3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5h)-furanone has been researched along with indomethacin in 5 studies
| Studies (3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5h)-furanone) | Trials (3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5h)-furanone) | Recent Studies (post-2010) (3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5h)-furanone) | Studies (indomethacin) | Trials (indomethacin) | Recent Studies (post-2010) (indomethacin) |
|---|---|---|---|---|---|
| 25 | 0 | 2 | 29,527 | 1,838 | 3,396 |
| Protein | Taxonomy | 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5h)-furanone (IC50) | indomethacin (IC50) |
|---|---|---|---|
| Chain A, membrane-associated prostaglandin E synthase-2 | Macaca fascicularis (crab-eating macaque) | 1000 | |
| Prostaglandin-H2 D-isomerase | Mus musculus (house mouse) | 1.1 | |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | 5.8 | |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | 0.9994 | |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | 0.7764 | |
| Cytochrome c oxidase subunit 2 | Homo sapiens (human) | 0.34 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 0.5605 | |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | 0.004 | |
| Interleukin-8 | Homo sapiens (human) | 0.05 | |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | 0.004 | |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | 6 | |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | 5 | |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | 0.011 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 0.4848 | |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | 0.2 | |
| Thromboxane-A synthase | Homo sapiens (human) | 0.1 | |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | 0.082 | |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | 4.5 | |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | 5.7 | |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | 0.2 | |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | 0.2 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 1.5128 | |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | 0.5504 | |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | 3.4486 | |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | 0.2 | |
| C-X-C chemokine receptor type 3 | Homo sapiens (human) | 0.05 | |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | 8.97 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 3.4647 | |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | 0.4233 | |
| Solute carrier family 22 member 6 | Homo sapiens (human) | 3 | |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | 0.49 | |
| Rho-associated protein kinase 2 | Rattus norvegicus (Norway rat) | 7.7 | |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | 0.5461 | |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | 0.96 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brideau, C; Chan, CC; Charleson, S; Cromlish, W; Ethier, D; Evans, JF; Ford-Hutchinson, AW; Gauthier, JY; Gordon, R; Gresser, M; Guay, J; Kargman, S; Kennedy, B; Leblanc, Y; Léger, S; Mancini, J; O'Neill, GP; Ouellet, M; Percival, MD; Perrier, H; Prasit, P; Riendeau, D; Rodger, I; Wang, Z; Zamboni, R | 1 |
| Li, CS; Mancini, JA; Ouellet, M; Riendeau, D; Salem, M; Styhler, A | 1 |
| Belley, M; Black, SC; Bosquet, J; Brideau, C; Chan, CC; Cirino, M; Rodger, IW | 1 |
| Hétu, PO; Riendeau, D | 1 |
| Cebrián, C; Escartín, A; Esquivias, P; Esteva, F; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S | 1 |
5 other study(ies) available for 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5h)-furanone and indomethacin
| Article | Year |
|---|---|
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
Topics: Administration, Oral; Animals; Biological Availability; CHO Cells; Cricetinae; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Sulfones | 1999 |
Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.
Topics: Alcohols; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Humans; Isoenzymes; Membrane Proteins; Phenylpropionates; Prostaglandin-Endoperoxide Synthases | 2004 |
Differential effect of a selective cyclooxygenase-2 inhibitor versus indomethacin on renal blood flow in conscious volume-depleted dogs.
Topics: Animals; Blood Pressure; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Furans; Heart Rate; Indomethacin; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Renal Circulation; Renin | 1998 |
Cyclo-oxygenase-2 contributes to constitutive prostanoid production in rat kidney and brain.
Topics: Animals; Arachidonic Acid; Brain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Furans; Indomethacin; Kidney; Male; Prostaglandins; Pyrazoles; Rats; Rats, Sprague-Dawley; Substrate Specificity | 2005 |
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Barrett Esophagus; Cell Transformation, Neoplastic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Disease Progression; Esophageal Neoplasms; Esophagitis; Esophagus; Female; Furans; Gastroesophageal Reflux; Indomethacin; Membrane Proteins; Metaplasia; Mucous Membrane; Rats; Rats, Wistar; Time Factors | 2012 |