3-(2,4-dimethoxybenzylidene)anabaseine has been researched along with nicotine in 25 studies
| Studies (3-(2,4-dimethoxybenzylidene)anabaseine) | Trials (3-(2,4-dimethoxybenzylidene)anabaseine) | Recent Studies (post-2010) (3-(2,4-dimethoxybenzylidene)anabaseine) | Studies (nicotine) | Trials (nicotine) | Recent Studies (post-2010) (nicotine) |
|---|---|---|---|---|---|
| 166 | 8 | 81 | 28,519 | 2,280 | 9,302 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (40.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Liljefors, T | 1 |
| Enz, A; Feuerbach, D; Frederiksen, MU; Gentsch, C; Hurth, K; Müller, W; Nozulak, J; Roy, BL | 1 |
| Arendash, GW; Kem, WR; Sanberg, PR; Sengstock, GJ | 1 |
| Akaike, A; Kihara, T; Kimura, J; Kochiyama, H; Kume, T; Maeda, T; Sawada, H; Shimohama, S | 1 |
| Kasahara, N; Miyake, H; Nanri, M; Watanabe, H; Yamamoto, J | 2 |
| Miyake, H; Nanri, M; Watanabe, H; Yamamoto, J | 1 |
| Arneric, SP; Delbono, O; Gopalakrishnan, M; Messi, ML; Molinari, EJ; Renganathan, M; Sullivan, JP | 1 |
| Gurley, DA; Lanthorn, TH | 1 |
| Akaike, A; Kihara, T; Shimohama, S | 1 |
| Anderson, KG; Haworth, SC; Kem, WR; van Haaren, F | 1 |
| Papke, RL | 1 |
| Margiotta, JF; McIntosh, JM; Nai, Q | 1 |
| Woodruff-Pak, DS | 1 |
| Briggs, CA; Gopalakrishnan, M; Grønlien, JH; Håkerud, M; Malysz, J; Thorin-Hagene, K; Ween, H | 1 |
| Hoedemaekers, CW; Kox, M; Pickkers, P; Pompe, JC; van der Hoeven, JG; van Velzen, JF | 1 |
| Al-Abed, Y; Chatterjee, PK; Metz, CN; Sherry, B | 1 |
| Bruchfeld, A; Chavan, S; Goldstein, RS; Kohn, N; Patel, NB; Qureshi, AR; Rosas-Ballina, M; Tracey, KJ | 1 |
| Freedman, R; Olincy, A | 1 |
| Koo, G; Qing, X; Redecha, P; Salmon, JE; Vukelic, M | 1 |
| Freedman, R | 1 |
| Fukunaga, K; Inagaki, R; Moriguchi, S; Sakagami, H; Shibata, M; Yi, L | 1 |
| Ashby, CR; Daley, LA; Gauthier, AG; Kennedy, TP; Lin, M; Mantell, LL; Wu, J | 1 |
| Gunn, MD; Huang, MN; Liddle, RA; Shahid, RA; Vigna, SR | 1 |
5 review(s) available for 3-(2,4-dimethoxybenzylidene)anabaseine and nicotine
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Humans; Ligands; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Protein Subunits; Receptors, Nicotinic | 2005 |
Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the α7 nicotinic receptor.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Humans; Nicotine; Nicotinic Agonists; Psychotic Disorders; Pyridines; Receptors, Nicotinic; Reflex, Startle; Smoking | 2012 |
α7-nicotinic acetylcholine receptor agonists for cognitive enhancement in schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Benzylidene Compounds; Cognition; Eye Movements; Fetal Development; Humans; Memory; Nicotine; Nicotinic Agonists; Pyridines; Schizophrenia; Sensory Gating; Smoking | 2014 |
From nicotine to the cholinergic anti-inflammatory reflex - Can nicotine alleviate the dysregulated inflammation in COVID-19?
Topics: alpha7 Nicotinic Acetylcholine Receptor; Antibodies, Monoclonal, Humanized; Benzylidene Compounds; Cholinergic Agents; Cigarette Smoking; COVID-19 Drug Treatment; Dexamethasone; HMGB1 Protein; Humans; Inflammation; Nicotine; Pandemics; Pyridines; SARS-CoV-2; Tobacco Use Disorder | 2021 |
20 other study(ies) available for 3-(2,4-dimethoxybenzylidene)anabaseine and nicotine
| Article | Year |
|---|---|
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Brain; Humans; Lactams; Mice; Nicotinic Agonists; Protein Binding; Rabbits; Receptors, Nicotinic | 2009 |
Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21.
Topics: Aging; Anabasine; Animals; Avoidance Learning; Benzylidene Compounds; Cognition; Learning; Male; Maze Learning; Memory; Memory, Short-Term; Nicotine; Nicotinic Agonists; Psychotropic Drugs; Pyridines; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity.
Topics: Amyloid beta-Peptides; Animals; Benzylidene Compounds; Bungarotoxins; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetus; Hexamethonium; Mecamylamine; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Pyridines; Rats; Receptors, Nicotinic | 1997 |
GTS-21, a nicotinic agonist, protects against neocortical neuronal cell loss induced by the nucleus basalis magnocellularis lesion in rats.
Topics: Animals; Benzylidene Compounds; Cell Death; Cerebral Cortex; Male; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Wistar; Substantia Innominata | 1997 |
Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzylidene Compounds; Brain Ischemia; Cell Death; GABA Modulators; Gerbillinae; Male; Memory; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Pentobarbital; Pyramidal Cells; Pyridines; Tacrine | 1998 |
Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Benzylidene Compounds; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Dimethylphenylpiperazinium Iodide; Humans; Insecticides; Iodine Radioisotopes; Kidney; Kinetics; Ligands; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Transfection; Up-Regulation | 1998 |
Nicotinic agonists competitively antagonize serotonin at mouse 5-HT3 receptors expressed in Xenopus oocytes.
Topics: Acetylcholine; Animals; Bacterial Toxins; Benzylidene Compounds; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Choline; Cyanobacteria Toxins; Dimethylphenylpiperazinium Iodide; DNA, Complementary; Female; Marine Toxins; Mice; Microcystins; Multigene Family; Nicotine; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Pyridines; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Serotonin Antagonists; Structure-Activity Relationship; Xenopus laevis | 1998 |
A comparative study on the effects of nicotine and GTS-21, a new nicotinic agonist, on the locomotor activity and brain monoamine level.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzylidene Compounds; Biogenic Monoamines; Blood Pressure; Brain; Cats; Cerebral Cortex; Dopamine; Heart Rate; Homovanillic Acid; Male; Motor Activity; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Wistar; Respiration | 1998 |
Effects of nicotinic receptor agonists on beta-amyloid beta-sheet formation.
Topics: Alkaloids; Amyloid beta-Peptides; Azocines; Benzylidene Compounds; Hydrogen-Ion Concentration; Nicotine; Nicotinic Agonists; Protein Structure, Secondary; Pyridines; Quinolizines | 1999 |
GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Anabasine; Animals; Azocines; Benzylidene Compounds; Cues; Discrimination Learning; Discrimination, Psychological; Generalization, Stimulus; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Rats; Rats, Long-Evans; Receptors, Nicotinic | 1999 |
Enhanced inhibition of a mutant neuronal nicotinic acetylcholine receptor by agonists: protection of function by (E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403).
Topics: Acetylcholine; Amino Acid Sequence; Animals; Benzylidene Compounds; Electrophysiology; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pyridines; Rats; Receptors, Nicotinic; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 2002 |
Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function.
Topics: Animals; Benzylidene Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Chick Embryo; Cholinergic Antagonists; Conotoxins; Kinetics; Neurons; Nicotine; Nicotinic Agonists; Protein Subunits; Pyridines; Receptors, Nicotinic | 2003 |
Mecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits tested with delay eyeblink classical conditioning.
Topics: Animals; Benzylidene Compounds; Blinking; Conditioning, Eyelid; Drug Interactions; Female; Mecamylamine; Memory Disorders; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents; Pyridines; Rabbits | 2003 |
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Benzylidene Compounds; Bridged Bicyclo Compounds; Calcium; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Genistein; Humans; Indoles; Isoxazoles; Kidney; Microinjections; Naphthalenes; Nicotine; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein-Tyrosine Kinases; Pyridines; Quinolines; Receptors, Cholinergic; Receptors, Nicotinic; Sensitivity and Specificity; Sulfonamides; Xenopus laevis | 2007 |
GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anti-Inflammatory Agents, Non-Steroidal; Benzylidene Compounds; Cells, Cultured; Cytokines; Down-Regulation; Drug Partial Agonism; Enzyme Activation; Humans; Inflammation; Janus Kinase 2; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphorylation; Pyridines; Receptors, Nicotinic; Signal Transduction; STAT3 Transcription Factor; Toll-Like Receptors; Transcription, Genetic | 2009 |
Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation.
Topics: Benzylidene Compounds; Blotting, Western; Cells, Cultured; Chemokine CCL2; Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Janus Kinase 2; Nicotine; Nicotinic Agonists; Phosphorylation; Pyridines; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins | 2009 |
Whole blood cytokine attenuation by cholinergic agonists ex vivo and relationship to vagus nerve activity in rheumatoid arthritis.
Topics: Adult; Aged; alpha7 Nicotinic Acetylcholine Receptor; Arthritis, Rheumatoid; Benzylidene Compounds; C-Reactive Protein; Case-Control Studies; Cholinergic Agonists; Cytokines; Dose-Response Relationship, Immunologic; Female; Heart Rate; HMGB1 Protein; Humans; Lipopolysaccharides; Male; Middle Aged; Nicotine; Prospective Studies; Pyridines; Receptors, Nicotinic; Tissue Culture Techniques; Tumor Necrosis Factor-alpha; Vagus Nerve | 2010 |
Cholinergic receptors modulate immune complex-induced inflammation in vitro and in vivo.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Ascitic Fluid; Benzylidene Compounds; Cell Adhesion; Cells, Cultured; Chemokine CXCL1; Chemotaxis, Leukocyte; Complement C5a; Cytokines; Female; Humans; I-kappa B Kinase; Immune Complex Diseases; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Nicotine; Nicotinic Agonists; Phagocytes; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Reactive Oxygen Species; Receptor, Anaphylatoxin C5a; Receptors, IgG; Recombinant Proteins; Respiratory Burst; Specific Pathogen-Free Organisms | 2013 |
Nicotine Rescues Depressive-like Behaviors via α7-type Nicotinic Acetylcholine Receptor Activation in CaMKIV Null Mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzamides; Benzylidene Compounds; Brain-Derived Neurotrophic Factor; Bridged Bicyclo Compounds; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Depression; Extracellular Signal-Regulated MAP Kinases; Mice, Knockout; Models, Biological; Neurogenesis; Nicotine; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines | 2020 |
Nicotinic stimulation of splenic T cells is protective in endoscopic retrograde cholangiopancreatography-induced acute pancreatitis in mice.
Topics: Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholangiopancreatography, Endoscopic Retrograde; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Pancreatitis; Spleen; T-Lymphocytes | 2022 |