Compounds; Papaverine; Penicillamine; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Vasodilation	2003
Potentiation of tumor necrosis factor-alpha expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway. Biochemical pharmacology, 2003, Jul-01, Volume: 66, Issue:1 Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Macrophages, Alveolar; Rats; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha	2003
YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway. Biochemical pharmacology, 2003, Jul-15, Volume: 66, Issue:2 Topics: Cell Division; Cyclic GMP; DNA; Endothelium, Vascular; G1 Phase; Humans; Indazoles; Platelet Aggregation Inhibitors; Resting Phase, Cell Cycle; Thymidine; Tritium	2003
Preparation of heme-free soluble guanylate cyclase. Protein expression and purification, 2003, Volume: 31, Issue:1 Topics: Benzoates; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Indazoles; Nitroprusside; Polysorbates; Proteins; Protoporphyrins; Spectrophotometry; Zinc	2003
Soluble guanylyl cyclase activator YC-1 inhibits human neutrophil functions through a cGMP-independent but cAMP-dependent pathway. Molecular pharmacology, 2003, Volume: 64, Issue:6 Topics: Adolescent; Adult; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Guanylate Cyclase; Humans; Indazoles; Neutrophils; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Superoxides	2003
Contribution of cGMP but not peroxynitrite to negative feedback regulation of penile erection elicited by nitric oxide in the hippocampal formation of the rat. Neuropharmacology, 2004, Volume: 46, Issue:1 Topics: Aminoquinolines; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Feedback; Hippocampus; Indazoles; Male; Microinjections; Nitric Oxide; Penile Erection; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Venous Pressure	2004
The NO signaling pathway differentially regulates KCC3a and KCC3b mRNA expression. Nitric oxide : biology and chemistry, 2003, Volume: 9, Issue:3 Topics: Animals; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gene Expression Regulation; Guanylate Cyclase; Indazoles; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Soluble Guanylyl Cyclase; Symporters; Thionucleotides	2003
Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells. FEBS letters, 2004, Feb-13, Volume: 559, Issue:1-3 Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinase Type II; Cyclic GMP-Dependent Protein Kinases; Dactinomycin; Guanylate Cyclase; Indazoles; Insulin; Insulin Secretion; Islets of Langerhans; Protein Isoforms; Rats; Signal Transduction; Thionucleotides; Transcription, Genetic	2004
Functional characterization of nitric oxide and YC-1 activation of soluble guanylyl cyclase: structural implication for the YC-1 binding site? Biochemistry, 2004, Mar-23, Volume: 43, Issue:11 Topics: Amino Acid Sequence; Animals; Asparagine; Binding Sites; COS Cells; Cyclic GMP; Cysteine; Cytosol; DNA Mutational Analysis; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Kinetics; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitric Oxide; Phenotype; Protein Subunits; Pyrazoles; Pyridines; Rats; Solubility; Tyrosine	2004
Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272. Circulation, 2004, Apr-13, Volume: 109, Issue:14 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Cell Line; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activation; Guanylate Cyclase; Humans; Indazoles; Kidney; Nitric Oxide; Nitric Oxide Donors; Phosphodiesterase Inhibitors; Pyrazoles; Pyridines; Quaternary Ammonium Compounds; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; S-Nitrosoglutathione; Soluble Guanylyl Cyclase; Transfection; Vasodilation	2004
cAMP modulates cGMP-mediated cerebral arteriolar relaxation in vivo. American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:6 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arterioles; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activators; Hydrolysis; Indazoles; Male; Multidrug Resistance-Associated Proteins; Nitric Oxide; Nitric Oxide Donors; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Vasodilation	2004
Soluble guanylyl cyclase is localised in the acinar cells and participates in amylase secretion in rat parotid gland. Archives of oral biology, 2004, Volume: 49, Issue:9 Topics: Amylases; Animals; Carbachol; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Guanylate Cyclase; Indazoles; Male; Muscarinic Agonists; Nitric Oxide; Nitric Oxide Donors; Parotid Gland; Rats; Rats, Wistar; S-Nitrosoglutathione; Signal Transduction	2004
YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells. Molecular pharmacology, 2004, Volume: 66, Issue:3 Topics: Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Humans; I-kappa B Kinase; I-kappa B Proteins; Indazoles; Interleukin-1; Isoenzymes; Lung; Membrane Proteins; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphatidylinositol 3-Kinases; Polyenes; Polyunsaturated Alkamides; Proline; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Thiocarbamates; Transcription Factors	2004
An evolutionarily conserved mechanism for sensitization of soluble guanylyl cyclase reveals extensive nitric oxide-mediated upregulation of cyclic GMP in insect brain. The European journal of neuroscience, 2004, Volume: 20, Issue:5 Topics: Amino Acid Sequence; Animals; Brain; Conserved Sequence; Cyclic GMP; Evolution, Molecular; Female; Grasshoppers; Guanylate Cyclase; Indazoles; Insect Proteins; Male; Molecular Sequence Data; Nitric Oxide; Periplaneta; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Up-Regulation	2004
Soluble guanylyl cyclase during postnatal porcine pulmonary maturation. American journal of physiology. Lung cellular and molecular physiology, 2005, Volume: 288, Issue:1 Topics: Aging; Animals; Animals, Newborn; Base Sequence; Cyclic GMP; Enzyme Activators; Guanylate Cyclase; Indazoles; Molecular Sequence Data; Nitric Oxide; Pulmonary Artery; RNA, Messenger; Sequence Homology, Nucleic Acid; Solubility; Swine; Vasodilation	2005
Activation of soluble guanylyl cyclase inhibits estradiol production and cyclic AMP accumulation from cultured rat granulosa cells. Fertility and sterility, 2004, Volume: 82 Suppl 3 Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Drug Synergism; Enzyme Activation; Enzyme Activators; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Guanylate Cyclase; Hormones; Immunoblotting; Indazoles; Isoenzymes; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Solubility	2004
YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:3 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Proliferation; Cyclic GMP; Cyclin-Dependent Kinase Inhibitor p27; DNA-Binding Proteins; G1 Phase; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Resting Phase, Cell Cycle; Transcription Factors; Tumor Suppressor Proteins	2005
Dynamic association of nitric oxide downstream signaling molecules with endothelial caveolin-1 in rat aorta. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1 Topics: Acetylcholine; Animals; beta-Cyclodextrins; Caveolae; Caveolin 1; Caveolins; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Immunohistochemistry; In Vitro Techniques; Indazoles; Isometric Contraction; Male; Microscopy, Electron; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasodilator Agents	2005
A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models. Thrombosis and haemostasis, 2005, Volume: 93, Issue:5 Topics: Animals; Blotting, Western; Cyclic GMP; Cytokines; Disease Models, Animal; DNA; Endotoxemia; Humans; Immunohistochemistry; Indazoles; Leukocytes; Leukocytes, Mononuclear; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Shock, Septic; Time Factors; Up-Regulation	2005
Nitric oxide/cyclic guanosine monophosphate signaling in the central complex of the grasshopper brain inhibits singing behavior. The Journal of comparative neurology, 2005, Jul-25, Volume: 488, Issue:2 Topics: Animals; Behavior, Animal; Brain; Cyclic GMP; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Functional Laterality; Grasshoppers; Immunohistochemistry; Indazoles; Male; Muscarine; Muscarinic Agonists; Muscle, Smooth, Vascular; Nitric Oxide; Nitrophenols; Organophosphorus Compounds; Signal Transduction; Time Factors; Vocalization, Animal	2005
YC-1-inhibited proliferation of rat mesangial cells through suppression of cyclin D1-independent of cGMP pathway and partially reversed by p38 MAPK inhibitor. European journal of pharmacology, 2005, Jul-04, Volume: 517, Issue:1-2 Topics: Animals; Blotting, Northern; Blotting, Western; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Enzyme Inhibitors; G1 Phase; Gene Expression; Glomerular Mesangium; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanylate Cyclase; Imidazoles; Indazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Rats; RNA, Messenger; Signal Transduction; Solubility; Tumor Suppressor Proteins	2005
Comparative relaxant effects of YC-1 and DETA/NO on spontaneous contractions and the levels of cGMP of isolated pregnant rat myometrium. European journal of pharmacology, 2005, Jul-11, Volume: 517, Issue:3 Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indazoles; Male; Methylene Blue; Muscle Relaxation; Myometrium; Nitric Oxide Donors; Pregnancy; Rats; Rats, Wistar; Time Factors; Triazenes; Uterine Contraction	2005
Interference of neutrophil-platelet interaction by YC-1: a cGMP-dependent manner on heterotypic cell-cell interaction. European journal of pharmacology, 2005, Sep-05, Volume: 519, Issue:1-2 Topics: Adult; Antibodies; Blood Platelets; Calcium; Cathepsin G; Cathepsins; Cell Adhesion; Cell Communication; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flow Cytometry; Guanylate Cyclase; Humans; Indazoles; Intracellular Space; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxadiazoles; P-Selectin; Quinoxalines; Serine Endopeptidases; Time Factors	2005
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Carotid Arteries; Catheterization; Cyclic GMP; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Immunohistochemistry; Indazoles; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neovascularization, Pathologic; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2006
Comparative relaxant effects of YC-1 and DEA/NO on the sheep sphincter of Oddi. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2006, Volume: 6, Issue:3 Topics: Animals; Cyclic GMP; Hydrazines; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Neuromuscular Blocking Agents; Nitrogen Oxides; Sheep; Sphincter of Oddi	2006
Contractile performance of adult ventricular rat cardiomyocytes is not directly jeopardized by NO/cGMP-dependent induction of pro-apoptotic pathways. Journal of molecular and cellular cardiology, 2007, Volume: 42, Issue:2 Topics: Animals; Apoptosis; Caspase 3; Cell Movement; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Indazoles; Male; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Signal Transduction	2007
Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction? Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:4 Topics: Animals; Arginine; Cyclic GMP; Diaphragm; Drug Synergism; Electric Stimulation; Enzyme Activators; Exocytosis; Guanylate Cyclase; Indazoles; Intracellular Fluid; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Xanthines	2007
YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia. British journal of pharmacology, 2007, Volume: 151, Issue:3 Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activators; Gene Expression; Guanylate Cyclase; Indazoles; Lipopolysaccharides; Luciferases; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Proline; Quinoxalines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Thionucleotides	2007
Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression. Molecular pharmacology, 2007, Volume: 72, Issue:2 Topics: Animals; Blood-Brain Barrier; Cell Hypoxia; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Ischemia; Male; Membrane Proteins; Permeability; Phosphoproteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein	2007
Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Bucladesine; Calcium; Cell Adhesion Molecules; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Indazoles; Kinetics; Microfilament Proteins; Nucleotides, Cyclic; Oligopeptides; Peptide Fragments; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Thionucleotides; Thrombin	2007
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation. Cardiovascular research, 2007, Oct-01, Volume: 76, Issue:1 Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase; Vasodilator Agents	2007
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft. Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:5 Topics: Aged; Analysis of Variance; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Hydrazines; In Vitro Techniques; Indazoles; Male; Middle Aged; Nitric Oxide Donors; Oxadiazoles; Peptides; Phenylephrine; Potassium Channels, Calcium-Activated; Quinoxalines; Radial Artery; Vasoconstrictor Agents; Vasodilation	2007
Modulation of human monocyte-derived dendritic cells maturation by a soluble guanylate cyclase activator, YC-1, in a cyclic nucleotide independent manner. International immunopharmacology, 2007, Volume: 7, Issue:10 Topics: Cell Differentiation; Cell Proliferation; Cyclic AMP; Cyclic GMP; Dendritic Cells; Guanylate Cyclase; Humans; Immunologic Factors; Indazoles; Interleukin-10; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Phosphorylation; Receptors, CCR7; Receptors, Chemokine; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; T-Lymphocytes	2007
ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIalpha. Biochemical and biophysical research communications, 2008, Apr-18, Volume: 368, Issue:4 Topics: Animals; Atrial Natriuretic Factor; Calcium; Cell Membrane; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Hepatocytes; Indazoles; Male; Nitroprusside; Rats; Rats, Wistar; Thionucleotides	2008
An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase. The Journal of biological chemistry, 2008, Jul-04, Volume: 283, Issue:27 Topics: Adenosine Triphosphate; Adenylyl Cyclases; Allosteric Regulation; Animals; Cattle; Cyclic GMP; Enzyme Activation; Guanosine Triphosphate; Guanylate Cyclase; Indazoles; Kinetics; Lung; Models, Chemical; Nitric Oxide; Protein Structure, Tertiary; Pyrazoles; Pyridines; Pyrophosphatases; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Thermodynamics	2008
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus. Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 378, Issue:5 Topics: Animals; Carbon Monoxide; Cyclic GMP; Gastric Fundus; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Knockout; Organometallic Compounds; Oxadiazoles; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase	2008
Enhancement of active shuttle avoidance response by the NO-cGMP-PKG activator YC-1. European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3 Topics: Amygdala; Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Indazoles; Long-Term Potentiation; Male; MAP Kinase Signaling System; Nitric Oxide; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger	2008
Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Benzoates; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Guanylate Cyclase; Humans; Indazoles; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Confocal; Nitric Oxide; Oxadiazoles; Quinoxalines; Trabecular Meshwork	2009
Effect of nitric oxide/cyclic guanosine mono-phosphate pathway on gallbladder relaxant response in bile duct-ligated guinea pigs. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2009, Volume: 42, Issue:3 Topics: Amrinone; Animals; Arginine; Bile Ducts; Cyclic GMP; Gallbladder; Guanidines; Guinea Pigs; Hydrazines; In Vitro Techniques; Indazoles; Ligation; Male; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Papaverine; Piperazines; Purines; Sildenafil Citrate; Sulfones	2009
The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects. Journal of cardiovascular pharmacology and therapeutics, 2009, Volume: 14, Issue:2 Topics: Animals; Apoptosis; Carotid Artery Injuries; Cell Proliferation; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Guanylate Cyclase; Indazoles; Male; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley	2009
Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes. Journal of molecular and cellular cardiology, 2009, Volume: 47, Issue:2 Topics: Animals; Calcium Channels, L-Type; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activation; Guanylate Cyclase; Indazoles; Ion Channel Gating; Isoproterenol; Mice; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide Synthase Type III; Phosphodiesterase 5 Inhibitors; Purinones; Receptors, Adrenergic, beta; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase	2009
YC-1 enhances natural killer cell differentiation from hematopoietic stem cells. International immunopharmacology, 2010, Volume: 10, Issue:4 Topics: Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Fetal Blood; Flow Cytometry; Hematopoietic Stem Cells; Humans; Imidazoles; Indazoles; Killer Cells, Natural; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Interleukin-15; Signal Transduction; STAT5 Transcription Factor	2010
Development of nitrergic neurons in the nervous system of the locust embryo. The Journal of comparative neurology, 2010, Apr-15, Volume: 518, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Citrulline; Cyclic GMP; Embryo, Nonmammalian; Enzyme Activators; Ganglia, Invertebrate; Indazoles; Locusta migratoria; NADPH Dehydrogenase; Nerve Regeneration; Nervous System; Neurites; Neurons; Neuropil; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Signal Transduction	2010
YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway. Investigational new drugs, 2011, Volume: 29, Issue:6 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Humans; Indazoles; Nitric Oxide; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; Signal Transduction	2011
Protective effects of YC-1 against glutamate induced PC12 cell apoptosis. Cellular and molecular neurobiology, 2011, Volume: 31, Issue:2 Topics: Animals; Apoptosis; Bisbenzimidazole; Cell Shape; Cell Survival; Cyclic GMP; Drug Synergism; Glutamates; Indazoles; Oxadiazoles; PC12 Cells; Protective Agents; Quinoxalines; Rats; Staining and Labeling	2011
The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine. Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:2 Topics: Analgesics, Opioid; Animals; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; Indazoles; Male; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Soluble Guanylyl Cyclase	2011
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:3 Topics: Animals; Blotting, Western; Cell Line; Cyclic AMP; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Indazoles; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; Morpholines; Oxadiazoles; Oxazines; Phosphoric Diester Hydrolases; Pyrimidines; Quinoxalines; Rats; Transcription, Genetic	2011
Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction. Postepy higieny i medycyny doswiadczalnej (Online), 2011, Aug-05, Volume: 65 Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Guanylate Cyclase; Indazoles; Male; Muscle, Smooth; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Trachea	2011
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model. Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:10 Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Female; Fetal Growth Retardation; Guanylate Cyclase; Indazoles; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Pre-Eclampsia; Pregnancy; Proteinuria; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Second Messenger Systems; Suramin; Vasodilation; Vasodilator Agents	2013
YC-1 induces lipid droplet formation in RAW 264.7 macrophages. Journal of biomedical science, 2016, Jan-15, Volume: 23 Topics: Animals; Cell Line; Cyclic GMP; Indazoles; Lipid Droplets; Lipoproteins, LDL; Macrophages; Mice; Second Messenger Systems	2016
S-nitrosothiols dilate the mesenteric artery more potently than the femoral artery by a cGMP and L-type calcium channel-dependent mechanism. Nitric oxide : biology and chemistry, 2016, 08-31, Volume: 58 Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclic GMP; Cysteine; Diltiazem; Female; Femoral Artery; Fetus; Indazoles; Male; Mesenteric Arteries; Nifedipine; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Sheep; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents	2016