3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid has been researched along with selfotel in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 22 (73.33) | 18.2507 |
| 2000's | 2 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bigge, CF; Drummond, JT; Humblet, C; Johnson, G; Malone, TC; Ortwine, DF; Pinter, GW | 1 |
| Baron, BM; McDonald, IA; Miller, F; Muench, D; White, HS; Whitten, JP | 1 |
| Bigge, CF; Bobovski, TP; Brahce, LJ; Coughenour, LL; Drummond, JT; Hays, SJ; Johnson, G; Novak, PM; Rice, MJ | 1 |
| Chambers, JW; Deeter, JB; Huser, DL; Jones, ND; Leander, JD; Ornstein, PL; Paschal, JW; Schaus, JM; Wong, DT | 1 |
| Angst, C; Bernard, PS; Blanchard, L; de Jesus, R; Hutchison, AJ; Jackson, RH; Murphy, DE; Schneider, J; Williams, M; Wilusz, EJ | 1 |
| Baudy, RB; Bramlett, DR; Conklin, M; Emrey, TA; Greenblatt, LP; Jirkovsky, IL; Kowal, DM; Russo, RJ; Simmonds, JT; Stein, RP | 1 |
| Abou-Gharbia, M; Baudy, RB; Bramlett, DR; Fletcher, H; Katz, AH; Kowal, DM; Moyer, JA; Tasse, RP; Yardley, JP; Zaleska, MM | 1 |
| Morimoto, K; Sato, M | 1 |
| Davies, J; Harris, NC | 1 |
| Ohno, M; Watanabe, S; Yamamoto, T | 1 |
| French, ED | 1 |
| Inoue, K; Katayama, K; Morimoto, K; Sato, K | 1 |
| Parada-Turska, J; Turski, WA | 1 |
| Ferkany, JW; Kaplita, PV | 1 |
| Kim, HS; Lehmann, J; Martin, LL; Rao, TS; Wood, PL | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Dziki, M; Ikonomidou, C; Parada-Turska, J; Turski, WA; Urbanska, E | 1 |
| Boast, CA; Gerhardt, SC; Jarvis, MF; Murphy, DE; Williams, M | 1 |
| Loo, PS; Sills, MA; Williams, M | 1 |
| Boast, CA; Etienne, PE; Gerhardt, SC; Lehmann, J; Liebman, JM; Pastor, G | 1 |
| Boast, CA; Pastor, G | 1 |
| Bristow, LJ; Hutson, PH; Thorn, L; Tricklebank, MD | 1 |
| Hargreaves, RJ; Hill, RG; Iversen, LL; Rigby, M; Smith, D | 1 |
| Foster, AC; Grimwood, S; Wilde, GJ | 1 |
| Darlington, CL; Sansom, AJ; Smith, PF | 1 |
| French, ED; Mura, A; Wang, T | 1 |
| Bespalov, A; Zvartau, E | 1 |
| Abou-Gharbia, M; Bramlett, DR; Garrison, DT; Kinney, WA; Kowal, DM; Miller, TL; Moyer, JA; Schmid, J; Tasse, RP; Zaleska, MM | 1 |
| Furuya, Y; Kagaya, T; Nishizawa, Y; Ogura, H | 1 |
| Gemignani, A; Paudice, P; Pittaluga, A; Raiteri, M | 1 |
30 other study(ies) available for 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and selfotel
| Article | Year |
|---|---|
Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.
Topics: Binding, Competitive; Isoquinolines; Models, Molecular; Molecular Conformation; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
(R)-4-oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclic GMP; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kindling, Neurologic; Mice; Mice, Inbred DBA; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Valine | 1990 |
New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure-activity relationships and pharmacological evaluation.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; In Vitro Techniques; N-Methylaspartate; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptic Membranes | 1990 |
Synthesis and pharmacology of a series of 3- and 4-(phosphonoalkyl)pyridine- and -piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists.
Topics: Animals; Aspartic Acid; Binding, Competitive; Biological Assay; Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Molecular Conformation; Molecular Structure; N-Methylaspartate; Organophosphorus Compounds; Picolinic Acids; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
4-(Phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids: synthesis, activity at N-methyl-D-aspartic acid receptors, and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Aspartic Acid; Chemical Phenomena; Chemistry; Male; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1989 |
Potent quinoxaline-spaced phosphono alpha-amino acids of the AP-6 type as competitive NMDA antagonists: synthesis and biological evaluation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; In Vitro Techniques; Male; Mice; Models, Molecular; Molecular Conformation; N-Methylaspartate; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
Design, synthesis, SAR, and biological evaluation of highly potent benzimidazole-spaced phosphono-alpha-amino acid competitive NMDA antagonists of the AP-6 type.
Topics: Animals; Arterial Occlusive Diseases; Benzimidazoles; Binding, Competitive; Brain; Carotid Artery Diseases; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; In Vitro Techniques; Infarction, Middle Cerebral Artery; Male; Mice; Models, Molecular; Neuroprotective Agents; Organophosphonates; Propionates; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 2001 |
NMDA receptor complex and kindling mechanisms.
Topics: Amygdala; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Kindling, Neurologic; Kynurenic Acid; Male; Neural Pathways; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1992 |
Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Cats; Electric Stimulation; Neurons; Pipecolic Acids; Piperazines; Receptors, N-Methyl-D-Aspartate; Red Nucleus; Somatosensory Cortex; Synapses; Synaptic Transmission | 1992 |
Effects of intrahippocampal injections of N-methyl-D-aspartate receptor antagonists and scopolamine on working and reference memory assessed in rats by a three-panel runway task.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hippocampus; Male; Memory; N-Methylaspartate; Pipecolic Acids; Piperazines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Scopolamine | 1992 |
Competitive NMDA receptor antagonists attenuate phencyclidine-induced excitations of A10 dopamine neurons.
Topics: Action Potentials; Animals; Anticonvulsants; Binding, Competitive; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Male; N-Methylaspartate; Neurons; Phencyclidine; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical | 1992 |
Effects of competitive and noncompetitive NMDA receptor antagonists on kindling and LTP.
Topics: Animals; Binding, Competitive; Dizocilpine Maleate; Electric Stimulation; Evoked Potentials; Kindling, Neurologic; Male; Neuronal Plasticity; Pipecolic Acids; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Excitatory amino acid antagonists and memory: effect of drugs acting at N-methyl-D-aspartate receptors in learning and memory tasks.
Topics: Animals; Avoidance Learning; Dizocilpine Maleate; Male; Memory; Mice; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Receptors, N-Methyl-D-Aspartate; Reference Values | 1990 |
Evidence for direct interactions between the NMDA and glycine recognition sites in brain.
Topics: Amino Acids; Animals; Brain Chemistry; In Vitro Techniques; Kynurenic Acid; Male; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
Selective activation of dopaminergic pathways in the mesocortex by compounds that act at the phencyclidine (PCP) binding site: tentative evidence for PCP recognition sites not coupled to N-methyl-D-aspartate (NMDA) receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Carbazoles; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Ligands; Male; Neural Pathways; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereoisomerism | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Excitatory amino acid antagonists protect mice against seizures induced by bicuculline.
Topics: Animals; Bicuculline; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mice; Muscimol; Pipecolic Acids; Piperazines; Piperidines; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1990 |
The novel N-methyl-D-aspartate (NMDA) antagonist CGS 19755 prevents ischemia-induced reductions of adenosine A1, NMDA, and PCP receptors in gerbil brain.
Topics: Adenosine; Animals; Autoradiography; Female; Flunitrazepam; Gerbillinae; Image Processing, Computer-Assisted; Ischemic Attack, Transient; Pipecolic Acids; Piperazines; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
The NMDA antagonists, CPP and CGS 19755, lack affinity for central benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Brain; Flunitrazepam; In Vitro Techniques; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Rats; Receptors, GABA-A | 1988 |
The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils.
Topics: Animals; Aspartic Acid; Brain; Female; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Motor Activity; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines | 1988 |
Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electronic Data Processing; Female; Gerbillinae; Ketamine; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Time Factors | 1987 |
Competitive NMDA receptor antagonists attenuate the behavioural and neurochemical effects of amphetamine in mice.
Topics: Amphetamine; Animals; Binding, Competitive; Corpus Striatum; Dihydroxyphenylalanine; Drug Interactions; Glycine; Male; Mice; Motor Activity; Neurons; Nucleus Accumbens; Pipecolic Acids; Piperazines; Receptors, N-Methyl-D-Aspartate | 1994 |
Competitive as well as uncompetitive N-methyl-D-aspartate receptor antagonists affect cortical neuronal morphology and cerebral glucose metabolism.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Cerebral Cortex; Glucose; Male; Neurons; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Interactions between the glutamate and glycine recognition sites of the N-methyl-D-aspartate receptor from rat brain, as revealed from radioligand binding studies.
Topics: Aminoquinolines; Animals; Binding Sites; Brain; Glutamates; Glutamic Acid; Glycine; Ligands; Pipecolic Acids; Piperazines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
Comparison of the effects of pretreatment with competitive or noncompetitive NMDA antagonists on vestibular compensation.
Topics: Animals; Calcium; Calcium Channel Blockers; Ear, Inner; Female; Guinea Pigs; Male; Nystagmus, Physiologic; Pipecolic Acids; Piperazines; Receptors, N-Methyl-D-Aspartate; Vestibule, Labyrinth | 1993 |
MK-801, phencyclidine (PCP), and PCP-like drugs increase burst firing in rat A10 dopamine neurons: comparison to competitive NMDA antagonists.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Illicit Drugs; Male; N-Methylaspartate; Neurons; Phencyclidine; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques; Tegmentum Mesencephali; Vibrissae | 1993 |
NMDA receptor antagonists prevent conditioned activation of intracranial self-stimulation in rats.
Topics: Animals; Conditioning, Operant; Electric Stimulation; Excitatory Amino Acid Antagonists; Male; Photic Stimulation; Pipecolic Acids; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Self Stimulation | 1997 |
Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere.
Topics: Animals; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclobutanes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Ischemic Attack, Transient; Mice; Models, Chemical; N-Methylaspartate; Organophosphonates; Pipecolic Acids; Piperazines; Rats | 1998 |
Competitive NMDA receptor antagonists disrupt prepulse inhibition without reduction of startle amplitude in a dopamine receptor-independent manner in mice.
Topics: Analysis of Variance; Animals; Apomorphine; Binding, Competitive; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Pipecolic Acids; Piperazines; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Reflex, Startle | 1999 |
The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Cholecystokinin; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; HIV Envelope Protein gp120; HIV-1; Indoles; Kynurenic Acid; Male; Maleimides; Neurons; Nitroarginine; Peptide Fragments; Pipecolic Acids; Piperazines; Piperidines; Potassium; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Somatostatin; Synaptic Transmission; Synaptosomes; Zinc | 2000 |