3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid has been researched along with 2-amino-7-phosphonoheptanoic acid in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (34.29) | 18.7374 |
| 1990's | 20 (57.14) | 18.2507 |
| 2000's | 3 (8.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bramlett, D; Garrison, DT; Kinney, WA; Kowal, DM; Lee, NE; Notvest, RR; Podlesny, EJ; Simmonds, JT; Tasse, RP | 1 |
| Bigge, CF; Drummond, JT; Humblet, C; Johnson, G; Malone, TC; Ortwine, DF; Pinter, GW | 1 |
| Bigge, CF; Brahce, LJ; Coughenour, LL; Drummond, JT; Johnson, G; Marcoux, FW; Ortwine, DF; Probert, AW; Retz, DM | 1 |
| Baron, BM; McDonald, IA; Miller, F; Muench, D; White, HS; Whitten, JP | 1 |
| Bigge, CF; Bobovski, TP; Brahce, LJ; Coughenour, LL; Drummond, JT; Hays, SJ; Johnson, G; Novak, PM; Rice, MJ | 1 |
| Chambers, JW; Deeter, JB; Huser, DL; Jones, ND; Leander, JD; Ornstein, PL; Paschal, JW; Schaus, JM; Wong, DT | 1 |
| Bigge, CF; Brahce, LJ; Coughenour, LL; Drummond, JT; Johnson, G; Malone, T; Marcoux, FW; Probert, AW | 1 |
| Baudy, RB; Bramlett, DR; Conklin, M; Emrey, TA; Greenblatt, LP; Jirkovsky, IL; Kowal, DM; Russo, RJ; Simmonds, JT; Stein, RP | 1 |
| Abou-Gharbia, M; Baudy, RB; Bramlett, DR; Fletcher, H; Katz, AH; Kowal, DM; Moyer, JA; Tasse, RP; Yardley, JP; Zaleska, MM | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Hisanaga, K; Sagar, SM; Sharp, FR | 1 |
| Davies, J; Harris, NC | 1 |
| Alasuzoff, I; Briggs, RS; Cowburn, RF; Porter, RH; Roberts, PJ | 1 |
| Bieger, D; Neuman, RS; Wang, YT | 1 |
| Bazil, MK; Gordon, FJ | 1 |
| Insel, TR; Skolnick, P; Trullas, R; Winslow, JT | 1 |
| Crawford, RD; Johnson, DD; Pedder, SC; Tuchek, JM; Wilcox, RI | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Lanthorn, TH; Rader, RK; Watson, GB | 1 |
| Arnolde, SM; Nevins, ME | 1 |
| Ben-Ari, Y; Cherubini, E; Corradetti, R; Gaiarsa, JL | 1 |
| Lehmann, J; Tsai, C; Wood, PL | 1 |
| Ben-Ari, Y; Cherubini, E; Neuman, R | 1 |
| Beart, PM; Davies, SN; Jones, MG; Lodge, D; Manallack, DT; Millar, J; Ornstein, PL; Verberne, AJ; Young, N | 1 |
| Ho, PM; Tang, AH | 1 |
| Balster, RL; Willetts, J | 1 |
| Bradford, HF; Croucher, MJ; Sunter, DC; Watkins, JC | 1 |
| Boast, CA; Pastor, G | 1 |
| Berger, I; Gillis, RA; Kelly, M; Magee, S; McManigle, JE; Norman, WP; Panico, WH; Taveira DaSilva, AM; Vitagliano, S | 1 |
| Herrling, PL; Krucker, T; Meier, CL; Salt, TE; Seno, N | 1 |
| Ammendola, D; De Sarro, A; De Sarro, G; Nava, F | 1 |
| Hasegawa, T; Kameyama, T; Kinoshita, H; Nabeshima, T; Yamamoto, I | 1 |
| Bianchi, L; Giovannini, MG; Michelassi, A; Mutolo, D; Pepeu, G | 1 |
| Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME | 1 |
| Baviera, M; Calcagno, E; Carli, M; Ceglia, I; Invernizzi, RW; Renoldi, G | 1 |
35 other study(ies) available for 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and 2-amino-7-phosphonoheptanoic acid
| Article | Year |
|---|---|
Bioisosteric replacement of the alpha-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Carboxylic Acids; Male; Mice; N-Methylaspartate; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship | 1992 |
Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.
Topics: Binding, Competitive; Isoquinolines; Models, Molecular; Molecular Conformation; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced alpha-amino acids as competitive N-methyl-D-aspartic acid antagonists.
Topics: Amino Acids; Animals; Binding, Competitive; Brain; Cells, Cultured; Models, Molecular; Molecular Conformation; N-Methylaspartate; Organophosphonates; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
(R)-4-oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclic GMP; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kindling, Neurologic; Mice; Mice, Inbred DBA; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Valine | 1990 |
New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure-activity relationships and pharmacological evaluation.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; In Vitro Techniques; N-Methylaspartate; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptic Membranes | 1990 |
Synthesis and pharmacology of a series of 3- and 4-(phosphonoalkyl)pyridine- and -piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists.
Topics: Animals; Aspartic Acid; Binding, Competitive; Biological Assay; Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Molecular Conformation; Molecular Structure; N-Methylaspartate; Organophosphorus Compounds; Picolinic Acids; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists.
Topics: Amino Acids; Animals; Aspartic Acid; Chemical Phenomena; Chemistry; Male; Mice; N-Methylaspartate; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Potent quinoxaline-spaced phosphono alpha-amino acids of the AP-6 type as competitive NMDA antagonists: synthesis and biological evaluation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; In Vitro Techniques; Male; Mice; Models, Molecular; Molecular Conformation; N-Methylaspartate; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
Design, synthesis, SAR, and biological evaluation of highly potent benzimidazole-spaced phosphono-alpha-amino acid competitive NMDA antagonists of the AP-6 type.
Topics: Animals; Arterial Occlusive Diseases; Benzimidazoles; Binding, Competitive; Brain; Carotid Artery Diseases; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; In Vitro Techniques; Infarction, Middle Cerebral Artery; Male; Mice; Models, Molecular; Neuroprotective Agents; Organophosphonates; Propionates; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 2001 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
N-methyl-D-aspartate antagonists block fos-like protein expression induced via multiple signaling pathways in cultured cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Blotting, Northern; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glutamates; Glutamic Acid; Immunohistochemistry; N-Methylaspartate; Neurons; Piperazines; Proto-Oncogene Proteins c-fos; Signal Transduction | 1992 |
Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Cats; Electric Stimulation; Neurons; Pipecolic Acids; Piperazines; Receptors, N-Methyl-D-Aspartate; Red Nucleus; Somatosensory Cortex; Synapses; Synaptic Transmission | 1992 |
Heterogeneity of NMDA receptors labelled with [3H]3-((+-)-2-carboxypiperazin-4-yl) propyl-1-phosphonic acid ([3H]CPP): receptor status in Alzheimer's disease brains.
Topics: 2-Amino-5-phosphonovalerate; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids; Animals; Binding Sites; Brain Chemistry; Cerebral Cortex; Humans; In Vitro Techniques; Kinetics; Male; Piperazines; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1992 |
Activation of NMDA receptors is necessary for fast information transfer at brainstem vagal motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Brain Stem; Electric Stimulation; Evoked Potentials, Somatosensory; Histocytochemistry; Male; Medulla Oblongata; Motor Neurons; Neural Pathways; Piperazines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Vagus Nerve | 1991 |
Spinal NMDA receptors mediate pressor responses evoked from the rostral ventrolateral medulla.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Evoked Potentials; Female; Glutamates; Heart Rate; Medulla Oblongata; Microinjections; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Sympathetic Nervous System | 1991 |
Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Female; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Social Isolation; Vocalization, Animal | 1990 |
Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Chickens; Diaminopimelic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Fever; Phenotype; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Synaptic Membranes | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Epileptiform activity in vitro can produce long-term synaptic failure and persistent neuronal depolarization.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Epilepsy; Hippocampus; In Vitro Techniques; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1989 |
A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazole; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
Giant synaptic potentials in immature rat CA3 hippocampal neurones.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Animals, Newborn; Bicuculline; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Ketamine; Membrane Potentials; Phencyclidine; Picrotoxin; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Homocysteic acid as a putative excitatory amino acid neurotransmitter: I. Postsynaptic characteristics at N-methyl-D-aspartate-type receptors on striatal cholinergic interneurons.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Amino Acids; Animals; Choline; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Homocysteine; Interneurons; Magnesium; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Tachyphylaxis; Tiletamine | 1988 |
Epileptiform bursts elicited in CA3 hippocampal neurons by a variety of convulsants are not blocked by N-methyl-D-aspartate antagonists.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Hippocampus; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; In Vitro Techniques; N-Methylaspartate; Neurons; Piperazines; Rats; Reflex; Spine; Valine | 1988 |
Both competitive and non-competitive antagonists of N-methyl-D-aspartic acid disrupt brightness discrimination in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Light; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred F344 | 1988 |
The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Methohexital; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Inhibition of the development of electrical kindling of the prepyriform cortex by daily focal injections of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electrodes, Implanted; Electrophysiology; Glutamine; Injections; Kindling, Neurologic; Male; Piperazines; Rats; Rats, Inbred Strains | 1988 |
Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electronic Data Processing; Female; Gerbillinae; Ketamine; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Time Factors | 1987 |
NMDA receptors are involved at the ventrolateral nucleus tractus solitarii for termination of inspiration.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Apnea; Blood Pressure; Cats; Female; Heart Rate; Male; Microinjections; N-Methylaspartate; Piperazines; Pulmonary Ventilation; Receptors, N-Methyl-D-Aspartate; Respiration; Solitary Nucleus; Vagotomy | 1995 |
Thalamocortical and corticocortical excitatory postsynaptic potentials mediated by excitatory amino acid receptors in the cat motor cortex in vivo.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Cats; Electric Stimulation; Electrophysiology; Evoked Potentials; Female; Male; Motor Cortex; Piperazines; Pyramidal Tracts; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thalamus | 1995 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acids; Glutamine; Imipenem; Kynurenic Acid; Mice; Mice, Inbred DBA; Muscimol; Piperazines; Piperidines; Quinoxalines; Seizures | 1995 |
Competitive NMDA antagonists enhance the catalepsy induced by delta 9-tetrahydrocannabinol in mice.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amantadine; Amino Acids; Animals; Anticonvulsants; Catalepsy; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Ergolines; Haloperidol; Male; Mice; Mice, Inbred Strains; Motor Activity; Piperazines; Quinpirole; Receptors, N-Methyl-D-Aspartate; Scopolamine | 1994 |
NMDA receptor antagonists decrease GABA outflow from the septum and increase acetylcholine outflow from the hippocampus: a microdialysis study.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Amino Acids; Animals; Dizocilpine Maleate; gamma-Aminobutyric Acid; Hippocampus; Male; Microdialysis; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Septal Nuclei; Tetrodotoxin | 1994 |
Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anticonvulsants; Convulsants; Dizocilpine Maleate; Electroencephalography; Injections, Intraventricular; Male; Motor Cortex; Neuroprotective Agents; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Stereotaxic Techniques | 1996 |
The 5-HT receptor antagonist M100,907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Extracellular Space; Fluorobenzenes; Glutamic Acid; Male; Microdialysis; Nicotine; Piperazines; Piperidines; Potassium Chloride; Prefrontal Cortex; Rats; Receptor, Serotonin, 5-HT2A; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Tetrodotoxin | 2004 |